Irish Child Health Database - Peer Reviewed Papers
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Infant, Newborn
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The aim of this study was to investigate the expression and production of elastin in the lung in newborn rats with congenital diaphragmatic hernia during mechanical ventilation
Abstract:
BACKGROUND/PURPOSE: Hypolastic lung in congenital diaphragmatic hernia (CDH) shows markedly thickened alveolar walls, increased interstitial tissue, and markedly diminished alveolar air space, showing morphologic immaturity. Decrease in lung compliance and distensibility often is seen in human CDH as well as experimentally produced CDH. Collagen and elastin, critical components of the more...
Categories:
mechanical ventilation; elastin; congenital diaphragmatic hernia;
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 37 Page: 1253-7 September 2002
N. Guarino; H. Teramoto; H. Shima; T. Oue; P. Puri
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The aim of this study was to examine whether low parental social class increases children's risk of subsequently developing Schizophrenia or modifies the presentation
Abstract:
OBJECTIVES: To examine if low parental social class increases children's risk of subsequently developing schizophrenia or modifies the presentation. DESIGN: Case-control study with historical controls. SETTING: Geographically defined region in south Dublin. Participants: 352 patients with first presentation of schizophrenia matched with the next registered same sex birth from the same more...
International Classification:
Mental and behavioural disorders - Schizophrenia, schizotypal and delusional disorders - schizophrenia
Categories:
low parental social class; -Schizophrenia
Geography:
Republic of Ireland
Bmj,
Vol: 323 Page: 1398-401 December 2001
F. Mulvany; E. O'Callaghan; N. Takei; M. Byrne; P. Fearon; C. Larkin
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This article discusses the effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
Abstract:
The importance of folate in reproduction can be appreciated by considering that the existence of the vitamin was first suspected from efforts to explain a potentially fatal megaloblastic anemia in young pregnant women in India. Today, low maternal folate status during pregnancy and lactation remains a significant cause of maternal morbidity in some communities. The folate status of the more...
Geography:
Republic of Ireland
Food Nutr Bull,
Vol: 29 Page: S101-11; discussion S112-5 June 2008
A. M. Molloy; P. N. Kirke; L. C. Brody; J. M. Scott; J. L. Mills
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This article discusses the use of antenatal glucocorticoids to induce maturation of preterm fetal lungs
Abstract:
Antenatal glucocorticoids have been used for 30 years to induce maturation of preterm fetal lungs. Stimulation of the pulmonary surfactant system has been regarded as the most important effect of antenatal glucocorticoids; however, as these drugs alter the expression of a large number of genes they affect the maturation of the lung in several other ways. Antioxidant enzyme production, more...
Geography:
Northern Ireland
Treat Respir Med,
Vol: 3 Page: 295-306 2004
D. G. Grier; H. L. Halliday
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The aim of this study was to study the effects of in vitro hypoxia and heat shock on normal adult and newborn neutrophil migration (CD11b) and persistence (apoptosis) following lipopolysaccharide stimulation.
Abstract:
BACKGROUND: Dysfunctional inflammatory responses have been implicated in several neonatal inflammatory disorders following infection and hypoxia. OBJECTIVES: We aimed to study the effects of in vitro hypoxia and heat shock (HS) on normal adult and newborn neutrophil migration (CD11b) and persistence (apoptosis) following lipopolysaccharide (LPS) stimulation. METHODS: The mechanism for more...
International Classification:
Immunology - neutrophil migration
Categories:
in vitro hypoxia and heat shock; neutrophil migration
Geography:
Republic of Ireland
Biol Neonate,
Vol: 90 Page: 34-9 2006
E. J. Molloy; A. J. O'Neill; B. T. Doyle; J. J. Grantham; C. T. Taylor; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson
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The aim of this study was to assess the efficacy and safety of 0.25% levobupivacaine administered as a caudal injection to paediatric patients aged less than 2 years old undergoing circumcision (group 1), or hernia repair or orchidopexy (group 2)
Abstract:
BACKGROUND: Levobupivacaine is the S(-)-enantiomer of racemic bupivacaine. Evidence suggests that it is less cardiotoxic than racemic bupivacaine and the R(+)-enantiomer, dexbupivacaine, while retaining similar local anaesthetic properties and potency to racemic bupivacaine. METHODS: This was an open study designed to assess the efficacy and safety of 0.25% levobupivacaine administered more...
International Classification:
Procedure - circumcision; hernia repair; ochidopexy
Categories:
circumcision; hernia repair; ochidopexy
Geography:
Northern Ireland
Paediatr Anaesth,
Vol: 13 Page: 114-21 February 2003
R. Taylor; R. Eyres; G. A. Chalkiadis; S. Austin
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The aim of this study was to describe elective caesarean and developmental dysplasia of the hip in term breech infants
Abstract:
We wished to establish whether delivery by Caesarean section influenced the incidence of developmental dysplasia of the hip in term breech infants compared with those delivered vaginally. We used maternal charts, singleton term breech presentation, mode of delivery and incidence of developmental dysplasia of the hip for births between January 1997 and October 2002. During the study more...
International Classification:
Pregnancy, childbirth and the puerperium - elective caesarean
Categories:
elective caesarean; developmental dysplasia of the hip
Geography:
Republic of Ireland
J Bone Joint Surg Br,
Vol: 87 Page: 984-5 July 2005
C. A. Lowry; V. B. Donoghue; C. O'Herlihy; J. F. Murphy
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The aim of this study was to examine a method for the detection of seizures in the newborn using the electrocardiogram signal
Abstract:
A method for the detection of seizures in the newborn using the electrocardiogram (ECG) signal is presented. Using a database of eight recordings, a method was developed for automatically annotating each 1-min epoch as "nonseizure" or "seizure". The system uses a linear discriminant classifier to process 41 heartbeat timing interval features. Performance assessment more...
International Classification:
Neonatal seizures
Categories:
seizures in the newborn
Geography:
Republic of Ireland and the United Kingdom
IEEE Trans Biomed Eng,
Vol: 54 Page: 673-82 April 2007
B. R. Greene; P. de Chazal; G. B. Boylan; S. Connolly; R. B. Reilly
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The aim of this study was to characterize the inflammation in biliary atresia by quantifying lymphocyte density and expression of TH1 cytokines such as IL2 and tumor necrosis factor alpha (TNF-alpha) in liver biopsies using qrt-PCR
Abstract:
AIM OF STUDY: Lymphocyte-mediated inflammation within the liver and bile ducts has been proposed as a potential mechanism in the pathogenesis of biliary atresia (BA). Recent reports have suggested that BA is associated with upregulation of TH1-type inflammatory cytokines. Quantitative real-time polymerase chain reaction (qrt-PCR) is a useful tool to assess immune cell density and more...
International Classification:
Congenital malformations of the digestive system - Other congenital malformations of the digestive system - biliary atresia
Categories:
biliary atresia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 41 Page: 300-5 February 2006
M. Shinkai; T. Shinkai; P. Puri; M. D. Stringer
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The aim of this study was to examine infants ranging in age from 3 weeks to 13 months who had shock of differing causes
Abstract:
We describe the findings from a group of five infants ranging in age from 3 weeks to 13 months who had shock of differing causes. In each case, sonographic evaluation of the abdomen revealed bilateral perirenal hyperechoic bands several millimeters thick, surrounding a thin, hypoechoic rim of fluid. The findings were identified during the acute phase of each child's illness and more...
International Classification:
Other - shock
Categories:
shock
Geography:
Northern Ireland
J Ultrasound Med,
Vol: 19 Page: 459-63 July 2000
A. Paterson; D. P. Frush; L. E. Sweeney; P. S. Thomas
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The aim of this study was to examine the relation between clinical risk factors and refractive development among preterm infants without retinopathy of prematurity
Abstract:
BACKGROUND/AIMS: Even in the absence of retinopathy of prematurity (ROP), premature birth signals increased risk for abnormal refractive development. The present study examined the relation between clinical risk factors and refractive development among preterm infants without ROP. METHODS: Cycloplegic refraction was measured at birth, term, 6, 12, and 48 months corrected age in a cohort more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - retinopathy of prematurity
Categories:
retinopathy of prematurity
Geography:
Northern Ireland
Br J Ophthalmol,
Vol: 86 Page: 1035-40 September 2002
K. J. Saunders; D. L. McCulloch; A. J. Shepherd; A. G. Wilkinson
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The aim of this review was to determine if endotracheal intubation and suction of the airways at birth in vigorous term meconium-stained babies is more beneficial than routine resuscitation including aspiration of the oro-pharynx
Abstract:
BACKGROUND: On the basis of evidence from non-randomised studies, it has been recommended that all babies born through thick meconium should have their tracheas intubated so that suctioning of their airways can be performed. The aim is to reduce the incidence and severity of meconium aspiration syndrome. However, for term babies who are vigorous at birth endotracheal intubation may be more...
International Classification:
Systematic Review
Geography:
Systematic Review
Cochrane Database Syst Rev,
2001
H. L. Halliday
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This article discusses issues around enterobacter sakazakii an emerging bacterial pathogen with implications for infant health
Abstract:
Enterobacter sakazakii (E. sakazakii) is an opportunistic pathogen and the aetiological agent in rare but life-threatening cases of meningitis, necrotizing enterocolitis, and sepsis in infants. Among infants, those at greatest risk are neonates (<28 days), particularly those born prematurely or of low birth weight (<2500 g). Consumption of contaminated powdered infant formula (PIF) has more...
Categories:
E. sakazakii
Geography:
Republic of Ireland
Minerva Pediatr,
Vol: 59 Page: 137-48 April 2007
N. R. Mullane; C. Iversen; B. Healy; C. Walsh; P. Whyte; P. G. Wall; T. Quinn; S. Fanning
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This article discussed issues surrounding enterobacter sakazakii an emerging pathogen in powdered infant formula
Abstract:
Enterobacter sakazakii represents a significant risk to the health of neonates. This bacterium is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. Infants aged <28 days are considered to be most at risk. Feeding with powdered infant formula (PIF) has been more...
Categories:
E. sakazakii
Geography:
Republic of Ireland
Clin Infect Dis,
Vol: 42 Page: 996-1002 April 2006
D. Drudy; N. R. Mullane; T. Quinn; P. G. Wall; S. Fanning
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This article discusses issues surrounding enterococcal infection in children
Abstract:
From relative obscurity, enterococci have become a leading cause of nosocomial infection. This has been attributed, in part, to the growth in susceptible host populations, increased use of intravascular devices, prolonged hospital stay, and widespread antibiotics use. Furthermore, the facility with which enterococci acquire resistance characteristics coupled with their capacity to more...
Geography:
Republic of Ireland
Semin Pediatr Infect Dis,
Vol: 17 Page: 128-39 July 2006
K. M. Butler
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The aim of this study was to was to determine both short- and long-term outcomes of extremely preterm birth data were collected for all births before 26 completed weeks of gestation
Abstract:
The principal objective of the EPICure studies was to determine both short- and long-term outcomes of extremely preterm birth. Data were collected for all births before 26 completed weeks of gestation in the UK and Republic of Ireland for 10 months in 1995. Of 811 infants admitted to neonatal units, 314 (39%) survived. Of these, 283 (92%) were assessed at 2.5 years and 241 (78%) at 6 more...
International Classification:
Premature - births
Categories:
outcomes of extremely preterm birth
Geography:
Republic of Ireland and the United Kingdom
Bjog,
Vol: 113 Suppl 3 Page: 10-2 December 2006
K. Costeloe
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This article discusses epidemiology consideration in elucidating environmental causes of birth defects.
Abstract:
Epidemiology can be used to elucidate environmental causes of birth defects. This paper discusses 1) different types of environmental causes; 2) the difficulties in comparing the prevalence of birth defects between populations, including the need for a population base and the implications of prenatal diagnosis; 3) the main study designs for observational epidemiological studies and the more...
Geography:
Northern Ireland
Am J Med Genet C Semin Med Genet,
Vol: 125C Page: 4-11 February 2004
H. Dolk
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This study reports on epidemiological and virological assessment of influenza activity in Europe during the 2004-2005 winter
Abstract:
The 2004-2005 influenza season in Europe started in late December 2004 and the first influenza activity occurred in the west and southwest (Spain, United Kingdom and Ireland). Influenza activity then moved gradually east across Europe during January and early February 2005, and from late February until late March, most movement was south to north. The intensity of clinical influenza more...
International Classification:
Surveillance - Diseases of the respiratory system - Influenza and pneumonia - influenza
Categories:
virological assessment; influenza
Geography:
International
Euro Surveill,
Vol: 11 Page: 111-8 2006
A. Meijer; W. J. Paget; T. J. Meerhoff; C. S. Brown; L. E. Meuwissen; J. van der Velden
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The aim of this study was to examine the incidence (age- and sex-specific) of childhood fractures in Britain using the general practice research database
Abstract:
A population-based British cohort study, including approximately 6% of the population, was used to derive age- and sex-specific incidence rates of fractures during childhood. Fractures were more common among boys than girls, with peak incidences at 14 and 11 years of age, respectively. At childhood peak, incidence rates were only surpassed later in life at 85 years of age among women more...
International Classification:
Injury, poisoning and certain other consequences of external causes - fractures
Categories:
childhood fractures
Geography:
the United Kingdom
J Bone Miner Res,
Vol: 19 Page: 1976-81 December 2004
C. Cooper; E. M. Dennison; H. G. Leufkens; N. Bishop; T. P. van Staa
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The aim of this study was to examine the epidemiology of hepatitis C infection in the ERHA/HSE Eastern region
Abstract:
Hepatitis C became statutorily notifiable in Ireland on 1 January 2004. Prior to 2004, only hepatitis A and hepatitis B were notifiable as distinct types of hepatitis. A third category notifiable under the Infectious Diseases Regulations 1981 was "viral hepatitis unspecified". The majority of cases notified under this heading were thought to be due to infection with hepatitis more...
International Classification:
Certain infectious and parasitic diseases - Viral hepatitis - hepatitis C
Categories:
hepatitis C
Geography:
Republic of Ireland
Ir Med J,
Vol: 100 Page: 365-6 February 2007
M. O. Meara; J. Barry; L. Mullen
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The aim of this study was to examine the epidemiology of children with traumatic brain injury admitted to paediatric intensive care units in the United Kingdom
Abstract:
AIMS: To describe the epidemiology of children with traumatic brain injury (TBI) admitted to paediatric intensive care units (PICUs) in the UK. METHODS: Prospective collection of clinical and demographic information from paediatric and adult intensive care units in the UK and Eire between February 2001 and August 2003. RESULTS: The UK prevalence rate for children (0-14 years) admitted more...
International Classification:
Injury, poisoning and certain other consequences of external causes - injury
Categories:
traumatic brain injury
Geography:
Republic of Ireland and the United Kingdom
Arch Dis Child,
Vol: 90 Page: 1182-7 November 2005
R. C. Parslow; K. P. Morris; R. C. Tasker; R. J. Forsyth; C. A. Hawley
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The aim of this study was to examine the relationship between epidural analgesia and caesarean and instrumental vaginal delivery rates
Abstract:
OBJECTIVE: We sought to examine the relationship between epidural analgesia and cesarean and instrumental vaginal delivery rates. STUDY DESIGN: This is a retrospective analysis of the first 1000 nulliparous pregnancies in women with a cephalic presentation in spontaneous labor at term in each of 3 different years, over which the epidural rate increased from 10% to 57%. RESULTS: Cesarean more...
International Classification:
Pregnancy, childbirth and the puerperium - epidural analgesia and cesarean and instrumental vaginal delivery rates
Categories:
epidural analgesia and cesarean and instrumental vaginal delivery rates
Geography:
Republic of Ireland
Am J Obstet Gynecol,
Vol: 182 Page: 358-63 February 2000
L. Impey; K. MacQuillan; M. Robson
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The aim of this study was to describe labour & epidural analgesia effects on plasma alpha1-acid glycoprotein concentrations and the association between ropivacaine concentration & neonate neurobehavioural function
Abstract:
This study was undertaken: (i) to quantify the effects of labour and epidural analgesia on plasma alpha1-acid glycoprotein concentration, (ii) to examine the effects of changes in plasma alpha1-acid glycoprotein concentration on plasma protein binding and placental transfer of ropivacaine, and (iii) to examine the association between umbilical venous ropivacaine concentration and more...
International Classification:
Pregnancy, childbirth and the puerperium - labour & epidural analgesia effects onplasma alpha1-acid glycoprotein concentration
Categories:
labour & epidural analgesia effects onplasma alpha1-acid glycoprotein concentration
Geography:
Republic of Ireland
Anaesthesia,
Vol: 56 Page: 418-23 May 2001
J. M. Porter; N. Kelleher; R. Flynn; G. D. Shorten
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The aim of this study was to examine nuclear factor of activated T cell 1 expression in cord blood cells
Abstract:
Cord blood (CB) cells are now an important source of stem cells for bone marrow reconstitution as a result of the decreased risk of graft-versus-host disease that was attributed to previously reported absent or diminished nuclear factor of activated T (NFAT) cell 1 expression by CB T cells. This study reexamines NFAT1 expression in CB T cells. CB T cells were examined for NFAT1 mRNA and more...
International Classification:
Other - Transcription factors -nuclear factor of activated T cell 1 expression
Categories:
nuclear factor of activated T cell 1 expression; cord blood cells
Geography:
Republic of Ireland
Transplantation,
Vol: 76 Page: 1526-8 November 2003
R. M. O'Neill; D. J. Reen
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This article reports on the "Principles and Operational guidelines for good clinical practice"
Abstract:
A child has the full right of protection of his/her life by provision of optional medical care. There is a need in paediatrics for better evidence based practice founded on quality research into efficacy and safety of children's medications. To protect the best interests of the child one must balance the ethical demand to do clinical studies with the necessity to avoid doing harm. To more...
Geography:
Republic of Ireland
Eur J Pediatr,
Vol: 163 Page: 53-7 February 2004
D. Gill
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This article discusses recommendations of a European panel of expert neonatologists
Abstract:
Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the recommendations of a European panel of expert neonatologists who developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. Strong evidence exists for the role of antenatal steroids in RDS prevention, but it more...
Geography:
Northern Ireland
J Perinat Med,
Vol: 35 Page: 175-86 2007
D. Sweet; G. Bevilacqua; V. Carnielli; G. Greisen; R. Plavka; O. Didrik Saugstad; U. Simeoni; C. P. Speer; I. Soler A. Valls; H. Halliday; Medicine Working Group on Prematurity of the World Association of Perinatal; Medicine European Association of Perinatal
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The aim of this study was to examine the appearance of unmetabolised folic acid both in cord blood from newborn full-term and premature infants and serum from 4 day old infants post formula feeding
International Classification:
Other - Folate and folic acid
Categories:
unmetabolised folic acid in cord blood; formula feeding
Geography:
Republic of Ireland
British Journal of Nutrition,
Vol: 94 Page: 727-730 2005
M. R. Sweeney; J. McPartlin; D. G. Weir; S. Daly; K. Pentieva; L. Daly; J. M. Scott
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This article discusses the 171 systematic reviews of interventions in neonatology published in the Cochrane Library provide evidence for neonatal care in many areas of the speciality
Abstract:
Randomized controlled trials were introduced into neonatal care in the 1950s when high inspired oxygen concentrations were discovered to be the cause of an epidemic of blindness in preterm babies due to retinopathy of prematurity. Systematic reviews of many randomized controlled trials were published in an important textbook in 1992, 'Effective Care of the Newborn Infant', which was the more...
Geography:
Northern Ireland
Best Pract Res Clin Obstet Gynaecol,
Vol: 19 Page: 155-66 February 2005
H. L. Halliday
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The aim of this study was to examine the clinical evidence for elective induction for post-term pregnancy.
Abstract:
Induction of labour is a valuable obstetric procedure, providing obstetricians with the means to intervene should the health of the fetus be in jeopardy. Currently the most common reason for induction of labour is prolonged pregnancy, as obstetricians and midwives are concerned about the risks of postmaturity such as stillbirth, intrapartum asphyxia and birth trauma which are often more...
International Classification:
Pregnancy, childbirth and the puerperium - elective induction for post-term pregnancy
Categories:
elective induction for post-term pregnancy
Geography:
Northern Ireland
Journal of Advanced Nursing,
Vol: 31 Page: 410-417 2000
C. Duff; M. Sinclair
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The aim of this study was to investigate the clinical disorder of recessive congenital methemoglobinemia
Abstract:
The clinical disorder of recessive congenital methemoglobinemia (RCM, OMIN 250800) is associated with mutations in NADH:cytochrome b5 reductase (cb5r) and manifests as cyanosis from birth. Screening a cyanotic infant indicated elevated methemoglobin levels and decreased cb5r activity suggesting RCM. Sequencing the DIA1 gene encoding cb5r revealed a novel mutation, C27161T (NCBI more...
Categories:
congenital methemoglobinemia
Geography:
Northern Ireland
Arch Biochem Biophys,
Vol: 447 Page: 59-67 March 2006
M. J. Percy; L. J. Crowley; J. Boudreaux; M. J. Barber
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The aim of this study was to examine the expression of HO-1 and endothelial nitric oxide synthase (eNOS) in the congenital diaphragmatic hernia lung
Abstract:
BACKGROUND/PURPOSE: Heme oxygenase (HO-1), an inducible isoform of HO is a regulator of vascular tone and cell proliferation through the production of endogenous carbon monoxide (CO). Endothelium-derived nitric oxide (NO) occurs in the endothelial layers of blood vessels and mediates vasorelaxation. Both CO and NO have similar properties and are potent vasodilators. The aim of this more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital diaphragmatic hernia
Categories:
endothelial nitric oxide synthase; -congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 808-13 May 2003
V. Solari; A. P. Piotrowska; P. Puri
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This case report discusses extraventricular choroid plexus papilloma in a neonate
International Classification:
Neoplasm - Report
Categories:
choroid plexus papilloma
Geography:
Republic of Ireland
Pediatr Radiol,
Vol: 38 Page: 593 May 2008
S. Stafrace; J. Molloy
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The aim of this study was to examine the relationship between coded diseases at the time of hospital discharge and costs of hospital re-admission.
Abstract:
This study examined whether there is a relationship between coded diseases at the time of hospital discharge and costs of hospital re-admission. We carried out a systematic review of data relating to emergency medical patients admitted to St. James' Hospital in Dublin between 1 January 2002 and 31 October 2004. Data on discharges from hospital were analyzed as recorded in the hospital more...
International Classification:
Health service provision
Categories:
hospital discharge and costs
Geography:
Republic of Ireland
Eur J Health Econ,
Vol: 7 Page: 123-8 June 2006
E. D. Moloney; K. Bennett; B. Silke
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This obstetric case shows two false negative Kleihauer tests and two persistently positive Kleihauer tests leading to unnecessary administration of anti-D immunoglobulin
Abstract:
This obstetric case shows two false negative Kleihauer tests and two persistently positive Kleihauer tests leading to unnecessary administration of anti-D immunoglobulin. A diagnosis of hereditary persistence foetal haemoglobin (HPFH) was only confirmed by access to flow cytometry making use of both anti-HbF and anti-D labels. The case highlights the importance of a high index of more...
International Classification:
Health service provision
Categories:
unnecessary administration of anti-D immunoglobulin
Geography:
Northern Ireland
Clin Lab Haematol,
Vol: 25 Page: 405-8 December 2003
R. Iyer; B. McElhinney; N. Heasley; M. Williams; K. Morris
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This study examined the long-term outcome of retained ureteral stumps in children undergoing heminephrectomy for nonfunctioning upper pole moieties in duplex kidneys
Abstract:
PURPOSE: We review the long-term outcome of retained ureteral stumps in children undergoing heminephrectomy for nonfunctioning upper pole moieties in duplex kidneys. MATERIALS AND METHODS: The medical records of 50 patients who underwent 50 upper pole heminephrectomies for a nonfunctioning upper pole moiety of a duplex kidney between January 1990 and December 2000 were reviewed more...
International Classification:
Procedure - heminephrectomy
Categories:
heminephrectomy
Geography:
Republic of Ireland
J Urol,
Vol: 168 Page: 679-80 August 2002
D. De Caluwe; B. Chertin; P. Puri
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[Read]
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This aim of this study was to examine current feeding practices among Irish infants in the first year of life
Abstract:
Because nutrition during infancy not only determines growth but also impacts on future adult health, it is essential that healthy eating habits be promoted from a very young age. This study examines current feeding practices among Irish infants in the first year of life. Although 51% of Irish mothers commenced breast-feeding their infants at birth, the number of women who continued to more...
International Classification:
Breastfeeding +/- formulae milk
Categories:
feeding practices
Geography:
Republic of Ireland
Ir Med J,
Vol: 93 Page: 248-50 November 2000
A. Twomey; B. Kiberd; T. Matthews; M. O'Regan
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This case report discusses a case of fetal meconium peritonitis
International Classification:
Diseases of the genitourinary system - Report
Categories:
fetal meconium peritonitis
Geography:
Republic of Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 88 Page: F74 January 2003
A. Das; A. Murphy; M. McMahon; S. M. Gormally; M. Corbally
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The aim of this study was to describe the first 10 cases of fetoscopic laser surgery for twin-to-twin transfusion syndrome by the Rotunda Hospital Fetal Treatment Programme
Abstract:
The aim of this study was to report the results of the first 10 cases of fetoscopic laser surgery for twin-to-twin transfusion syndrome by the Rotunda Hospital Fetal Treatment Programme. All cases of severe TTTS managed by our team from 2006 to 2007 were included. All fetoscopic laser surgeries were performed by a single specialist in fetal medicine. All pregnancies were followed up to more...
International Classification:
Pregnancy, childbirth and the puerperium - twin-to-twin transfusion syndrome
Categories:
twin-to-twin transfusion syndrome
Geography:
Republic of Ireland
Ir Med J,
Vol: 101 Page: 191-3 June 2008
S. Said; K. Flood; F. Breathnach; A. Fleming; C. B. Kinsella; M. Geary; F. D. Malone
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This study reports a study whose primary aim was to explore the relationship between social support for first-time mothers and their confidence in infant care practices. A secondary aim was to identify their sources of support in the postnatal period
Abstract:
AIM: This paper reports a study whose primary aim was to explore the relationship between social support for first-time mothers and their confidence in infant care practices. A secondary aim was to identify their sources of support in the postnatal period. BACKGROUND: Policy documents emphasize the importance of support for new mothers in the postnatal period in caring for their more...
International Classification:
Health service provision
Categories:
social support for first-time mothers
Geography:
Republic of Ireland
J Adv Nurs,
Vol: 50 Page: 479-88 June 2005
P. Leahy Warren
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The aim of this study was to examine the distribution and frequency of 25S rRNA intron genotypes of Candida albicans isolated from different anatomical sites of patients in an intensive care unit setting
Abstract:
A study is performed to examine the distribution and frequency of 25S rRNA intron genotypes of Candida albicans isolated from different anatomical sites of patients in an intensive care unit (ICU) setting. Germ-tube positive Candida isolates (n=65) from 65 patients are included and isolates are characterised by 25S intron genotyping, whereby all can be subdivided into four genotypes more...
International Classification:
Fungi - Candida albicans
Categories:
Candida albicans
Geography:
Northern Ireland
Br J Biomed Sci,
Vol: 62 Page: 24-7 2005
B. C. Millar; J. Xu; R. McMullan; M. J. Walker; S. Hedderwick; J. E. Moore
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The aim of this study was to describe characteristics of fundus fluorescein angiography in retinopathy prematurity, explore possible benefits of fundus fluorescein angiography over conventional indirect ophthalmoscopy in screening and managing ROP
Abstract:
OBJECTIVES: To describe the characteristics of fundus fluorescein angiography in retinopathy of prematurity (ROP) and to explore the possible benefits of fundus fluorescein angiography over conventional indirect ophthalmoscopy in the screening for and management of ROP. PATIENTS AND METHODS: Beginning in January 2003, 23 consecutive patients were recruited for a nonrandomized, more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - retinopathy of prematurity
Categories:
retinopathy of prematurity
Geography:
Republic of Ireland
J Pediatr Ophthalmol Strabismus,
Vol: 43 Page: 85-90 2006 Mar-Apr
E. Y. Ng; B. Lanigan; M. O'Keefe
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This article discusses the published literature on fungal endocarditis in children and to discuss the incidence due to a wide range of fungi, primarily Aspergillus and Candida species
Abstract:
Fungal endocarditis in the neonate and pediatric population is associated with a high degree of morbidity and mortality, with diagnosis in the majority of cases made postmortem. The aim of this article is to review published literature on fungal endocarditis in children and to discuss the incidence due to a wide range of fungi, primarily Aspergillus and Candida species, as well as its more...
Geography:
Northern Ireland
Pediatr Cardiol,
Vol: 26 Page: 517-36 2005 Sep-Oct
B. C. Millar; J. Jugo; J. E. Moore
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The aim of this study was to examine the impact of antenatal diagnosis of gatroschisis and exomphalos on the management of delivery
Abstract:
Antenatal detection of anterior abdominal wall defects (gastroschisis and exomphalos) enables detailed prenatal planning and counselling with appropriate intrauterine transfer, delivery in a tertiary referral centre with prompt access to paediatric surgery and early surgical intervention. The authors believed that there was a relatively low rate of antenatal detection in Ireland and more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Congenital malformations and deformations of the musculoskeletal system - exomphalos
Categories:
gatroschisis; exomphalos
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 23 Page: 1059-63 November 2007
F. L. Murphy; T. A. Mazlan; F. Tarheen; M. T. Corbally; P. Puri
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This study aimed to describe the gaussian process modeling of EEG for the detection of neonatal seizures
Abstract:
Gaussian process (GP) probabilistic models have attractive advantages over parametric and neural network modeling approaches. They have a small number of tuneable parameters, can be trained on relatively small training sets, and provide a measure of prediction certainty. In this paper, these properties are exploited to develop two methods of highlighting the presence of neonatal more...
International Classification:
Effectiveness of measurement tool - gaussian process modeling of EEG for the detection of neonatal seizures
Geography:
Republic of Ireland and the United Kingdom
IEEE Trans Biomed Eng,
Vol: 54 Page: 2151-62 December 2007
S. Faul; G. Gregorcic; G. Boylan; W. Marnane; G. Lightbody; S. Connolly
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The aim of this study was to examine the prevalence of the genetic form of hereditary hemochromatosis in the Irish population
Abstract:
In populations of northern European ancestry, hereditary hemochromatosis (HH) is tightly linked to mutations within the hemochromatosis gene (HFE gene). Over 93% of Irish HH patients are homozygous for the HFE gene C282Y mutation, providing a reliable diagnostic marker of the disease in this population. However, the prevalence of the C282Y mutation and that of the second HFE gene more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified - Abnormal findings on examination of blood, without diagnosis - hereditary hemochromatosis
Categories:
hereditary hemochromatosis
Geography:
Republic of Ireland
Genet Test,
Vol: 5 Page: 127-30 2001 Summer
V. Byrnes; E. Ryan; S. Barrett; P. Kenny; P. Mayne; J. Crowe
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The aim of this study was to investigate the ACE I/D genotype, the M235 T polymorphism of the angiotensinogen gene and the A1166 C polymorphism of AT1R in the lungs of congenital diaphragmatic hernia complicated by persistent pulmonary hypertension
Abstract:
BACKGROUND/PURPOSE: The renin-angiotensin system plays an important role in pulmonary artery remodelling. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the angiotensin converting enzyme (ACE), the angiotensinogen (AGT) gene, and the angiotensin II type 1 receptor (ATIR) have been associated with the development of pulmonary hypertension. more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital diaphragmatic hernia
Categories:
angiotensinogen; -congenital diaphragmatic hernia complicated by persistent pulmonary hypertension
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 39 Page: 302-6; discussion 302-6 March 2004
V. Solari; P. Puri
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This case report discusses the genitopatellar syndrome
Abstract:
Genitopatellar syndrome is a newly described condition, subject of a single literature report to date. The condition comprises absent patellae, genital and renal malformations, joint dislocation, and mental retardation. Recurrence has been recorded in two kindreds, consistent with autosomal recessive inheritance. more...
International Classification:
Syndrome
Categories:
Genitopatellar syndrome
Geography:
Republic of Ireland
Am J Med Genet,
Vol: 111 Page: 313-5 August 2002
W. Reardon
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The aim of this study was to examine genomic diversity of cultivable Lactobacillus populations residing in the neonatal and adult gastrointestinal tract
Abstract:
The objective of this study was to investigate the cultivable Lactobacillus population in adult and infant faecal material to identify strains shared across a number of individuals. A range of lactobacilli isolated on Lactobacillus-selective agar from faeces of 16 infants and 11 adults were genetically fingerprinted and further characterized by 16S rRNA gene sequencing. The relatedness more...
International Classification:
Other - Lactobacillus
Categories:
Lactobacillus; gastrointestinal tract
Geography:
Republic of Ireland
FEMS Microbiol Ecol,
Vol: 59 Page: 127-37 January 2007
R. Wall; G. Fitzgerald; S. Hussey; T. Ryan; B. Murphy; P. Ross; C. Stanton
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The aim of this study was to investigate the expression of glial-derived growth factor and RET in infantile hypertrophic pyloric stenosis
Abstract:
BACKGROUND/PURPOSE: Glial-derived growth factor (GDNF), which is the ligand of RET is reported to be essential for the development of enteric nervous system. A GDNF knockout mouse model has shown that the gastric region is a critical passing site between GDNF-RET-independent neuroblasts (colonizing the esophagus) and GDNF-RET-dependent neuroblasts (colonizing the small and large bowel). more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
glial-derived growth factor; -infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 35 Page: 835-9 June 2000
N. Guarino; H. Shima; T. Oue; P. Puri
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The aim of this study was to examine the expression of glucocorticoid receptor gene and its isoforms in the congenital diaphragmatic hernia lung
Abstract:
BACKGROUND/PURPOSE: In experimentally produced congenital diaphragmatic hernia (CDH), antenatal glucocorticoids have been shown to improve morphologic and biochemical lung immaturity and normalize the thickened pulmonary vascular wall. The action of glucocorticoids on a target tissue is mediated by glucocorticoid receptors (GRs), which have 2 isoforms; GRalpha binds glucocorticoids and more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital diaphragmatic hernia
Categories:
glucocorticoid receptor gene; -congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 37 Page: 715-8 May 2002
V. Solari; P. Puri
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The aim of the review was to determine the effects of glutamine supplementation on morbidity and weight gain in preterm babies.
Abstract:
BACKGROUND: The amino acid glutamine is the preferred respiratory fuel for rapidly proliferating cells under normal conditions. Recent research has suggested a number of roles for glutamine during critical illness. This research has been largely performed in experimental animals and in adults in a variety of disease settings. There is little information on the role of glutamine in more...
International Classification:
Systematic Review
Categories:
glutamine supplementation weight gain preterm babies
Geography:
Systematic Review
Cochrane Database Syst Rev,
2000
T. R. Tubman; S. W. Thompson
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