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Irish Child Health Database - Peer Reviewed Papers

Database Search

Proteins/genetics/metabolism

Your search returns 2 documents

• 1.   Altered gene expression in highly purified enterocytes from patients with active coeliac disease

  The aim of this study was to examine gene expression in a highly purified isolate of enterocytes taken from patients with active coeliac disease

  

  Abstract:

  BACKGROUND: Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion of gluten in genetically susceptible individuals. Genes within the HLA-DQ locus are considered to contribute some 40% of the genetic influence on this disease. However, information on other disease causing genes is sparse. Since enterocytes are considered to play a central role in more...

  International Classification:

  Diseases of the digestive system - Other diseases of the digestive system - coeliac disease

  Categories:

  coeliac disease

  Geography:

  Republic of Ireland

  BMC Genomics, Vol: 9 Page: 377 2008
  S. Bracken; G. Byrne; J. Kelly; J. Jackson; C. Feighery

  [Preview] [Read]

• 2.   Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function

  The aim of this study was to investigate evaluate neonatal and adult neutrophils for their ability to combat bacterial infection by examining their functional activity (CD11b and reactive oxygen intermediates) and their persistence at inflammatory sites

  

  Abstract:

  Neutropenia is a common sequela of neonatal sepsis. Recent clinical trials have shown the beneficial effects of colony-stimulating factors (CSFs) on outcome in this group, but the exact mechanism remains unknown. Neonates and mothers who were at high-risk for infection were recruited for cord blood sampling in a university tertiary referral maternity hospital. Neonatal and adult more...

  International Classification:

  Immunology - neutrophils and bacterial infection

  Categories:

  neutrophils; bacterial infection

  Geography:

  Republic of Ireland

  Pediatr Res, Vol: 57 Page: 806-12 June 2005
  E. J. Molloy; A. J. O'Neill; J. J. Grantham; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson

  [Preview] [Read]