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Irish Child Health Database - Peer Reviewed Papers

Database Search

Hirschsprung Disease/ metabolism/pathology

Your search returns 2 documents

• 1.   Altered cytoskeleton in smooth muscle of aganglionic bowel

  The aim of this study was to examine the distribution of the cytoskeletal proteins in the smooth muscle of the aganglionic bowel

  

  Abstract:

  CONTEXT: Intestinal motility is under the control of smooth muscle cells, enteric plexus, and hormonal factors. In Hirschsprung disease (HD), the aganglionic colon remains spastic or tonically enhanced and unable to relax. The smooth muscle cell's cytoskeleton consists of proteins or structures whose primary function is to link or connect protein filaments to each other or to the more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  cytoskeletal proteins; aganglionic bowel(Hirschsprung disease)

  Geography:

  Republic of Ireland

  Arch Pathol Lab Med, Vol: 126 Page: 692-6 June 2002
  L. Nemeth; U. Rolle; P. Puri

  [Preview] [Read]

• 2.   Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung's disease

  The aim of this study was to analyse the expression of P2Y1 and P2Y2 receptors in the intestine of patients with Hirschsprung's disease

  

  Abstract:

  Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the intestine. ATP has long been established as an inhibitory more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  expression of P2Y1 and P2Y2 receptors; -Hirschsprung's disease

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 24 Page: 77-80 January 2008
  O' Donnell AM ; P. Puri

  [Preview] [Read]