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Hematopoietic Stem Cell Transplantation
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The aim of this study was to audit reports of Cytomegalovirus infection to determine prevalence and outcome in the national paediatric Haemopoietic Stem Cell Transplant unit, with particular reference to surveillance and treatment
Abstract:
A retrospective audit of CMV infection was undertaken to determine prevalence and outcome in the national paediatric Haemopoietic Stem Cell Transplant (HSCT) unit, with particular reference to surveillance and treatment. All patients undergoing HSCT (125 allogeneic, 50 autologous) from January 1994 to December 2004 were included. Nine underwent a second transplant for graft failure or more...
International Classification:
Certain infectious and parasitic diseases - Viral infections characterized by skin and mucous membrane lesions- cytomegalovirus infection
Categories:
cytomegalovirus infection
Geography:
Republic of Ireland
Irish Medical Journal,
Vol: 101 Page: 17-21 2008
A. L. Chong; F. Clinton; F. Breatnach; A. O'Marcaigh; K. Butler; A. O'Meara
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The aim of this study was to assess the effectiveness of high-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma
Abstract:
Background: The current standard treatment for patients with high-risk neuroblastoma includes initial induction chemotherapy with a 21-day interval between induction treatments. We aimed to assess whether an intensive chemotherapy protocol that had a 10-day interval between treatments would improve event-free survival (EFS) in patients aged 1 year or over with high-risk neuroblastoma. more...
International Classification:
Evaluation of the effectiveness of treatments - neuroblastoma
Categories:
chemotherapy for neuroblastoma
Geography:
International
The Lancet Oncology,
Vol: 9 Page: 247-256 2008
A. D. Pearson; C. R. Pinkerton; I. J. Lewis; J. Imeson; C. Ellershaw; D. Machin
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The aim of this study was to examine how aspects of cord blood T-cell biology that Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation.
Abstract:
The use of human umbilical cord blood as an alternative source of stem cells to bone marrow for the reconstitution of the immune system is associated with less frequent and less severe incidence of graft-versus-host disease (GVHD). This study focuses on aspects of cord blood T-cell biology that may contribute to a perceived increased tolerance associated with the neonatal immune more...
International Classification:
Other - cord blood T-cell biology
Categories:
aspects of cord blood T-cell biology
Geography:
Republic of Ireland
Br J Haematol,
Vol: 116 Page: 702-9 March 2002
E. Rainsford; D. J. Reen
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This case report discusses a case of successful allogeneic hematopoietic stem cell transplantation with full myeloablative conditioning in a patient with pre-existing invasive mucormycosis.
Abstract:
We report a case of successful allogeneic hematopoietic stem cell transplantation (HSCT) with full myeloablative conditioning in a patient with pre-existing invasive mucormycosis. The mucormycosis involved the maxilla, the nasal septum, and the hard palate. Sustained antifungal therapy and aggressive surgery both before and after HSCT were required. more...
International Classification:
Organ transplants
Categories:
allogeneic hematopoietic stem cell transplantation
Geography:
Republic of Ireland
Pediatr Blood Cancer,
Vol: 50 Page: 393-5 February 2008
A. Piccin; J. D. Russell; P. Fleming; K. Butler; M. McDermott; O. P. Smith; A. O'Marcaigh
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This study examined the follow-up of 23 patients with Hurler syndrome at a mean of 8.5 years after successful hematopoietic stem cell transplant
Abstract:
Hurler syndrome is an autosomal recessive metabolic storage disease. Hematopoietic stem cell transplant increases life expectancy, but the effects on associated musculoskeletal abnormalities remains unclear, and long-term data are limited. We detail the follow-up of 23 patients at a mean of 8.5 years after successful hematopoietic stem cell transplant.All patients underwent clinical more...
International Classification:
Syndrome - Hurler
Categories:
Hurler syndrome
Geography:
Republic of Ireland
J Pediatr Orthop,
Vol: 28 Page: 163-8 March 2008
C. Taylor; P. Brady; A. O'Meara; D. Moore; F. Dowling; E. Fogarty
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The aim of this study was to assess chimaeric analysis and its influence on survival and GvHD occurrence in 45 of the original 71 patients in whom serial samples were available
Abstract:
We previously reported a randomized trial comparing Cyclosporin-A (CsA) and short-term methotrexate versus CsA alone for graft-versus-host disease (GvHD) prophylaxis in 71 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) from a human leucocyte antigen-identical sibling for severe aplastic anaemia (SAA). We found a better survival in the group receiving the more...
International Classification:
Evaluation of the effectiveness of procedures - chimaeric - analysis of molecular structures
Categories:
chimaeric - analysis of molecular structures
Geography:
International
Bone Marrow Transplant,
Vol: 39 Page: 109-14 January 2007
S. McCann; J. Passweg; A. Bacigalupo; A. Locasciulli; F. Locatelli; J. Ryan; H. Schrezenmeier; M. Lawler
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