Irish Child Health Database - Peer Reviewed Papers
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Pregnancy
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The aim of this study was to examine the hypothesis which predicts that infusions of information into an environment will lead to knowledge gain by groups with higher socioeconomic status at rates that outpace the knowledge gain of lower SES groups
Abstract:
The knowledge gap hypothesis predicts that infusions of information into an environment will lead to knowledge gain by groups with higher socioeconomic status (SES) at rates that outpace the knowledge gain of lower SES groups, leading to a growing relative gap between them. Four information source variables were examined in the present study: education, baby care experience, friend and more...
International Classification:
Education
Categories:
education; inequalities
Geography:
International
J Health Commun,
Vol: 3 Page: 29-51 1998 Jan-Mar
C. Gaziano; J. O'Leary
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The aim of this study was to examine the intermediates of choline oxidation in maternal and umbilical cord plasma and to determine the relations between this pathway and folate-dependent homocysteine remethylation
Abstract:
BACKGROUND: Little is known about the interactions between choline and folate and homocysteine metabolism during pregnancy despite the facts that pregnancy places considerable stress on maternal folate and choline stores and that choline is a critical nutrient for the fetus. Choline, via betaine, is an important folate-independent source of methyl groups for remethylating homocysteine more...
International Classification:
Other - Folate and folic acid
Categories:
folate-dependent homocysteine remethylation
Geography:
Republic of Ireland and the United Kingdom
American Journal of Clinical Nutrition,
Vol: 82 Page: 836-842 2005
A. M. Molloy; J. L. Mills; C. Cox; S. F. Daly; M. Conley; L. C. Brody; P. N. Kirke; J. M. Scott; P. M. Ueland
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The aim of this study was to examine the effects of chorioamnionitis and antenatal corticosteroids on bronchoalveolar lavage fluid levels of MMP-9, and its inhibitor, TIMP-1 in preterm infants.
Abstract:
OBJECTIVE: Matrix metalloproteinase-9 (MMP-9) degrades type IV collagen, the major constituent of lung basement membrane. We studied the effects of chorioamnionitis and antenatal corticosteroids on bronchoalveolar lavage (BAL) fluid levels of MMP-9, and its inhibitor, TIMP-1 in preterm infants. STUDY DESIGN: A prospective study was performed on serial BAL samples from 79 ventilated more...
International Classification:
Pregnancy, childbirth and the peurperium - chorioamnionitis
Categories:
chorioamnionitis; antenatal corticosteroids
Geography:
Northern Ireland
Am J Obstet Gynecol,
Vol: 188 Page: 871-5 April 2003
A. E. Curley; D. G. Sweet; C. M. Thornton; M. D. O'Hara; E. Chesshyre; J. Pizzotti; M. S. Wilbourn; H. L. Halliday; J. A. Warner
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The aim of this study was to determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life
Abstract:
OBJECTIVE: To determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life. DESIGN: Prospective observational study. SETTING: Regional neonatal intensive care unit. PATIENTS: Thirty five ventilated preterm babies < 33 weeks gestation, seven more...
International Classification:
Pregnancy, childbirth and the puerperium - chorioamnionitis
Categories:
chorioamnionitis;
Geography:
Northern Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 89 Page: F61-4 January 2004
A. E. Curley; D. G. Sweet; K. J. MacMahon; C. M. O'Connor; H. L. Halliday
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The aim of this study was to examine the correlates of Cerebal Palsy in a population sample and compare clinical findings with information available from MRI brain studies
Abstract:
CONTEXT: Magnetic resonance imaging (MRI) findings have been reported for specific clinical cerebral palsy (CP) subgroups or lesion types but not in a large population of children with all CP subtypes. Further information about the causes of CP could help identify preventive strategies. OBJECTIVE: To investigate the correlates of CP in a population sample and compare clinical findings more...
International Classification:
Diseases of the nervous system - Cerebral palsy and other paralytic syndromes - cerebral palsy
Categories:
cerebral palsy
Geography:
International
Jama,
Vol: 296 Page: 1602-8 October 2006
M. Bax; C. Tydeman; O. Flodmark
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This article discusses the clinical relevance of macroprolactin
Geography:
Republic of Ireland
Clin Endocrinol (Oxf),
Vol: 62 Page: 633-43 June 2005
J. Gibney; T. P. Smith; T. J. McKenna
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This article discusses consensus statements on neonatal viability
Abstract:
The gestational age and birth weight cut off for intact survival in extremely preterm infants is unclear. There is uncertainty among obstetricians and neonatologists about when it is inadvisable to institute intensive care. The suggested definition in relation to viability is when mortality does not exceed 50% but the corresponding figure for disability is undetermined. On foot of these more...
Geography:
Republic of Ireland
Ir Med J,
Vol: 100 Page: 561-4 September 2007
C. Vavasseur; A. Foran; J. F. Murphy
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The aim of this study was to examine consent and antenatal HIV testing
Abstract:
The mood of nihilism that affected HIV is now changing. The availability of new therapies allows for cautious optimism--especially in relation to mother-to-child transmission of HIV and preventative interventions. This has prompted a widespread policy shift towards HIV testing in pregnancy. In this context, informed consent is an ethical issue which needs to be addressed. This study more...
International Classification:
Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV
Categories:
consent; HIV; AIDS
Geography:
Republic of Ireland and the United Kingdom
AIDS Care,
Vol: 12 Page: 307-12 June 2000
L. Sherr; A. Bergenstrom; C. N. Hudson
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The aim of this study was to examine a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population
Abstract:
Genetic and environmental factors contribute to the etiology of neural tube defects (NTDs). While periconceptional folic acid supplementation is known to significantly reduce the risk of NTDs, folate metabolic pathway related factors do not account for all NTDs. Evidence from mouse models indicates that the tumor protein p53 (TP53) is involved in implantation and normal neural tube more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
genetic variation in TP53; -neural tube defect
Geography:
Republic of Ireland
Am J Med Genet A,
Vol: 146A Page: 2617-25 October 2008
F. Pangilinan; K. Geiler; J. Dolle; J. Troendle; D. A. Swanson; A. M. Molloy; M. Sutton; M. Conley; P. N. Kirke; J. M. Scott; J. L. Mills; L. C. Brody
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This case report discusses the delaying preterm delivery at the threshold of viability
International Classification:
Certain conditions originating in the perinatal period - Report
Categories:
delaying preterm delivery
Geography:
Republic of Ireland
J Obstet Gynaecol,
Vol: 24 Page: 459-60 June 2004
M. Eogan; P. McKenna
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The aim of this study was to examine the changes in folate consumption and the prevalence of neural tube defects in the British and Irish populations during the past two decades
Abstract:
OBJECTIVES: To measure the changes in folate consumption and the prevalence of neural tube defects in the British and Irish populations during the past two decades. DESIGN: Ecological study. MAIN OUTCOME MEASURES: Average daily dietary folate consumption for Britain for the period 1980-1996 was estimated from the National Food Survey. Annual neural tube defect prevalences for the same more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
folate consumption; neural tube defects
Geography:
Republic of Ireland and the United Kingdom
Bjog,
Vol: 107 Page: 885-9 July 2000
M. Murphy; D. Whiteman; D. Stone; B. Botting; C. Schorah; J. Wild
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This study examined children with an antenatal diagnosis of pelvi-ureteric junction obstruction requiring pyeloplasty for deteriorating renal function during the follow-up, specifically assessing recovery of function after surgery
Abstract:
OBJECTIVE: To evaluate retrospectively children with an antenatal diagnosis of pelvi-ureteric junction (PUJ) obstruction who required pyeloplasty for deteriorating renal function during the follow-up, specifically assessing the recovery of function after surgery. PATIENTS AND METHODS: Between 1988 and 2000, 44 consecutive patients with a prenatal diagnosis of PUJ obstruction who were more...
International Classification:
Other - antenatal diagnosis of pelvi-ureteric junction obstruction
Categories:
antenatal diagnosis of pelvi-ureteric junction obstruction
Geography:
Republic of Ireland
BJU Int,
Vol: 90 Page: 72-5 July 2002
B. Chertin; U. Rolle; A. Farkas; P. Puri
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The aim of this study was to examine the relationship between tobacco smoking during pregnancy and neonatal Polycythaemia, and to assess the dose-response relationship
Abstract:
The objective of this observational study was to determine the relationship between tobacco smoking during pregnancy and neonatal Polycythaemia, and to assess the dose-response relationship. Thirty two pregnant women who smoked tobacco (cases), and ninety pregnant women who did not smoke (controls), were randomly selected from the annual obstetrics population in the Erinville hospital more...
International Classification:
Certain conditions originating in the perinatal period - neonatal polycythaemia
Categories:
maternal smoking; -neonatal Polycythaemia
Geography:
Republic of Ireland
Ir Med J,
Vol: 93 Page: 175-6 September 2000
E. al-Alawi; D. Jenkins
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The aim of this study was to quantify the relationship between precise angle of episiotomy from the perineal midline and risk of third-degree tear
Abstract:
OBJECTIVE: Mediolateral episiotomy is associated with lower rates of significant perineal tears than midline episiotomy. However, the relationship between precise angle of episiotomy from the perineal midline and risk of third-degree tear has not been established. This study quantifies this relationship. DESIGN: Case-control study. SETTING: National Maternity Hospital, Dublin, Ireland. more...
International Classification:
Pregnancy, childbirth and the puerperium
Categories:
angle of episiotomy; -third-degree tear
Geography:
Republic of Ireland
BJOG: An International Journal of Obstetrics & Gynaecology,
Vol: 113 Page: 190-194 2006
M. Eogan; L. Daly; P. R. O'Connell; C. O'Herlihy
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The aim of this study was to test the hypothesize that expression of GATA4 and GATA6 is reduced in early stages of gestation in a congenital diaphragmatic hernia hypoplastic heart
Abstract:
PURPOSE: The high incidence of cardiac malformations in humans and animal models with congenital diaphragmatic hernia (CDH) is well known. The precise molecular mechanisms underlying cardiac maldevelopment in CDH are still unclear. It has been reported that GATA4 and GATA6, members of the GATA transcription factor family, act cooperatively to regulate cardiovascular development, and the more...
Categories:
GATA4 and GATA6; congenital diaphragmatic hernia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 43 Page: 362-6 February 2008
H. Takayasu; H. Sato; K. Sugimoto; P. Puri
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The aim of this study was to test the hypothesize that Wnt-mediated signaling is altered in nitrofen-induced hypoplastic lungs
Abstract:
PURPOSE: The pathogenesis of pulmonary hypoplasia associated with congenital diaphragmatic hernia is poorly understood. Recently, it has been reported that Wnt signaling pathway plays a critical role in branching lung morphogenesis. Mice lacking Wnt7b gene die soon after birth because of respiratory failure and display severe lung hypoplasia. Wnt2 gene is expressed in the distal airway more...
Categories:
Wnt-mediated signaling; hypoplastic lungs
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 426-30 February 2007
H. Takayasu; N. Nakazawa; S. Montedonico; P. Puri
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This case report discusses early continuous video-electroencephalography from 3 hours after birth in an infant with the characteristic clinical and radiologic features of acute near-total intrauterine asphyxia
Abstract:
The evolution of electroencephalographic changes after acute hypoxic-ischemic injury is poorly understood, as a clear time of insult is often absent and continuous electroencephalographic monitoring in the first 3 days after such injury has not been previously reported. Infants who suffer sudden profound asphyxia, often termed "acute near-total intrauterine asphyxia", have more...
International Classification:
Certain conditions originating in the perinatal period - Report
Categories:
near-total intrauterine asphyxia
Geography:
Republic of Ireland
Pediatr Neurol,
Vol: 35 Page: 52-6 July 2006
D. M. Murray; G. B. Boylan; C. A. Ryan; S. Connolly
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The aim of this study was to assess the effectiveness and potential cost of an echocardiographic screening program for congenital heart disease
Abstract:
OBJECTIVES: To assess the effectiveness and potential cost of an echocardiographic screening program for congenital heart disease (CHD). PATIENTS AND METHODS: Between 01/11/94 and 28/02/98 there were 9697 deliveries in The Royal Maternity Hospital Belfast. Mothers were randomized before delivery. 4875 infants were allocated to the scan group, while 4822 were assigned to clinical more...
International Classification:
Evaluation of the effectiveness of procedures - echocardiographic screening program for congenital heart disease
Categories:
echocardiographic screening program for congenital heart disease
Geography:
Northern Ireland
J Perinat Med,
Vol: 30 Page: 307-12 2002
A. Sands; B. Craig; C. Mulholland; C. Patterson; J. Dornan; F. Casey
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The aim of this study was to examine the effect of fetal sex on birth weight, duration of labour, mode of delivery and birth outcome
International Classification:
Pregnancy, childbirth and the puerperium - delivery outcomes
Categories:
delivery outcomes
Geography:
Republic of Ireland
Bmj,
Vol: 326 Page: 137 January 2003
M. A. Eogan; M. P. Geary; M. P. O'Connell; D. P. Keane
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The aim of this study was to investigate SP mRNA expression in hypoplastic congenital diaphragmatic hernia lung in rats during mechanical ventilation in order to determine the effect of O2 on SP synthesis in congenital diaphragmatic hernia
Abstract:
The hypoplastic lung in congenital diaphragmatic hernia (CDH) has both a quantitative and qualitative reduction in surfactant. Recently, the role of oxygen (O2) as a regulator of pulmonary surfactant-associated protein (SP) gene expression has been reported. The mRNA level of SP has been demonstrated to be increased in the lungs of animals exposed to hyperoxia. The aim of this study was more...
Categories:
SP mRNA expression; congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 16 Page: 473-7 2000
H. Shima; N. Guarino; P. Puri
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The aim of this study was to investigate the expression and production of elastin in the lung in newborn rats with congenital diaphragmatic hernia during mechanical ventilation
Abstract:
BACKGROUND/PURPOSE: Hypolastic lung in congenital diaphragmatic hernia (CDH) shows markedly thickened alveolar walls, increased interstitial tissue, and markedly diminished alveolar air space, showing morphologic immaturity. Decrease in lung compliance and distensibility often is seen in human CDH as well as experimentally produced CDH. Collagen and elastin, critical components of the more...
Categories:
mechanical ventilation; elastin; congenital diaphragmatic hernia;
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 37 Page: 1253-7 September 2002
N. Guarino; H. Teramoto; H. Shima; T. Oue; P. Puri
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The aim of this study was to evaluate the effect of nitric oxide on the morphogenesis of hypoplastic lung using nitrofen-induced rat lung explant model
Abstract:
BACKGROUND/PURPOSE: Nitric oxide (NO) is an important cell-signaling molecule, and its generators, nitric oxide synthases, are expressed temporospatially in fetal rat lung. Recently, NO has been reported to modulate branching of the fetal rat lung lobe in vitro. We designed this study to evaluate the effect of NO on the morphogenesis of hypoplastic lung using nitrofen-induced rat lung more...
Categories:
nitric oxide; hypoplastic lung
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 17-21 January 2005
M. Shinkai; T. Shinkai; M. E. Pirker; S. Montedonico; P. Puri
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The aim of this study was to determine the effect of further vaginal delivery on anal sphincter function in women after apparently uncomplicated primiparous forceps delivery
Abstract:
PURPOSE: The study was designed to determine the effect of further vaginal delivery on anal sphincter function in women after apparently uncomplicated primiparous forceps delivery. METHODS: Fifty-two secundigravid women whose first child was forceps-assisted were compared with a control group of 20 women who had undergone spontaneous first vaginal delivery. Both groups were studied more...
International Classification:
Pregnancy, childbirth and the puerperium - anal sphincter function
Categories:
uncomplicated primiparous forceps delivery; -vaginal delivery; anal sphincter function
Geography:
Republic of Ireland
Dis Colon Rectum,
Vol: 51 Page: 1361-6 September 2008
R. Mahony; M. Behan; P. R. O'Connell; C. O'Herlihy
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This article discusses the effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
Abstract:
The importance of folate in reproduction can be appreciated by considering that the existence of the vitamin was first suspected from efforts to explain a potentially fatal megaloblastic anemia in young pregnant women in India. Today, low maternal folate status during pregnancy and lactation remains a significant cause of maternal morbidity in some communities. The folate status of the more...
Geography:
Republic of Ireland
Food Nutr Bull,
Vol: 29 Page: S101-11; discussion S112-5 June 2008
A. M. Molloy; P. N. Kirke; L. C. Brody; J. M. Scott; J. L. Mills
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This article discusses the use of antenatal glucocorticoids to induce maturation of preterm fetal lungs
Abstract:
Antenatal glucocorticoids have been used for 30 years to induce maturation of preterm fetal lungs. Stimulation of the pulmonary surfactant system has been regarded as the most important effect of antenatal glucocorticoids; however, as these drugs alter the expression of a large number of genes they affect the maturation of the lung in several other ways. Antioxidant enzyme production, more...
Geography:
Northern Ireland
Treat Respir Med,
Vol: 3 Page: 295-306 2004
D. G. Grier; H. L. Halliday
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The aim of this study was to describe elective caesarean and developmental dysplasia of the hip in term breech infants
Abstract:
We wished to establish whether delivery by Caesarean section influenced the incidence of developmental dysplasia of the hip in term breech infants compared with those delivered vaginally. We used maternal charts, singleton term breech presentation, mode of delivery and incidence of developmental dysplasia of the hip for births between January 1997 and October 2002. During the study more...
International Classification:
Pregnancy, childbirth and the puerperium - elective caesarean
Categories:
elective caesarean; developmental dysplasia of the hip
Geography:
Republic of Ireland
J Bone Joint Surg Br,
Vol: 87 Page: 984-5 July 2005
C. A. Lowry; V. B. Donoghue; C. O'Herlihy; J. F. Murphy
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The aim of this study was to was to determine both short- and long-term outcomes of extremely preterm birth data were collected for all births before 26 completed weeks of gestation
Abstract:
The principal objective of the EPICure studies was to determine both short- and long-term outcomes of extremely preterm birth. Data were collected for all births before 26 completed weeks of gestation in the UK and Republic of Ireland for 10 months in 1995. Of 811 infants admitted to neonatal units, 314 (39%) survived. Of these, 283 (92%) were assessed at 2.5 years and 241 (78%) at 6 more...
International Classification:
Premature - births
Categories:
outcomes of extremely preterm birth
Geography:
Republic of Ireland and the United Kingdom
Bjog,
Vol: 113 Suppl 3 Page: 10-2 December 2006
K. Costeloe
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This article discusses epidemiology consideration in elucidating environmental causes of birth defects.
Abstract:
Epidemiology can be used to elucidate environmental causes of birth defects. This paper discusses 1) different types of environmental causes; 2) the difficulties in comparing the prevalence of birth defects between populations, including the need for a population base and the implications of prenatal diagnosis; 3) the main study designs for observational epidemiological studies and the more...
Geography:
Northern Ireland
Am J Med Genet C Semin Med Genet,
Vol: 125C Page: 4-11 February 2004
H. Dolk
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The aim of this study was to examine the relationship between epidural analgesia and caesarean and instrumental vaginal delivery rates
Abstract:
OBJECTIVE: We sought to examine the relationship between epidural analgesia and cesarean and instrumental vaginal delivery rates. STUDY DESIGN: This is a retrospective analysis of the first 1000 nulliparous pregnancies in women with a cephalic presentation in spontaneous labor at term in each of 3 different years, over which the epidural rate increased from 10% to 57%. RESULTS: Cesarean more...
International Classification:
Pregnancy, childbirth and the puerperium - epidural analgesia and cesarean and instrumental vaginal delivery rates
Categories:
epidural analgesia and cesarean and instrumental vaginal delivery rates
Geography:
Republic of Ireland
Am J Obstet Gynecol,
Vol: 182 Page: 358-63 February 2000
L. Impey; K. MacQuillan; M. Robson
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The aim of this study was to describe labour & epidural analgesia effects on plasma alpha1-acid glycoprotein concentrations and the association between ropivacaine concentration & neonate neurobehavioural function
Abstract:
This study was undertaken: (i) to quantify the effects of labour and epidural analgesia on plasma alpha1-acid glycoprotein concentration, (ii) to examine the effects of changes in plasma alpha1-acid glycoprotein concentration on plasma protein binding and placental transfer of ropivacaine, and (iii) to examine the association between umbilical venous ropivacaine concentration and more...
International Classification:
Pregnancy, childbirth and the puerperium - labour & epidural analgesia effects onplasma alpha1-acid glycoprotein concentration
Categories:
labour & epidural analgesia effects onplasma alpha1-acid glycoprotein concentration
Geography:
Republic of Ireland
Anaesthesia,
Vol: 56 Page: 418-23 May 2001
J. M. Porter; N. Kelleher; R. Flynn; G. D. Shorten
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This study aimed to explore a minimum set of outcome measures for evaluating models of maternity care from the perspective of key stakeholders
Abstract:
Background: Comparing the relative effectiveness of interventions on specific outcomes across trials can be problematic due to differences in the choice and definitions of outcome measures used by researchers. We sought to identify a minimum set of outcome measures for evaluating models of maternity care from the perspective of key stakeholders. Methods: A 3-round, electronic Delphi more...
International Classification:
Practice/knowledge - maternity care
Categories:
maternity care
Geography:
Republic of Ireland
Birth: Issues in Perinatal Care,
Vol: 34 Page: 164-172 2007
Declan Devane; Cecily M. Begley; Mike Clarke; Dell Horey; Colm Oboyle
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This case report discusses a case of a large oral teratoma in a foetus diagnosed on antenatal ultrasound
Abstract:
We report a case of a large oral teratoma in a foetus diagnosed on antenatal ultrasound. Due to the anticipated difficulty in securing the airway at birth an ex-utero intrapartum treatment (EXIT) procedure was planned. In this case simultaneous excision of the tumour mass was carried out while on placental support this allowed safe procurement of the airway and successful delivery of an more...
International Classification:
Neoplasm - Report
Categories:
oral teratoma
Geography:
Republic of Ireland
Irish Medical Journal,
Vol: 100 Page: 632-633 2007
E. Lang; J. Loughrey; K. Hunter; H. Rowley
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The aim of this study was to examine the clinical evidence for elective induction for post-term pregnancy.
Abstract:
Induction of labour is a valuable obstetric procedure, providing obstetricians with the means to intervene should the health of the fetus be in jeopardy. Currently the most common reason for induction of labour is prolonged pregnancy, as obstetricians and midwives are concerned about the risks of postmaturity such as stillbirth, intrapartum asphyxia and birth trauma which are often more...
International Classification:
Pregnancy, childbirth and the puerperium - elective induction for post-term pregnancy
Categories:
elective induction for post-term pregnancy
Geography:
Northern Ireland
Journal of Advanced Nursing,
Vol: 31 Page: 410-417 2000
C. Duff; M. Sinclair
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The aim of this study was to investigate mRNA expression of ET-1, eNOS, and CGRP in congenital diaphragmatic hernia lung in the perinatal period
Abstract:
The high mortality in patients with congenital diaphragmatic hernia (CDH) has been attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PPH). Endothelin-1 (ET-1), nitric oxide (NO), and calcitonin gene-related peptide (CGRP) have been reported to be important vasoactive mediators in the perinatal pulmonary circulation. The exact mechanism by which these vasoactive more...
Categories:
mRNA expression; congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 21 Page: 143-7 March 2005
T. Shinkai; H. Shima; V. Solari; P. Puri
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This obstetric case shows two false negative Kleihauer tests and two persistently positive Kleihauer tests leading to unnecessary administration of anti-D immunoglobulin
Abstract:
This obstetric case shows two false negative Kleihauer tests and two persistently positive Kleihauer tests leading to unnecessary administration of anti-D immunoglobulin. A diagnosis of hereditary persistence foetal haemoglobin (HPFH) was only confirmed by access to flow cytometry making use of both anti-HbF and anti-D labels. The case highlights the importance of a high index of more...
International Classification:
Health service provision
Categories:
unnecessary administration of anti-D immunoglobulin
Geography:
Northern Ireland
Clin Lab Haematol,
Vol: 25 Page: 405-8 December 2003
R. Iyer; B. McElhinney; N. Heasley; M. Williams; K. Morris
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The aim of this study was to measure fetal cardiac troponin I in umbilical artery blood in relation to intrapartum events and umbilical artery pH
Abstract:
The objective of this study was to measure fetal cardiac troponin I in umbilical artery blood in relation to intrapartum events and umbilical artery pH. Umbilical artery blood samples were obtained after delivery from 110 infants and cardiac troponin I was measured. The onset of labor, mode of delivery, presence of meconium, and umbilical artery pH were examined in relation to cardiac more...
International Classification:
Other - cardiac troponin I
Categories:
fetal cardiac troponin I
Geography:
Republic of Ireland
Am J Perinatol,
Vol: 21 Page: 147-52 April 2004
F. McAuliffe; K. Mears; S. Fleming; H. Grimes; J. J. Morrison
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The aim of this study was to describe the first 10 cases of fetoscopic laser surgery for twin-to-twin transfusion syndrome by the Rotunda Hospital Fetal Treatment Programme
Abstract:
The aim of this study was to report the results of the first 10 cases of fetoscopic laser surgery for twin-to-twin transfusion syndrome by the Rotunda Hospital Fetal Treatment Programme. All cases of severe TTTS managed by our team from 2006 to 2007 were included. All fetoscopic laser surgeries were performed by a single specialist in fetal medicine. All pregnancies were followed up to more...
International Classification:
Pregnancy, childbirth and the puerperium - twin-to-twin transfusion syndrome
Categories:
twin-to-twin transfusion syndrome
Geography:
Republic of Ireland
Ir Med J,
Vol: 101 Page: 191-3 June 2008
S. Said; K. Flood; F. Breathnach; A. Fleming; C. B. Kinsella; M. Geary; F. D. Malone
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The aim of this study was to identify needs, perceptions and experiences of first-time mothers in the postnatal period
Abstract:
* The aim of this research was to identify needs, perceptions and experiences of first-time mothers in the postnatal period.
* Data were collected through focus groups and in-depth interviews from a sample of 13 women, 61% were aged 20 years or less, from an urban city area in Southern Ireland. Through content analysis, key themes were identified relating to birth and hospitalization, more...
International Classification:
Focus groups - attitudes, needs, perceptions-first time mothers
Categories:
first-time mothers
Geography:
Republic of Ireland
Journal of Clinical Nursing,
Vol: 12 Page: 260-267 2003
C. Cronin
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This study aimed to increase knowledge and use of folic acid among relatives with neural tube defects
Abstract:
BACKGROUND: Relatives in families where a child has a neural tube defect (NTD) may be at higher risk of having an affected child. Little is known of their level of knowledge and use of folic acid. AIM: To carry out an intervention study intended to increase knowledge and use of folic acid among relatives. METHODS: One hundred aunts and female first cousins (relatives of the proband) more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
folic acid; neural tube defects
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 172 Page: 118-22 2003 Jul-Sep
J. Byrne
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The aim of this study was to assess the outcome of 39 pregnancies for congenital anomalies in 20 mothers with maternal phenylketonuria
Abstract:
BACKGROUND: Maternal phenylketonuria (PKU) can result in multiple congenital anomalies. In Northern Ireland, the prevalence of PKU is relatively high at 1 in 4000. OBJECTIVE: To assess the outcome of 39 pregnancies in 20 mothers. RESULTS: Dietary control was established before conception in 17 pregnancies (44%). Five mothers with hyperphenylalaninaemia had 11 pregnancies. There were no more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital anomalies
Categories:
congenital anomalies; maternal phenylketonuria
Geography:
Northern Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 87 Page: F141-3 September 2002
A. C. Magee; K. Ryan; A. Moore; E. R. Trimble
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The aim of this study was to examine the impact of antenatal diagnosis of gatroschisis and exomphalos on the management of delivery
Abstract:
Antenatal detection of anterior abdominal wall defects (gastroschisis and exomphalos) enables detailed prenatal planning and counselling with appropriate intrauterine transfer, delivery in a tertiary referral centre with prompt access to paediatric surgery and early surgical intervention. The authors believed that there was a relatively low rate of antenatal detection in Ireland and more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Congenital malformations and deformations of the musculoskeletal system - exomphalos
Categories:
gatroschisis; exomphalos
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 23 Page: 1059-63 November 2007
F. L. Murphy; T. A. Mazlan; F. Tarheen; M. T. Corbally; P. Puri
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The aim of this study was to determine the gene-level expression of insulin-like growth factor-1 and epidermal growth factor in the hearts of rats with nitrofen-induced congenital diaphragmatic hernia
Abstract:
Newborns with congenital diaphragmatic hernia (CDH) still have high mortality. Recently, a possible role of cardiac maldevelopment has been suggested. Human and experimental studies have demonstrated that heart weight is significantly reduced in the presence of CDH. Recent studies have suggested an important role for insulin-like growth factor-I (IGF-I) in the regulation of cardiac more...
Categories:
insulin-like growth factor-1; epidermal growth factor; congenital diaphragmatic hernia
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 17 Page: 284-7 May 2001
H. Teramoto; P. Puri
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This article discusses gestational diabetes mellitus
Geography:
Republic of Ireland
World of Irish Nursing & Midwifery,
Vol: 14 Page: 41-42 2006
M. Coffey
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The aim of this study was to investigate evaluate neonatal and adult neutrophils for their ability to combat bacterial infection by examining their functional activity (CD11b and reactive oxygen intermediates) and their persistence at inflammatory sites
Abstract:
Neutropenia is a common sequela of neonatal sepsis. Recent clinical trials have shown the beneficial effects of colony-stimulating factors (CSFs) on outcome in this group, but the exact mechanism remains unknown. Neonates and mothers who were at high-risk for infection were recruited for cord blood sampling in a university tertiary referral maternity hospital. Neonatal and adult more...
International Classification:
Immunology - neutrophils and bacterial infection
Categories:
neutrophils; bacterial infection
Geography:
Republic of Ireland
Pediatr Res,
Vol: 57 Page: 806-12 June 2005
E. J. Molloy; A. J. O'Neill; J. J. Grantham; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson
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The aim of this study was to identified cases of invasive group B streptococcal disease in infants younger than 90 days through surveillance involving paediatricians, microbiologists, and parents
Abstract:
The incidence, morbidity, and mortality of group B streptococcal disease in the UK and Republic of Ireland are largely unknown. Between Feb 1, 2000, and Feb 28, 2001, we identified cases of invasive group B streptococcal disease in infants younger than 90 days through surveillance involving paediatricians, microbiologists, and parents. 568 cases were identified, equivalent to a total more...
International Classification:
Bacterium - Group B Strep
Categories:
Group B Strep
Geography:
Republic of Ireland and the United Kingdom
Lancet,
Vol: 363 Page: 292-4 January 2004
P. T. Heath; G. Balfour; A. M. Weisner; A. Efstratiou; T. L. Lamagni; H. Tighe; L. A. O'Connell; M. Cafferkey; N. Q. Verlander; A. Nicoll; A. C. McCartney
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The aim of this study was to examine the current trends of Hepatitis C infection in an Irish antenatal population
Abstract:
BACKGROUND: Hepatitis C infection (HCV) has an estimated seroprevalence of 1-2% in women of child-bearing age and vertical transmission rate of 5-15%. AIMS: To characterise the current trends of HCV in an Irish antenatal population. METHODS: Infants of HCV seropositive women, born 1994 to 1999, were referred to the Paediatric Infectious Diseases service. Maternal details were collected more...
International Classification:
Certain infectious and parasitic diseases - Viral hepatitis - hepatitis C
Categories:
hepatitis C
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 169 Page: 180-2 2000 Jul-Sep
C. M. Healy; M. T. Cafferkey; A. Conroy; S. Dooley; W. W. Hall; M. Beckett; R. Mackey; T. A. Clarke; M. J. White; W. A. Gorman; K. M. Butler
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The aim of this study was to evaluate the effects of supplementing pregnant ewe's diet with high levels of minerals and vitamin E on immunoglobulin G absorption by the lamb and if any altered efficacy of IgG absorption was due to colostrum or the lamb
Abstract:
A 2 x 2 factorial arrangement of treatments with 78 mature ewes was used to evaluate the effects of supplementing the pregnant ewe's diet with high levels of minerals and vitamin E on immunoglobulin G (IgG) absorption by the lamb and whether any altered efficacy of IgG absorption was due to the colostrum or to the lamb. The ewes were estrus-synchronized in October and housed in wk 10 of more...
Categories:
dietary supplementation immunoglobulin G absorption
Geography:
Republic of Ireland
J Anim Sci,
Vol: 83 Page: 871-8 April 2005
T. M. Boland; N. Keane; P. Nowakowski; P. O. Brophy; T. F. Crosby
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This article discusses the third annual High/Scope Ireland Conference which discusses issues such as literacy rates, school success and employability as well as decreased levels of substance misuse, delinquent & criminal activity and teenage pregnancy
Abstract:
The third annual High/Scope Ireland Conference provided a forum for speakers workshop leaders and delegates from across Ireland, the UK, USA, Europe and South Africa to share their experiences of High/Scope in action. Research demonstrates that long term benefits for High/Scope participants include increased literacy rates, school success and employability as well as decreased levels of more...
Geography:
Northern Ireland
Child Care in Practice,
Vol: 11 Page: 433-456 2005
Lynne Peyton
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This article discusses homebirth
Geography:
Republic of Ireland
Midwifery Today Int Midwife,
2005 Autumn
J. Hagan
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This article discusses the inherited metabolic disorders HPA and PKU - Hyperphenylalaninaemia
Abstract:
Focus on the inherited metabolic disorders HPA and PKU. more...
Geography:
Republic of Ireland
World of Irish Nursing & Midwifery,
Vol: 13 Page: 43-44 2005
A. Clark; E. Treacy
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The aim of this study was to examine the distribution and determinants of C. Burnetii past infection
Abstract:
Despite the widespread prevalence of infection with Coxiella burnetii, there have been few large population-based studies examining the epidemiology of this infection. The aim of this study was to examine the distribution and determinants of C. burnetii past infection in Northern Ireland (NI). Coxiella burnetii phase II specific IgG antibodies were measured by enzyme-linked more...
International Classification:
Bacterium - C. Burnetii
Categories:
C. burnetii
Geography:
Northern Ireland
Zoonoses Public Health,
Vol: 55 Page: 189-94 May 2008
C. McCaughey; J. McKenna; C. McKenna; P. V. Coyle; H. J. O'Neill; D. E. Wyatt; B. Smyth; L. J. Murray
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