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Nucleic Acid Hybridization/methods
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The aim of this study was to examine the evolution of unbalanced gain of distal chromosome 2p in neuroblastoma
Abstract:
Neuroblastoma, one of the most common tumors of childhood, presents at diagnosis with a vast number of recurrent chromosomal imbalances that include hyperdiploidy for whole chromosomes, partial loss of 1p, 3p, 4p, 11q, 14q, partial gain of 1q, 7q, 17q and amplification of MYCN. These abnormalities are nonrandomly distributed in neuroblastoma as loss of 3p and 11q rarely occur in MYCN more...
International Classification:
Neoplasms - Malignant neoplasms - neuroblastoma
Categories:
neuroblastoma
Geography:
International
Cytogenet Genome Res,
Vol: 106 Page: 49-54 2004
R. L. Stallings; P. Carty; L. McArdle; M. Mullarkey; M. McDermott; A. O'Meara; E. Ryan; D. Catchpoole; F. Breatnach
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The aim of this study was to screen for genomic imbalances in patients with acute leukaemia using conventional and molecular and fluorescence in situ hybridisation methods
Abstract:
AIMS: To screen for genomic imbalances in patients with acute leukaemia using conventional (G-banding) and molecular (comparative genomic hybridisation (CGH) and fluorescence in situ hybridisation (FISH)) methods to determine whether an integrative screening approach increases abnormality detection rate. METHODS: G-banded analysis was performed on unstimulated bone marrow (BM) or more...
International Classification:
Neoplasms - Malignant neoplasms - leukaemia
Categories:
leukaemia (acute)
Geography:
Northern Ireland
J Clin Pathol,
Vol: 61 Page: 903-8 August 2008
P. McGrattan; S. Campbell; R. Cuthbert; F. G. Jones; M. F. McMullin; M. Humphreys
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This study aimed to examine molecular cytogenetic analysis of recurrent unbalanced t(11;17) in neuroblastoma
Abstract:
Loss of 11q material occurs in approximately 30% of advanced stage neuroblastoma and defines a distinct genetic subtype of this disease. These tumors almost always possess unbalanced gain of the 17q, along with many additional recurrent chromosomal imbalances. Loss of 11q and gain of 17q is often the consequence of an unbalanced translocation between the long arms of both chromosomes, more...
International Classification:
Effectiveness of measurement tool - molecular cytogenetic analysis
Geography:
Republic of Ireland
Cancer Genet Cytogenet,
Vol: 154 Page: 44-51 October 2004
R. L. Stallings; P. Carty; L. McArdle; M. Mullarkey; M. McDermott; F. Breatnach; A. O'Meara
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