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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » G » Ganglia, Autonomic/metabolism/pathology

Ganglia, Autonomic/metabolism/pathology

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1. Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung's disease

The aim of this study was to analyse the expression of P2Y1 and P2Y2 receptors in the intestine of patients with Hirschsprung's disease

Abstract:

Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the intestine. ATP has long been established as an inhibitory more...

International Classification:

Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

Categories:

expression of P2Y1 and P2Y2 receptors; -Hirschsprung's disease

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 24 Page: 77-80 January 2008
O' Donnell AM ; P. Puri

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