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1. Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats

The aim of this study was to determine the gene level expression of fibroblast growth factors-10 and FGF-7 in the lung of nitrofen-induced congenital diaphragmatic hernia

Abstract:

BACKGROUND/PURPOSE: Newborns with congenital diaphragmatic hernia (CDH) still have a high mortality rate, which has been attributed to pulmonary hypoplasia and pulmonary hypertension. Fibroblast growth factors (FGFs) are essential components of the gene network that regulates lung development. Recent studies suggest that the new member of FGF family, FGF-10, plays a fundamental role in more...

Categories:

gene level expression; congenital diaphragmatic hernia

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 38 Page: 1021-4 July 2003
H. Teramoto; A. Yoneda; P. Puri

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2. Gene expression of insulin-like growth factor-1 and epidermal growth factor is downregulated in the heart of rats with nitrofen-induced diaphragmatic hernia

The aim of this study was to determine the gene-level expression of insulin-like growth factor-1 and epidermal growth factor in the hearts of rats with nitrofen-induced congenital diaphragmatic hernia

Abstract:

Newborns with congenital diaphragmatic hernia (CDH) still have high mortality. Recently, a possible role of cardiac maldevelopment has been suggested. Human and experimental studies have demonstrated that heart weight is significantly reduced in the presence of CDH. Recent studies have suggested an important role for insulin-like growth factor-I (IGF-I) in the regulation of cardiac more...

Categories:

insulin-like growth factor-1; epidermal growth factor; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 17 Page: 284-7 May 2001
H. Teramoto; P. Puri

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3. Glutathione S-transferase: a potential new marker of intestinal ischemia

The aim of this study was to determine if Glutathione S-transferase levels correlated with histologic changes of intestinal ischemia in a controlled animal model of mesenteric intestinal ischemia

Abstract:

BACKGROUND/PURPOSE: The accurate and early diagnosis of intestinal ischemia remains difficult chiefly because of a lack of a suitable marker that is noninvasive and easy to use. The glutathione S-transferases (GST) are a family of cytosolic enzymes involved in detoxification and released from a variety of cells when the cell membrane is damaged. The enzymes are distributed widely in the more...

Categories:

Glutathione S-transferase levels; mesenteric intestinal ischemia

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 37 Page: 1543-8 November 2002
S. Khurana; M. T. Corbally; F. Manning; T. Armenise; B. Kierce; C. Kilty

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4. Helicobacter pylori infection of human and murine primary gastric cells

The aim of this study was to examine the effect of Helicobacter pylori infection on human and murine primary gastric cells was determined

Abstract:

The effect of Helicobacter pylori infection on human and murine primary gastric cells was determined. CagA was phosphorylated following adherence of H. pylori to primary human gastric cells. However, it did not adhere to human primary duodenal cells or murine gastric cells, and CagA could not be detected in cell lysates. Identification of an easily available animal model of infection in more...

International Classification:

Bacterium - Helicobacter pylori

Categories:

Helicobacter pylori infection

Geography:

Republic of Ireland

Infect Immun, Vol: 72 Page: 5464-9 September 2004
M. Clyne; B. Drumm

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5. High mineral and vitamin E intake by pregnant ewes lowers colostral immunoglobulin G absorption by the lamb

The aim of this study was to evaluate the effects of supplementing pregnant ewe's diet with high levels of minerals and vitamin E on immunoglobulin G absorption by the lamb and if any altered efficacy of IgG absorption was due to colostrum or the lamb

Abstract:

A 2 x 2 factorial arrangement of treatments with 78 mature ewes was used to evaluate the effects of supplementing the pregnant ewe's diet with high levels of minerals and vitamin E on immunoglobulin G (IgG) absorption by the lamb and whether any altered efficacy of IgG absorption was due to the colostrum or to the lamb. The ewes were estrus-synchronized in October and housed in wk 10 of more...

Categories:

dietary supplementation immunoglobulin G absorption

Geography:

Republic of Ireland

J Anim Sci, Vol: 83 Page: 871-8 April 2005
T. M. Boland; N. Keane; P. Nowakowski; P. O. Brophy; T. F. Crosby

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6. History of surfactant from 1980

This article discusses the story of surfactant from 1980

Abstract:

The first successful trial of surfactant treatment for respiratory distress syndrome (RDS) was reported in 1980. Since then there have been numerous randomised trials demonstrating first, the efficacy of surfactant treatment in reducing pulmonary air leaks and increasing survival and second, assessing various other aspects of therapy. These studies show that multiple doses may be needed more...

Geography:

Northern Ireland

Biol Neonate, Vol: 87 Page: 317-22 2005
H. L. Halliday

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7. Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes

The aim of the study was to examine the urban-rural variation in mortality and hospital admission rates for unintentional injury in Ireland

Abstract:

It has been recognized recently that human cryptosporidiosis is usually caused by Cryptosporidium parvum genotype I ("human" C. parvum), which is not found in animals. Compared to C. parvum genotype II, little is known of the biology of invasion of the human-restricted C. parvum genotype I. The aims of the present study were (i) to explore and compare with genotype II the more...

International Classification:

Injury, poisoning and certain other consequences of external causes - unintentional injury

Categories:

urban-rural variation in mortality

Geography:

Republic of Ireland

Infect Immun, Vol: 72 Page: 6125-31 October 2004
A. Hashim; M. Clyne; G. Mulcahy; D. Akiyoshi; R. Chalmers; B. Bourke

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8. Human seroprevalence to Coxiella burnetii (Q fever) in Northern Ireland

The aim of this study was to examine the distribution and determinants of C. Burnetii past infection

Abstract:

Despite the widespread prevalence of infection with Coxiella burnetii, there have been few large population-based studies examining the epidemiology of this infection. The aim of this study was to examine the distribution and determinants of C. burnetii past infection in Northern Ireland (NI). Coxiella burnetii phase II specific IgG antibodies were measured by enzyme-linked more...

International Classification:

Bacterium - C. Burnetii

Categories:

C. burnetii

Geography:

Northern Ireland

Zoonoses Public Health, Vol: 55 Page: 189-94 May 2008
C. McCaughey; J. McKenna; C. McKenna; P. V. Coyle; H. J. O'Neill; D. E. Wyatt; B. Smyth; L. J. Murray

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9. Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia

The aim of this study was to investigate molecular markers for AECs-I [ICAM-1, T1alpha, aquaporin 5 ] and molecular markers for AECs-II [thyroid transcription factor-1), surfactant protein in the nitrofen-induced congenital diaphragmatic hernia lung

Abstract:

Pulmonary hypoplasia is the principal cause of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Still, relatively little is known about the mechanisms causing lung hypoplasia associated with CDH. The differentiation from alveolar epithelial cells type II (AECs-II) into alveolar epithelial cells type I (AECs-I) is one of the key processes in lung development more...

Categories:

molecular markers; congenital diaphragmatic hernia lung

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 23 Page: 405-10 May 2007
H. Takayasu; N. Nakazawa; S. Montedonico; K. Sugimoto; H. Sato; P. Puri

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10. Increased expression of ICAM-1 and VCAM-1 in the lung of nitrofen-induced congenital diaphragmatic hernia in rats

The aim of this study was to investigate pulmonary ICAM-1 and VCAM-1 expression in congenital diaphragmatic hernia lung in rats and to determine the effect of antenatal glucocorticoid

Abstract:

Recently, increased expression of inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been reported in both humans and animal models with CDH and the decreased TNF-alpha expression in CDH lung after antenatal dexamethasone (Dex) treatment. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 are induced by several inflammatory cytokines such as more...

Categories:

antenatal glucocorticoid; congenital diaphragmatic hernia lung

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 19 Page: 365-70 July 2003
K. Unemoto; M. Sakai; H. Shima; N. Guarino; P. Puri

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11. Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model

The aim of this study was to examine the hypothesis that adriamycin administration could promote upregulation of FN expression increasing gut-notochord adherence and development of abnormal ventral notochordal branching in the Adriamycin rat model

Abstract:

BACKGROUND: The VACTERL association is a spectrum of clinical conditions, including esophageal atresia (EA) and tracheoesophageal fistula (TEF), which affects approximately 1 in 5,000 live human births. The administration of intraperitoneal Adriamycin to pregnant rats reliably induces anomalies, such as EA and TEF, in their offspring, in what is known as the Adriamycin rat model (ARM). more...

Categories:

adriamycin; abnormal ventral notochordal branching

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 20 Page: 276-82 April 2004
A. Mortell; A. M. O'Donnell; S. Giles; J. Bannigan; P. Puri

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12. Increased vascular endothelial growth factor peptide and gene expression in hypoplastic lung in nitrofen induced congenital diaphragmatic hernia in rats

The aim of this study was to investigate mRNA and protein levels of vascular endothelial growth factor in congenital diaphragmatic hernia lung and to determine whether antenatal Dex treatment has any effect Vascular endothelial growth factor production

Abstract:

Persistent pulmonary hypertension (PPH) in congenital diaphragmatic hernia (CDH) lung has been shown to be associated with structural changes in the pulmonary vasculature, including medial and adventitial thickening. Vascular endothelial growth factor (VEGF) is a potent mitogenic and permeability factor targeting predominantly endothelial cells. mRNA encoding VEGF is detected in all more...

Categories:

mRNA and protein levels; congenital diaphragmatic hernia lung; vascular endothelial growth factor

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 18 Page: 221-6 May 2002
T. Oue; A. Yoneda; H. Shima; Y. Taira; P. Puri

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13. Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis

The aim of this study was to describe Bordetella pertussis respiratory infection, its expression of mRNA transcripts for IL-1beta and TNFalpha and transient expression of IL-6 in the hippocampus and hypothalamus

Abstract:

Parenteral injection of endotoxin has been used as a model to examine the role of pro-inflammatory cytokines in the centrally controlled responses to Gram-negative bacterial infection. However, the events that occur following mucosal exposure to live bacteria have received little attention. In this study, we have used a murine model to demonstrate that respiratory infection with more...

Categories:

Bordetella pertussis respiratory infection; hippocampus and hypothalamus

Geography:

Republic of Ireland

J Neuroimmunol, Vol: 102 Page: 172-81 January 2000
C. E. Loscher; S. Donnelly; M. A. Lynch; K. H. Mills

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14. Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells

The aim of this study was to compare the mechanisms of Cryptosporidium parvum and Cryptosporidium hominis invasion using a primary cell model of infection

Abstract:

Cryptosporidiosis in humans is caused by the zoonotic pathogen Cryptosporidium parvum and the anthroponotic pathogen Cryptosporidium hominis. To what extent the recently recognized C. hominis species differs from C. parvum is unknown. In this study we compared the mechanisms of C. parvum and C. hominis invasion using a primary cell model of infection. Cultured primary bovine and human more...

Categories:

Cryptosporidium parvum; Cryptosporidium hominis; mechanisms of infection

Geography:

Republic of Ireland

Infect Immun, Vol: 74 Page: 99-107 January 2006
A. Hashim; G. Mulcahy; B. Bourke; M. Clyne

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15. Is nutrition an aetiological factor for inflammatory bowel disease?

This article discusses the relationship between components of the diet and inflammatory bowel disease, including ulcerative colitis and Crohn's disease

Abstract:

Inflammatory bowel disease (IBD) is a chronic inflammatory process, the aetiology of which is complex and probably multi-factorial. Nutrition has been proposed to be an important aetiological factor for IBD. The present review critically examines the relationship between components of the diet (such as sugar, fat, fibre, fruit and vegetables, and protein) and IBD, including ulcerative more...

Geography:

Republic of Ireland

Eur J Gastroenterol Hepatol, Vol: 15 Page: 607-13 June 2003
K. D. Cashman; F. Shanahan

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16. Key apoptosis regulating proteins are down-regulated during postnatal tissue development

The aim of this study was to investigate if key apoptosis regulating proteins are down-regulated during postnatal tissue development

Abstract:

The intrinsic apoptotic pathway is essential for murine development. We have previously shown that key mediators of this pathway, such as Bim, Apaf-1 and caspase-3, are down-regulated during the postnatal development of the retina. In this study, we demonstrate that this expression pattern is a feature of other distinct tissues such as the brain, heart and skeletal muscle. Caspase-9 more...

Categories:

apoptosis regulating proteins; postnatal tissue development

Geography:

Republic of Ireland

Int J Dev Biol, Vol: 51 Page: 415-23 2007
S. D. Madden; M. Donovan; T. G. Cotter

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17. Kidney development in the nitrofen-induced pulmonary hypoplasia and congenital diaphragmatic hernia in rats

The aims of this study were to investigate the effects of pulmonary hypoplasia on renal development and to evaluate retinoids status of kidneys in the nitrofen model of congenital diaphragmatic hernia

Abstract:

BACKGROUND/PURPOSE: The relationship of the developing lung and kidney is not completely understood. Renal enlargement has been reported in association with pulmonary hypoplasia in congenital diaphragmatic hernia (CDH). Recent studies suggest that retinoids may be involved in the pathogenesis of CDH. The aims of this study were to investigate the effects of pulmonary hypoplasia on renal more...

Categories:

pulmonary hypoplasia; renal development; congenital diaphragmatic hernia

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 42 Page: 239-43 January 2007
S. Montedonico; N. Nakazawa; T. Shinkai; J. Bannigan; P. Puri

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18. Linkage mapping of the locus for inherited ovine arthrogryposis (IOA) to sheep chromosome 5

The aim of this study was to undertake a genome scan using 187 microsatellite genetic markers and all backcross animals were phenotyped at birth for the presence and severity of arthrogryposis

Abstract:

Arthrogryposis is a congenital malformation affecting the limbs of newborn animals and infants. Previous work has demonstrated that inherited ovine arthrogryposis (IOA) has an autosomal recessive mode of inheritance. Two affected homozygous recessive (art/art) Suffolk rams were used as founders for a backcross pedigree of half-sib families segregating the IOA trait. A genome scan was more...

Categories:

genome scan; genetic markers; arthrogryposis

Geography:

Republic of Ireland

Mamm Genome, Vol: 18 Page: 43-52 January 2007
A. M. Murphy; D. E. MacHugh; S. D. Park; E. Scraggs; C. S. Haley; D. J. Lynn; M. P. Boland; M. L. Doherty

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19. Low incidence of concurrent enteric infection associated with sporadic and outbreak-related human cryptosporidiosis in Northern Ireland

The aim of this study was to examine the frequency of mixed enteric infections with C.parvum and to determine the coinfecting organism in both sporadic and outbreak-related cryptosporidiosis

International Classification:

Certain infectious and parasitic diseases - Intestinal infectious diseases - cryptosporidiosis

Categories:

enteric infections; C.parvum

Geography:

Northern Ireland

J Clin Microbiol, Vol: 40 Page: 3107-8 August 2002
J. E. Moore; L. Crothers; B. C. Millar; E. Crothers; P. J. Rooney; L. Xiao; J. S. Dooley; C. J. Lowery

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20. Low risk of inhibitor formation in haemophilia patients after a change in treatment from Chinese hamster ovary cell-produced to baby hamster kidney cell-produced recombinant factor VIII

This study examined the low risk of inhibitor formation in haemophilia patients after a change in treatment from Chinese hamster ovary cell-produced to baby hamster kidney cell-produced recombinant factor VIII

Abstract:

This retrospective survey of haemophilia A patients from multiple treatment centres in Ireland assessed the development of inhibitors following a switch in the prescribed treatment from recombinant factor VIII (rFVIII) produced by Chinese hamster ovary (CHO) cells (rFVIII-CHO) to rFVIII produced by baby hamster kidney (BHK) cells (rFVIII-BHK). Ninety-four patients participated in the more...

International Classification:

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - Coagulation defects, purpura and other haemorrhagic conditions - haemophilia

Categories:

inhibitor formation in haemophilia patients

Geography:

Republic of Ireland

Thromb Haemost, Vol: 98 Page: 1188-92 December 2007
E. Singleton; J. Smith; M. Kavanagh; B. Nolan; B. White

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21. Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans

This study examined the range in classification of overweight - according to four standard assessment methods

Abstract:

Candida albicans and C. dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two infection models. Under all induction conditions tested C. albicans consistently produced hyphae more efficiently than C. dubliniensis. In the oral reconstituted human epithelial more...

International Classification:

Longitudinal - classification of overweight

Categories:

classification of overweight - according to four standard assessment methods

Geography:

Republic of Ireland

Fungal Genet Biol, Vol: 44 Page: 920-31 September 2007
C. Stokes; G. P. Moran; M. J. Spiering; G. T. Cole; D. C. Coleman; D. J. Sullivan

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22. Mammalian sleep

This article examines the biological background to the development of ideas on rapid eye movement sleep (REM sleep), so-called paradoxical sleep (PS), and its relation to dreaming.

Abstract:

This review examines the biological background to the development of ideas on rapid eye movement sleep (REM sleep), so-called paradoxical sleep (PS), and its relation to dreaming. Aspects of the phenomenon which are discussed include physiological changes and their anatomical location, the effects of total and selective sleep deprivation in the human and animal, and REM sleep behavior more...

Geography:

Republic of Ireland

Naturwissenschaften, Vol: 92 Page: 203-20 May 2005
H. Staunton

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23. Management of anticoagulation and its reversal during paediatric cardiopulmonary bypass: a review of current UK practice

This study aimed to obtain an overview of current practice of management of anticoagulation and its reversal from paediatric cardiac surgical units of Great Britain and Ireland

Abstract:

Protocols for management of heparin and protamine administration in patients undergoing open-heart surgery have been developed from experience gained mainly in adult practice. However, it has been demonstrated that there are marked differences between paediatric and adult patients in their response to systemic anticoagulation and its reversal. The aim of this study was to obtain an more...

International Classification:

Practice/knowledge - anticoagulation

Categories:

anticoagulation

Geography:

Republic of Ireland and the United Kingdom

Perfusion, Vol: 15 Page: 191-201 June 2000
M. Codispoti; P. S. Mankad

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24. Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects

This article discusses methylphenidate for attention-deficit hyperactivity disorder: a review of its neuropharmacological, neuropsychological and adverse clinical effects

Geography:

Republic of Ireland

Hum Psychopharmacol, Vol: 19 Page: 151-80 April 2004
B. E. Leonard; D. McCartan; J. White; D. J. King

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25. Modulation of immune cell function by polyunsaturated fatty acids

The article discusses modulation of immune cell function by polyunsaturated fatty acids

Abstract:

The n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential dietary constituents. They are important as a source of energy, as structural components of cell membranes, and as signalling molecules. They have been demonstrated to be potent modulators of the immune response, and research has endeavoured to optimise the ratio of n-3 to n-6 PUFAs in the lipid component of total more...

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 21 Page: 335-40 May 2005
B. Sweeney; P. Puri; D. J. Reen

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26. Molecular genotyping of human cryptosporidiosis in Northern Ireland: epidemiological aspects and review

The aim of this study was to examine the genotype of C. parvum oocysts isolated from human faeces in sporadic cases of cryptosporidiosis in Northern Ireland

Abstract:

BACKGROUND: Cryptosporidium parvum is the most common of the protozoal pathogens associated with gastrointestinal disease in Northern Ireland. Genotyping techniques are valuable in helping to elucidate sources and modes of transmission of this parasite. There have been no reports on the prevalence of genotypes in Northern Ireland, mainly due to a lack of discriminatory genotyping more...

International Classification:

Certain infectious and parasitic diseases - Intestinal infectious diseases - cryptosporidiosis

Categories:

cryptosporidiosis

Geography:

Northern Ireland

Ir J Med Sci, Vol: 170 Page: 246-50 2001 Oct-Dec
C. J. Lowery; B. C. Millar; J. E. Moore; J. Xu; L. Xiao; P. J. Rooney; L. Crothers; J. S. Dooley

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27. Multiple gastrointestinal atresias result from disturbed morphogenesis

The aim of this study was to determine the incidence and histopathologic findings of multiple gastrointestinal atresias in order to understand the pathogenesis

Abstract:

Multiple gastrointestinal atresias (MGA) have been reported to account for 6% to 32% of all intestinal atresias. Controversy exists regarding the pathogenesis. Many investigators believe MGA to be the result of multiple ischemic infarctions of the intestinal tract. However, some have suggested that MGA results from a malformative process early in fetal life. Prenatal exposure to more...

Categories:

gastrointestinal atresias

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 17 Page: 361-4 July 2001
L. Fourcade; H. Shima; E. Miyazaki; P. Puri

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28. New hypothesis on the pathogenesis of ileocecal intussusception

The aim of this study was to examine the age-related changes in the nitrergic innervation of the ileocecal valve to gain insights into the pathogenesis of intussusception

Abstract:

PURPOSE: Ileocecal intussusception is a relatively common surgical emergency in infants and young children. The etiology of intussusception is not clearly understood. Nitric oxide (NO) is a major inhibitory neurotransmitter in the enteric nervous system, which causes relaxation of the smooth muscles. In a lipopolysaccharide-induced experimental model of intussusception, altered more...

Categories:

nitrergic innervation of the ileocecal valve; intussusception

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 42 Page: 1515-9 September 2007
T. Cserni; S. Paran; P. Puri

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29. Non-multifactorial neural tube defects

This article discusses known chromosome alterations and the candidate genes residing in the altered region, as well as syndromes associated with neural tube defects and causative genes, if known

Abstract:

Although most neural tube defects (anencephaly, spina bifida) occur as isolated malformations, a substantial proportion are attributable to chromosome anomalies, known teratogens, or component manifestations of multiple anomaly syndromes. This review describes known chromosome alterations and the candidate genes residing in the altered region, as well as syndromes associated with neural more...

Geography:

Republic of Ireland

Am J Med Genet C Semin Med Genet, Vol: 135C Page: 69-76 May 2005
S. A. Lynch

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30. Notable sequential alterations in notochord volume during development in the Adriamycin rat model

The aim of this study was to assess notochord volume sequentially from gestational days 10 to 14 to test the hypothesis that notochord hypertrophy occurs maximally soon after Adriamycin administration

Abstract:

BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the vertebral, anorectal, cardiac, tracheoesophageal, renal, and limb association. An important finding in the ARM is that Adriamycin induces abnormal notochord morphology in the region of the foregut. Having recently demonstrated notochord hypertrophy in ARM embryos, the authors designed this study to more...

Categories:

notochord volume; Adriamycin

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 40 Page: 403-6 February 2005
A. Mortell; J. Gillick; S. Giles; J. Bannigan; P. Puri

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31. Notochord anomalies in the adriamycin rat model: A morphologic and molecular basis for the VACTERL association

The aim of this study was to test the hypothesize that notochord anomalies allow ectopic expression of molecular signals in the developing embryo and thus lead to VACTERL malformations

Abstract:

BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a reliable model of the VACTERL association. The notochord is structurally abnormal in the region of the foregut, midgut, and hindgut in the ARM. The authors hypothesised that notochord anomalies allow ectopic expression of molecular signals in the developing embryo and thus lead to VACTERL malformations. This study was designed to more...

Categories:

notochord anomalies; VACTERL malformations - Vertebral Anal Cardiac Fistula +/- eosophageal atresia : Renal or Radius Limb anomalies

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 38 Page: 469-73; discussion 469-73 March 2003
J. Gillick; E. Mooney; S. Giles; J. Bannigan; P. Puri

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32. Ocular toxocariasis in schoolchildren

The aim of this study was to examine the extent of consultant-diagnosed toxocaral eye disease among a population of schoolchildren

Abstract:

Ocular toxocariasis in humans is typically a unilateral disease caused by second-stage larvae of the Toxocara species. Serological evidence of widespread infection in humans provides little information on clinical disease. There is only a single previous estimate of the prevalence of ocular toxocariasis (from Alabama). The present survey examined the extent of consultant-diagnosed more...

International Classification:

Certain infectious and parasitic diseases - Helminthiases - toxocaral eye disease

Categories:

consultant-diagnosed toxocaral eye disease

Geography:

Republic of Ireland

Clin Infect Dis, Vol: 39 Page: 173-8 July 2004
B. Good; C. V. Holland; M. R. Taylor; J. Larragy; P. Moriarty; M. O'Regan

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33. Ocular wounding prevents pre-retinal neovascularization and upregulates PEDF expression in the inner retina

The aim of this study was to investigate a possible anti-angiogenic effect of penetrating ocular injury in a murine model of oxygen induced proliferative retinopathy (OIR) and determined if such a procedure alters PEDF expression in the retina

Abstract:

PURPOSE: Perforation injury to the eye can protect against retinal degeneration and pigment epithelial derived factor (PEDF) may play a role in this neuro-protective effect. PEDF has also been shown to possess potent anti-angiogenic properties. The current study has investigated a possible anti-angiogenic effect of penetrating ocular injury in a murine model of oxygen induced more...

International Classification:

Injury, poisoning and certain other consequences of external causes - injury

Categories:

ocular injuries

Geography:

Republic of Ireland

Mol Vis, Vol: 10 Page: 432-8 June 2004
A. W. Stitt; D. Graham; T. A. Gardiner

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34. Pathogenesis of Hirschsprung's disease and its variants: recent progress

The article discusses pathogenesis of Hirschsprung's disease and its variants: recent progress

Abstract:

The enteric nervous system (ENS) is a complex network of interconnected neurons within the wall of the intestine that controls intestinal motility, regulates mucosal secretion and blood flow, and also modulates sensation from the gut. The cells that form the ENS in mammals are derived primarily from vagal neural crest cells. During the past decade there has been an explosion of more...

Geography:

Republic of Ireland

Semin Pediatr Surg, Vol: 13 Page: 18-24 February 2004
P. Puri; T. Shinkai

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35. Patterns of milk and food intake in infants from birth to age 36 months: the Euro-growth study

The aim of this study was to describe patterns of milk and food intake in infants from birth to age 36 months

Abstract:

BACKGROUND: Little detailed information is available on feeding practices of infants in Europe. The Euro-Growth Study is a longitudinal, observational, multicenter study of milk feeding, the introduction of complementary solid foods, and vitamin and mineral supplementation. Current practice is compared with international feeding recommendations. METHOD: Healthy term infants (n = 2,245) more...

International Classification:

Diet and lifestyle

Categories:

diet

Geography:

International

J Pediatr Gastroenterol Nutr, Vol: 31 Suppl 1 Page: S76-85 2000
V. Freeman; M. van't Hof; F. Haschke

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36. Postnatal development of the mucosal plexus in the porcine small and large intestine

The aim of this study was to investigate the development of enteric mucosal innervation in the pig at various ages of life

Abstract:

Knowledge regarding the foetal and postnatal development of the enteric nervous system is crucial for the understanding of congenital disorders. While lot of information exists regarding the myenteric and submucosal plexuses, the development of the mucosal plexus has not been previously studied. The mucosal innervation seems to play an important role in the local reflex activity of the more...

Categories:

enteric mucosal innervation

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 22 Page: 997-1001 December 2006
T. S. Paran; U. Rolle; P. Puri

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37. Prenatal and postnatal neuromuscular development of the ureterovesical junction

The aim of this study was to analyzed the development of smooth muscle components of the ureterovesical junction and their nerve supply in the fetal, newborn and adolescent pig

Abstract:

PURPOSE: The mechanisms underlying functional maturation of the ureterovesical junction during infancy are still not fully understood. We analyzed the development of smooth muscle components of the ureterovesical junction and their nerve supply in the fetal, newborn and adolescent pig. MATERIALS AND METHODS: Bladder specimens were obtained from porcine fetuses at gestational ages 60 more...

Categories:

ureterovesical junction; nerve supply in the fetal

Geography:

Republic of Ireland

J Urol, Vol: 177 Page: 1546-51 April 2007
M. E. Pirker; U. Rolle; T. Shinkai; M. Shinkai; P. Puri

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38. Prepubertal unilateral spermatic vessel ligation decreases haploid cell population of ipsilateral testis postpubertally in rats

The aim of this study was to describe how prepubertal unilateral spermatic vessel ligation decreases haploid cell population of ipsilateral testis postpubertally in rats

Abstract:

DNA flow cytometry is a sensitive and rapid technique to evaluate the germ cell maturation of testis. The haploid cell population of testis specifically denotes testicular maturation. High ligation of spermatic vessels (HLSV) and low ligation of spermatic vessels (LLSV) have been described in the surgical treatment of high undescended testis. Estimation of germ cell population of testis more...

Categories:

haploid cell population of ipsilateral testis

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 21 Page: 360-3 May 2005
M. Srinivas; B. Kilmartin; S. N. Das; P. Puri

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39. Prevalence of gastrointestinal bacterial pathogens in a population of zoo animals

The aim of this study was to the prevalence of gastrointestinal bacterial pathogens - Campylobacter, Escherichia coli O157:H7, Salmonella, Shigella, Yersinia, Arcobacter

Abstract:

Faecal prevalence of gastrointestinal bacterial pathogens, including Campylobacter, Escherichia coli O157:H7, Salmonella, Shigella, Yersinia, as well as Arcobacter, were examined in 317 faecal specimens from 44 animal species in Belfast Zoological Gardens, during July-September 2006. Thermophilic campylobacters including Campylobacter jejuni, Campylobacter coli and Campylobacter lari, more...

Categories:

faecal prevalence of gastrointestinal bacterial pathogens Campylobacter, Escherichia coli O157:H7, Salmonella, Shigella, Yersinia, Arcobacter

Geography:

Northern Ireland

Zoonoses Public Health, Vol: 55 Page: 166-72 April 2008
J. Stirling; M. Griffith; I. Blair; M. Cormican; J. S. Dooley; C. E. Goldsmith; S. G. Glover; A. Loughrey; C. J. Lowery; M. Matsuda; R. McClurg; K. McCorry; D. McDowell; A. McMahon; B. Cherie Millar; Y. Nagano; J. R. Rao; P. J. Rooney; M. Smyth; W. J. Snelling; J. Xu; J. E. Moore

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40. Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: implications for long-term immunity in children

The aim of this study was to examine the murine respiratory challenge model to demonstrate persistent vaccine-induced protection against Bordetella pertussis in the absence of circulating antibody at the time of challenge

Abstract:

Most vaccines used for humans work through humoral immunity, yet many appear to be protective even after specific circulating antibody levels have waned to undetectable levels. Furthermore, it has been difficult to define a serologic correlate of protection against a number of infectious diseases, including those caused by Bordetella pertussis. B. pertussis clearance in immunized mice more...

Categories:

murine respiratory challenge model; vaccine-induced protection; Bordetella pertussis

Geography:

Republic of Ireland

J Infect Dis, Vol: 181 Page: 2087-91 June 2000
B. P. Mahon; M. T. Brady; K. H. Mills

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41. Rabbit antithymocyte globulin as induction immunotherapy for pediatric deceased donor kidney transplantation

This study studied the long-term results and safety of antithymocyte globulin as induction immunotherapy in all children undergoing transplantation at our institution since 1991

Abstract:

PURPOSE: There is scant literature describing the long-term outcome of the use of antithymocyte globulin induction immunotherapy in pediatric deceased donor kidney transplants. We retrospectively studied the long-term results and safety of antithymocyte globulin as induction immunotherapy in all children undergoing transplantation at our institution since 1991. MATERIALS AND METHODS: A more...

International Classification:

Organ transplants

Categories:

antithymocyte globulin as induction immunotherapy; -organ transplants

Geography:

Republic of Ireland

J Urol, Vol: 174 Page: 703-7 August 2005
M. H. Kamel; P. Mohan; D. M. Little; A. Awan; D. P. Hickey

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42. Rabbit antithymocyte globulin related decrease in platelet count reduced risk of pediatric renal transplant graft thrombosis

The aim of the study was to compare the potential protective effect for the decrease in platelet count associated with RATG therapy against pediatric renal transplant graft vascular thrombosis

Abstract:

Graft thrombosis is a serious complication in pediatric renal transplantation. We assess a potential protective effect for the decrease in platelet count associated with RATG therapy against pediatric renal transplant graft vascular thrombosis. Between January 1986 and December 1998, 120 kidney transplants were performed in 95 pediatric recipients. Patients were divided into two groups. more...

International Classification:

Organ transplants

Categories:

renal transplant graft vascular thrombosis

Geography:

Republic of Ireland

Pediatr Transplant, Vol: 10 Page: 816-21 November 2006
M. H. Kamel; P. Mohan; P. J. Conlon; D. M. Little; P. O'Kelly; D. P. Hickey

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43. Random mutagenesis to identify novel Helicobacter mustelae virulence factors

The aim of this study was to examine the relationship between Helicobacter mustelae and AGS cells in rats

Abstract:

Helicobacter mustelae is a gastric pathogen of ferrets, where it causes disorders similar to those caused by Helicobacter pylori in humans. The H. mustelae ferret model therefore has potential for the in vivo study of Helicobacter pathogenesis in general. In this study a library of 500 individual H. mustelae mutants was generated using an in vitro random insertion mutagenesis technique. more...

Categories:

Helicobacter mustelae; AGS cells

Geography:

Republic of Ireland

FEMS Immunol Med Microbiol, Vol: 50 Page: 257-63 July 2007
T. O. Croinin; A. McCormack; A. H. van Vliet; J. G. Kusters; B. Bourke

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44. Reduced expression of aquaporin 5 water channel in nitrofen-induced hypoplastic lung with congenital diaphragmatic hernia rat model

The aim of this study was to test the hypothesize that AQP5 is reduced in hypoplastic lungs and therefore this study determined AQP5 expression in normal and hypoplastic lungs

Abstract:

PURPOSE: Pulmonary hypoplasia remains the principal cause of high morbidity and mortality in patients with congenital diaphragmatic hernia (CDH). The precise mechanisms causing lung hypoplasia remains unclear. Aquaporins (AQPs) are reported to constitute a family of water channels that facilitate membrane water permeability in various tissues of animals. Aquaporin 5 has been reported to more...

Categories:

AQP5 expression; hypoplastic lungs

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 42 Page: 415-9 February 2007
H. Takayasu; N. Nakazawa; S. Montedonico; P. Puri

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45. Regional differences in nitrergic neuronal density in the developing porcine urinary bladder

The aim of this study was to investigate the changes in density and morphology of the intramural nitrergic neurons of the porcine urinary bladder during development using whole-mount preparation

Abstract:

Nitric oxide (NO) is involved in normal bladder physiology by regulating local arteriolar tone and smooth muscle relaxation and modulating the production of extracellular matrix proteins in vitro. Little information is available regarding the nitrergic innervation of the bladder during development. In this study we investigated the changes in density and morphology of the intramural more...

Categories:

morphology of the intramural nitrergic neurons of the urinary bladder;

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 21 Page: 161-8 March 2005
M. E. Pirker; S. Montedonico; U. Rolle; H. Austvoll; P. Puri

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46. Reptile-associated Salmonellosis in residents in the South East of Ireland 2005 - 2007

This study reports on reptile-associated Salmonellosis in residents in the South East of Ireland 2005 - 2007

International Classification:

Surveillance - Certain infectious and parasitic diseases - Intestinal infectious diseases - Salmonellosis

Categories:

reptile-associated Salmonellosis

Geography:

Republic of Ireland

Euro Surveill, Vol: 13 Page: April 2008
A. M. O'Byrne; M. Mahon

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47. Retinoic acid rescues lung hypoplasia in nitrofen-induced hypoplastic foetal rat lung explants

The aim of this study was to test the hypothesis that retinoids are involved in the pathogenesis of associated pulmonary hypoplasia in congenital diaphragmatic hernia

Abstract:

There is increasing evidence to suggest that the retinoid pathway is involved in the pathogenesis of congenital diaphragmatic hernia (CDH). We hypothesised that retinoids are involved in the pathogenesis of associated pulmonary hypoplasia in CDH and therefore designed this study to investigate the effects of retinoid acid on nitrofen-induced hypoplastic lungs. Pregnant rats were exposed more...

Categories:

retinoids; pulmonary hypoplasia; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 22 Page: 2-8 January 2006
S. Montedonico; N. Nakazawa; P. Puri

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48. Selective chemical ablation of the enteric plexus in mice

The aim of this study was to asses the selective chemical ablation of the enteric plexus in mice

Abstract:

Although genetically aganglionic mice such as piebald lethal and lethal spotted mice exhibit striking similarities to the human condition of Hirschsprung's disease (HD), the aganglionic segment is very short and always located in the distal part of the rectum. Topical application of benzalkonium chloride (BAC) to the rectum of rats has been reported to result in segmental aganglionosis. more...

Categories:

enteric plexus

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 18 Page: 234-7 May 2002
A. Yoneda; H. Shima; L. Nemeth; T. Oue; P. Puri

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49. Structural immaturity of the heart in congenital diaphragmatic hernia in rats

The aim of this study was to evaluate the expression of important extracellular matrix components in rats heart with induced congenital diaphragm to test the hypothesis that an alteration of extracellular matrix may contribute to cardiac maldevelopment

Abstract:

PURPOSE: The form and function of the heart are the final result of an integration of cells, tissues, and extracellular material. The extracellular matrix (ECM) is a complex array of different molecular components, and it plays an important role for the transfer of mechanical force in both contraction and relaxation phases in the cardiac cycle. ECM plays also a significant role in the more...

Categories:

extracellular matrix; congenital diaphragmatic hernia; cardiac maldevelopment

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 36 Page: 770-3 May 2001
N. Guarino; H. Shima; P. Puri

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50. Subtyping intimin genes from enteropathogenic Escherichia coli associated with outbreaks and sporadic cases in the United Kingdom and Eire

This study aimed to compare PCR-RFLP methods for subtyping the intimin gene from strains of typical and atypical enteropathogenic Escherichia coli and Verocytotoxin-producing E. coli

Abstract:

PCR-RFLP methods for subtyping the intimin gene from strains of typical and atypical enteropathogenic Escherichia coli (EPEC) and Verocytotoxin-producing E. coli (VTEC) were compared. A novel HhaI PCR-RFLP method was developed that was rapid, easy to use and amplified an 1852 bp fragment of the intimin gene from all isolates examined. This method was used to investigate the intimin more...

International Classification:

Effectiveness of measurement tool - PCR-RFLP subtyping methods

Categories:

PCR-RFLP subtyping methods; Escherichia coli

Geography:

Republic of Ireland and the United Kingdom

Mol Cell Probes, Vol: 17 Page: 149-56 August 2003
C. Jenkins; A. J. Lawson; T. Cheasty; G. A. Willshaw; P. Wright; G. Dougan; G. Frankel; H. R. Smith

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51. Surfactants: past, present and future

This article discusses surfactant therapy as a contribution to care of the preterm newborn during the past 25 years.

Abstract:

In 1929 Kurt von Neergaard performed experiments suggesting the presence of pulmonary surfactant and its relevance to the newborn's first breath. Almost 25 years later, Richard Pattle, John Clements and Chris Macklin, each working on the effects of nerve gases on the lungs, contributed to the understanding of the physiology of pulmonary surfactant. About 5 years later Mary Ellen Avery more...

Geography:

Northern Ireland

J Perinatol, Vol: 28 Suppl 1 Page: S47-56 May 2008
H. L. Halliday

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Irish Child Health Database - Peer Reviewed Papers

Database Search

Animals

1. Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats

Abstract:

Categories:

Geography:

2. Gene expression of insulin-like growth factor-1 and epidermal growth factor is downregulated in the heart of rats with nitrofen-induced diaphragmatic hernia

Abstract:

Categories:

Geography:

3. Glutathione S-transferase: a potential new marker of intestinal ischemia

Abstract:

Categories:

Geography:

4. Helicobacter pylori infection of human and murine primary gastric cells

Abstract:

International Classification:

Categories:

Geography:

5. High mineral and vitamin E intake by pregnant ewes lowers colostral immunoglobulin G absorption by the lamb

Abstract:

Categories:

Geography:

6. History of surfactant from 1980

Abstract:

Geography:

7. Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes

Abstract:

International Classification:

Categories:

Geography:

8. Human seroprevalence to Coxiella burnetii (Q fever) in Northern Ireland

Abstract:

International Classification:

Categories:

Geography:

9. Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia

Abstract:

Categories:

Geography:

10. Increased expression of ICAM-1 and VCAM-1 in the lung of nitrofen-induced congenital diaphragmatic hernia in rats

Abstract:

Categories:

Geography:

11. Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model

Abstract:

Categories:

Geography:

12. Increased vascular endothelial growth factor peptide and gene expression in hypoplastic lung in nitrofen induced congenital diaphragmatic hernia in rats

Abstract:

Categories:

Geography:

13. Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis

Abstract:

Categories:

Geography:

14. Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells

Abstract:

Categories:

Geography:

15. Is nutrition an aetiological factor for inflammatory bowel disease?

Abstract:

Geography:

16. Key apoptosis regulating proteins are down-regulated during postnatal tissue development

Abstract:

Categories:

Geography:

17. Kidney development in the nitrofen-induced pulmonary hypoplasia and congenital diaphragmatic hernia in rats

Abstract:

Categories:

Geography:

18. Linkage mapping of the locus for inherited ovine arthrogryposis (IOA) to sheep chromosome 5

Abstract:

Categories:

Geography:

19. Low incidence of concurrent enteric infection associated with sporadic and outbreak-related human cryptosporidiosis in Northern Ireland

International Classification:

Categories:

Geography: