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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » A » Anticoagulants/pharmacokinetics/therapeutic use

Anticoagulants/pharmacokinetics/therapeutic use

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1. An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia

The aim of the study was to conduct an open-label prospective study assessing the efficacy of activated protein C replacement therapy in patients with severe meningococcal septicemia, purpura fulminans, and multiorgan failure

Abstract:

Activated protein C (APC) is a natural anticoagulant that plays a pivotal role in coagulation homeostasis. Severe inherited or acquired deficiency results in a clinical syndrome called purpura fulminans. In addition, APC also appears to have potent cytokine-modifying properties and is protective in animal models of sepsis. The dual functional properties of APC are particularly relevant more...

International Classification:

Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease

Categories:

severe meningococcal septicemia

Geography:

Republic of Ireland

Blood, Vol: 96 Page: 3719-24 December 2000
B. White; W. Livingstone; C. Murphy; A. Hodgson; M. Rafferty; O. P. Smith

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