Irish Child Health Database - Peer Reviewed Papers
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Infant, Newborn
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The aim of this study was to examine how aspects of cord blood T-cell biology that Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation.
Abstract:
The use of human umbilical cord blood as an alternative source of stem cells to bone marrow for the reconstitution of the immune system is associated with less frequent and less severe incidence of graft-versus-host disease (GVHD). This study focuses on aspects of cord blood T-cell biology that may contribute to a perceived increased tolerance associated with the neonatal immune more...
International Classification:
Other - cord blood T-cell biology
Categories:
aspects of cord blood T-cell biology
Geography:
Republic of Ireland
Br J Haematol,
Vol: 116 Page: 702-9 March 2002
E. Rainsford; D. J. Reen
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This study examined outcomes after internal sphincter myectomy in patients with Internal Anal Sphincter Achalasia
Abstract:
BACKGROUND: Internal anal sphincter achalasia (IASA), also referred to as ultrashort segment Hirschsprung's disease (HD), is a clinical condition with presentation similar to HD, but with the presence of ganglion cells on rectal biopsy. The diagnosis of IASA is made on anorectal manometry, which shows the absence of rectosphincteric reflex on rectal balloon inflation. Altered more...
International Classification:
Diseases of the digestive system - Anal Sphincter Achalasia
Categories:
Internal Anal Sphincter Achalasia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 736-8 May 2001
D. De Caluwe; A. Yoneda; U. Akl; P. Puri
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The aim of this study was to evaluate the effectiveness of policies and recommendations on folic acid aimed at reducing the occurrence of neural tube defects
Abstract:
OBJECTIVES: To evaluate the effectiveness of policies and recommendations on folic acid aimed at reducing the occurrence of neural tube defects. DESIGN: Retrospective cohort study of births monitored by birth defect registries. SETTING: 13 birth defects registries monitoring rates of neural tube defects from 1988 to 1998 in Norway, Finland, Northern Netherlands, England and Wales, more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
policies on folic acid
Geography:
International
Bmj,
Vol: 330 Page: 571 March 2005
L. D. Botto; A. Lisi; E. Robert-Gnansia; J. D. Erickson; S. E. Vollset; P. Mastroiacovo; B. Botting; G. Cocchi; C. de Vigan; H. de Walle; M. Feijoo; L. M. Irgens; B. McDonnell; P. Merlob; A. Ritvanen; G. Scarano; C. Siffel; J. Metneki; C. Stoll; R. Smithells; J. Goujard
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The aim of this review was to assess efficacy and safety of interventions, designed for prevention of hypothermia in preterm and/or low birthweight infants, applied within 10 minutes after birth in the delivery suite compared with routine thermal care
Abstract:
BACKGROUND: Hypothermia incurred during routine postnatal resuscitation is a world-wide issue (across all climates), with associated morbidity and mortality. Keeping vulnerable preterm infants warm is problematic even when recommended routine thermal care guidelines are followed in the delivery suite. OBJECTIVES: To assess efficacy and safety of interventions, designed for prevention of more...
International Classification:
Premature - infants
Categories:
hypothermia in preterm and/or low birthweight infants
Geography:
Systematic Review
Cochrane Database Syst Rev,
2005
E. M. McCall; F. A. Alderdice; H. L. Halliday; J. G. Jenkins; S. Vohra
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This article discusses intestinal neuronal dysplasia
Abstract:
Intestinal neuronal dysplasia (IND) is a clinical condition that resembles Hirschsprung's disease. In the past many years investigators have raised doubts about the existence of IND as a distinct histopathologic entity. One strong piece of evidence that IND is a real entity stems from animal models. Recently, two different HOX11L1 knockout mouse models and a heterozygous endothelin B more...
Geography:
Republic of Ireland
Semin Pediatr Surg,
Vol: 12 Page: 259-64 November 2003
P. Puri
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This study reviewed the authors experience of intestinal neuronal dysplasia over an 8 year period
Abstract:
PURPOSE: Intestinal neuronal dysplasia (IND) is a disease of the enteric nervous system, which clinically resembles Hirschsprung's disease. The authors reviewed their experience of IND over an 8-year period. METHODS: Between 1992 and 1999, 418 patients underwent rectal suction biopsy for persistent constipation. Thirty-three (7.8%) patients had histologic evidence of IND. There were 26 more...
International Classification:
Other - lintestinal neuronal dysplasia
Categories:
intestinal neuronal dysplasia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 777-9 May 2001
J. Gillick; H. Tazawa; P. Puri
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This case report discusses a case of prelabor rupture of membranes at 20 weeks' gestation where a hydrogel sealant was applied to the cervical canal in order to maintain an adequate liquor volume in the second trimester
Abstract:
We report a case of prelabor rupture of membranes at 20 weeks' gestation where a hydrogel sealant was applied to the cervical canal in order to maintain an adequate liquor volume in the second trimester. The use of this agent for the purpose of creating plug has not been reported to date. more...
International Classification:
Certain conditions originating in the perinatal period - Report
Categories:
prelabor rupture of membranes
Geography:
Republic of Ireland
J Perinat Med,
Vol: 33 Page: 458-60 2005
F. Breathnach; S. Daly; E. Griffin; N. Gleeson
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The aim of this study was to examine the use of intracranial pressure monitoring and to establish which ICP-targeted therapies are being used in children with severe traumatic brain injury in the United Kingdom
Abstract:
OBJECTIVE: To identify factors associated with the use of intracranial pressure (ICP) monitoring and to establish which ICP-targetted therapies are being used in children with severe traumatic brain injury (TBI) in the United Kingdom. To evaluate current practice against recently published guidelines. DESIGN AND SETTING: Prospective data collection of clinical and demographic more...
International Classification:
Injury, poisoning and certain other consequences of external causes - injury
Categories:
severe traumatic brain injury
Geography:
Republic of Ireland and the United Kingdom
Intensive Care Med,
Vol: 32 Page: 1606-12 October 2006
K. P. Morris; R. J. Forsyth; R. C. Parslow; R. C. Tasker; C. A. Hawley
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This study aimed to explore the rates and types of intravenous fluids being prescribed postoperatively for children in the United Kingdom
Abstract:
BACKGROUND: Postoperative deaths and neurological injury have resulted from hyponatraemia associated with the use of hypotonic saline solutions following surgery. We aimed to determine the rates and types of intravenous fluids being prescribed postoperatively for children in the UK. METHODS: A questionnaire was sent to members of the British Association of Paediatric Surgeons (BAPS) and more...
International Classification:
Practice/knowledge - intravenous fluids
Categories:
intravenous fluids;
Geography:
Republic of Ireland and the United Kingdom
BMC Surg,
Vol: 8 Page: 10 2008
P. Davies; T. Hall; T. Ali; K. Lakhoo
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The aim of this study was to examine the epidemiology of invasive fungal infection in very low birthweight (VLBW: <1500 g) infants in the United Kingdom
Abstract:
OBJECTIVE: To describe the epidemiology of invasive fungal infection in very low birthweight (VLBW: <1500 g) infants in the United Kingdom. DESIGN: National prospective surveillance study between February 2003 and February 2004 using the British Paediatric Surveillance Unit reporting system reconciled with cases identified through routine laboratory reporting to the Health Protection more...
International Classification:
Premature - infants
Categories:
invasive fungal infection; very low birthweight
Geography:
the United Kingdom
Arch Dis Child Fetal Neonatal Ed,
Vol: 91 Page: F188-92 May 2006
L. Clerihew; T. L. Lamagni; P. Brocklehurst; W. McGuire
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The aim of this study was to examine the incidence of invasive pneumococcal disease in children in Ireland
Abstract:
BACKGROUND: Streptococcus pneumoniae is an important cause of childhood illness. Recently a safe and effective 7-valent conjugate pneumococcal vaccine for children has been licensed in the EU. AIMS: To calculate the incidence of invasive pneumococcal disease (IPD) in children in Ireland, to estimate the burden of disease and to anticipate the protective effect of the conjugate vaccine. more...
International Classification:
Bacterium - pneumococcal disease
Categories:
invasive pneumococcal disease
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 177 Page: 225-31 September 2008
J. J. Fitzsimons; A. L. Chong; M. T. Cafferkey; K. M. Butler
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This aim of this study was to examine a cluster of children with Down's syndrome born to mothers who had attended a school in Dundalk, Ireland
Abstract:
OBJECTIVES: To investigate a reported cluster of Down's syndrome in offspring of former pupils of a girls' school in Ireland, to establish the prevalence of Down's syndrome among live births in the area around the school, and to review the literature on the possible causes of reported clusters of Down's syndrome. METHODS: Questionnaire survey of obstetric and personal histories of women more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Chromosomal abnormalities, not elsewhere classified - Down Syndrome
Categories:
Down's syndrome
Geography:
Republic of Ireland
Occup Environ Med,
Vol: 57 Page: 793-804 December 2000
G. Dean; N. C. Nevin; M. Mikkelsen; G. Karadima; M. B. Petersen; M. Kelly; J. O'Sullivan
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This study aimed to explore current practice on neonatal vitamin K prophylaxis
International Classification:
Practice/knowledge - Vitamin K prophylaxis
Categories:
neonatal vitamin K prophylaxis
Geography:
Republic of Ireland
Bmj,
Vol: 323 Page: 1068 November 2001
R. K. Philip; R. Gul; M. Dunworth; N. Keane
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The aim of this study was to examine causes-specific death rates and trends in the Irish neonatal mortality population 2002
International Classification:
Deaths - causes-specific
Categories:
causes-specific neonatal death rates
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 174 Page: 65-6 2005 Oct-Dec
E. Finan; S. M. Gormally
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The aim of this study was to categorized Irish neonatal mortality
Abstract:
All Paediatricians in Ireland were requested to fill a questionnaire which dealt with data pertaining to all live-born infants over 500 g birth weight who died within the first 28 days of life in 1999. Deaths were categorized according to Wigglesworth Classification into Lethal Malformation, Immaturity (Prematurity), Asphyxia and "Specific". Each hospital and patient was more...
International Classification:
Deaths - neonatal
Categories:
neonatal mortality
Geography:
Republic of Ireland
Ir Med J,
Vol: 95 Page: 267-8, 270 October 2002
A. Foran; E. Dempsey; A. Watters; S. M. Gormally
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This case report discusses whether a once daily dose of gentamicin safe and effective in the treatment of urinary tract infection in infants and children
International Classification:
Diseases of the genitourinary system - Report
Categories:
urinary tract infection
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 92 Page: 823-4 September 2007
M. Shahid; R. Cooke
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The aim of this study was to examine the results of 15 years' experience undertaking extended arch aortoplasty the operation of choice for infant aortic coarctation
Abstract:
BACKGROUND: Recurrent coarctation is an ever-present complication of surgical treatment of coarctation of aorta (CoA) among infants. No single operation appears to have a clear superiority. METHODS: From January 1, 1986, to June 30, 2002, a consecutive series of 181 patients less than 1 year of age (range 1 to 300 days, median 13.5 days) were referred for CoA repair. Neonates accounted more...
International Classification:
Procedure - aortoplasty
Categories:
arch aortoplasty
Geography:
Republic of Ireland
Ann Thorac Surg,
Vol: 77 Page: 1353-7; discussion 1357-8 April 2004
A. E. Wood; H. Javadpour; D. Duff; P. Oslizlok; K. Walsh
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The aim of this study was to examine infant weight gain over a ten year period
Abstract:
Weight gain between birth and 9 months of 12 903 term Millennium Cohort Study infants was investigated in order to determine differences according to sex, ethnicity and country of birth. The standardised weights and weight gains were also compared with a cohort of mainly white infants born 10 years earlier to determine whether weight gain has changed over the last decade. There were more...
International Classification:
Other - Anthropometry-infant weight
Categories:
infant weight gain
Geography:
the United Kingdom
Int J Obes (Lond),
Vol: 30 Page: 1094-6 July 2006
A. R. Tate; C. Dezateux; T. J. Cole
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This study examined the incidence of major associated malformations in jejunal atresia and ileal atresia to determine if there is a positive correlation between the proximity of the intestinal atresia and the association of other major anomalies
Abstract:
PURPOSE: Duodenal atresia is associated with a higher incidence of associated congenital malformations than jejunoileal atresia, supporting the hypothesis that the duodenal obstruction occurs early in fetal life. In this study, the authors analyzed the incidence of major associated malformations in jejunal atresia (JA) and ileal atresia (IA) to determine if there is a positive more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - jejunal atresia
Categories:
jejunal atresia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 774-6 May 2001
B. Sweeney; R. Surana; P. Puri
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This case report discusses Katargener's Syndrome in pregnancy
International Classification:
Syndrome
Categories:
Katargener's syndrome in pregnancy
Geography:
Republic of Ireland
J Obstet Gynaecol,
Vol: 22 Page: 89-90 January 2002
S. Cooley; S. Lalchandani; D. P. Keane
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The aim of this study was to test the hypothesize that labor may alter neutrophil phenotype and thereby decrease neonatal complications
Abstract:
Labor is a mild proinflammatory state that is associated with fetal leukocytosis. Elective cesarean section has been linked with increased neonatal morbidity, which may be partially immune mediated. We hypothesized that labor may alter neutrophil phenotype and thereby decrease neonatal complications. We characterized neutrophil function and survival in normal neonates after either more...
International Classification:
Pregnancy, childbirth and the puerperium - labor
Categories:
labor; neutrophil
Geography:
Republic of Ireland
Pediatr Res,
Vol: 56 Page: 99-103 July 2004
E. J. Molloy; A. J. O'Neill; J. J. Grantham; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson
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The aim of this study was to examine recent paediatric and adolescent (adeno)tonsillectomy (T +/- Ads) rates in several countries of the European Union, the US, Canada and Australia.
Abstract:
This article compares recent paediatric and adolescent (adeno)tonsillectomy (T +/- Ads) rates in several countries of the European Union, the US, Canada and Australia. Trends in paediatric and adolescent surgical rates in the Netherlands and UK from 1974 to 1998 are studied as well. In 1998, the paediatric T +/- Ads rate varied from 19 per 10000 children in Canada to 118 per 10000 in more...
International Classification:
Procedure - (adeno)tonsillectomy
Categories:
(adeno)tonsillectomy
Geography:
International
Clin Otolaryngol Allied Sci,
Vol: 29 Page: 161-4 April 2004
E. H. Van Den Akker; A. W. Hoes; M. J. Burton; A. G. Schilder
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The aim of this study was to identify the reasons for the late presentation of developmental dysplasia of the hip in the presence of a screening programme
Abstract:
BACKGROUND: A neonatal screening programme for developmental dysplasia of the hip (DDH) is ongoing in Cork. Despite early screening, infants continue to present at later ages with DDH. The impact of late diagnosis is significant. Established DDH causes significant morbidity and may have major medicolegal implications. AIM: To identify the reasons for the late presentation of DDH in the more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Congenital malformations and deformations of the musculoskeletal system - dysplasia of the hip
Categories:
developmental dysplasia of the hip
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 171 Page: 139-40 2002 Jul-Sep
R. Gul; J. C. Coffey; G. Khayyat; A. J. McGuinness
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These case reports discuss 2 cases of the left atrial appendage rarely mimicking a posterior mitral valve leaflet vegetation, leading to an erroneous diagnosis of infective endocarditis
Abstract:
Infective endocarditis is emerging as a significant cause of morbidity in the neonatal intensive care with an incidence ranging from 0.07 to 4.3%. The rise in incidence may be explained by the increasing availability of echocardiography facilities in the neonatal unit. The diagnosis of infective endocarditis has major therapeutic implications as the neonate is treated with potentially more...
International Classification:
Diseases of the circulatory system - Report
Categories:
left atrial appendage
Geography:
Republic of Ireland
Neonatology,
Vol: 93 Page: 113-6 2008
A. F. El-Khuffash; E. J. Molloy; K. Walsh
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The aim of this study was to examine the relationships between maternal and cord leptin concentrations, maternal and neonatal outcomes, and measures of glycemic control in diabetic and nondiabetic pregnancy
Abstract:
OBJECTIVE: The purpose of this study was to examine the relationships between maternal and cord leptin concentrations, maternal and neonatal outcomes, and measures of glycemic control in diabetic and nondiabetic pregnancy. STUDY DESIGN: This was a prospective study of 60 type 1 diabetic and 50 nondiabetic pregnancies in a university teaching hospital. Serum leptin and hemoglobin A(1c) more...
International Classification:
Other - maternal and cord leptin concentrations
Categories:
maternal and cord leptin concentrations
Geography:
Northern Ireland
Am J Obstet Gynecol,
Vol: 188 Page: 1326-32 May 2003
J. G. Manderson; C. C. Patterson; D. R. Hadden; A. I. Traub; H. Leslie; D. R. McCance
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This article discusses lessons from Sudden Infant Death Syndrome
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 169 Page: 17-8 2000 Jan-Mar
P. J. Kearney
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The aim of this study was to undertake a genome scan using 187 microsatellite genetic markers and all backcross animals were phenotyped at birth for the presence and severity of arthrogryposis
Abstract:
Arthrogryposis is a congenital malformation affecting the limbs of newborn animals and infants. Previous work has demonstrated that inherited ovine arthrogryposis (IOA) has an autosomal recessive mode of inheritance. Two affected homozygous recessive (art/art) Suffolk rams were used as founders for a backcross pedigree of half-sib families segregating the IOA trait. A genome scan was more...
Categories:
genome scan; genetic markers; arthrogryposis
Geography:
Republic of Ireland
Mamm Genome,
Vol: 18 Page: 43-52 January 2007
A. M. Murphy; D. E. MacHugh; S. D. Park; E. Scraggs; C. S. Haley; D. J. Lynn; M. P. Boland; M. L. Doherty
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This article discusses the liquid paraffin: a reappraisal of its role in the treatment of constipation
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 85 Page: 121-4 August 2001
F. Sharif; E. Crushell; K. O'Driscoll; B. Bourke
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The aim of this study was to investigate the long term functional and structural outcomes of premature babies who received diode laser photocoagulation for threshold retinopathy of prematurity
Abstract:
AIMS: To assess the long term functional and structural outcomes of premature babies who received diode laser photocoagulation for threshold retinopathy of prematurity (ROP). METHODS: 25 patients (43 eyes) treated with laser were recalled for assessment at a mean follow up of 11 years. A further seven patients (14 eyes) with subthreshold ROP, which had regressed spontaneously without more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - retinopathy of prematurity
Categories:
diode laser photocoagulation; retinopathy of prematurity; - ocular outcomes;
Geography:
Republic of Ireland
Br J Ophthalmol,
Vol: 90 Page: 754-9 June 2006
E. McLoone; M. O'Keefe; S. McLoone; B. Lanigan
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This study examined the long-term clinical outcome in patients with Hirschsprung's disease and associated Down's syndrome
Abstract:
BACKGROUND/PURPOSE: Down's syndrome (DS) is the most common chromosomal abnormality associated with Hirschsprung's disease (HD). The purpose of this study was to review the long-term clinical outcome in patients with HD and associated DS. METHODS: Between 1975 and 2003, 39 (15%) of the 259 patients with HD had been associated with DS. Follow-up was carried out by means of examination of more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
Hirschsprung's disease
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 810-2 May 2005
M. Menezes; P. Puri
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This study examined the efficacy of chlorambucil/vinblastine/procarbazine/prednisolone in the treatment of childhood Hodgkin's lymphoma stages II-IV and radiotherapy alone in stage I patients
Abstract:
BACKGROUND: The aim of United Kingdom Children's Cancer Study Group (UKCCSG) HD82 was to establish the efficacy of chlorambucil/vinblastine/procarbazine/prednisolone (ChlVPP) in the treatment of childhood Hodgkin's lymphoma stages II-IV and radiotherapy (RT) alone in stage I patients. We report on the status of these patients to a follow-up of 20 years. METHODS: Treatment consisted of more...
International Classification:
Neoplasms - Malignant neoplasms - Hodgkin's lymphoma
Categories:
Hodgkin's lymphoma; treatments
Geography:
Northern Ireland
Eur J Cancer,
Vol: 43 Page: 1171-9 May 2007
M. Capra; M. Hewitt; M. Radford; J. Hayward; C. L. Weston; D. Machin
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This study examined the risk factors in the development of enterocolitis and the long-term outcome in patients with Hirschsprung's disease
Abstract:
Enterocolitis remains the most serious complication of Hirschsprung's disease (HD). The purpose of this study was to evaluate the risk factors in the development of enterocolitis and the long-term outcome in these patients. The hospital records of 259 consecutive patients with HD during 1975-2003 were examined. The data was analysed for age at presentation, associated anomalies, level more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
Hirschsprung's disease
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 22 Page: 316-8 April 2006
M. Menezes; P. Puri
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This study examined the long-term outcome of retained ureteral stumps in children undergoing heminephrectomy for non-functioning lower pole moieties in duplex kidneys
Abstract:
OBJECTIVES: Duplication of the ureter and renal pelvis is the most common upper urinary tract anomaly in childhood. The anatomical and functional divisions between upper and lower moieties of duplex kidney are extremely variable. The underlying pathological condition associated with a lower moiety is usually massive vesicoureteral reflux (VUR) to the lower collecting system and only more...
International Classification:
Procedure - heminephrectomy
Categories:
heminephrectomy; duplex kidneys
Geography:
Republic of Ireland
Eur Urol,
Vol: 42 Page: 63-6 July 2002
D. De Caluwe; B. Chertin; P. Puri
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The aim of the study was to assess the long-term refractive and biometric outcomes of diode laser-treated eyes in threshold retinopathy of prematurity
Abstract:
PURPOSE: To assess the long-term refractive and biometric outcomes of diode laser-treated eyes in threshold retinopathy of prematurity (ROP). METHODS: Cycloplegic autorefraction and biometry (Zeiss IOLMaster) were performed, at a mean follow-up of 11 years, on 16 laser-treated eyes with threshold ROP and 9 comparison eyes with subthreshold untreated ROP. RESULTS: The laser-treated eyes more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - retinopathy of prematurity
Categories:
retinopathy of prematurity
Geography:
Republic of Ireland
J Aapos,
Vol: 10 Page: 454-9 October 2006
E. M. McLoone; M. O'Keefe; S. F. McLoone; B. M. Lanigan
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This study examined long-term results of delayed primary anastomosis for pure oesophageal atresia
Abstract:
The management of a newborn with pure oesophageal atresia continues to be challenging. We started treating babies with pure oesophageal atresia by delayed primary anastomosis in 1977. The purpose of this study was to review the long-term outcome in infants with pure oesophageal atresia (EA) treated by delayed primary anastomosis with special emphasis on gastroesophageal reflux (GOR) more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - oesophageal atresia
Categories:
oesophageal atresia
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 23 Page: 647-51 July 2007
T. Sri Paran; D. Decaluwe; M. Corbally; P. Puri
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This study evaluated the long-term results of primary avulsion of posterior urethral valves using a Fogarty balloon catheter
Abstract:
PURPOSE: Posterior urethral valves are the most common cause of bladder outlet obstruction in infancy and cause renal failure in 25% to 30% of these children before adolescence. Transurethral ablation under direct vision is the most commonly used method of treatment for posterior urethral valves. Since 1987 we have used a Fogarty balloon catheter for primary avulsion of the posterior more...
International Classification:
Procedure - surgery
Categories:
avulsion of posterior urethral valves
Geography:
Republic of Ireland
J Urol,
Vol: 168 Page: 1841-3; discussion 1843 October 2002
B. Chertin; D. Cozzi; P. Puri
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This case report discusses a 2-week-old female who infant presented with acute decompensated left ventricular failure
Abstract:
A 2-week-old female infant presented with acute decompensated left ventricular failure. Echocardiography diagnosed left ventricular noncompaction cardiomyopathy with dilated phenotype and a left ventricular shortening fraction <10%. The infant was mechanically ventilated for 2 weeks and then successfully extubated. She was maintained on intravenous milrinone for 6 months until she more...
International Classification:
Diseases of the circulatory system - Report
Categories:
acute decompensated left ventricular failure
Geography:
Republic of Ireland
Pediatr Cardiol,
Vol: 28 Page: 317-8 2007 Jul-Aug
C. J. McMahon; H. Murchan; T. Prendiville; M. Burch
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The aim of this study was to describe the impact of different strategies to prevent mother-to-child transmission of HIV at a population level
Abstract:
AIM: In the United Kingdom (UK) and Ireland, avoidance of breastfeeding and alternative combinations of antiretroviral therapy regimen and mode of delivery are recommended according to maternal clinical status. The aim of this analysis was to explore the impact of different strategies to prevent mother-to-child transmission at a population level. DESIGN: Comprehensive national more...
International Classification:
Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV
Categories:
HIV
Geography:
Republic of Ireland and the United Kingdom
Aids,
Vol: 22 Page: 973-81 May 2008
C. L. Townsend; M. Cortina-Borja; C. S. Peckham; A. de Ruiter; H. Lyall; P. A. Tookey
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This study examined the relationship between superior vena cava flow in first 24 h and adverse outcome in very low birthweight infants
Abstract:
BACKGROUND: Superior vena cava (SVC) flow assesses blood flow from the upper body, and may provide a reliable assessment of systemic blood flow. AIM: (i) To assess the relationship between SVC flow in first 24 h and adverse outcome in very low birthweight (VLBW) infants (ii) To assess correlation between SVC flow and left and right ventricular outputs and anterior cerebral artery (ACA) more...
International Classification:
Other - superior vena cava flow
Categories:
superior vena cava flow
Geography:
Republic of Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 93 Page: F368-71 September 2008
J. Miletin; E. M. Dempsey
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The aim of this study was to examine Irish lung cancer mortality data for the years 1954-2000 to predict European age standardized mortality rates (EASMRs) and numbers of deaths for the period 2001-2015.
Abstract:
PURPOSE AND METHODOLOGY: Poisson regression models of Irish lung cancer mortality data for the years 1954-2000 were used to predict European age standardized mortality rates (EASMRs) and numbers of deaths for the period 2001-2015. Predictions for the whole population and for the age group 0-64 years were the main focus of this analysis. The models employed in this analysis were written more...
International Classification:
Deaths - lung cancer
Categories:
lung cancer mortality
Geography:
International
Lung Cancer,
Vol: 46 Page: 157-63 November 2004
P. O'Lorcain; H. Comber
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This study aimed to explore quality improvement and service planning in neonatal care
Abstract:
We describe a prospective two year study aimed at assessing information collected throughout a geographically defined region as a basis for clinical governance, quality improvement and service planning in neonatal intensive and special care. All 13 Northern Ireland units returned a range of socio-demographic, obstetric and neonatal data for all admissions or readmissions within 28 days more...
International Classification:
Practice/knowledge - neonatal service planning
Categories:
neonatal service planning
Geography:
Northern Ireland
Ir Med J,
Vol: 96 Page: 171-4 June 2003
J. Jenkins; F. Alderdice; E. McCall
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The aim of this study was to describe the risk of malignancy and mortality in patients with a positive endomysial or anti-gliadin antibody test in Northern Ireland
Abstract:
AIM: To determine the risk of malignancy and mortality in patients with a positive endomysial or anti-gliadin antibody test in Northern Ireland. METHODS: A population-based retrospective cohort study design was used. Laboratory test results used in the diagnosis of coeliac disease were obtained from the Regional Immunology Laboratory, cancer statistics from the Northern Ireland Cancer more...
International Classification:
Other - malignancy; mortality; positive endomysial; anti-gliadin antibody test
Categories:
malignancy; mortality; positive endomysial; anti-gliadin antibody tes
Geography:
Northern Ireland
World J Gastroenterol,
Vol: 13 Page: 146-51 January 2007
L. A. Anderson; S. A. McMillan; R. G. Watson; P. Monaghan; A. T. Gavin; C. Fox; L. J. Murray
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This study aimed to obtain an overview of current practice of management of anticoagulation and its reversal from paediatric cardiac surgical units of Great Britain and Ireland
Abstract:
Protocols for management of heparin and protamine administration in patients undergoing open-heart surgery have been developed from experience gained mainly in adult practice. However, it has been demonstrated that there are marked differences between paediatric and adult patients in their response to systemic anticoagulation and its reversal. The aim of this study was to obtain an more...
International Classification:
Practice/knowledge - anticoagulation
Categories:
anticoagulation
Geography:
Republic of Ireland and the United Kingdom
Perfusion,
Vol: 15 Page: 191-201 June 2000
M. Codispoti; P. S. Mankad
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This article discusses the management, and outcome from same, of bronchopulmonary dysplasia, a common cause of morbidity and mortality in preterm neonates
Abstract:
Bronchopulmonary dysplasia (BPD) is a common cause of morbidity and mortality in preterm neonates and at present its management is unclear. Over the past three decades there has been a growing use of corticosteroids in the postnatal period; first for the treatment and then, more recently, for the prevention of BPD. The first published use of corticosteroids to treat neonatal lung more...
Geography:
Northern Ireland
Drugs,
Vol: 65 Page: 15-29 2005
D. G. Grier; H. L. Halliday
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This article discusses issues of management of hepatitis B in children
Abstract:
Children with hepatitis B infection require management by physicians knowledgeable about the natural history of this disorder and experienced in the treatment of children. Selection of appropriate pediatric patients for treatment will prevent some cases of advanced liver disease later in life. New treatments under development for adults may benefit children as well, once they have been more...
Geography:
Republic of Ireland
Clin Liver Dis,
Vol: 8 Page: 387-401 May 2004
A. Broderick; M. M. Jonas
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This study examined management of vascular birth marks
Abstract:
Vascular birthmarks comprise a diverse group of congenital lesions and represent a significant cosmetic and functional burden for patients. They remain a diagnostic and management challenge for physicians due to their extremely variable clinical presentation and often complex anatomical associations. As each type of vascular lesion has a treatment program individual to it, optimal more...
International Classification:
Other - vascular birth marks
Categories:
vascular birth marks
Geography:
Republic of Ireland
Ir Med J,
Vol: 100 Page: 425-7 April 2007
G. M. O'Regan; R. Watson; D. Orr; D. O'Donovan; J. Russell; E. Phelan; M. Ryan; O. Brosnahan; A. Irvine
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The aim of this study was to investigate neurone density and morphology of the myenteric plexus in premature infants
Abstract:
BACKGROUND: The gastrointestinal tract appears morphologically prepared for oral feeding by the end of the second trimester, but many of the physiological processes required for efficient enteral nutrition are not developed fully until 33 to 34 weeks' gestation. Myenteric plexus is well recognized as an important regulator of peristaltic activity. Whole-mount preparation technique more...
International Classification:
Other - Physical part of the body - myenteric plexus
Categories:
neurone density; -myenteric plexus
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 35 Page: 748-52 May 2000
L. Nemeth; L. Fourcade; P. Puri
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The aim of this study was to test the hypothesize that exposure to antenatal risk factors for sepsis alters the perinatal neutrophil phenotype
Abstract:
The diagnosis of neonatal sepsis is difficult, resulting in unnecessary treatment to minimize morbidity and mortality. We hypothesized that exposure to antenatal risk factors for sepsis alters the perinatal neutrophil phenotype. The study setting was a tertiary referral university-affiliated maternity and neonatal hospital. Neutrophils from adults, normal neonates, neonates with more...
International Classification:
Pregnancy, childbirth and the puerperium
Categories:
antenatal sepsis;- altered perinatal neutrophil phenotype
Geography:
Republic of Ireland
Clin Exp Immunol,
Vol: 151 Page: 244-50 February 2008
E. J. Molloy; A. J. O'Neill; J. J. Grantham-Sloan; D. W. Webb; R. W. Watson
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The aim of this study was to examine the Millennium Cohort Study to determine whether a mother's employment status and employment characteristics are related to breast-feeding initiation.
Abstract:
Maternal employment rates have increased rapidly in recent years and little is known about how this influences whether women start breast feeding. We examined data from the Millennium Cohort Study to determine whether a mother's employment status (full-time, part-time, self-employed, on leave, not employed/student) and employment characteristics are related to breast-feeding initiation. more...
International Classification:
Pregnancy, childbirth and the puerperium - breast-feeding
Categories:
breast-feeding
Geography:
Republic of Ireland
Paediatr Perinat Epidemiol,
Vol: 21 Page: 242-7 May 2007
S. S. Hawkins; L. J. Griffiths; C. Dezateux; C. Law
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This aim of this study was to examine maternal folate status and neural tube defects in Ireland and the need for a national food fortification program
Abstract:
To determine the present risk of a Neural Tube Defect [NTD] pregnancy in the caucasian primigravid population in Dublin by comparing the serum folate and red cell folate status of primigravid patients attending the first prenatal booking clinic with data from the late 80's. This Cross-sectional population study looking at blood folate status of over 400 sequential primigravid caucasian more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
maternal folate status; neural tube defects; national food fortification program
Geography:
Republic of Ireland
Ir Med J,
Vol: 100 Page: 469-72 May 2007
T. Walsh; S. O'Broin; S. Cooley; J. Donnelly; C. Collins; H. McMillan; R. F. Harrison; C. McMahon; M. Geary
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The aim of this study was to assess the incidence of meconium that can only have been passed intrapartum and to determine its neonatal associations and whether its absence is a useful sign
Abstract:
OBJECTIVE: Clear amniotic fluid is frequently considered a reassuring sign during labor. Our aim was to examine the incidence of meconium that can only have been passed intrapartum and to determine its neonatal associations and whether its absence is a useful sign. METHODS: This was a prospective cohort study of 8394 "low risk" laboring women at term with clear amniotic fluid more...
International Classification:
Evaluation of the impact of intrapartum meconium monitoring on managing pregnant women
Categories:
intrapartum meconium
Geography:
Republic of Ireland and the United Kingdom
Obstet Gynecol,
Vol: 102 Page: 89-93 July 2003
C. Greenwood; S. Lalchandani; K. MacQuillan; O. Sheil; J. Murphy; L. Impey
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