Irish Child Health Database - Peer Reviewed Papers
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Hypertrophy
Your search returns 11 documents
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The aim of this study was to test the hypothesis that Shh-expressing ectopic notochord could contribute to an increased volume of notochord relative to total embryo volume, resulting in an increased concentration of Shh in the notochord of embryos
Abstract:
BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the Vertebral, Anorectal, Cardiac, Tracheoesophageal, Renal, Limb (VACTERL) association. The notochord, which expresses Sonic Hedgehog (Shh), has been found to be grossly malformed with ventral ectopic branches in the foregut region of embryos in the ARM. The authors designed this study to test the more...
Categories:
Shh-expressing ectopic notochord; total embryo volume
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 39 Page: 859-63 June 2004
A. Mortell; A. M. O'Donnell; S. Giles; J. Bannigan; P. Puri
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The aim of this study was to examine the immunocolocalization of HO-2 and interstitial cells of Cajal in the normal pylorus and in infantile hypertrophic pyloric stenosis
Abstract:
CONTEXT: Interstitial cells of Cajal (ICCs) are pacemaker cells, which are of fundamental importance in regulating gastrointestinal motility. Recent evidence suggests that carbon monoxide is a neurotransmitter involved in neurotransmission between ICC and smooth muscle cells. Heme oxygenase-2 (HO-2) is the major physiological mechanism for the generation of carbon monoxide in the more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
hypertrophic pyloric stenosis; immunocolocalization of HO-2 and interstitial cells of Cajal; -infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Arch Pathol Lab Med,
Vol: 127 Page: 1182-6 September 2003
A. P. Piotrowska; V. Solari; P. Puri
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The aim of this study was to investigate the expression of glial-derived growth factor and RET in infantile hypertrophic pyloric stenosis
Abstract:
BACKGROUND/PURPOSE: Glial-derived growth factor (GDNF), which is the ligand of RET is reported to be essential for the development of enteric nervous system. A GDNF knockout mouse model has shown that the gastric region is a critical passing site between GDNF-RET-independent neuroblasts (colonizing the esophagus) and GDNF-RET-dependent neuroblasts (colonizing the small and large bowel). more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
glial-derived growth factor; -infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 35 Page: 835-9 June 2000
N. Guarino; H. Shima; T. Oue; P. Puri
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This study investigated immunohistochemical localization of epidermal growth factors-related peptides and its mRNA expression in pyloric smooth muscle cells to determine involvment with pyloric muscle hypertrophy in infantile hypertrophic pyloric stenosis
Abstract:
Infantile hypertrophic pyloric stenosis (IHPS) is characterized by hypertrophy of the pyloric muscle. The growth of smooth muscle cells is regulated by several growth factors. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor are potent mitogens for smooth muscle cells. In the present study, we investigated immunohistochemical localization of EGF and EGF-related more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
epidermal growth factors; -infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Pediatr Res,
Vol: 47 Page: 201-7 February 2000
H. Shima; K. Ohshiro; P. Puri
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The aim of this study was to examine the management of infants with infantile hypertrophic pyloric stenosis in a well-equipped regional centre
Abstract:
BACKGROUND: It has been suggested that only specialist paediatric surgeons should manage infantile hypertrophic pyloric stenosis (IHPS). AIM: The aim of this retrospective study was to ascertain whether the majority of these infants might be managed in a well-equipped regional centre. METHODS: Using the Hospital Inpatient Enquiry database, all cases of IHPS within a single more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - hypertrophic pyloric stenosis
Categories:
infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 169 Page: 100-2 2000 Apr-Jun
P. D. Kiely; S. Tierney; M. Barry; P. V. Delaney; J. Drumm; P. A. Grace
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The aim of this study was to examine the status of the enteric nervous system in normal and in inflamed appendixes
Abstract:
OBJECTIVE: The pathogenesis of appendicitis remains poorly understood. However, there is increasing evidence of involvement of the enteric nervous system in immune regulation and in inflammatory responses. This study was set up to characterize the status of the enteric nervous system in normal and in inflamed appendixes. METHODS: S100- and 2',2'-cyclic nucleotide 3' more...
International Classification:
Diseases of the digestive system - Diseases of appendix - appendixes
Categories:
enteric nervous system; inflamed appendixes
Geography:
Republic of Ireland
Arch Pathol Lab Med,
Vol: 124 Page: 1429-33 October 2000
S. Xiong; P. Puri; L. Nemeth; D. S. O'Briain; D. J. Reen
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The aim of this study was to define the nature and diagnostic importance of hypertrophic nerves in Hirschsprung disease and to clarify their relation to nearby smaller nerve fibres
Abstract:
OBJECTIVE: Hypertrophic nerves have long been considered a histopathologic feature of the aganglionic segment in Hirschsprung disease, but they remain incompletely explained. The purpose of this study was to define the nature and diagnostic importance of hypertrophic nerves in Hirschsprung disease and to clarify their relation to nearby smaller nerve fibers. METHODS: We used an more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
hypertrophic nerves; - Hirschsprung disease
Geography:
Republic of Ireland
Arch Pathol Lab Med,
Vol: 124 Page: 1314-9 September 2000
Y. Kakita; K. Oshiro; D. S. O'Briain; P. Puri
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The aim of this study was to further understand the reported abnormalities in pyloric innervation in infantile hypertrophic pyloric stenosis, by analyzing the expression of Trk receptors and the neurotrophins content in hypertrophic pyloric stenosis
Abstract:
BACKGROUND/PURPOSE: Increasing evidence suggests that the enteric nervous system is under the control of neurotrophins. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), promote differentiation, growth, and survival of various central and peripheral nervous system neurons. The biological effects of neurotrophins more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
abnormalities in pyloric innervation; infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 1280-4 August 2001
N. Guarino; A. Yoneda; H. Shima; P. Puri
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The aim of this study was to ascertain whether the majority of infants with hypertrophic pyloric stenosis might be managed in a well-equipped regional centre
Abstract:
BACKGROUND: It has been suggested that only specialist paediatric surgeons should manage infantile hypertrophic pyloric stenosis (IHPS). AIM: The aim of this retrospective study was to ascertain whether the majority of these infants might be managed in a well-equipped regional centre. METHODS: Using the Hospital Inpatient Enquiry database, all cases of IHPS within a single more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - hypertrophic pyloric stenosis
Categories:
hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Ir J Med Sci,
Vol: 169 Page: 93 2000 Apr-Jun
M. T. Corbally
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The aim of this study was to analyze the expression of desmin in infantile hypertrophic pyloric stenosis
Abstract:
Recent reports indicate that extracellular matrix and cytoskeleton plasmalemmal elements are altered in infantile hypertrophic pyloric stenosis (IHPS). Desmin is a cytoskeletal protein that is important for the organization and function of muscular fibers. It has been found to be increased in the smooth muscle in chronic intestinal pseudo-obstruction and in skeletal muscle in some forms more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
desmin; -hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 16 Page: 282-4 2000
N. Guarino; H. Shima; P. Puri
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This study examined if Ramstedt's pyloromyotomy can be preformed safely in the district general hospital setting or whether it should be restricted to specialist pediatric units only
Abstract:
BACKGROUND: Ramstedt's pyloromyotomy has long been the standard operation for the treatment of infantile hypertrophic pyloric stenosis. Controversy exists over whether this procedure can be performed safely in the district general hospital setting or whether it should be restricted to specialist pediatric units only. METHODS: Retrospective analysis was performed on the medical records more...
International Classification:
Procedure - femoral epiphysis fixation
Categories:
Ramstedt's pyloromyotomy
Geography:
Northern Ireland
J Pediatr Surg,
Vol: 38 Page: 1333-6 September 2003
J. S. White; W. D. Clements; P. Heggarty; S. Sidhu; E. Mackle; I. Stirling
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