Irish Child Health Database - Peer Reviewed Papers
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Infant, Newborn
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The aim of the review was to determine the effects of glutamine supplementation on morbidity and weight gain in preterm babies.
Abstract:
BACKGROUND: The amino acid glutamine is the preferred respiratory fuel for rapidly proliferating cells under normal conditions. Recent research has suggested a number of roles for glutamine during critical illness. This research has been largely performed in experimental animals and in adults in a variety of disease settings. There is little information on the role of glutamine in more...
International Classification:
Systematic Review
Categories:
glutamine supplementation weight gain preterm babies
Geography:
Systematic Review
Cochrane Database Syst Rev,
2000
T. R. Tubman; S. W. Thompson
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The aim of the review was to determine the effects of glutamine supplementation on morbidity and weight gain in preterm babies
Abstract:
BACKGROUND: The amino acid glutamine is the preferred respiratory fuel for rapidly proliferating cells under normal conditions. Recent research has suggested a number of roles for glutamine during critical illness. This research has been largely performed in experimental animals and in adults in a variety of disease settings. There is little information on the role of glutamine in more...
International Classification:
Systematic Review
Categories:
glutamine supplementation
Geography:
Systematic Review
Cochrane Database Syst Rev,
2001
T. R. Tubman; S. W. Thompson
[Preview]
[Read]
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The aim of this review was to determine the effects of glutamine supplementation on mortality and morbidity in preterm infants
Abstract:
BACKGROUND: Glutamine endogenous biosynthesis may be insufficient for tissue needs in states of metabolic stress. Trials in adults have suggested that glutamine supplementation improves clinical outcomes in critically ill adults. It has been suggested that glutamine supplementation may benefit preterm infants, particularly very low birth weight infants. OBJECTIVES: To determine the more...
International Classification:
Systematic Review
Categories:
glutamine supplementation in preterm infants
Geography:
Systematic Review
Cochrane Database Syst Rev,
2005
T. R. Tubman; S. W. Thompson; W. McGuire
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The aim of this study was to investigate evaluate neonatal and adult neutrophils for their ability to combat bacterial infection by examining their functional activity (CD11b and reactive oxygen intermediates) and their persistence at inflammatory sites
Abstract:
Neutropenia is a common sequela of neonatal sepsis. Recent clinical trials have shown the beneficial effects of colony-stimulating factors (CSFs) on outcome in this group, but the exact mechanism remains unknown. Neonates and mothers who were at high-risk for infection were recruited for cord blood sampling in a university tertiary referral maternity hospital. Neonatal and adult more...
International Classification:
Immunology - neutrophils and bacterial infection
Categories:
neutrophils; bacterial infection
Geography:
Republic of Ireland
Pediatr Res,
Vol: 57 Page: 806-12 June 2005
E. J. Molloy; A. J. O'Neill; J. J. Grantham; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson
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The aim of this study was to identified cases of invasive group B streptococcal disease in infants younger than 90 days through surveillance involving paediatricians, microbiologists, and parents
Abstract:
The incidence, morbidity, and mortality of group B streptococcal disease in the UK and Republic of Ireland are largely unknown. Between Feb 1, 2000, and Feb 28, 2001, we identified cases of invasive group B streptococcal disease in infants younger than 90 days through surveillance involving paediatricians, microbiologists, and parents. 568 cases were identified, equivalent to a total more...
International Classification:
Bacterium - Group B Strep
Categories:
Group B Strep
Geography:
Republic of Ireland and the United Kingdom
Lancet,
Vol: 363 Page: 292-4 January 2004
P. T. Heath; G. Balfour; A. M. Weisner; A. Efstratiou; T. L. Lamagni; H. Tighe; L. A. O'Connell; M. Cafferkey; N. Q. Verlander; A. Nicoll; A. C. McCartney
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These case reports discuss two cases of haemangioma presenting as perianal ulcer in neonates
Abstract:
Perianal haemangiomas are not uncommon, however, their presentation in the neonate as an ulcer prior to the development of a clinical haemangioma is extremely rare. Two such cases are reported. more...
International Classification:
Neoplasm - Report
Categories:
haemangioma
Geography:
Northern Ireland and the Republic of Ireland
J Perinatol,
Vol: 24 Page: 327-8 May 2004
N. Abid; A. Rashid
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The aim of this study was to audit an antenatal and neonatal haemoglobinopathies screening program targeting high-risk ethnic groups in the National Maternity Hospital in 2003
Abstract:
Recent changes in population movement mean that an increasing number of mothers who deliver in Ireland and their infants are at risk of haemoglobinopathies, in particular sickle cell anaemia. Early detection of sickle cell anaemia improves outcome. For this reason, many hospitals have established antenatal and neonatal screening programmes targeting high-risk ethnic groups. We audited more...
International Classification:
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - antenatal and neonatal haemoglobinopathies
Categories:
antenatal and neonatal haemoglobinopathies
Geography:
Republic of Ireland
Ir Med J,
Vol: 99 Page: 184-5 June 2006
T. R. Leahy; W. Gorman; J. Murphy; C. McMahon
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This study aimed to review when the diagnosis of congenital cataracts was made in our region, by whom it was made, and the visual outcome at 2 years of age or more
Abstract:
Best medical evidence indicates that surgical treatment of significant congenital cataracts is required within the first 3 months of life for optimal visual outcome. The aim of the present study was to review when the diagnosis of congenital cataracts was made in our region, by whom it was made, and the visual outcome at 2 years of age or more. This was a retrospective study in a region more...
International Classification:
Practice/knowledge - congenital cataracts
Categories:
congenital cataracts
Geography:
Republic of Ireland
Ir Med J,
Vol: 100 Page: 398-400 March 2007
O. Sotomi; C. A. Ryan; G. O'Connor; B. P. Murphy
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The aim of the study was to investigate the impact of applying a new series of health expectations by comparing estimates of healthy life expectancy (HLE) and disability-free life expectancy (DFLE) based on the old and new methods for one year (2001)
Abstract:
A previous article set out proposals for constructing a new series of health expectancies which aimed to widen the coverage to the UK and all four of its constituent countries and to improve the methods used in the calculations. This article investigates the impact of applying the new methods by comparing estimates of healthy life expectancy (HLE) and disability-free life expectancy more...
International Classification:
Other - disability-free life expectancy
Categories:
estimates of healthy life, and disability-free life expectancy
Geography:
the United Kingdom
Health Stat Q,
2006 Spring
C. Breakwell; M. Bajekal
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The aim of this study was to describe neonatal electrocardiogram and respiration signals from labelled seizure data for five neonatal patient
Abstract:
An investigation of changes in the neonatal electrocardiogram (ECG) and respiration signals from labelled seizure data for five neonatal patient records is reported. A decrease during seizure of 5.70% in the mean RR-interval was found. The mean respiration rate per epoch was found to decrease by a mean 18.44% during seizure. No significant change in the RR-interval standard deviation or more...
International Classification:
Neonatal seizures
Categories:
neonatal seizures
Geography:
Republic of Ireland
Med Biol Eng Comput,
Vol: 44 Page: 27-34 March 2006
B. R. Greene; P. de Chazal; G. Boylan; R. B. Reilly; C. O'Brien; S. Connolly
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The aim of this study was to describe heat-accelerated fixation and rapid dissection of the pediatric brain at autopsy
Abstract:
We investigated whether it is possible to accelerate the examination of a pediatric brain at autopsy and thus facilitate its return to the body before a funeral without compromising the quality of the neuropathologic examination. Accelerated fixation and next-day dissection of the brain was performed in selected cases over a 2-year period by using a microwave histologic tissue processor more...
International Classification:
Organ transplants
Categories:
organ retention
Geography:
Republic of Ireland
Pediatr Dev Pathol,
Vol: 7 Page: 595-600 2004 Nov-Dec
C. Barrett; F. Brett; D. Grehan; M. B. McDermott
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This study aimed to determine whether adjustments related to patient age are made in the scanning parameters that are determinants of radiation dose for helical CT of pediatric patients
Abstract:
OBJECTIVE: Our objective was to determine whether adjustments related to patient age are made in the scanning parameters that are determinants of radiation dose for helical CT of pediatric patients. SUBJECTS AND METHODS: This prospective investigation included all body (chest and abdomen) helical CT examinations (n = 58) of neonates, infants, and children (n = 32) referred from outside more...
International Classification:
Effectiveness of measurement tool - determinants of radiation dose for helical CT
Geography:
Northern Ireland
AJR Am J Roentgenol,
Vol: 176 Page: 297-301 February 2001
A. Paterson; D. P. Frush; L. F. Donnelly
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This article discusses how advice from nurses and midwives, as well as a better support network, will improve breastfeeding rates
Abstract:
Advice from nurses and midwives, as well as a better support network, will improve breastfeeding rates, writes Patrick Gleeson. more...
Geography:
Republic of Ireland
World of Irish Nursing & Midwifery,
Vol: 15 Page: 27-27 2007
P. Gleeson
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This study reports on heterogeneous influenza activity across Europe during the winter of 2002-2003
Abstract:
Influenza activity varied across Europe during the 2002-2003 season both in terms of the intensity of clinical activity and the circulating virus types/subtypes. Influenza B was generally predominant in the 'western' parts of Europe (Portugal, Spain, the United Kingdom and Ireland) and influenza A (H3N2) in the 'central' and 'eastern' areas (Germany, Italy, Denmark, Switzerland, Poland, more...
International Classification:
Surveillance - Diseases of the respiratory system - Influenza and pneumonia - influenza
Categories:
influenza
Geography:
International
Euro Surveill,
Vol: 8 Page: 230-9 December 2003
W. J. Paget; T. J. Meerhoff; H. Rebelo de Andrade
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The aim of this study was to document the immunogenicity and persistence of antibody to polyribosyl-ribitol Phosphate as well as the protection against Haemophilus influenzae type b (Hib) disease in premature infants immunised at the routine schedule
International Classification:
Bacterium - Haemophilus influenzae
Categories:
antibody to polyribosyl-ribitol Phosphate; -Hib disease
Geography:
the United Kingdom
Archives of Disease in Childhood,
Vol: 88 Page: 206-210 2003
P. T. Heath; R. Booy; J. McVernon; J. Bowen-Morris; H. Griffiths; M. P. E. Slack; A. C. Moloney; M. E. Ramsay; E. R. Moxon
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The aim of this study was to assess high frequency oscillatory ventilation reduce death and chronic lung disease when compared with conventional ventilation in preterm infants who are 23-28 weeks gestational age
Abstract:
QUESTION: In preterm infants who are 23-28 weeks gestational age, does high frequency oscillatory ventilation (HFOV) reduce death and chronic lung disease when compared with conventional ventilation (CV)?
Design:
Randomised (unclear allocation concealment), unblinded, controlled trial with 8-13 weeks of follow up for the primary outcome.
Setting:
25 centres: 22 in the UK and 1 each in more...
International Classification:
Evaluation of the effectiveness of two ventilation methods
Categories:
ventilation in preterm infants
Geography:
International
Evidence-Based Nursing,
Vol: 6 Page: 41-41 2003
C. Cheng; P. Shah
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The aim of this study was to examine the association between the incidence of type 1 diabetes mellitus and remoteness (a proxy measure for exposure to infections) using recently developed techniques for statistical analysis of small-area data
Abstract:
AIMS/HYPOTHESIS: We investigated the association between the incidence of type 1 diabetes mellitus and remoteness (a proxy measure for exposure to infections) using recently developed techniques for statistical analysis of small-area data. SUBJECTS, MATERIALS AND METHODS: New cases in children aged 0 to 14 years in Northern Ireland were prospectively registered from 1989 to 2003. more...
International Classification:
Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus
Categories:
type 1 diabetes mellitus
Geography:
Northern Ireland
Diabetologia,
Vol: 49 Page: 2074-7 September 2006
C. R. Cardwell; D. J. Carson; C. C. Patterson
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This article discusses the story of surfactant from 1980
Abstract:
The first successful trial of surfactant treatment for respiratory distress syndrome (RDS) was reported in 1980. Since then there have been numerous randomised trials demonstrating first, the efficacy of surfactant treatment in reducing pulmonary air leaks and increasing survival and second, assessing various other aspects of therapy. These studies show that multiple doses may be needed more...
Geography:
Northern Ireland
Biol Neonate,
Vol: 87 Page: 317-22 2005
H. L. Halliday
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The aim of this study was to examine the feasibility of using broadband (Internet protocol) transmission instead of ISDN lines for home support of children with complex congenital heart disease
Abstract:
We originally developed a home support service for babies with complex congenital heart disease, in which videoconferencing was delivered via three ISDN lines. We have now investigated the feasibility of using broadband (Internet protocol) transmission instead of ISDN lines. Five patients were enrolled (age range 14-58 days) and 78 videoconferences were conducted over a six-month more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - heart disease
Categories:
Telemedic; congenital heart disease
Geography:
Northern Ireland
J Telemed Telecare,
Vol: 14 Page: 140-2 2008
B. A. McCrossan; B. Grant; G. J. Morgan; A. J. Sands; B. Craig; F. A. Casey
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This article discusses homebirth
Geography:
Republic of Ireland
Midwifery Today Int Midwife,
2005 Autumn
J. Hagan
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The aim of this study was to examine the incidence of acute pancreatitis by examining emergency admissions to acute public hospitals over an 8-year period
Abstract:
OBJECTIVE: To investigate trends in the incidence of acute pancreatitis by examining emergency admissions to acute public hospitals over an 8-year period; to compare trends for alcohol-related pancreatitis admissions with biliary tract-related admissions and to profile the patients admitted with an acute pancreatitis diagnosis. METHODS: All in-patient emergency admissions for which an more...
International Classification:
Diseases of the digestive system - Disorders of gallbladder, biliary tract and pancreas - pancreatitis
Categories:
acute pancreatitis
Geography:
Republic of Ireland
J Public Health (Oxf),
Vol: 29 Page: 398-404 December 2007
A. O'Farrell; S. Allwright; D. Toomey; D. Bedford; K. Conlon
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The aim of this study was to examine local admission rates of premature infants from clinical bronchioloitis, assess local mortality and morbidity, secondary to seasonal bronchioloitis and examine seasonal and annual variation
International Classification:
Diseases of the respiratory system - Other acute lower respiratory infections - bronchiolitis
Categories:
bronchiolitis
Geography:
Republic of Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 90 Page: F92 January 2005
P. Bala; C. A. Ryan; B. P. Murphy
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The aim of this study was to examine how varying criteria for a diagnosis of Sudden Infant Death Syndrome significantly alters the SIDS rate in Ireland
Abstract:
There is increasing concern with using SIDS as a diagnosis, especially where the postmortem examination reveals additional findings that may be contributory to the death exclusion. This report shows how varying the criteria for a diagnosis of SIDS significantly alters the SIDS rate in Ireland. more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified- Ill-defined and unknown causes of mortality - Ill-defined and unknown causes of mortality - Sudden infant death syndrome
Categories:
sudden infant death syndrome
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 90 Page: 1082-3 October 2005
K. M. Sheehan; C. McGarvey; D. M. Devaney; T. Matthews
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This article discusses the inherited metabolic disorders HPA and PKU - Hyperphenylalaninaemia
Abstract:
Focus on the inherited metabolic disorders HPA and PKU. more...
Geography:
Republic of Ireland
World of Irish Nursing & Midwifery,
Vol: 13 Page: 43-44 2005
A. Clark; E. Treacy
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This paper discusses the Health Service Excutive-Employers Agency extension of parental leave
Geography:
Republic of Ireland
World of Irish Nursing,
Vol: 12 Page: 12-12 2004
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This article discusses hypocapnia
Geography:
Republic of Ireland
N Engl J Med,
Vol: 347 Page: 43-53 July 2002
J. G. Laffey; B. P. Kavanagh
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The aim of this study was to examine the number of adverse drug reactions in children in the United Kingdom and Ireland
Abstract:
This British Paediatric Surveillance Unit (BPSU) study on adverse drug reactions (ADRs) in children was initiated because of concern that there might be under-reporting of serious ADRs in children using the yellow card scheme. We aimed to quantify the frequency of fatal ADRs in children under the age of 16 years in the United Kingdom and Ireland. The surveillance period ran for 13 more...
International Classification:
Drugs, pharmacological treatment - adverse reactions
Categories:
adverse drug reactions
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 93 Page: 609-11 July 2008
K. Cheng; S. Masters; T. Stephenson; R. Cooke; R. Ferner; M. Ashworth; A. J. Nunn
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The aim of this study was to examine incidence rates, presenting features, and visual outcome of idiopathic intracranial hypertension
Abstract:
OBJECTIVES: To determine the age and sex specific incidence rates, presenting features, and visual outcome of idiopathic intracranial hypertension in Northern Ireland. METHODS: A case-note review of all patients with idiopathic intracranial hypertension, diagnosed at the Royal Victoria Hospital, Belfast between 1991 and 1995. RESULTS: Forty-two patients were identified corresponding to more...
International Classification:
Diseases of the nervous system - Other disorders of the nervous system - idiopathic intracranial hypertension
Categories:
idiopathic intracranial hypertension
Geography:
Northern Ireland
Ulster Med J,
Vol: 70 Page: 31-5 May 2001
J. J. Craig; D. A. Mulholland; J. M. Gibson
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The aim of this study was to examine the frequency of neonatal NK receptor-positive (NKR+) T cells and their expansionary properties with interleukin-2 (IL-2), IL-7, or IL-15
Abstract:
Expression of one or more natural killer (NK) receptors on T cells may correlate with effector function. This study investigated the frequency of neonatal NK receptor-positive (NKR+) T cells and their expansionary properties with interleukin-2 (IL-2), IL-7, or IL-15. While cord blood contains significantly decreased frequencies of NKR+ T cells compared with adult blood, newborn more...
International Classification:
Immunology - interleukin-2,
Categories:
interleukin-2 (IL-2), IL-7, or IL-15
Geography:
Republic of Ireland
Blood,
Vol: 102 Page: 2195-7 September 2003
S. Cookson; D. Reen
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The aim of this study was to examine the mechanisms involved in the regulation of cytokine-mediated expansion of naive T cells in the absence of Ag, in particular the role of caspase activation and susceptibility to apoptosis of recent thymic emigrants
Abstract:
Homeostasis of T cells is essential to the maintenance of the T cell pool and TCR diversity. In this study, mechanisms involved in the regulation of cytokine-mediated expansion of naive T cells in the absence of Ag, in particular the role of caspase activation and susceptibility to apoptosis of recent thymic emigrants (RTEs), were examined. Low level caspase-8 and caspase-3 activation more...
International Classification:
Immunology - thymic emigrants
Categories:
cytokine-mediated expansion of naive T cells; - recent thymic emigrants
Geography:
Republic of Ireland
J Immunol,
Vol: 170 Page: 4524-31 May 2003
R. M. O'Neill; J. Hassan; D. J. Reen
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This study aimed to explore the views of parents and health professionals regarding immunisation
Abstract:
A knowledge, attitude and practice study on vaccinations was undertaken among Irish parents and healthcare professionals between May and August 2001. Parents expressed fear of vaccine side effects, mistrust of health services, and felt poorly informed on the vaccination issues. According to group discussions, health professionals felt they lack time and user-friendly materials to more...
International Classification:
Practice/knowledge - Vaccinations
Categories:
immunisation
Geography:
Republic of Ireland
Euro Surveill,
Vol: 8 Page: 145-50 June 2003
S. Cotter; F. Ryan; H. Hegarty; T. J. McCabe; E. Keane
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The aim of this study was to investigate the immunocolocalization of the HO-2 and interstitial cells of Cajal in normal and aganglionic bowel of Hirschsprung's disease
Abstract:
PURPOSE: Interstitial cells of Cajal (ICCs) are pacemaker cells that play an important role in the control of gut motility. Carbon monoxide (CO) has been proposed as an endogenous messenger molecule between ICC and smooth muscle cells in the gastrointestinal tract (GIT). Heme oxygenase-2 (HO-2) is the main physiologic mechanism for generating CO in human cells. The aim of this study was more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
immunocolocalization of the HO-2 and interstitial cells of Cajal;-Hirschsprung's disease
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 73-7 January 2003
A. P. Piotrowska; V. Solari; D. de Caluwe; P. Puri
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[Read]
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The aim of this study was to examine the in vivo model of congenital cytomegalovirus to examine both the humoral and cell-mediated immune responses in vertically infected neonates and their mothers
Abstract:
Cytomegalovirus (CMV) is the most common cause of congenital infection worldwide and occurs as a result of transplacental transmission of the virus. The human neonate is highly susceptible to infection due to a combination of immaturity of the immune system and antigenic inexperience. This study uses the in vivo model of congenital CMV to examine both the humoral and cell-mediated more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other viral diseases - congenital cytomegalovirus
Categories:
congenital cytomegalovirus
Geography:
Republic of Ireland
Clin Exp Immunol,
Vol: 147 Page: 465-71 March 2007
J. Hassan; S. Dooley; W. Hall
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[Read]
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This case report discusses a case of a successful emergency caesarean section in a schizophrenic patient on clozapine treatment.
Abstract:
Clozapine is an atypical antipsychotic agent with a novel pharmacological profile and multiple clinical properties. Because of its side effects, it is recommended in treatment of severe resistant schizophrenia for which purpose it is remarkably effective. Little is known about the safety profile of clozapine during pregnancy and labour and because it is now used more commonly to manage more...
International Classification:
Mental and behavioural disorders - Schizophrenia, schizotypal and delusional disorders - schizophrenia Report
Categories:
schizophrenic
Geography:
Northern Ireland
Int J Obstet Anesth,
Vol: 15 Page: 59-62 January 2006
J. Doherty; P. F. Bell; D. J. King
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[Read]
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This case report discusses a case of an infant with Fraser syndrome who required a surgical airway because of a severe stenosis of her airway secondary to a glottic web
Abstract:
Congenital webbing of the vocal cords is rare, and is usually incompatible with life. We report a case of an infant with Fraser syndrome who required a surgical airway because of a severe stenosis of her airway secondary to a glottic web. The decision process leading to tracheostomy in this neonate is described. The pertinent features of Fraser syndrome in relation to airway management more...
International Classification:
Syndrome
Categories:
Fraser syndrome
Geography:
Republic of Ireland
Paediatr Anaesth,
Vol: 14 Page: 276-8 March 2004
S. Crowe; A. Westbrook; M. Bourke; B. Lyons; J. Russell
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The aim of this study was to examine changes in the quality of care provided since the initiation of a system for collection and analysis of neonatal data in a neonatal facility.
Abstract:
PROBLEM: Ten percent of infants born will require admission to a neonatal facility. Coordinated activity to monitor and improve the quality of care for this high risk, high cost group of infants is considered a high priority. At the time of initiation of this project no system for collection and analysis of neonatal data existed in Northern Ireland. DESIGN: In 1994 an ongoing more...
International Classification:
Health service provision
Categories:
neonatal facilities
Geography:
Northern Ireland
Qual Saf Health Care,
Vol: 14 Page: 202-6 June 2005
J. Jenkins; F. Alderdice; E. McCall
[Preview]
[Read]
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In brief: Childhood health
Geography:
Republic of Ireland
Nursing Times,
Vol: 103 Page: 8-8 2007
[Preview]
[Read]
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The aim of this study was to examine the incidence and management of hypoglyceaemia in children under 16 Years
International Classification:
Endocine, nutritional and metabolic diseases - Other disorders of glucose regulation and pancreatic internal secretion - hypoglyceaemia
Categories:
hypoglyceaemia
Geography:
Northern Ireland
Br J Gen Pract,
Vol: 50 Page: 324 April 2000
D. Carson; M. C. McGovern
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[Read]
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The aim of this study was to examine the annual incidence of systemic lupus erythematosus (SLE) over a 10-year period in the UK
Abstract:
OBJECTIVE: To estimate the annual incidence of systemic lupus erythematosus (SLE) over a 10-year period in the UK, and to examine age-, sex-, and region-specific rates. METHODS: The study was based on the UK General Practice Research Database (GPRD), which covers approximately 5% of the UK population. We estimated SLE incidence rates, during the period 1990-1999, among persons more...
International Classification:
Diseases of the skin and subcutaneous tissue - Other disorders of the skin and subcutaneous tissue - systemic lupus erythematosus
Categories:
systemic lupus erythematosus
Geography:
the United Kingdom
Arthritis Rheum,
Vol: 57 Page: 612-8 May 2007
E. C. Somers; S. L. Thomas; L. Smeeth; W. M. Schoonen; A. J. Hall
[Preview]
[Read]
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This case report discusses an incidental finding of endocarditis in a preterm neonate
International Classification:
Diseases of the circulatory system - Report
Categories:
endocarditis
Geography:
Republic of Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 92 Page: F134 March 2007
A. El-Khuffash; E. J. Molloy
[Preview]
[Read]
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The aim of this study was to compare the infiltration of T lymphocytes and the expression of a chemokine receptor, CXCR3, predominantly expressed on type 1 polarized T cells in liver and excised biliary remnants in infants with biliary atresia
Abstract:
BACKGROUND: Lymphocyte-mediated inflammatory damage of the bile ducts has been proposed as a potential mechanism in the pathogenesis of biliary atresia (BA). Chemokines regulate leukocyte migration and act as critical organizers of cell distribution in inflammatory responses. The aim of this study was to analyze the infiltration of T lymphocytes and the expression of a chemokine more...
International Classification:
Congenital malformations of the digestive system - Other congenital malformations of the digestive system - biliary atresia
Categories:
biliary atresia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 41 Page: 950-4 May 2006
M. Shinkai; T. Shinkai; P. Puri; M. D. Stringer
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This study investigated immunohistochemical localization of epidermal growth factors-related peptides and its mRNA expression in pyloric smooth muscle cells to determine involvment with pyloric muscle hypertrophy in infantile hypertrophic pyloric stenosis
Abstract:
Infantile hypertrophic pyloric stenosis (IHPS) is characterized by hypertrophy of the pyloric muscle. The growth of smooth muscle cells is regulated by several growth factors. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor are potent mitogens for smooth muscle cells. In the present study, we investigated immunohistochemical localization of EGF and EGF-related more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
epidermal growth factors; -infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Pediatr Res,
Vol: 47 Page: 201-7 February 2000
H. Shima; K. Ohshiro; P. Puri
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The aim of this study was to examine if total parenteral nutrition-dependent infants may be particularly sensitive to polyunsaturated fatty acids effects, having a relatively poor capacity to both use and clear PUFAs.
Abstract:
Polyunsaturated fatty acids (PUFAs), known modulators of the immune response, are the source of essential fatty acids in total parenteral nutrition-dependent patients. Critically ill infants on TPN have an increased incidence of sepsis, and lipid emulsions depress various immune functions. Recent studies have demonstrated that PUFAs induce apoptosis in various tissue cells in vitro and more...
International Classification:
Other - parenteral nutrition-dependence
Categories:
parenteral nutrition-dependence
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 620-8 April 2007
B. Sweeney; P. Puri; D. J. Reen
[Preview]
[Read]
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This article discusses the Infant Feeding Survey 2000
Geography:
the United Kingdom
Pract Midwife,
Vol: 5 Page: 24-6 June 2002
S. Brooker
[Preview]
[Read]
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The aim of this study was to examine factors affecting initiation, exclusivity and duration of infant feeding
Abstract:
The study objective was to determine the initiation rate, duration and exclusiveness of breastfeeding, in women resident in the North Eastern Health Board (NEHB) region. An additional aim was to identify determinants that influence the initiation and duration of all types of breastfeeding. All eligible mothers completed a self-administered questionnaire. For breastfeeding mothers there more...
International Classification:
Breastfeeding +/- formulae milk
Categories:
infant feeding
Geography:
Republic of Ireland
Ir Med J,
Vol: 97 Page: 197-9 2004 Jul-Aug
M. Ward; A. Sheridan; F. Howell; I. Hegarty; A. O'Farrell
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This study reports on infant Staphylococcal scalded skin syndrome, Ireland, 2007
International Classification:
Surveillance - Diseases of the skin and subcutaneous tissue - Infections of the skin and subcutaneous tissue - Staphylococcal scalded skin syndrome
Categories:
Staphylococcal scalded skin syndrome
Geography:
Republic of Ireland
Euro Surveill,
Vol: 12 Page: E070614 5 June 2007
N. H. O'Connell; M. Mannix; R. K. Philip; C. MacDonagh-White; B. Slevin; R. Monahan; L. Boyle; D. Whyte; A. Kearns
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The aim of this study was to examine the management of infants with infantile hypertrophic pyloric stenosis in a well-equipped regional centre
Abstract:
BACKGROUND: It has been suggested that only specialist paediatric surgeons should manage infantile hypertrophic pyloric stenosis (IHPS). AIM: The aim of this retrospective study was to ascertain whether the majority of these infants might be managed in a well-equipped regional centre. METHODS: Using the Hospital Inpatient Enquiry database, all cases of IHPS within a single more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - hypertrophic pyloric stenosis
Categories:
infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 169 Page: 100-2 2000 Apr-Jun
P. D. Kiely; S. Tierney; M. Barry; P. V. Delaney; J. Drumm; P. A. Grace
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The aim of this study was to evaluate the effect of patent ductus arteriosus on the myocardium by measuring levels of cardiac troponin T (cTnT), as a marker of ischemic myocardial damage.
Abstract:
OBJECTIVE: To evaluate the effect of patent ductus arteriosus (PDA) on the myocardium by measuring levels of cardiac troponin T (cTnT), a marker of ischemic myocardial damage. STUDY DESIGN: Eighty infants with a median gestation of 28 weeks (interquartile range ([IQR] = 26.1 to 29.5 weeks) and median birth weight of 1.06 kg (IQR = 0.87 to 1.21 kg) underwent echocardiographic and cTnT more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Congenital malformations of the circulatory system - patent ductus arteriosus
Categories:
patent ductus arteriosus
Geography:
Republic of Ireland
J Pediatr,
Vol: 153 Page: 350-3 September 2008
A. F. El-Khuffash; E. J. Molloy
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The aim of this study was to determine the effects of maternal diabetes on fetal iron status using serum transferrin receptors and their ratio to ferritin in cord blood.
Abstract:
OBJECTIVE: To determine the effects of maternal diabetes on fetal iron status using serum transferrin receptors (STfR) and their ratio to ferritin (TfR-F index) in cord blood. METHODS: Iron, ferritin, erythropoietin, STfR and haemoglobin concentration were measured and TfR-F index calculated in 97 maternal/cord blood pairs. Forty-nine women had type 1 diabetes (diagnosed before more...
International Classification:
Pregnancy, childbirth and the puerperium
Categories:
maternal diabetes; - fetal iron status
Geography:
Northern Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 92 Page: F399-401 September 2007
A. M. Verner; J. Manderson; T. R. Lappin; D. R. McCance; H. L. Halliday; D. G. Sweet
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The aim of this study was to examine the hypothesis that the infecting meningococcal serogroup modulates the presentation, course, and outcome of invasive meningococcal disease (IMD)
Abstract:
To test the hypothesis that the infecting meningococcal serogroup modulates the presentation, course, and outcome of invasive meningococcal disease (IMD), we performed a retrospective review of cases of IMD in 407 children from 2 tertiary referral centers and 2 regional centers in Ireland. Patients infected with serogroup C meningococci (n=104) were older than those infected with more...
International Classification:
Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease
Categories:
invasive meningococcal disease
Geography:
Republic of Ireland
Clin Infect Dis,
Vol: 34 Page: 1323-30 May 2002
C. M. Healy; K. M. Butler; E. O. Smith; O. P. Hensey; T. Bate; A. C. Moloney; P. MacMahon; J. Cosgrove; M. T. Cafferkey
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The aim of this study was to examine how aspects of cord blood T-cell biology that Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation.
Abstract:
The use of human umbilical cord blood as an alternative source of stem cells to bone marrow for the reconstitution of the immune system is associated with less frequent and less severe incidence of graft-versus-host disease (GVHD). This study focuses on aspects of cord blood T-cell biology that may contribute to a perceived increased tolerance associated with the neonatal immune more...
International Classification:
Other - cord blood T-cell biology
Categories:
aspects of cord blood T-cell biology
Geography:
Republic of Ireland
Br J Haematol,
Vol: 116 Page: 702-9 March 2002
E. Rainsford; D. J. Reen
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