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Antibody Specificity
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The aim of this study was to examine the persistence of the T-cell response and the effect of booster immunization in 4-6-year-old children
Abstract:
Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also contributes to protection against Bordetella pertussis, and it has already been demonstrated that Pa induce T cells that secrete type-1 and type-2 cytokines in children. In more...
International Classification:
Vaccination
Categories:
immunization
Geography:
Republic of Ireland
Clin Exp Immunol,
Vol: 121 Page: 193-200 August 2000
E. J. Ryan; L. Nilsson; N. Kjellman; L. Gothefors; K. H. Mills
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The aim of this study was to examine the clinical significance of anti-p155/140 autoantibodies in juvenile dermatomyositis
Abstract:
OBJECTIVES: Myositis-specific autoantibodies (MSAs) may define homogeneous clinical subsets of adult patients with dermatomyositis (DM). Recently, there have been descriptions of novel autoantibodies in DM. This study was conducted to establish the clinical significance of anti-p155/140 autoantibodies in juvenile DM (JDM). METHODS: The first 116 children recruited to the JDM National more...
International Classification:
Diseases of the musculoskeletal system and connective tissue - Systemic connective tissue disorders - dermatomyositis
Categories:
juvenile dermatomyositis
Geography:
Republic of Ireland
Rheumatology (Oxford),
Vol: 47 Page: 324-8 March 2008
H. Gunawardena; L. R. Wedderburn; J. North; Z. Betteridge; J. Dunphy; H. Chinoy; J. E. Davidson; R. G. Cooper; N. J. McHugh
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The aim of this study was to examine the in vivo model of congenital cytomegalovirus to examine both the humoral and cell-mediated immune responses in vertically infected neonates and their mothers
Abstract:
Cytomegalovirus (CMV) is the most common cause of congenital infection worldwide and occurs as a result of transplacental transmission of the virus. The human neonate is highly susceptible to infection due to a combination of immaturity of the immune system and antigenic inexperience. This study uses the in vivo model of congenital CMV to examine both the humoral and cell-mediated more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other viral diseases - congenital cytomegalovirus
Categories:
congenital cytomegalovirus
Geography:
Republic of Ireland
Clin Exp Immunol,
Vol: 147 Page: 465-71 March 2007
J. Hassan; S. Dooley; W. Hall
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The aim of this study was to examine the immune responses to purified virus capsid proteins, VP1 and VP2, of recently infected children and compared with responses from long-term convalescent volunteers
Abstract:
Parvovirus B19 is the causative agent of "fifth disease" of childhood. It has been implicated in a variety of conditions, including unsuccessful pregnancy and rheumatoid arthritis, and is a potential contaminant of blood products. There has been little study of immunity to parvovirus B19, and the exact nature of the protective humoral and cell-mediated immune response is more...
International Classification:
Immunology - responses and infection
Categories:
immune responses to purified virus capsid proteins; -infection
Geography:
Republic of Ireland
J Virol,
Vol: 74 Page: 9903-10 November 2000
A. Corcoran; S. Doyle; D. Waldron; A. Nicholson; B. P. Mahon
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