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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » D » Diabetes Mellitus, Type 1/epidemiology/ genetics

Diabetes Mellitus, Type 1/epidemiology/ genetics

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1. The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes

The aim of this study was to investigate case-control and family-based association studies, using the transmission disequilibrium test, to investigate if allele 1 is associated with early-onset type 1 diabetes

Abstract:

A recent study employing Australian and UK type 1 diabetes families has demonstrated significant transmission bias to affected offspring of a polymorphism (1188A allele; termed allele 1) in the 3' untranslated region (3'UTR) of the interleukin 12B (IL12B) gene which encodes the IL-12p40 subunit of the pro-inflammatory cytokine IL-12. However, results from replication studies in other more...

International Classification:

Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus

Categories:

allele 1; - type 1 diabetes

Geography:

Northern Ireland

Genes Immun, Vol: 3 Page: 433-5 November 2002
R. M. McCormack; A. P. Maxwell; D. J. Carson; C. C. Patterson; D. Middleton; D. A. Savage

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