Irish Child Health Database - Peer Reviewed Papers
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Age of Onset
Your search returns 17 documents
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The aim of this study was to examine the incidence of Helicobacter pylori infection in children and the risk factors for infection
Abstract:
BACKGROUND & AIMS: Helicobacter pylori is most likely acquired in childhood, but the incidence of infection has not been determined prospectively by using an appropriate noninvasive test. The aim of this study was to determine the age-specific incidence of Helicobacter pylori infection in children and the risk factors for infection. METHODS: Three hundred twenty-seven healthy index more...
International Classification:
Bacterium - Helicobacter pylori
Categories:
Helicobacter pylori
Geography:
Republic of Ireland
Gastroenterology,
Vol: 130 Page: 65-72; quiz 211 January 2006
M. Rowland; L. Daly; M. Vaughan; A. Higgins; B. Bourke; B. Drumm
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The aim of this study was to examine the clinical significance of anti-p155/140 autoantibodies in juvenile dermatomyositis
Abstract:
OBJECTIVES: Myositis-specific autoantibodies (MSAs) may define homogeneous clinical subsets of adult patients with dermatomyositis (DM). Recently, there have been descriptions of novel autoantibodies in DM. This study was conducted to establish the clinical significance of anti-p155/140 autoantibodies in juvenile DM (JDM). METHODS: The first 116 children recruited to the JDM National more...
International Classification:
Diseases of the musculoskeletal system and connective tissue - Systemic connective tissue disorders - dermatomyositis
Categories:
juvenile dermatomyositis
Geography:
Republic of Ireland
Rheumatology (Oxford),
Vol: 47 Page: 324-8 March 2008
H. Gunawardena; L. R. Wedderburn; J. North; Z. Betteridge; J. Dunphy; H. Chinoy; J. E. Davidson; R. G. Cooper; N. J. McHugh
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The aim of this study was to examine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma
Abstract:
PURPOSE: To determine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma. PATIENTS AND METHODS: The genetic alterations and morphologic features that underpin three histopathologic risk classifications were analyzed in 108 neuroblastoma patients. Tumors were subdivided into four groups based on the three most frequent and prognostically more...
International Classification:
Neoplasms - Malignant neoplasms - neuroblastoma
Categories:
neuroblastoma
Geography:
Republic of Ireland and the United Kingdom
J Clin Oncol,
Vol: 19 Page: 3080-90 June 2001
M. Lastowska; C. Cullinane; S. Variend; S. Cotterill; N. Bown; S. O'Neill; K. Mazzocco; P. Roberts; J. Nicholson; C. Ellershaw; A. D. Pearson; M. S. Jackson
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This study compared clinical examination using green light with clinical examination using white light in detecting early diabetic retinopathy in juvenile diabetic patients with disease for 10 or more years
Abstract:
PURPOSE: To compare clinical examination using green light with clinical examination using white light in detecting early diabetic retinopathy (DR) in juvenile diabetic patients with disease for 10 or more years. METHODS: All patients were examined clinically using both green light and white light to determine the presence of DR. Each patient underwent seven-field fundus photography, more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - diabetic retinopathy
Categories:
diabetic retinopathy
Geography:
Republic of Ireland
Eye,
Vol: 14 Page: 847-50 December 2000
M. Cahill; D. Wallace; S. Travers; H. Lipinski; S. Aldington; C. Costigan; D. Mooney
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The aim of this study was to describe the differences between males and females in the seasonality of birth and month of clinical onset of disease in children with type 1 diabetes mellitus in Ireland
Abstract:
The aim was to study the monthly rhythm of birth and clinical onset in 303 children with type 1 diabetes mellitus (DM1) aged 0-15 years (156 males, 147 females) born between 1980 and 1996 in Ireland and compare to 951,717 infants born in the general population during the same period. Analysis was performed using the cosine fit for rhythm and t-test between the seasons of the year. more...
International Classification:
Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus
Categories:
type 1 diabetes mellitus
Geography:
Republic of Ireland
J Pediatr Endocrinol Metab,
Vol: 16 Page: 779-82 June 2003
E. F. Roche; H. Lewy; H. M. Hoey; Z. Laron
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This case report discusses an unusual form of "pseudodominant" inheritance to illustrate how a diagnosis of Friedreich's ataxia in a parent does not preclude the diagnosis in the child.
Abstract:
Friedreich's ataxia (FA) is an autosomal recessive condition caused by a GAA trinucleotide repeat expansion in the X25 gene on chromosome 9. We describe an unusual form of "pseudodominant" inheritance to illustrate how a diagnosis of FA in a parent does not preclude the diagnosis in the child. more...
International Classification:
Diseases of the nervous system - Report
Categories:
Friedreich's ataxia
Geography:
Northern Ireland
Arch Dis Child,
Vol: 83 Page: 74-5 July 2000
M. C. McGovern; M. Stewart; P. J. Morrison; D. Webb; S. Hawkins
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The aim of this study was to examine whether low parental social class increases children's risk of subsequently developing Schizophrenia or modifies the presentation
Abstract:
OBJECTIVES: To examine if low parental social class increases children's risk of subsequently developing schizophrenia or modifies the presentation. DESIGN: Case-control study with historical controls. SETTING: Geographically defined region in south Dublin. Participants: 352 patients with first presentation of schizophrenia matched with the next registered same sex birth from the same more...
International Classification:
Mental and behavioural disorders - Schizophrenia, schizotypal and delusional disorders - schizophrenia
Categories:
low parental social class; -Schizophrenia
Geography:
Republic of Ireland
Bmj,
Vol: 323 Page: 1398-401 December 2001
F. Mulvany; E. O'Callaghan; N. Takei; M. Byrne; P. Fearon; C. Larkin
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This case report discusses the clinical and pathological findings in two siblings in whom the 4977 base pair mitochondrial DNA deletion was identified in muscle-derived mitochondrial DNA
Abstract:
The common 4977 base pair mitochondrial deletion has been identified in association with a number of distinct clinical phenotypes. These include the Kearns-Sayre syndrome, the Pearson marrow-pancreas syndrome, and chronic progressive external ophthalmoplegia. We report the clinical and pathological findings in two siblings in whom the 4977 base pair mitochondrial DNA deletion was more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Report
Categories:
4977 base pair mitochondrial DNA deletion
Geography:
Republic of Ireland
Am J Med Genet,
Vol: 111 Page: 191-4 August 2002
D. G. McDonald; J. B. McMenamin; M. A. Farrell; O. Droogan; A. J. Green
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The aim of this study was to examine the prevalence of cannabis use among young people in school year 11 in Northern Ireland
Abstract:
The relatively high levels of cannabis use among young people is a cause of concern because of the positive relationship between its early onset use, antisocial behaviours and associated lifestyle. Amongst a survey of 3919 young people at school year 11 in Northern Ireland (aged 14/15 years) 142 reported daily cannabis use. These young people also reported particularly high levels of more...
International Classification:
Drugs - cannabis
Categories:
cannabis use
Geography:
Northern Ireland
Drug Alcohol Depend,
Vol: 88 Page: 19-27 April 2007
P. McCrystal; A. Percy; K. Higgins
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The aim of this study was to describe a genome-wide search on individuals with early-onset homogeneous bipolar affective disorder type I proband
Abstract:
Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify vulnerability genes. Thus, the probability of detecting major disease-causing genes might be increased by focusing on families with early-onset BPAD type I probands. This study was conducted as part more...
International Classification:
Mental and behavioural disorders - Mood [affective] disorders - bipolar affective disorder
Categories:
homogeneous bipolar affective disorder
Geography:
International
Mol Psychiatry,
Vol: 11 Page: 685-94 July 2006
B. Etain; F. Mathieu; M. Rietschel; W. Maier; M. Albus; P. McKeon; S. Roche; C. Kealey; D. Blackwood; W. Muir; F. Bellivier; C. Henry; C. Dina; S. Gallina; H. Gurling; A. Malafosse; M. Preisig; F. Ferrero; S. Cichon; J. Schumacher; S. Ohlraun; M. Borrmann-Hassenbach; P. Propping; R. Abou Jamra; T. G. Schulze; A. Marusic; Z. M. Dernovsek; B. Giros; T. Bourgeron; A. Lemainque; D. Bacq; C. Betard; C. Charon; M. M. Nothen; M. Lathrop; M. Leboyer
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This article discusses how molecular genetics advances have, in the last decade, allowed a better understanding of autosomal dominant and autosomal recessive spinocerebellar ataxias
Abstract:
Over 25 autosomal dominant and autosomal recessive spinocerebellar ataxias have been isolated over the last decade. The recognition of paediatric ataxia phenotypes and, in addition, other movement disorders including hereditary choreiform and parkinsonian syndromes, has improved our knowledge of these diseases. Advances in molecular genetics has allowed fuller delineation and better more...
Geography:
Northern Ireland
Eur J Paediatr Neurol,
Vol: 7 Page: 217-9 2003
P. J. Morrison
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The aim of this study was to describe the clinical, psychiatric, and genetic features of rapid-onset dystonia-parkinsonism from three generations of an Irish family
Abstract:
BACKGROUND: Rapid-onset dystonia-parkinsonism (RDP) is an autosomal dominant disorder linked to chromosome 19q13 that is characterized by sudden onset of primarily bulbar and upper limb dystonia with parkinsonism. METHODS: The authors evaluated 12 individuals from three generations of an Irish family and obtained detailed medical records on a deceased member. The authors describe the more...
International Classification:
Diseases of the nervous system - Extrapyramidal and movement disorders - dystonia-parkinsonism
Categories:
dystonia-parkinsonism
Geography:
Republic of Ireland
Neurology,
Vol: 55 Page: 991-5 October 2000
S. J. Pittock; C. Joyce; V. O'Keane; B. Hugle; M. O. Hardiman; F. Brett; A. J. Green; D. E. Barton; M. D. King; D. W. Webb
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The aim of this study was to undertake genomic analysis on the connective tissue growth factor gene, which has been implicated in the pathogenesis of diabetic nephropathy
Abstract:
Connective tissue growth factor (CTGF) has been implicated in the pathogenesis of diabetic nephropathy; however, to date there have been no reports of genomic analysis on this gene. The CTGF gene was comprehensively screened using WAVE (dHPLC) technology and direct capillary sequencing. Single nucleotide polymorphisms (SNPs) with minor allele frequencies greater than 5% were further more...
International Classification:
Endocrine, nutritional and metabolic diseases - diabetic nephropathy
Categories:
connective tissue growth factor gene; -diabetic nephropathy
Geography:
Northern Ireland
J Hum Genet,
Vol: 51 Page: 383-6 2006
A. J. McKnight; D. A. Savage; C. C. Patterson; H. R. Brady; A. P. Maxwell
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This study examined the outcome of full pulmonary function studies and surface topography to establish the efficacy of management protocols in a group that is too small and too varied for more formal assessment
Abstract:
STUDY DESIGN: Retrospective review of patient records, clinical and radiographic, and patient recall for full pulmonary function studies and surface topography. OBJECTIVES: Assessment of outcome of treatment policy after age 15 during the previous 30 years to establish the efficacy of management protocols in a group that is too small and too varied for more formal assessment. BACKGROUND more...
International Classification:
Procedure - pulmonary function studies
Categories:
pulmonary function studies
Geography:
Republic of Ireland
Spine,
Vol: 28 Page: 2397-406 October 2003
C. J. Goldberg; I. Gillic; O. Connaughton; D. P. Moore; E. E. Fogarty; G. J. Canny; F. E. Dowling
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This case report discusses two unusual cases of axonal neuropathy associated with short-chain acyl-CoA dehydrogenase deficiency are described.
Abstract:
Two unusual cases of axonal neuropathy associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency are described. These two unrelated infants presented with profound generalised weakness, particularly affecting the upper limbs. Clinical examination revealed generalised peripheral hypotonia and weakness, with absent deep tendon reflexes. An axonal polyneuropathy was confirmed on more...
International Classification:
Diseases of the nervous system - Report
Categories:
axonal neuropathy
Geography:
Republic of Ireland
Neuropediatrics,
Vol: 35 Page: 312-6 October 2004
M. A. Kurian; L. Hartley; Z. Zolkipli; M. A. Little; D. Costigan; E. R. Naughten; S. Olpin; F. Muntoni; M. D. King
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The aim of this study was to investigate case-control and family-based association studies, using the transmission disequilibrium test, to investigate if allele 1 is associated with early-onset type 1 diabetes
Abstract:
A recent study employing Australian and UK type 1 diabetes families has demonstrated significant transmission bias to affected offspring of a polymorphism (1188A allele; termed allele 1) in the 3' untranslated region (3'UTR) of the interleukin 12B (IL12B) gene which encodes the IL-12p40 subunit of the pro-inflammatory cytokine IL-12. However, results from replication studies in other more...
International Classification:
Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus
Categories:
allele 1; - type 1 diabetes
Geography:
Northern Ireland
Genes Immun,
Vol: 3 Page: 433-5 November 2002
R. M. McCormack; A. P. Maxwell; D. J. Carson; C. C. Patterson; D. Middleton; D. A. Savage
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This study investigated the risk of type 1 diabetes after tonsillectomy and/or adenoidectomy
International Classification:
Procedure - tonsillectomy
Categories:
type 1 diabetes after tonsillectomy and/or adenoidectomy
Geography:
Northern Ireland
Diabetes Care,
Vol: 30 Page: 2564-5 October 2007
C. R. Cardwell; D. J. Carson; E. J. McNaboe; C. C. Patterson
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