Irish Child Health Database - Peer Reviewed Papers
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Infant, Newborn
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The aim of this study was to assess the incidence of meconium that can only have been passed intrapartum and to determine its neonatal associations and whether its absence is a useful sign
Abstract:
OBJECTIVE: Clear amniotic fluid is frequently considered a reassuring sign during labor. Our aim was to examine the incidence of meconium that can only have been passed intrapartum and to determine its neonatal associations and whether its absence is a useful sign. METHODS: This was a prospective cohort study of 8394 "low risk" laboring women at term with clear amniotic fluid more...
International Classification:
Evaluation of the impact of intrapartum meconium monitoring on managing pregnant women
Categories:
intrapartum meconium
Geography:
Republic of Ireland and the United Kingdom
Obstet Gynecol,
Vol: 102 Page: 89-93 July 2003
C. Greenwood; S. Lalchandani; K. MacQuillan; O. Sheil; J. Murphy; L. Impey
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This article discusses the guidelines concerning procedural pain management in the neonate
Geography:
Republic of Ireland
Paediatr Anaesth,
Vol: 18 Suppl 1 Page: 19-35 May 2008
R. Howard; B. Carter; J. Curry; N. Morton; K. Rivett; M. Rose; J. Tyrrell; S. Walker; G. Williams
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This article discusses the pain control nurse's role in anticipating and safely and effectively controlling pain in children
Abstract:
Pain should be anticipated and safely and effectively controlled in all children. The pain control nurse specialist is vital to achieving this. Alison Moore reports. more...
Geography:
Republic of Ireland
World of Irish Nursing & Midwifery,
Vol: 13 Page: 39-39 2005
A. Moore
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This article discusses megacystis microcolon intestinal hypoperistalsis syndrome
Abstract:
Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare and the most severe form of functional intestinal obstruction in the newborn. The major features of this congenital and usually lethal anomaly are abdominal distension, bile-stained vomiting, and absent or decreased bowel peristalsis. Abdominal distension is a consequence of the distended, unobstructed urinary more...
Geography:
Republic of Ireland
Semin Pediatr Surg,
Vol: 14 Page: 58-63 February 2005
P. Puri; M. Shinkai
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This article discusses the meningococcus C vaccination programme
Geography:
Republic of Ireland
Ir Med J,
Vol: 93 Page: 164 September 2000
J. F. Murphy
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This case report discusses a 3-year-old girl with severe microgastria and total amelia who has been managed conservatively with minimal surgical intervention.
Abstract:
The Microgastria-limb reduction anomaly is a rare disorder of unknown aetiology in which microgastria is associated with limb defects, along with splenic and other variable congenital abnormalities. In 15 previously reported cases, none have had the most extreme form of amelia. We report the clinical progress of a 3-year-old girl with severe microgastria and total amelia who has been more...
International Classification:
Other - microgastria
Categories:
microgastria
Geography:
Northern Ireland
Clin Dysmorphol,
Vol: 11 Page: 187-90 July 2002
C. Stewart; M. Stewart; F. Stewart
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These case reports discuss two infants with miliary neonatal hemangiomatosis who had fulminant cardiac failure and cardiac septal hypertrophy
Abstract:
Miliary neonatal hemangiomatosis is a rare, life-threatening condition associated with cutaneous and multiorgan involvement. We report two infants with this condition who had fulminant cardiac failure and cardiac septal hypertrophy. The first was a 5-day-old boy who presented with increasing numbers of cutaneous hemangiomata associated with worsening cardiac failure. Magnetic resonance more...
International Classification:
Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism - Report
Categories:
hemangiomatosis
Geography:
Northern Ireland
Pediatr Dermatol,
Vol: 21 Page: 469-72 2004 Jul-Aug
A. H. O'Hagan; A. D. Irvine; A. Sands; D. O'Donaghue; F. Casey; E. A. Bingham
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The aim of this study was to examine isolate different strains of the genus Bifidobacterium from the fecal material of neonates and to assess their ability to produce the cis-9, trans-11 conjugated linoleic acid (CLA) isomer from free linoleic acid
Abstract:
This study was designed to isolate different strains of the genus Bifidobacterium from the fecal material of neonates and to assess their ability to produce the cis-9, trans-11 conjugated linoleic acid (CLA) isomer from free linoleic acid. Fecal material was collected from 24 neonates aged between 3 days and 2 months in a neonatal unit (Erinville Hospital, Cork, Ireland). A total of 46 more...
International Classification:
Bacterium - genus Bifidobacterium
Categories:
genus Bifidobacterium
Geography:
Republic of Ireland
Appl Environ Microbiol,
Vol: 70 Page: 4635-41 August 2004
E. Rosberg-Cody; R. P. Ross; S. Hussey; C. A. Ryan; B. P. Murphy; G. F. Fitzgerald; R. Devery; C. Stanton
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This article discusses some of the factors involved in normal and abnormal lung modelling and inflammation and glucocorticosteroid-induced remodelling in the perinatal period, in the context of neonatal chronic lung disease, are reviewed
Abstract:
Neonatal chronic lung disease (CLD) is the major long-term pulmonary complication of preterm birth affecting about 20% of infants who need mechanical ventilation. CLD is the result of abnormal repair processes following inflammatory lung injury that lead to remodeling of the lung. Inflammation may be initiated by a variety of stimuli including mechanical ventilation, oxygen toxicity and more...
Geography:
Northern Ireland
Treat Respir Med,
Vol: 4 Page: 347-59 2005
D. G. Sweet; H. L. Halliday
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The aim of this review was to determine if moderately early postnatal corticosteroid treatment vs control (placebo or nothing) is of benefit in the prevention and/or treatment of early chronic lung disease in the preterm infant
Abstract:
BACKGROUND: Corticosteroids have been used late in the neonatal period to treat chronic lung disease (CLD) in preterm babies and early to try to prevent it. CLD is likely to be the result of persisting inflammation in the lung and the use of powerful anti-inflammatory drugs like dexamethasone has some rationale. Early use tends to be associated with increased adverse effects so that more...
International Classification:
Systematic Review
Geography:
Systematic Review
Cochrane Database Syst Rev,
2001
H. L. Halliday; R. A. Ehrenkranz
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This study aimed to explore deaths in neonatal intensive care units
Abstract:
With the ever-increasing availability of aggressive medical treatment and technical support, neonatologists are offered an increasing ability to prolong life. While "end-of-life" decisions within NICUs have been studied internationally, there is limited data available for Ireland. Through the auspices of the Irish Faculty of Paediatrics 2002 Neonatal Mortality Ouestionnaire, more...
International Classification:
Practice/knowledge - intensive care neonatal deaths
Categories:
intensive care neonatal deaths
Geography:
Republic of Ireland
Ir Med J,
Vol: 99 Page: 106-8 April 2006
E. Finan; T. Bolger; S. M. Gormally
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The article discusses modulation of immune cell function by polyunsaturated fatty acids
Abstract:
The n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential dietary constituents. They are important as a source of energy, as structural components of cell membranes, and as signalling molecules. They have been demonstrated to be potent modulators of the immune response, and research has endeavoured to optimise the ratio of n-3 to n-6 PUFAs in the lipid component of total more...
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 21 Page: 335-40 May 2005
B. Sweeney; P. Puri; D. J. Reen
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This case report discusses a case of Moebius sequence and hypogonadotrophic hypogonadism with detailed neurologic, endocrine, and autopsy findings
Abstract:
A distinct form of Moebius sequence is associated with hypogonadotrophic hypogonadism. There have been five such cases to date. We now add a further case with detailed neurologic, endocrine, and autopsy findings and offer a hypothesis drawing parallels with the already established basis of hypogonadotrophic hypogonadism in the X-linked form of Kallman syndrome. more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Report
Categories:
Moebius sequence; hypogonadotrophic hypogonadism
Geography:
Republic of Ireland
Am J Med Genet A,
Vol: 123A Page: 107-10 November 2003
J. E. Jennings; C. Costigan; W. Reardon
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The aim of this study was to examine temporal changes in the morbidity and mortality persons with perinatally acquired HIV infection, many of whom are now adolescents.
Abstract:
BACKGROUND: Recent evidence suggests that decreases in morbidity and mortality in cohorts of adults infected with human immunodeficiency virus (HIV) are showing signs of reversal. We describe changes over time in these characteristics and in the response to treatment among children in the United Kingdom and Ireland with perinatally acquired HIV infection, many of whom are now more...
International Classification:
Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV
Categories:
perinatally acquired HIV infection
Geography:
Republic of Ireland and the United Kingdom
Clin Infect Dis,
Vol: 45 Page: 918-24 October 2007
A. Judd; K. Doerholt; P. A. Tookey; M. Sharland; A. Riordan; E. Menson; V. Novelli; E. G. Lyall; J. Masters; G. Tudor-Williams; T. Duong; D. M. Gibb
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The aim of the study was to compare surfactant administration to infants born at less than 32 weeks gestation was compared between two time periods (1 April 1994 to 31 March 1996 and 1 April 1999 to 31 March 2001)
Abstract:
Surfactant administration to infants born at less than 32 weeks gestation was compared between two time periods (1 April 1994 to 31 March 1996 and 1 April 1999 to 31 March 2001). Overall administration increased significantly from 41% to 54%, and within one hour of birth from 13% to 60%. Regional data collection and feedback helps promote quality improvement and implementation of more...
International Classification:
Other - Surfactant administration
Categories:
Surfactant administration
Geography:
Northern Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 91 Page: F125-6 March 2006
J. L. Hughes; E. McCall; F. Alderdice; J. Jenkins
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This study determined the feasibility and efficacy of morphine sedation/analgesia in the laser treatment of retinopathy of prematurity
Abstract:
PURPOSE: To determine the feasibility and efficacy of morphine sedation/analgesia in the laser treatment of retinopathy of prematurity (ROP). METHODS: A retrospective study was carried out on all infants who underwent laser treatment for ROP over a 7 year period. Morphine infusion commenced 6 hrs prior to treatment at a rate of 10 microg/kg/hr. This rate increased to 20 microg/kg/hr at more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - retinopathy of prematurity
Categories:
retinopathy of prematurity
Geography:
Republic of Ireland
Acta Ophthalmol Scand,
Vol: 85 Page: 644-7 September 2007
C. Kirwan; M. O'Keefe; M. Prendergast; A. Twomey; J. Murphy
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The aim of this study was to examine colorectal cancer mortality predictions for Ireland for all ages and for the age group 0-64 years.
Abstract:
OBJECTIVE: Colorectal cancer mortality predictions for Ireland are presented for all ages and for the age group 0-64 years. METHODS: Log and log-linear Poisson regression modelling was fitted to colorectal cancer mortality data for each year between 1950 and 2002 to predict average European age standardized mortality rates (EASMRs) per 100,000 person years (100,000 PY(-1)) and average more...
International Classification:
Deaths - colorectal cancer
Categories:
colorectal cancer mortality
Geography:
Republic of Ireland
Colorectal Dis,
Vol: 8 Page: 393-401 June 2006
P. O'Lorcain; S. Deady; H. Comber
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The aim of this study was to examine the effect of risk factors, including mode of delivery, on the vertical transmission rate of hepatitis C
Abstract:
BACKGROUND: Little information is available about the timing of mother-to-child transmission of hepatitis C virus (HCV), and no interventions to decrease transmission rates have been identified. We examined the effect of risk factors, including mode of delivery, on the vertical transmission rate. METHODS: Data from HCV-infected women and their infants from three hospitals in Ireland and more...
International Classification:
Certain infectious and parasitic diseases - Viral hepatitis - hepatitis C
Categories:
hepatitis C
Geography:
Republic of Ireland and the United Kingdom
Lancet,
Vol: 356 Page: 904-7 September 2000
D. M. Gibb; R. L. Goodall; D. T. Dunn; M. Healy; P. Neave; M. Cafferkey; K. Butler
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The aim of this study was to examine the hypothesize that neuromotor and executive-function deficits may independently contribute to school failure in extreme premature birth and motor and executive function at 6 years of age
Abstract:
BACKGROUND: Studies of very preterm infants have demonstrated impairments in multiple neurocognitive domains. We hypothesized that neuromotor and executive-function deficits may independently contribute to school failure. METHODS: We studied children who were born at < or = 25 completed weeks' gestation in the United Kingdom and Ireland in 1995 at early school age. Children underwent more...
International Classification:
Premature - births
Categories:
school failure
Geography:
Republic of Ireland and the United Kingdom
Pediatrics,
Vol: 120 Page: 793-804 October 2007
N. Marlow; E. M. Hennessy; M. A. Bracewell; D. Wolke
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This study aimed to describe a multi-channel method for patient specific and patient independent, EEG based neonatal seizure detection
Abstract:
A multi-channel method for patient specific and patient independent, EEG based neonatal seizure detection is presented. Two classifier configurations are proposed and tested, along with a number of classifier models. Existing methods for neonatal seizure detection have been empirical threshold based or based on a single EEG channel. The optimum patient specific classifier for EEG based more...
International Classification:
Effectiveness of measurement tool - EEG based neonatal seizure detection
Categories:
EEG based neonatal seizure detection
Geography:
Republic of Ireland and the United Kingdom
Conf Proc IEEE Eng Med Biol Soc,
Vol: 1 Page: 4679-84 2006
B. R. Greene; R. B. Reilly; G. Boylan; P. de Chazal; S. Connolly
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This study aimed to describe the technique of reconstructing 3D volume-reformatted 'transparency' images using insufflated air as a negative contrast medium
Abstract:
Oesophageal atresia (OA) is an important congenital malformation in which prompt diagnosis and appropriate management can significantly improve outcome. The surgical approach to repair of OA and associated tracheo-oesophageal fistulae (TOF) depends upon correct evaluation of the tracheobronchial tree. Three-dimensional imaging of the tracheobronchial tree using CT data to produce shaded more...
International Classification:
Effectiveness of measurement tool - reconstructing 3D volume-reformatted 'transparency' images using insufflated air as a negative contrast medium
Geography:
Northern Ireland
Pediatr Radiol,
Vol: 35 Page: 624-6 June 2005
J. A. Soye; J. Yarr; A. C. Dick; A. Paterson
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This case report discusses a patient in whom Infantile myofibromatosis was diagnosed, on the basis of multiple soft tissue tumours present from birth, who subsequently developed generalized and ultimately fatal fibromuscular dysplasia
Abstract:
Infantile myofibromatosis (IM) is a condition characterized by the formation of spindle cell tumors of skin, soft tissue, and viscera. Although small vessel involvement by the process is a frequently identified and indeed diagnostically useful histological finding, involvement of large vessels is not widely reported. Fibromuscular dysplasia (FMD) is a noninflammatory arteriopathy more...
International Classification:
Diseases of the skin and subcutaneous tissue - Report
Categories:
Infantile myofibromatosis
Geography:
Republic of Ireland
Pediatr Dev Pathol,
Vol: 7 Page: 385-90 2004 Jul-Aug
C. Wright; M. T. Corbally; R. Hayes; M. B. McDermott
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This case report discusses multiple airway abnormalities in a patient with Rothmund-Thomson syndrome
Abstract:
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder that is characterized by skin manifestations, juvenile cataracts, and extracutaneous manifestations. The presence of congenital airway abnormalities has not previously been documented in Rothmund-Thomson syndrome. We report the case of a child with Rothmund-Thomson syndrome suffering from multiple airway more...
International Classification:
Syndrome
Categories:
Rothmund-Thomson syndrome
Geography:
Republic of Ireland
Int J Pediatr Otorhinolaryngol,
Vol: 68 Page: 469-72 April 2004
M. A. Hafidh; P. Sheahan; J. D. Russell
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The aim of this study was to examine the prevalence of multiple sclerosis in Northern Ireland
Abstract:
The uneven worldwide distribution of multiple sclerosis has been of interest to epidemiologists, neurologists and statisticians for over a century, prevalence rates for the disease apparently being determined by variations in age, gender, geography, race and ethnic group. Northern Ireland has been recognised as an area of high MS prevalence since the truly seminal work of Allison and more...
International Classification:
Diseases of the nervous system - Demyelinating diseases of the central nervous system - multiple sclerosis
Categories:
multiple sclerosis
Geography:
Northern Ireland
Ulster Med J,
Vol: 69 Page: 97-105 November 2000
G. V. McDonnell; S. A. Hawkins
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This study discusses the occurrence of mumps in Ireland 2004-2008
International Classification:
Surveillance - Certain infectious and parasitic diseases - Other viral diseases - mumps
Categories:
mumps
Geography:
Republic of Ireland
Euro Surveill,
Vol: 13 Page: April 2008
S. Gee; D. O'Flanagan; M. Fitzgerald; S. Cotter
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The aim of this study was to examine the expression of each mAChR subtype in aganglionic colon to further understand the pathophysiology of Hirschsprung's disease
Abstract:
In Hirschsprung's disease (HD) there exists an overabundance of acetylcholine (ACh), which in turn stimulates excessive production of the enzyme acetylcholinesterase. Muscarinic ACh receptors (mAChRs) play an important role in smooth-muscle contraction. Recent studies have indicated five different subtypes of mAChRs encoded by five different genes, ml to m5. The purpose of this study more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
expression of mAChR subtypes; Hirschsprung's disease
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 16 Page: 267-71 2000
T. Oue; A. Yoneda; H. Shima; P. Puri
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The aim of this study was to examine DNA variants in the RET gene in total intestinal aganglionosis patients using the WAVE DNA Fragment Analysis System
Abstract:
BACKGROUND/PURPOSE: Total intestinal aganglionosis (TIA) extending from the duodenum to the rectum is the most rare form of Hirschprung's disease (HSCR) and usually is fatal. RET is the major gene associated with HSCR, and germline mutations of this gene account for up 50% of familial and up to 15 to 20% of sporadic cases in HSCR. The aim of this study was to investigate DNA variants in more...
International Classification:
Other - intestinal aganglionosis
Categories:
total intestinal aganglionosis
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 497-501 March 2003
V. Solari; S. Ennis; A. Yoneda; L. Wong; A. Messineo; M. E. Hollwarth; A. Green; P. Puri
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The aim of this study was to undertake an national audit of neonatal intubation practices
International Classification:
Factors influencing health status and contact with health services - persons encountering health services for examination and investigation - neonatal intubation
Categories:
neonatal intubation practices
Geography:
Republic of Ireland
Ir Med J,
Vol: 98 Page: 118-9 April 2005
C. S. O'Gorman; R. Bhatia; W. A. Gorman; A. Twomey
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The aim of this study was to examine the incidence meningococcal disease and the enhanced surveillance of meningococcal disease (ESMD) which was implemented nationally across ten regions of England, Wales and Northern Ireland from 1 January 1999.
Abstract:
Enhanced surveillance of meningococcal disease (ESMD) was implemented nationally across ten regions of England, Wales and Northern Ireland from 1 January 1999. It aims to deliver more sensitive surveillance than laboratory reporting by including clinically diagnosed but laboratory unconfirmed cases. Consultants in Communicable Disease Control (CsCDC) report all clinically diagnosed more...
International Classification:
Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease
Categories:
meningococcal disease
Geography:
the United Kingdom
Epidemiol Infect,
Vol: 129 Page: 459-70 December 2002
M. Shigematsu; K. L. Davison; A. Charlett; N. S. Crowcroft
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This article discusses national guidelines for the active management of HIV in pregnancy
Abstract:
The number of HIV positive women becoming pregnant in Ireland is increasing, with many pregnancies occurring in women from countries of high HIV prevalence. The management of such patients offers the challenge of reducing the risk of maternal-fetal transmission of HIV infection, avoiding fetal-infant toxicities, and maintaining future maternal antiretroviral options. Guidelines for the more...
Geography:
Republic of Ireland
Ir Med J,
Vol: 94 Page: 137-40 May 2001
S. Clarke; K. Butler; C. Bergin; F. Lyons; G. Sheehan; M. Horgan; F. Mulcahy
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This article reviews the reasons for the low initiation rates of breastfeeding among Irish women
Abstract:
Embarrassment and lack of employer support are just two reasons why breastfeeding initiation rates are so low among Irish women write Claire O'Donnell and Rhona O'Connell. more...
Geography:
Republic of Ireland
World of Irish Nursing & Midwifery,
Vol: 15 Page: 18-19 2007
C. O'Donnell; R. O'Connell
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This article discusses reasons for the currently low rates for vaginal births after caesarean (VBAC) in Ireland
Geography:
Republic of Ireland
AIMS Journal,
Vol: 14 Page: 9-10 2002
J. Stephenson; J. Wright
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This article discusses necrotising enterocolitis and localised intestinal perforation
Geography:
Northern Ireland
Pediatr Surg Int,
Vol: 22 Page: 477-84 June 2006
V. E. Boston
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This case report discusses neonatal abstinence syndrome due to prolonged administration of fentanyl in pregnancy
International Classification:
Syndrome
Categories:
Neonatal abstinence syndrome
Geography:
Republic of Ireland
Bjog,
Vol: 107 Page: 570-2 April 2000
J. Regan; F. Chambers; W. Gorman; R. MacSullivan
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The aim of this study was to examine the rate of detection of neonatal alloimmune thrombocytopenia in the Irish population
Abstract:
AIMS: To estimate the rate of detection of neonatal alloimmune thrombocytopenia (NAITP) in the Irish population, to investigate clinical presentation and outcome in affected infants, and to determine the extent, if any, to which this condition is underdiagnosed at present. METHODS: Cases were collected in a retrospective fashion from a review of platelet serology laboratory records from more...
International Classification:
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - Coagulation defects, purpura and other haemorrhagic conditions - thrombocytopenia
Categories:
neonatal alloimmune thrombocytopenia
Geography:
Republic of Ireland
J Clin Pathol,
Vol: 55 Page: 289-92 April 2002
A. Davoren; P. McParland; C. A. Barnes; W. G. Murphy
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The aim of this study was to determine the incidence and persistence of neonatal brachial plexus paralysis and evaluated whether its occurrence could be predicted by maternal characteristics or partographic analysis in a large cohort of recent cases
Abstract:
OBJECTIVE: Brachial plexus paralysis is a serious form of neonatal morbidity. We determined its incidence and persistence of disability and evaluated whether its occurrence could be predicted by maternal characteristics or partographic analysis in a large cohort of recent cases. STUDY DESIGN: During the years 1994 through 1998, all infants with neonatal evidence of obstetric brachial more...
International Classification:
Certain conditions originating in the perinatal period - brachial plexus paralysis
Categories:
maternal characteristics or partographic analysis; -neonatal brachial plexus paralysis
Geography:
Republic of Ireland
Am J Obstet Gynecol,
Vol: 187 Page: 1209-12 November 2002
V. Donnelly; A. Foran; J. Murphy; P. McParland; D. Keane; C. O'Herlihy
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This article discusses neonatal brain imaging
Geography:
Republic of Ireland
Pediatr Radiol,
Vol: 36 Page: 581 July 2006
V. Donoghue
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The aim of this study was to evaluate alterations in perinatal neutrophil phenotype following systemic hypoxia-ischemia compared with normal controls
Abstract:
Systemic hypoxia-ischemia at birth may alter the neonatal neutrophil phenotype. In this study, we evaluated alterations in perinatal neutrophil phenotype following systemic hypoxia-ischemia compared with normal controls. Neutrophils from adults (n = 15), normal newborns (n = 20), newborns requiring resuscitation at birth (n = 17), and their respective maternal samples were incubated more...
International Classification:
Immunology - neutrophil responses
Categories:
neutrophil; -hypoxia-ischemia orencephalopathy
Geography:
Republic of Ireland
Am J Perinatol,
Vol: 24 Page: 525-30 October 2007
E. J. Molloy; A. J. O'Neill; J. J. Grantham-Sloan; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson
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The aim of this study was to examine neonatal human autologous dendritic cells pulsed with recombinant protein antigen prime the generation of non-polarized CD4 T-cell effectors
Abstract:
The functional capability of human neonatal CD4 T cells to respond to vaccine antigens is frequently described as Th2 biased, but whether this is due to defective T-cell or antigen-presenting cell (APC) function is unclear. In this study, we used purified T cells and autologous monocyte-derived dendritic cells (MDDCs) as APCs to model primary and secondary neonatal CD4 T-cell responses more...
International Classification:
Other - autologous dendritic cells
Categories:
neonatal human autologous dendritic cells
Geography:
Republic of Ireland
Int Immunol,
Vol: 19 Page: 703-12 June 2007
N. C. Matthews; U. F. Power; D. J. Reen
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This study aimed to explore current resusucition practices in neonatal units in maternity units in Ireland
Abstract:
New evidence-based guidelines have been launched with recommendations that may impact how resuscitations, particularly of LBW infants, are enacted. AIM: to determine current resuscitation practices in Maternity units in Ireland and benchmarked these results to a recent study in the United States. METHODS: A 20-question survey was developed and mailed to a lead more...
International Classification:
Practice/knowledge - resuscitation
Categories:
resuscitation
Geography:
Republic of Ireland
Ir Med J,
Vol: 101 Page: 142-4 May 2008
O. Braima; C. A. Ryan
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This case report discusses a case of sigmoid volvulus in a neonate secondary to anal stenosis and review the diagnosis and management of this serious condition
Abstract:
Sigmoid volvulus is an exceptionally rare cause of intestinal obstruction in neonates. Only 7 cases have been reported in the English and French literature. The authors report a recent case of sigmoid volvulus in a neonate secondary to anal stenosis and review the diagnosis and management of this serious condition. The authors believe that carefully performed radiologic reduction is the more...
International Classification:
Diseases of the digestive system - Report
Categories:
sigmoid volvulus
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 1079-81 July 2001
D. De Caluwe; J. Kelleher; M. T. Corbally
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The aim of this study was to determine if the National Neonatal Transport Programme introduced in 2001 improved clinical condition of newborns at the end of transfer
Abstract:
BACKGROUND: The transport of critically ill newborns by specialised transport teams has been shown to be associated with a significant improvement in their clinical condition on arrival at the receiving hospital. AIM: To determine if the National Neonatal Transport Programme introduced in 2001 improved clinical condition of newborns at the end of transfer. METHODS: A retrospective study more...
International Classification:
Other - clinical condition of newborn
Categories:
clinical condition of newborns
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 173 Page: 105-8 2004 Apr-Jun
D. Mullane; H. Byrne; T. A. Clarke; W. Gorman; E. Griffin; K. Ramesh; T. Rohinath
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The aim of this study was to assess infants of <34 weeks' gestation, <28 days old, and with severe respiratory failure requiring ventilatory support to receive or not receive inhaled nitric oxide
Abstract:
BACKGROUND: Although inhaled nitric oxide (iNO) may be a promising treatment for newborn infants with severe respiratory failure, the results from 3 previous small trials were inconclusive. METHODS: Infants of <34 weeks' gestation, <28 days old, and with severe respiratory failure requiring ventilatory support were randomized to receive or not receive iNO. The study was not blinded. more...
International Classification:
Evaluation of the effectiveness of treatments - severe respiratory failure
Categories:
severe respiratory failure
Geography:
Republic of Ireland and the United Kingdom
Pediatrics,
Vol: 115 Page: 926-36 April 2005
D. Field; D. Elbourne; A. Truesdale; R. Grieve; P. Hardy; A. C. Fenton; N. Subhedar; J. Ahluwalia; H. L. Halliday; J. Stocks; K. Tomlin; C. Normand
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The aim of this study was to assess neonatal ventilation with inhaled nitric oxide vs. ventilatory support without inhaled nitric oxide for infants with severe respiratory failure born at or near term
Abstract:
BACKGROUND: Evidence from European centres to support the use of nitric oxide (NO) in mature newborns with evidence of severe respiratory failure is sparse. METHODS: Infants of >33 weeks' gestation, <28 days old, and with severe respiratory failure requiring ventilatory support were randomised to receive or not to receive inhaled NO (iNO). The study was not blinded. RESULTS: Sixty more...
International Classification:
Evaluation of the effectiveness of treatments - neonatal ventilation
Categories:
neonatal ventilation
Geography:
International
Neonatology,
Vol: 91 Page: 73-82 2007
D. Field; D. Elbourne; P. Hardy; A. C. Fenton; J. Ahluwalia; H. L. Halliday; N. Subhedar; K. Heinonen; O. Aikio; R. Grieve; A. Truesdale; K. Tomlin; C. Normand; J. Stocks
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This study aimed to explore the current use of vitamin K prophylaxis in newborns and review the efficacy and effectiveness of regimens used
Abstract:
OBJECTIVE: To determine current use of vitamin K (VK) prophylaxis in newborns and review the efficacy and effectiveness of regimens used. DESIGN: Efficacy and effectiveness calculated using current practice details, data from Southern Ireland and two previous surveys, together with contemporaneous studies of vitamin K deficiency bleeding (VKDB). SETTING: Current survey: United Kingdom more...
International Classification:
Practice/knowledge - Vitamin K
Categories:
vitamin K prophylaxis
Geography:
Republic of Ireland and the United Kingdom
Arch Dis Child,
Vol: 92 Page: 754-8 September 2007
A. Busfield; A. McNinch; J. Tripp
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The objective of our study was to determine the birth prevalence of neural tube defects (over 25-years) at a single institution in an area of high prevalence for NTDs and to investigate if a decreasing prevalence resulted in a change in the type of NTDs
Abstract:
OBJECTIVE: Severe neural tube defects (NTDs) tend to occur with disproportionate frequency in areas of high prevalence. The objective of our study was to determine the birth prevalence of NTDs during a 25-year period at a single institution based in an area of high prevalence for NTDs and to investigate if a decreasing prevalence resulted in a change in the type of NTDs. STUDY DESIGN: more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
neural tube defects; type of neural tube defect
Geography:
Republic of Ireland
Eur J Obstet Gynecol Reprod Biol,
Vol: 119 Page: 161-3 April 2005
A. M. Cotter; S. F. Daly
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This study reviewed the imaging features of glutaric aciduria type 1, and to document the findings not previously reported and compare our findings with the imaging characteristics of GA-1 previously reported
Abstract:
OBJECTIVE: To review the imaging features of glutaric aciduria type 1 (GA-1) in a group of 20 patients, the largest published series to date. To document the findings not previously reported and compare our findings with the imaging characteristics of GA-1 previously reported in the literature. MATERIALS AND METHODS: For 14 patients the original scans were examined and in the remaining more...
International Classification:
Diseases of the digestive system - Diseases of appendix - appendicoliths
Categories:
glutaric aciduria type 1
Geography:
Republic of Ireland
Pediatr Radiol,
Vol: 33 Page: 823-30 December 2003
E. L. Twomey; E. R. Naughten; V. B. Donoghue; S. Ryan
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The aim of this study was to examine neurologic and developmental disability in children who were born at 25 or fewer completed weeks of gestation in the United Kingdom and Ireland
Abstract:
BACKGROUND AND METHODS: Small studies show that many children born as extremely preterm infants have neurologic and developmental disabilities. We evaluated all children who were born at 25 or fewer completed weeks of gestation in the United Kingdom and Ireland from March through December 1995 at the time when they reached a median age of 30 months. Each child underwent a formal more...
International Classification:
Premature - children
Categories:
Neurologic and developmental disability; preterm births
Geography:
Republic of Ireland and the United Kingdom
N Engl J Med,
Vol: 343 Page: 378-84 August 2000
N. S. Wood; N. Marlow; K. Costeloe; A. T. Gibson; A. R. Wilkinson
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The aim of the study was to compare neurologic and developmental disability at six years of age in infants born extremely preterm
Abstract:
BACKGROUND: Birth before 26 weeks of gestation is associated with a high prevalence of neurologic and developmental disabilities in the infant during the first two years of life. METHODS: We studied at the time of early school age children who had been born at 25 or fewer completed weeks of gestation in the United Kingdom and Ireland in 1995. Each child had been evaluated at 30 months more...
International Classification:
Premature - infants
Categories:
neurologic and developmental disability
Geography:
Republic of Ireland and the United Kingdom
N Engl J Med,
Vol: 352 Page: 9-19 January 2005
N. Marlow; D. Wolke; M. A. Bracewell; M. Samara
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The aim of this study was to develop a growth reference chart for children with uncomplicated down syndrome in the United Kingdom and Ireland
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Chromosomal abnormalities, not elsewhere classified - Down Syndrome
Categories:
growth reference chart
Geography:
Republic of Ireland and the United Kingdom
Archives of Disease in Childhood,
Vol: 87 Page: 104-108 2002
M. E. Styles; T. J. Cole; J. Dennis; M. A. Preece
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This article discusses a technique in which an internal fixation suture is placed to prevent dislodgement or migration of Broviac catheters
Abstract:
Broviac catheters are in common use for administration of parenteral nutrition, cancer chemotherapy, and antibiotic therapy within the paediatric population. Inadvertent dislodgement of these catheters is common during the initial weeks before the Dacron cuff is anchored by the ingrowth of fibrous tissue. The authors describe a technique in which an internal fixation suture is placed to more...
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 51-2 January 2003
T. Sri Paran; M. Corbally; R. I. Fitzgerald
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