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Sensitivity and Specificity
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This article discusses a fuzzy logic based apnoea monitor for sudden infant death syndrome risk infants which greatly improves the reliability and usefulness of monitoring
Abstract:
A unit has been designed which monitors newborn infants at risk of Sudden Infant Death Syndrome (SIDS) in a home environment. The unit monitors respiration, electrocardiogram (ECG) and haemoglobin oxygen saturation (SpO2) in combination, in order to detect any potentially life threatening event at an early stage. Provision is made for the generation of both audible and silent alarms and more...
Geography:
Republic of Ireland
J Med Eng Technol,
Vol: 30 Page: 397-411 2006 Nov-Dec
M. J. Burke; R. Downes
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The aim of this study was to accelerate the identification of susceptibility genes in diabetic nephropathy using genome-wide fluorescence-based DNA microsatellite
Abstract:
In an effort to accelerate the identification of susceptibility genes in diabetic nephropathy, the first genome-wide fluorescence-based DNA microsatellite (n=6000) association screen was performed, using pools of genomic DNA derived from Irish patients with (cases; n=200) and without (controls; n=200) type 1 diabetic nephropathy. Allele image profiles were generated for 5353 (89.2%) more...
International Classification:
Endocrine, nutritional and metabolic diseases - diabetic nephropathy
Categories:
susceptibility genes; -diabetic nephropathy
Geography:
Northern Ireland
J Am Soc Nephrol,
Vol: 17 Page: 831-6 March 2006
A. J. McKnight; A. P. Maxwell; S. Sawcer; A. Compston; E. Setakis; C. C. Patterson; H. R. Brady; D. A. Savage
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The aim of this study was to assess realtime teledermatology, store-and-forward teledermatology and conventional outpatient dermatological care were evaluated in a randomized control trial
Abstract:
The clinical effectiveness of realtime teledermatology, store-and-forward teledermatology and conventional outpatient dermatological care were evaluated in a randomized control trial. A total of 204 patients took part--102 patients were randomized to the realtime teledermatology consultation, 96 of whose cases were also referred using a store-and-forward technique, and 102 to the more...
International Classification:
Evaluation of the effectiveness of two treatments - in dermatological care
Categories:
dermatological care
Geography:
Northern Ireland
J Telemed Telecare,
Vol: 6 Suppl 1 Page: S1-3 2000
M. A. Loane; S. E. Bloomer; R. Corbett; D. J. Eedy; N. Hicks; H. E. Lotery; C. Mathews; J. Paisley; K. Steele; R. Wootton
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This article discussed the use of general imaging strategies in abdominal pain in pediatrics
Abstract:
Acute abdominal pain is the most common condition necessitating surgical admission to a paediatric hospital. The vast majority of cases are due to either appendicitis or acute non-specific abdominal pain; however, there are many other conditions presenting with acute abdominal pain in childhood which can mimic appendicitis. Some of these conditions are rarely encountered in adult more...
Geography:
Republic of Ireland
Eur Radiol,
Vol: 14 Suppl 4 Page: L123-37 March 2004
R. Hayes
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This study sought to identify adults and children as under- (UR), acceptable (AR), or over-reporters (OR) of energy intake (EI) using energy expenditure measured by doubly labelled water
Abstract:
OBJECTIVE: To identify adults and children as under- (UR), acceptable (AR), or over-reporters (OR) of energy intake (EI) using energy expenditure measured by doubly labelled water (DLW) (EE(DLW)), and to use this as a reference to determine the sensitivity and specificity of (i) EE measured by heart rate (EE(HR)), and (ii) the Goldberg cut-off technique for classifying subjects into the more...
International Classification:
Diagnostic tool laboratory (doubly labelled water) - energy intake and expenditure
Categories:
energy intake; using energy expenditure; doubly labelled water
Geography:
Northern Ireland
Eur J Clin Nutr,
Vol: 57 Page: 455-63 March 2003
M. B. Livingstone; P. J. Robson; A. E. Black; W. A. Coward; J. M. Wallace; M. C. McKinley; J. J. Strain; P. G. McKenna
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This study examined DMSA with MRI for the detection of renal parenchymal defects in children presenting for radiological investigation after a first UTI
Abstract:
BACKGROUND: Renal parenchymal defects may be a consequence of urinary tract infections (UTI) in childhood. MRI is a non-radiation imaging modality compared with DMSA scanning. OBJECTIVE: To compare DMSA with MRI for the detection of renal parenchymal defects in children presenting for radiological investigation after a first UTI. MATERIALS AND METHODS: Both DMSA and MRI were performed more...
International Classification:
Diagnostic tool (imaging techniques) - renal parenchymal defects
Categories:
renal parenchymal defects
Geography:
Republic of Ireland
Pediatr Radiol,
Vol: 35 Page: 275-81 March 2005
E. C. Kavanagh; S. Ryan; A. Awan; S. McCourbrey; R. O'Connor; V. Donoghue
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The aim of this study was to examine 51 environmental and food E. sakazakii isolates and 6 E. sakazakii type strains
Abstract:
Enterobacter sakazakii has emerged as a rare cause of neonatal meningitis, septicemia and enterocolitis. Contaminated infant milk formula (IMF) has been identified as one infection route. A small number of clinical outbreaks have been epidemiologically linked to IMF contaminated post-pasteurization during manufacture and/or mishandled when reconstituted. Currently no agreed standardized more...
International Classification:
Bacterium - Enterobacter sakazakii
Categories:
E. sakazakii type strains
Geography:
Republic of Ireland
Int J Food Microbiol,
Vol: 110 Page: 127-34 July 2006
D. Drudy; M. O'Rourke; M. Murphy; N. R. Mullane; R. O'Mahony; L. Kelly; M. Fischer; S. Sanjaq; P. Shannon; P. Wall; M. O'Mahony; P. Whyte; S. Fanning
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This article discusses characterization of changes in blood vessel width and tortuosity in retinopathy of prematurity using image analysis
Abstract:
Many retinal diseases are characterised by changes to retinal vessels. For example, a common condition associated with retinopathy of prematurity (ROP) is so-called plus disease, characterised by increased vascular dilation and tortuosity. This paper presents a general technique for segmenting out vascular structures in retinal images, and characterising the segmented blood vessels. The more...
Geography:
Republic of Ireland
Med Image Anal,
Vol: 6 Page: 407-29 December 2002
C. Heneghan; J. Flynn; M. O'Keefe; M. Cahill
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This study examined a generic adenovirus nested polymerase chain amplification assay designed to be capable of detecting all respiratory adenoviruses.
Abstract:
BACKGROUND: respiratory adenoviruses are common, often resulting in serious sporadic and epidemic infections and impaired immunity can dramatically increase their severity. They are now thought capable of establishing latency. Diagnosis by culture is slow while direct antigen detection by immunofluorescence lacks sensitivity. Molecular diagnosis can be both rapid and sensitive but the more...
International Classification:
Diagnostic tool laboratory - adenovirus
Categories:
Dimercaptosuccinic acid scan (DMSA); Magnetic resonance imaging (MRI)
Geography:
Northern Ireland
J Clin Virol,
Vol: 26 Page: 331-8 April 2003
S. Mitchell; H. J. O'Neill; G. M. Ong; S. Christie; P. Duprex; D. E. Wyatt; C. McCaughey; V. J. Armstrong; S. Feeney; L. Metwally; P. V. Coyle
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The aim of this study was to examine the clinical significance of anti-p155/140 autoantibodies in juvenile dermatomyositis
Abstract:
OBJECTIVES: Myositis-specific autoantibodies (MSAs) may define homogeneous clinical subsets of adult patients with dermatomyositis (DM). Recently, there have been descriptions of novel autoantibodies in DM. This study was conducted to establish the clinical significance of anti-p155/140 autoantibodies in juvenile DM (JDM). METHODS: The first 116 children recruited to the JDM National more...
International Classification:
Diseases of the musculoskeletal system and connective tissue - Systemic connective tissue disorders - dermatomyositis
Categories:
juvenile dermatomyositis
Geography:
Republic of Ireland
Rheumatology (Oxford),
Vol: 47 Page: 324-8 March 2008
H. Gunawardena; L. R. Wedderburn; J. North; Z. Betteridge; J. Dunphy; H. Chinoy; J. E. Davidson; R. G. Cooper; N. J. McHugh
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This study aimed to describe a combination of an ECG-based classifier system with a novel multi-channel EEG-based classifier system to develop an improved neonatal seizure detection performance
Abstract:
OBJECTIVE: Neonatal seizures are the most common central nervous system disorder in newborn infants. A system that could automatically detect the presence of seizures in neonates would be a significant advance facilitating timely medical intervention. METHODS: A novel method is proposed for the robust detection of neonatal seizures through the combination of simultaneously-recorded more...
International Classification:
Effectiveness of measurement tool - ECG-based classifier system, multi-channel EEG-based
Categories:
ECG-based classifier system; multi-channel EEG-based classifier; neonatal seizure
Geography:
Republic of Ireland
Clin Neurophysiol,
Vol: 118 Page: 1348-59 June 2007
B. R. Greene; G. B. Boylan; R. B. Reilly; P. de Chazal; S. Connolly
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This case report discusses a case of a double aortic arch in a 9-month-old girl that was diagnosed by barium esophagography
Abstract:
The diagnosis of a vascular ring can be made on the basis of characteristic findings on barium esophagography. We report a case of a double aortic arch in a 9-month-old girl that was diagnosed in this manner, and we briefly review the anatomic characteristics of vascular rings. more...
International Classification:
Diseases of the circulatory system - Report
Categories:
double aortic arch
Geography:
Republic of Ireland
Ear Nose Throat J,
Vol: 81 Page: 554-5 August 2002
L. J. Skinner; S. Ryan; J. D. Russell
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The aim of this study was to examine the distribution and morphology of the neuronal structures in the human upper urinary tract
Abstract:
PURPOSE: To our knowledge innervation of the upper urinary tract and its role in motility and sensation are not clearly understood. The whole mount preparation technique provides 3-dimensional (D) morphology of the innervation and its relationship of branching and interconnecting nerve fibers to each other and to the neighboring tissues. Confocal laser scanning microscopy provides more...
International Classification:
Diseases of the genitourinary system - Other diseases of urinary system - upper urinary tract
Categories:
upper urinary tract
Geography:
Republic of Ireland
J Urol,
Vol: 166 Page: 255-8 July 2001
L. Nemeth; D. S. O'Briain; P. Puri
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This study compared clinical examination using green light with clinical examination using white light in detecting early diabetic retinopathy in juvenile diabetic patients with disease for 10 or more years
Abstract:
PURPOSE: To compare clinical examination using green light with clinical examination using white light in detecting early diabetic retinopathy (DR) in juvenile diabetic patients with disease for 10 or more years. METHODS: All patients were examined clinically using both green light and white light to determine the presence of DR. Each patient underwent seven-field fundus photography, more...
International Classification:
Diseases of the eye and adnexa - Disorders of choroid and retina - diabetic retinopathy
Categories:
diabetic retinopathy
Geography:
Republic of Ireland
Eye,
Vol: 14 Page: 847-50 December 2000
M. Cahill; D. Wallace; S. Travers; H. Lipinski; S. Aldington; C. Costigan; D. Mooney
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This study examined the sensitivity for duodenal villous atrophy in a large series of patients undergoing GI endoscopy specifically for duodenal biopsy
Abstract:
OBJECTIVE: Endoscopic markers of duodenal villous atrophy (VA) can facilitate diagnosis of celiac disease during routine upper GI endoscopy. We studied their sensitivity for VA in a large series of patients undergoing GI endoscopy specifically for duodenal biopsy. Poor sensitivity in this setting would have significant and adverse implications for their performance during routine more...
International Classification:
Diagnostic tool (endoscopy) - duodenal biopsy
Categories:
duodenal villous atrophy; duodenal biopsy
Geography:
Northern Ireland
Am J Gastroenterol,
Vol: 96 Page: 2126-8 July 2001
W. Dickey; D. Hughes
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The aim of this study was to test the hypothesize that expression of GATA4 and GATA6 is reduced in early stages of gestation in a congenital diaphragmatic hernia hypoplastic heart
Abstract:
PURPOSE: The high incidence of cardiac malformations in humans and animal models with congenital diaphragmatic hernia (CDH) is well known. The precise molecular mechanisms underlying cardiac maldevelopment in CDH are still unclear. It has been reported that GATA4 and GATA6, members of the GATA transcription factor family, act cooperatively to regulate cardiovascular development, and the more...
Categories:
GATA4 and GATA6; congenital diaphragmatic hernia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 43 Page: 362-6 February 2008
H. Takayasu; H. Sato; K. Sugimoto; P. Puri
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The aim of this study was to test the hypothesize that Wnt-mediated signaling is altered in nitrofen-induced hypoplastic lungs
Abstract:
PURPOSE: The pathogenesis of pulmonary hypoplasia associated with congenital diaphragmatic hernia is poorly understood. Recently, it has been reported that Wnt signaling pathway plays a critical role in branching lung morphogenesis. Mice lacking Wnt7b gene die soon after birth because of respiratory failure and display severe lung hypoplasia. Wnt2 gene is expressed in the distal airway more...
Categories:
Wnt-mediated signaling; hypoplastic lungs
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 426-30 February 2007
H. Takayasu; N. Nakazawa; S. Montedonico; P. Puri
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The aim of this study was to examine a method for the detection of seizures in the newborn using the electrocardiogram signal
Abstract:
A method for the detection of seizures in the newborn using the electrocardiogram (ECG) signal is presented. Using a database of eight recordings, a method was developed for automatically annotating each 1-min epoch as "nonseizure" or "seizure". The system uses a linear discriminant classifier to process 41 heartbeat timing interval features. Performance assessment more...
International Classification:
Neonatal seizures
Categories:
seizures in the newborn
Geography:
Republic of Ireland and the United Kingdom
IEEE Trans Biomed Eng,
Vol: 54 Page: 673-82 April 2007
B. R. Greene; P. de Chazal; G. B. Boylan; S. Connolly; R. B. Reilly
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This study aimed to describe the development of a polyacrylamide gel electrophoresis method for the rapid separation of 16S rRNA PCR amplicons from aetiological agents of acute meningitis
Abstract:
AIMS: The aim of this study was to develop a polyacrylamide gel electrophoresis (PAGE) method for the rapid separation of 16S rRNA PCR amplicons from aetiological agents of acute meningitis. METHODS AND RESULTS: Blood samples from 40 patients with suspected acute meningococcal meningitis were examined for the presence of causal agents, including Neisseria meningitidis employing two more...
International Classification:
Effectiveness of measurement tool - polyacrylamide gel electrophoresis
Categories:
polyacrylamide gel electrophoresis; acute meningitis
Geography:
Northern Ireland
J Appl Microbiol,
Vol: 94 Page: 197-206 2003
J. Xu; B. C. Millar; J. E. Moore; K. Murphy; H. Webb; A. J. Fox; M. Cafferkey; M. J. Crowe
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The aim of this study was to examine dietary survey data from Sweden and Ireland, revealing a declining ratio of energy intake to estimated basal metabolic rate, %energy from fat, saturated fat and carbohydrate fell while that of protein increased
Abstract:
An analysis of dietary survey data from Sweden and Ireland revealed that with a declining ratio of energy intake to estimated basal metabolic rate (EI:BMR), %energy from fat, saturated fat and carbohydrate fell while that of protein increased. However, where the definition of under-reporting is less strict, as in the Irish database (EI:BMR) < 1.27), the quantitative effect on more...
International Classification:
Diet and life style
Categories:
diet; basal metabolic rate
Geography:
International
Br J Nutr,
Vol: 81 Suppl 2 Page: S127-31 April 1999
W. Becker; S. Foley; E. Shelley; M. Gibney
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The aim of this study was to define the expression of epidermal growth factor and monocyte chemotactic peptide-1 in severe reflux nephropathy in order to further understand the pathogenesis of reflux nephropathy
Abstract:
OBJECTIVES: Reflux nephropathy (RN) is recognised as a major cause of end stage renal failure in children and young adults. The histological findings of RN are tubular atrophy and interstitial monocyte infiltration. Epidermal growth factor (EGF) produced by tubular cells playing a pivotal role in the modulation of tubular cell growth, while monocyte chemotactic peptide-1 (MCP-1) is a more...
International Classification:
Diseases of the genitourinary system - reflux nephropathy
Categories:
epidermal growth factor; monocyte chemotactic peptide-1; - reflux nephropathy
Geography:
Republic of Ireland
Eur Urol,
Vol: 44 Page: 144-9 July 2003
B. Chertin; A. Farkas; P. Puri
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The aim of this study was to examine exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children
Abstract:
BACKGROUND: Exhaled nitric oxide has been proposed as a marker for airway inflammation in asthma. The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children. METHODS: Children were recruited from elective surgical lists and a non-bronchoscopic bronchoalveolar lavage (BAL) was more...
International Classification:
Diseases of the respiratory system - Chronic lower respiratory diseases - asthma
Categories:
asthma
Geography:
Northern Ireland
Thorax,
Vol: 57 Page: 383-7 May 2002
T. J. Warke; P. S. Fitch; V. Brown; R. Taylor; J. D. Lyons; M. Ennis; M. D. Shields
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The aim of this study was to examine children attending a routine asthma clinic and evaluate the relationship between exhaled nitric oxide levels and clinical parameters including decision making.
Abstract:
BACKGROUND: Exhaled nitric oxide (ENO) has been shown to be a noninvasive marker of eosinophilic inflammation in asthmatic children. Few studies have evaluated the relationship between ENO levels and the clinical features of children with asthma. The aim of this study was to examine children attending a routine asthma clinic and evaluate the relationship between ENO levels and clinical more...
International Classification:
Diseases of the respiratory system - Chronic lower respiratory diseases - asthma
Categories:
asthma
Geography:
Northern Ireland
J Asthma,
Vol: 41 Page: 751-7 October 2004
T. J. Warke; V. Mairs; P. S. Fitch; V. McGovern; M. Ennis; M. D. Shields
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This study developed a sensitive, multi-dimensional measure to assess parental perception of health-related QoL in children aged 0-12 years with food allergy
Abstract:
BACKGROUND: To date, there is no food allergy-specific questionnaire that allows parents to report children's health-related QoL (HRQL) from the child's perspective. OBJECTIVE: The aim of this study was to develop a sensitive, multi-dimensional measure to assess parental perception of HRQL in children aged 0-12 years with food allergy. METHODS: The Food Allergy QoL - Parent Form more...
International Classification:
Diagnostic tool (questionaire/scale) - quality of life
Categories:
health-related QoL
Geography:
International
Clin Exp Allergy,
Vol: 38 Page: 977-86 June 2008
A. DunnGalvin; B. M. de BlokFlokstra; A. W. Burks; A. E. Dubois; J. O. Hourihane
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This study aimed to describe the gaussian process modeling of EEG for the detection of neonatal seizures
Abstract:
Gaussian process (GP) probabilistic models have attractive advantages over parametric and neural network modeling approaches. They have a small number of tuneable parameters, can be trained on relatively small training sets, and provide a measure of prediction certainty. In this paper, these properties are exploited to develop two methods of highlighting the presence of neonatal more...
International Classification:
Effectiveness of measurement tool - gaussian process modeling of EEG for the detection of neonatal seizures
Geography:
Republic of Ireland and the United Kingdom
IEEE Trans Biomed Eng,
Vol: 54 Page: 2151-62 December 2007
S. Faul; G. Gregorcic; G. Boylan; W. Marnane; G. Lightbody; S. Connolly
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This study assess the predictability of the initial herring classification
Abstract:
The Herring lateral pillar classification has been shown to be a useful predictor of subsequent femoral head deformity in Perthes disease. The initial Herring classification, however, can often be misleading with regard to outcome, as further collapse can occur. The purpose of this study was to assess the predictability of the initial Herring classification. The radiographs of 253 more...
International Classification:
Predictability of herring classification
Categories:
predictability; herring classification
Geography:
Northern Ireland
J Pediatr Orthop,
Vol: 22 Page: 479-82 2002 Jul-Aug
K. Lappin; D. Kealey; A. Cosgrove
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The aim of this study was to examine how varying criteria for a diagnosis of Sudden Infant Death Syndrome significantly alters the SIDS rate in Ireland
Abstract:
There is increasing concern with using SIDS as a diagnosis, especially where the postmortem examination reveals additional findings that may be contributory to the death exclusion. This report shows how varying the criteria for a diagnosis of SIDS significantly alters the SIDS rate in Ireland. more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified- Ill-defined and unknown causes of mortality - Ill-defined and unknown causes of mortality - Sudden infant death syndrome
Categories:
sudden infant death syndrome
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 90 Page: 1082-3 October 2005
K. M. Sheehan; C. McGarvey; D. M. Devaney; T. Matthews
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This study examined the sensitivity and specificity of two selective media for the isolation of Burkholderia cepacia from sputum specimens in patients with cystic fibrosis
Abstract:
AIMS: To evaluate the sensitivity and specificity of two selective media for the isolation of Burkholderia cepacia from sputum specimens in patients with cystic fibrosis (CF). METHODS: In total, 149 expectorated sputum specimens from 113 patients with CF (32 cepacia colonised patients and 81 non-cepacia colonised patients) attending three CF centres were examined for the presence of B more...
International Classification:
Diagnostic tool laboratory - Burkholderia cepacia
Categories:
media (gel); Burkholderia cepacia; cystic fibrosis
Geography:
Northern Ireland
J Clin Pathol,
Vol: 54 Page: 803-5 October 2001
R. M. Wright; J. E. Moore; A. Shaw; K. Dunbar; M. Dodd; K. Webb; A. O. Redmond; M. Crowe; P. G. Murphy; S. Peacock; J. S. Elborn
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This study examined the development of an improved PCR assay with reference to sensitivity for the direct detection of Burkholderia cepacia genomovar III and Burkholderia multivorans organisms from cystic fibrosis sputum employing the recA locus
Abstract:
Optimum detection of the Burkholderia cepacia complex (BCC) from sputum of patients with cystic fibrosis (CF) is essential in preventing patient-to-patient transmission of this organism. The aim of this study was to develop an improved PCR assay with reference to sensitivity for the direct detection of BCC organisms from CF sputum employing the recA locus. The sensitivity results of more...
International Classification:
Diagnostic tool laboratory - Burkholderia cepacia
Categories:
sensitivity; Burkholderia cepacia genomovar III; Burkholderia multivorans; cystic fibrosis
Geography:
Northern Ireland
J Microbiol Methods,
Vol: 49 Page: 183-91 April 2002
J. E. Moore; J. Xu; B. C. Millar; M. Crowe; J. S. Elborn
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This study examined the diagnostic yield of limited colorectal endoscopy with total colonoscopy in children with recurrent painless rectal bleeding
Abstract:
INTRODUCTION: Most patients with recurrent painless rectal bleeding warrant endoscopic examination of the lower gastrointestinal tract. This is often limited to rectum or distal colon. The purpose of this study was to compare the diagnostic yield of limited colorectal endoscopy with total colonoscopy in children with recurrent painless rectal bleeding. METHODS: Retrospective review of more...
International Classification:
Diagnostic tool (endoscopy) - rectal bleeding
Categories:
limited colorectal endoscopy; otal colonoscopy
Geography:
Northern Ireland
J Pediatr Surg,
Vol: 40 Page: 1920-2 December 2005
G. Clarke; A. Robb; I. Sugarman; W. A. McCallion
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This study examined the limitations to carbon 13-labeled urea breath testing for Helicobacter pylori in infants
Abstract:
We determined the validity of the carbon 13-labeled urea breath test in young children. We found that although the 13C-labeled urea breath test had a specificity greater than 90%, borderline or false positive results occurred more frequently in children younger than 2 years compared with older children. False positive results may be caused by oral-urease-producing organisms because more...
International Classification:
Diagnostic tool laboratory (urea breath test) - Helicobacter pylori
Categories:
carbon 13-labeled urea breath; Helicobacter pylori
Geography:
Republic of Ireland
J Pediatr,
Vol: 139 Page: 734-7 November 2001
C. Imrie; M. Rowland; B. Bourke; B. Drumm
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This study examined the relationship between superior vena cava flow in first 24 h and adverse outcome in very low birthweight infants
Abstract:
BACKGROUND: Superior vena cava (SVC) flow assesses blood flow from the upper body, and may provide a reliable assessment of systemic blood flow. AIM: (i) To assess the relationship between SVC flow in first 24 h and adverse outcome in very low birthweight (VLBW) infants (ii) To assess correlation between SVC flow and left and right ventricular outputs and anterior cerebral artery (ACA) more...
International Classification:
Other - superior vena cava flow
Categories:
superior vena cava flow
Geography:
Republic of Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 93 Page: F368-71 September 2008
J. Miletin; E. M. Dempsey
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The aim of this study was to investigate neurone density and morphology of the myenteric plexus in premature infants
Abstract:
BACKGROUND: The gastrointestinal tract appears morphologically prepared for oral feeding by the end of the second trimester, but many of the physiological processes required for efficient enteral nutrition are not developed fully until 33 to 34 weeks' gestation. Myenteric plexus is well recognized as an important regulator of peristaltic activity. Whole-mount preparation technique more...
International Classification:
Other - Physical part of the body - myenteric plexus
Categories:
neurone density; -myenteric plexus
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 35 Page: 748-52 May 2000
L. Nemeth; L. Fourcade; P. Puri
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This article discusses studies in which energy intake was reported and energy expenditure was measured using the doubly labeled water technique
Abstract:
Energy intake (EI) is the foundation of the diet, because all other nutrients must be provided within the quantity of food needed to fulfill the energy requirement. Thus if total EI is underestimated, it is probable that the intakes of other nutrients are also underestimated. Under conditions of weight stability, EI equals energy expenditure (EE). Because at the group level weight may more...
Geography:
Northern Ireland
J Nutr,
Vol: 133 Suppl 3 Page: 895S-920S March 2003
M. B. Livingstone; A. E. Black
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This study aimed to explore on the reliability of a modified version of the "Index of Orthodontic Treatment Need" for use in oral health surveys.
Abstract:
This paper reports the results of a study of the reliability of a modified version of the Index of Orthodontic Treatment Need (IOTN) for use in oral health surveys. Twelve non-specialist dental examiners were trained in the use of the Modified IOTN using a standardised teaching protocol lasting approximately 1.5 hours. Following a school-based calibration exercise it was found that more...
International Classification:
Practice/knowledge - Index of Orthodontic Treatment Need
Categories:
Index of Orthodontic Treatment Need
Geography:
Northern Ireland
Community Dent Oral Epidemiol,
Vol: 29 Page: 220-5 June 2001
D. J. Burden; C. M. Pine; G. Burnside
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The aim of this study was to examine the effect of risk factors, including mode of delivery, on the vertical transmission rate of hepatitis C
Abstract:
BACKGROUND: Little information is available about the timing of mother-to-child transmission of hepatitis C virus (HCV), and no interventions to decrease transmission rates have been identified. We examined the effect of risk factors, including mode of delivery, on the vertical transmission rate. METHODS: Data from HCV-infected women and their infants from three hospitals in Ireland and more...
International Classification:
Certain infectious and parasitic diseases - Viral hepatitis - hepatitis C
Categories:
hepatitis C
Geography:
Republic of Ireland and the United Kingdom
Lancet,
Vol: 356 Page: 904-7 September 2000
D. M. Gibb; R. L. Goodall; D. T. Dunn; M. Healy; P. Neave; M. Cafferkey; K. Butler
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This study examined the usefulness of plasma NT-proBNP in diagnosing haemodynamically significant patent ductus arteriosus (hsPDA) in neonates and examine some factors that might affect this
Abstract:
BACKGROUND: B-type natriuretic peptide (BNP) is a marker for ventricular dysfunction secreted as a pre-prohormone, pro-B-type natriuretic peptide (proBNP), and cleaved into BNP and a biologically inactive fragment, N-terminal pro-B-type natriuretic peptide (NT-proBNP). Little is known about the clinical usefulness of NT-proBNP in preterm infants. OBJECTIVE: To evaluate the usefulness of more...
International Classification:
Diagnostic tool (biological measure) - patent ductus arteriosus
Categories:
plasma NT-proBNP; patent ductus arteriosus
Geography:
Republic of Ireland
Arch Dis Child Fetal Neonatal Ed,
Vol: 93 Page: F257-60 July 2008
I. Farombi-Oghuvbu; T. Matthews; P. D. Mayne; H. Guerin; J. D. Corcoran
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This aim of this study was to screen renal transplant patients for the presence of parvovirus B19 before and after transplantation
Abstract:
Renal transplant patients were screened for the presence of parvovirus B19, before transplantation and monthly for 4 months after transplantation, by means of a sensitive nested PCR assay. Upon screening plasma from 110 patients, we found that two asymptomatic patients were B19 DNA positive. One of these patients was PCR positive in the plasma sample taken 2 months after more...
International Classification:
Organ transplants - renal
Categories:
renal transplant; parvovirus B19;
Geography:
Northern Ireland
Transplantation,
Vol: 69 Page: 2198-202 May 2000
Z. R. Zolnourian; M. D. Curran; B. K. Rima; P. V. Coyle; H. J. O'Neill; D. Middleton
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The aim of this study was to describe the development and validation of an assay to detect gastric pepsin in the bronchoalveolar lavage of children
Abstract:
OBJECTIVES: Gastro-oesophageal reflux (GOR)-related aspiration is associated with respiratory disease, but the current "gold standard" investigation, the lipid-laden macrophage index (LLMI), is flawed. A specific marker of GOR-related aspiration should originate in the stomach, but not the lung. An assay to detect gastric pepsin in the bronchoalveolar lavage (BAL) of children more...
International Classification:
Other - gastric pepsin
Categories:
gastric pepsin; bronchoalveolar lavage
Geography:
Northern Ireland
J Pediatr Surg,
Vol: 41 Page: 289-93 February 2006
S. Farrell; C. McMaster; D. Gibson; M. D. Shields; W. A. McCallion
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This study aimed to compare manual methodology and automated technologies; impedance, optical density and CD61 immunoplatelet method (available on the Cell Dyn 4000) with the reference method of flow cytometric analysis in a paediatric population
Abstract:
Accurate and precise platelet counting is important for the clinical management of children with platelet disorders. Current automated technologies are often unable to discriminate platelets from non-platelet particles particularly in circumstances where platelet anisocytosis is common. This study compares manual methodology and the automated technologies; impedance, optical density and more...
International Classification:
Effectiveness of measurement tool - optical density
Categories:
impedance; optical density; CD61 immunoplatelet; flow cytometric analysis
Geography:
Republic of Ireland
Clin Lab Haematol,
Vol: 27 Page: 250-7 August 2005
P. Felle; C. McMahon; S. Rooney; P. Donnelly; F. Ni Chonchubhair
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This study examined the accuracy of sonographic determination of chorionicity in twin pregnancies at 10-14 weeks of gestation
Abstract:
OBJECTIVE: To examine the accuracy of sonographic determination of chorionicity in twin pregnancies at 10-14 weeks of gestation. DESIGN: Prospective study on the sonographic prediction of chorionicity at 10-14 weeks of gestation. PARTICIPANTS: During a 30 month period, from October 1997 to May 2000, 165 women attending the departments of fetal medicine or ultrasound. METHODS: more...
International Classification:
Diagnostic tool (imaging techniques) - chorionicity in twin pregnancies
Categories:
sonographic; chorionicity in twin pregnancies
Geography:
Republic of Ireland
Bjog,
Vol: 109 Page: 182-6 February 2002
S. G. Carroll; P. W. Soothill; S. A. Abdel-Fattah; H. Porter; I. Montague; P. M. Kyle
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The aim of this study was to examine application of the novel technique of glycosylase mediated polymorphism detection to the detection of two of the most common mutations of the PAH gene in the Irish population that cause phenylketonuria, R408W and I65T,
Abstract:
Mutation detection methods based upon chemical or enzymatic cleavage of DNA offer excellent detection efficiencies coupled with high throughput and low unit cost. We describe the application of the novel technique of Glycosylase Mediated Polymorphism Detection (GMPD) to the detection of two of the most common mutations of the PAH gene in the Irish population that cause phenylketonuria more...
International Classification:
Endocrine, nutritional and metabolic diseases - Metabolic disorders - phenylketonuria
Categories:
glycosylase mediated polymorphism detection; -phenylketonuria; R408W; I65T;
Geography:
Republic of Ireland
Hum Mutat,
Vol: 17 Page: 432 May 2001
K. A. O'Donnell; O. Tighe; C. O'Neill; E. Naughten; P. D. Mayne; T. V. McCarthy; P. Vaughan; D. T. Croke
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This study examined the design and development of highly sensitive real-time reverse transcription PCR assays for the detection of norovirus genogroups I, II and IV, sapovirus genogroups I, II and IV, and human astrovirus from stool samples
Abstract:
The design and development of highly sensitive real-time reverse transcription PCR assays for the detection of norovirus genogroups I, II and IV, sapovirus genogroups I, II and IV, and human astrovirus from stool samples is described. Examination of 140 stool samples from paediatric patients exhibiting symptoms of diarrhoea and/or vomiting resulted in increased detection levels as more...
International Classification:
Diagnostic tool laboratory - norovirus
Categories:
norovirus genogroups I, II and IV; sapovirus genogroups I, II and IV,; human astrovirus;
Geography:
Republic of Ireland
J Virol Methods,
Vol: 146 Page: 36-44 December 2007
C. Logan; J. J. O'Leary; N. O'Sullivan
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The aim of this study was to examine the development of real-time PCR assays for the detection of group F adenovirus, rotavirus A, and rotavirus C from stool specimens
Abstract:
Viral pathogens are the most common cause of gastroenteritis in developed countries. Human rotavirus and adenovirus infections are major causes of acute outbreaks and sporadic cases of gastroenteritis, occurring primarily among children less than 2 years of age. Patient hospitalization is often required, with enormous infection control implications. This work describes the development more...
International Classification:
International committee on Taxonomy of Viruses - adenovirus & rotavirus
Categories:
real-time PCR assays; - group F adenovirus & rotavirus A &C
Geography:
Republic of Ireland
J Clin Microbiol,
Vol: 44 Page: 3189-95 September 2006
C. Logan; J. J. O'Leary; N. O'Sullivan
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The aim of this study was to test the hypothesize that AQP5 is reduced in hypoplastic lungs and therefore this study determined AQP5 expression in normal and hypoplastic lungs
Abstract:
PURPOSE: Pulmonary hypoplasia remains the principal cause of high morbidity and mortality in patients with congenital diaphragmatic hernia (CDH). The precise mechanisms causing lung hypoplasia remains unclear. Aquaporins (AQPs) are reported to constitute a family of water channels that facilitate membrane water permeability in various tissues of animals. Aquaporin 5 has been reported to more...
Categories:
AQP5 expression; hypoplastic lungs
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 415-9 February 2007
H. Takayasu; N. Nakazawa; S. Montedonico; P. Puri
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This study aimed to evaluate the relationship between perceptual assessment and acoustic measurements of nasality using controlled speech stimuli.
Abstract:
BACKGROUND: Nasometry has supplemented perceptual assessments of nasality, using speech stimuli, which are devoid of nasal consonants. However, such speech stimuli are not representative of conversational speech. A weak relationship has been found in previous studies between perceptual ratings of hypernasality and nasalance scores for passages containing nasal consonants. AIMS: This more...
International Classification:
Effectiveness of measurement tool - perceptual assessment, controlled speech stimuli
Categories:
perceptual assessment; acoustic measurements of nasality; controlled speech stimuli.
Geography:
Republic of Ireland
Int J Lang Commun Disord,
Vol: 43 Page: 265-82 2008 May-Jun
T. Sweeney; D. Sell
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This aim of this study was to examine at the amount of training required to accurately assess ductal patency in very low birth weight infants and to show that this service could be provided by non-cardiologists
Abstract:
The aim of our study was to look at the amount of training required to accurately assess ductal patency in very low birth weight infants and to show that this service could be provided by non-cardiologists. Training consisted of an introductory echocardiography course, a CD package, and a total of 3 hours of teaching with a paediatric cardiologist. All of this was accomplished within more...
International Classification:
Premature - infants
Categories:
ductal patency;
Geography:
Republic of Ireland
Irish Medical Journal,
Vol: 99 Page: 240-242 2006
M. Walsh; D. Coleman; J. Murphy; A. Twomey
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The aim of this study was to further understand the reported abnormalities in pyloric innervation in infantile hypertrophic pyloric stenosis, by analyzing the expression of Trk receptors and the neurotrophins content in hypertrophic pyloric stenosis
Abstract:
BACKGROUND/PURPOSE: Increasing evidence suggests that the enteric nervous system is under the control of neurotrophins. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), promote differentiation, growth, and survival of various central and peripheral nervous system neurons. The biological effects of neurotrophins more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
abnormalities in pyloric innervation; infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 1280-4 August 2001
N. Guarino; A. Yoneda; H. Shima; P. Puri
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These case reports discuss three cases of arterial anastomoses between the celiac trunk and superior mesenteric artery
Abstract:
Arterial anastomoses between the celiac trunk (CT) and superior mesenteric artery (SMA) include three variants. 1) The main anastomosis is the gastroduodenal artery (GDA), which is an important branch of the common hepatic artery and anastomoses with branches of the inferior pancreatic duodenal artery, a branch of the SMA. 2) The dorsal pancreatic artery (DPA) is usually a branch of the more...
International Classification:
Procedure - surgery, arterial anastomoses
Categories:
arterial anastomoses
Geography:
Republic of Ireland
Surg Radiol Anat,
Vol: 23 Page: 277-80 2001
J. G. McNulty; N. Hickey; F. Khosa; P. O'Brien; J. P. O'Callaghan
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The aim of this study was to determine the histochemical colocalization of cholinergic and nitrergic neurons in the porcine distal large bowel myenteric plexus from fetal to adulthood
Abstract:
PURPOSE: Cholinergic and nitrergic neurons form 2 main subpopulations of the myenteric neurons, and they have been the targets of detailed morphological investigations in bowel motility disorders. However, little is known regarding the colocalization of neurotransmitters within the same enteric neurons. The aim of this study was to determine the histochemical colocalization of more...
Categories:
histochemical colocalization of neurons; distal large bowel myenteric plexus
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 42 Page: 300-4 February 2007
T. Cserni; S. Paran; P. Puri
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The aim of this study was to examine s ocular toxocariasis and the resultant damage it causes to vision
Abstract:
Ocular toxocariasis damages vision and may cause blindness. It is a relatively 'new' disease, the histological changes having been described in 1950 and the causative organism identified in 1956. Many aspects of the epidemiology of toxocariasis are unclear. It is generally accepted that the usual route of entry to the eye is via the blood stream. Once the eye is invaded characteristic more...
International Classification:
Certain infectious and parasitic diseases - Helminthiases - ocular toxocariasis
Categories:
ocular toxocariasis
Geography:
Republic of Ireland
J Helminthol,
Vol: 75 Page: 109-18 June 2001
M. R. Taylor
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