Irish Child Health Database - Peer Reviewed Papers
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Gene Amplification
Your search returns 3 documents
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The aim of this study was to examine if gains of chromosomal regions 7q and 11p are important abnormalities in neuroblastoma
Abstract:
Neuroblastoma exhibiting deletion of a segment of the long arm of chromosome 11 represents a genetic subtype of tumor that is distinct from those exhibiting MYCN amplification or 1p deletion. The 11q- genetic subtype is further characterized by gain of 17q and loss of distal 3p material. Gain of 11p material has also been reported in neuroblastoma with 11q loss, but at a considerably more...
International Classification:
Neoplasms - Malignant neoplasms - neuroblastoma
Categories:
neuroblastoma
Geography:
Republic of Ireland
Cancer Genet Cytogenet,
Vol: 140 Page: 133-7 January 2003
R. L. Stallings; J. Howard; A. Dunlop; M. Mullarkey; M. McDermott; F. Breatnach; A. O'Meara
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The aim of this study was to examine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma
Abstract:
PURPOSE: To determine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma. PATIENTS AND METHODS: The genetic alterations and morphologic features that underpin three histopathologic risk classifications were analyzed in 108 neuroblastoma patients. Tumors were subdivided into four groups based on the three most frequent and prognostically more...
International Classification:
Neoplasms - Malignant neoplasms - neuroblastoma
Categories:
neuroblastoma
Geography:
Republic of Ireland and the United Kingdom
J Clin Oncol,
Vol: 19 Page: 3080-90 June 2001
M. Lastowska; C. Cullinane; S. Variend; S. Cotterill; N. Bown; S. O'Neill; K. Mazzocco; P. Roberts; J. Nicholson; C. Ellershaw; A. D. Pearson; M. S. Jackson
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The aim of this study was to examine the evolution of unbalanced gain of distal chromosome 2p in neuroblastoma
Abstract:
Neuroblastoma, one of the most common tumors of childhood, presents at diagnosis with a vast number of recurrent chromosomal imbalances that include hyperdiploidy for whole chromosomes, partial loss of 1p, 3p, 4p, 11q, 14q, partial gain of 1q, 7q, 17q and amplification of MYCN. These abnormalities are nonrandomly distributed in neuroblastoma as loss of 3p and 11q rarely occur in MYCN more...
International Classification:
Neoplasms - Malignant neoplasms - neuroblastoma
Categories:
neuroblastoma
Geography:
International
Cytogenet Genome Res,
Vol: 106 Page: 49-54 2004
R. L. Stallings; P. Carty; L. McArdle; M. Mullarkey; M. McDermott; A. O'Meara; E. Ryan; D. Catchpoole; F. Breatnach
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