Irish Child Health Database - Peer Reviewed Papers
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This article discusses surfactant therapy as a contribution to care of the preterm newborn during the past 25 years.
Abstract:
In 1929 Kurt von Neergaard performed experiments suggesting the presence of pulmonary surfactant and its relevance to the newborn's first breath. Almost 25 years later, Richard Pattle, John Clements and Chris Macklin, each working on the effects of nerve gases on the lungs, contributed to the understanding of the physiology of pulmonary surfactant. About 5 years later Mary Ellen Avery more...
Geography:
Northern Ireland
J Perinatol,
Vol: 28 Suppl 1 Page: S47-56 May 2008
H. L. Halliday
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This article discusses adriamycin rat/mouse model and its importance to the paediatric surgeon
Abstract:
The teratogenic effect of Adriamycin (doxorubicin) in the rat model, and more recently in the mouse, has provided paediatric surgeons with a reliable, easily reproducible method of studying the embryology and molecular biology for a range of complex congenital anomalies. Concomitantly these animal models have stimulated interest among embryologists for the effect on the notochord, more...
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 24 Page: 113-8 January 2008
J. Gillick; A. Mortell; M. Dawrant; S. Giles; J. Bannigan; P. Puri
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The aim of this study was to determine the histochemical colocalization of cholinergic and nitrergic neurons in the porcine distal large bowel myenteric plexus from fetal to adulthood
Abstract:
PURPOSE: Cholinergic and nitrergic neurons form 2 main subpopulations of the myenteric neurons, and they have been the targets of detailed morphological investigations in bowel motility disorders. However, little is known regarding the colocalization of neurotransmitters within the same enteric neurons. The aim of this study was to determine the histochemical colocalization of more...
Categories:
histochemical colocalization of neurons; distal large bowel myenteric plexus
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 300-4 February 2007
T. Cserni; S. Paran; P. Puri
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The aim of this study was to examine the reaction rate of lactase on milk lactose by measuring milk osmolality; and explored the effect of formula reconstitution on milk osmolality
Abstract:
These experiments investigated the reaction rate of lactase on milk lactose by measuring milk osmolality; and explored the effect of formula reconstitution on milk osmolality. The investigations measured milk osmolality with the Fiske Os, freezing-point osmometer. Lactase (Lactaid) incubated with pure lactose solutions established the validity of the method. Lactase was incubated for 24 more...
International Classification:
Breastfeeding +/- formulae milk
Categories:
formula milk
Geography:
Republic of Ireland
Int J Food Sci Nutr,
Vol: 50 Page: 311-7 September 1999
A. J. Malone; P. J. Kearney; P. F. Duggan
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The aim of this study was to investigate effect of vagal neural crest ablation on the chick embryo cloaca
Abstract:
The cloaca, the caudal limit of the avian gastrointestinal tract, acts as a collecting chamber into which the gastrointestinal, urinary, and genital tracts discharge. It is intrinsically innervated by the enteric nervous system, which is derived from neural crest emigres that migrate from the vagal and sacral regions of the neural tube. Abnormal cloacal development can cause a number of more...
Categories:
vagal neural crest ablation
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 21 Page: 180-3 March 2005
A. M. Donnell; J. Bannigan; P. Puri
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The aim of this study was to examine s ocular toxocariasis and the resultant damage it causes to vision
Abstract:
Ocular toxocariasis damages vision and may cause blindness. It is a relatively 'new' disease, the histological changes having been described in 1950 and the causative organism identified in 1956. Many aspects of the epidemiology of toxocariasis are unclear. It is generally accepted that the usual route of entry to the eye is via the blood stream. Once the eye is invaded characteristic more...
International Classification:
Certain infectious and parasitic diseases - Helminthiases - ocular toxocariasis
Categories:
ocular toxocariasis
Geography:
Republic of Ireland
J Helminthol,
Vol: 75 Page: 109-18 June 2001
M. R. Taylor
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The aim of this study was to characterises escherichia coli as the principal gram-negative causative agent of sepsis and meningitis in neonates
Abstract:
Escherichia coli is the principal gram-negative causative agent of sepsis and meningitis in neonates. The pathogenesis of meningitis due to E. coli K1 involves mucosal colonization, transcytosis of epithelial cells, survival in the blood stream and eventually invasion of the meninges. The latter two aspects have been well characterized at a molecular level in the last decade. Less is more...
International Classification:
Diseases of the nervous system - Inflammatory diseases of the central nervous system - meningitis
Categories:
escherichia coli; sepsis; meningitis
Geography:
Republic of Ireland
FEMS Microbiol Lett,
Vol: 269 Page: 248-55 April 2007
R. P. Fagan; S. G. Smith
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The aim of this study was to investigate the presence of heart hypoplasia in nitrofen-induced congenital diaphragmatic hernia in rats and the role of specific tissue growth factors (bFGF and PDGF) in its genesis
Abstract:
Newborn infants with congenital diaphragmatic hernia (CDH) still have high mortality. Recently, the possible role of a cardiac maldevelopment in the high mortality has been suggested. Human and animal studies have demonstrated that heart weight is significantly reduced in the presence of CDH. Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) are pleiotropic more...
Categories:
growth factors; congenital diaphragmatic hernia
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 16 Page: 243-6 2000
N. Guarino; H. Shima; P. Puri
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This study reports the impact of a contaminated city water supply on an emergency department
Abstract:
In March 2007 Galway City and County's water supply was officially contaminated by cryptosporidiosis. The medical and nursing staff at the city's only Emergency Department had noted a rise in an atypical form of gastroenteritis in the preceding months. A retrospective audit of 11,723 charts from January 1st 2007 to 22nd March (day after contamination was confirmed) was performed to more...
International Classification:
Surveillance - contaminated city water
Categories:
contaminated water
Geography:
Republic of Ireland
Ir Med J,
Vol: 101 Page: 78-9 March 2008
N. C. Collins; S. Carr; S. Nasim; M. Mulkeen; A. J. Martin; J. J. O'Donnell
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This article discusses exogenous surfactant for respiratory distress syndrome in the newborn
Abstract:
This year is the 20th anniversary of the first successful trial of exogenous surfactant for respiratory distress syndrome in the newborn and it is perhaps a good time to review recent advances in basic science and clinical practice as they relate to surfactant therapy. more...
Geography:
Northern Ireland
Early Hum Dev,
Vol: 61 Page: 67-83 March 2001
A. E. Curley; H. L. Halliday
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This article discusses the public health importance of Ascaris lumbricoides
Abstract:
Numerous studies have shown that anthelminthic treatment can be effective in improving growth rates when given to malnourished children with ascariasis. Recent investigations have also indicated that Ascaris infections can affect mental processing in some school children. Poor socio-economic conditions are among the key factors linked with higher prevalences of ascariasis, as are more...
Geography:
Republic of Ireland
Parasitology,
Vol: 121 Suppl Page: S51-71 2000
P. O'Lorcain; C. V. Holland
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The aim of this study was to investigate the role of nitric oxide in the pathogenesis of injury to the bladder mucosa after bladder outlet obstruction
Abstract:
OBJECTIVE: To investigate the role of nitric oxide (NO) in the pathogenesis of injury to the bladder mucosa after bladder outlet obstruction (BOO). MATERIALS AND METHODS: The response of bladder mucosa to BOO consists of thickening with fibrous connective tissue; NO is a multipurpose messenger important in blood vessel relaxation, neuronal communication and inflammatory activities of more...
Categories:
nitric oxide; bladder injury
Geography:
Republic of Ireland
BJU Int,
Vol: 94 Page: 392-9 August 2004
B. Chertin; U. Rolle; V. Solari; S. Cascio; P. Puri
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The aim of this study was to test the hypothesized that low oxygen tension promotes lung growth in embryonic organ culture by investigating embryonic lung growth in normoxic and hypoxic conditions
Abstract:
BACKGROUND/PURPOSE: Oxygen tension is an important physiologic mediator of embryonic and fetal development. In vitro studies have demonstrated that the proper embryonic development is dependent upon low oxygen tension and even short exposure to normoxic environments (21%) can be detrimental to embryonic development. We hypothesized that low oxygen tension promotes lung growth in more...
Categories:
low oxygen tension; embryonic lung growth
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 32-5 January 2005
T. Shinkai; M. Shinkai; M. E. Pirker; S. Montedonico; P. Puri
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The aim of this study was to investigate the exact timing of the appearance of neural crest cells in the cloaca of chick embryos
Abstract:
Neural crest cell (NCC) migration and formation of the enteric nervous system (ENS) is an essential process in the development of the normal human gut. Abnormalities of the ENS lead to a number of neurochristopathies. In avian embryos, the cloaca acts as a common chamber into which gastrointestinal, urinary and genital tracts emerge. Previous studies have elucidated the specific more...
Categories:
neural crest cells
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 20 Page: 229-32 April 2004
A. M. O'Donnell; A. Mortell; J. Giles; J. Bannigan; P. Puri
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The aim of this study was to examine annual primary/national school attendance data over a 10 year period as a proxy health status measure
Abstract:
As a result of community concerns over animal and human ill health centred around a rural town in the Republic of Ireland, a series of epidemiological studies were conducted. The absence of adequate health-information systems forced researchers to investigate alternative methods of assessing child health in the 'at-risk' area. This study aimed to examine annual primary/national school more...
International Classification:
Other - Health status measure
Categories:
health status measure
Geography:
Republic of Ireland
Public Health,
Vol: 117 Page: 417-23 November 2003
F. Houghton; M. Gleeson; K. Kelleher
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This study aimed to examined the temperature sensitive of Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based (mass spectometry ) newborn screening
Abstract:
Medium-chain acyl-CoA dehydrogenase (MCAD) is a homotetrameric flavoprotein which catalyses the initial step of the beta-oxidation of medium-chain fatty acids. Mutations in MCAD may cause disease in humans. A Y42H mutation is frequently found in babies identified by newborn screening with MS/MS, yet there are no reports of patients presenting clinically with this mutation. As a basis more...
International Classification:
Effectiveness of measurement tool - temperature sensitive of Y42H mutation in medium-chain acyl-CoA dehydrogenase
Geography:
Republic of Ireland
Eur J Biochem,
Vol: 271 Page: 4053-63 October 2004
L. O'Reilly; P. Bross; T. J. Corydon; S. E. Olpin; J. Hansen; J. M. Kenney; S. E. McCandless; D. M. Frazier; V. Winter; N. Gregersen; P. C. Engel; B. S. Andresen
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The aim of this study was to describe tinea capitis in a paediatric population
Abstract:
Tinea capitis is an increasing problem in Europe. The pattern of infection is changing with an increase in pathogenic anthropophilic dermatophytes particularly Trichophyton tonsurans. We aimed to determine the frequency of tinea capitis in a paediatric population attending dermatology outpatients and examine the clinical spectrum of disease. A retrospective analysis was performed of all more...
International Classification:
Certain infectious and parasitic diseases - Mycoses - Tinea capitis
Categories:
Tinea capitis
Geography:
Republic of Ireland
Ir Med J,
Vol: 99 Page: 294-5 2006 Nov-Dec
B. C. Hackett; K. O'Connell; M. Cafferkey; B. F. O'Donnell; F. M. Keane
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The aim of this study was to describe unilateral spermatic vessel ligation in prepubertal rats decreases microvascular blood flow to ipsilateral testis postpubertally
Abstract:
High ligation of spermatic vessels (HLSV) and low ligation of spermatic vessels (LLSV) have been described in the surgical treatment of high undescended testis. Testicular capillary blood flow utilizing laser Doppler flowmetry after these maneuvers has not been studied thus far; hence, this study was designed. Thirty male rats, aged 30 days, were randomized into three groups: group I, more...
Categories:
decreases microvascular blood; ipsilateral testis
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 19 Page: 395-9 July 2003
M. Srinivas; B. Kilmartin; P. Basham; P. Puri
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The aim of this study was to examine 24-hour urinary fluoride excretion in young children exposed to different fluoride regimes
Abstract:
AIMS: To compare 24-hour urinary fluoride excretion in young children exposed to different fluoride regimes. DESIGN: Twenty-four-hour urine samples were collected from children aged between 1.8 and 5.2 years. Samples were collected from Cork, Ireland (n=19) where the water is fluoridated to a concentration between 0.8 and 1.0 mg/l; Knowsley, UK, where the water fluoride concentration is more...
International Classification:
Dental
Categories:
fluoride
Geography:
Republic of Ireland
Community Dent Health,
Vol: 19 Page: 12-7 March 2002
C. E. Ketley; J. A. Cochran; M. A. Lennon; D. M. O'Mullane; H. V. Worthington
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The aim of this study was to investigate the contribution of vagal neural crest cells to the total population of enteric neurons and glia within the chick embryo cloaca, using quail-chick chimeras
Abstract:
Intrinsic innervation of the developing chick cloaca is provided by the enteric nervous system, a network of neurons and glia that lies within its walls. The enteric nervous system originates from neural crest cells that migrate from the vagal and sacral regions of the neural tube during the early stages of development. Abnormal cloacal development can cause a number of anorectal more...
Categories:
neural crest cells; enteric neurons and glia
Geography:
Northern Ireland
Pediatr Surg Int,
Vol: 22 Page: 983-6 December 2006
O' Donnell AM ; J. Bannigan; P. Puri
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This article discusses issues of animal wastes and effluents from farming operations
Abstract:
Animal wastes and effluents from farming operations, including manures and slurries, are frequently applied as fertilizer to land used for crop or silage production and cattle grazing. It is well documented that potentially harmful pathogens including verocytoxigenic Escherichia coli (VTEC) are shed in animal faeces and there is growing concern in many countries about the number of more...
Geography:
Republic of Ireland
J Appl Microbiol,
Vol: 94 Suppl Page: 94S-103S 2003
G. Duffy
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The aim of this study was to present evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination
Abstract:
Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children. In contrast, the new acellular pertussis vaccines (Pa) have a considerably improved safety profile. The lack of an appropriate animal model has restricted more...
Categories:
toxin-induced interleukin-1beta; neuronal side effects of vaccination
Geography:
Republic of Ireland
Infect Immun,
Vol: 69 Page: 4217-23 July 2001
S. Donnelly; C. E. Loscher; M. A. Lynch; K. H. Mills
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This article discusses the necessity of Ethics committees to control research
Geography:
Republic of Ireland
Paediatr Nurs,
Vol: 15 Page: 19 December 2003
L. Shields; A. Iwycross
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This article discusses the causal organisms associated with the zoonoses Campylobacter, Escherichia coli, a description of previous outbreaks at farms and zoos, as well as infection control measures to help prevent such zoonotic infections.
Abstract:
The popularity of open farms and petting zoos has increased markedly over the last 5 years, with most children in developed countries now having the opportunity to visit such a facility at some stage in their childhood, either through school or family visits. The open access policy of these establishments allows visitors to be in direct contact with animals such as sheep (lambs), goats, more...
Geography:
Northern Ireland
Vector Borne Zoonotic Dis,
Vol: 8 Page: 85-92 2008 Spring
J. Stirling; M. Griffith; J. S. Dooley; C. E. Goldsmith; A. Loughrey; C. J. Lowery; R. McClurg; K. McCorry; D. McDowell; A. McMahon; B. C. Millar; J. Rao; P. J. Rooney; W. J. Snelling; M. Matsuda; J. E. Moore
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