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The aim of this study was to compare the educational and employment experiences of teenage mothers and match peers from a similar social background
Abstract:
Teenage motherhood has been linked with poor health, poor educational attainment, poor employment prospects and socio-economic deprivation. Much of the evidence has come from large surveys and the nature of these inter-relationships remains unclear. A case-control study was designed to compare the educational and employment experiences of teenage mothers with those of an age matched more...
International Classification:
Other - Teenage mothers
Categories:
educational; employment; - teenage mothers
Geography:
Republic of Ireland
Int J Adolesc Med Health,
Vol: 14 Page: 117-23 2002 Apr-Jun
T. Bradley; M. E. Cupples; H. Irvine
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The aim of this study was to accelerate the identification of susceptibility genes in diabetic nephropathy using genome-wide fluorescence-based DNA microsatellite
Abstract:
In an effort to accelerate the identification of susceptibility genes in diabetic nephropathy, the first genome-wide fluorescence-based DNA microsatellite (n=6000) association screen was performed, using pools of genomic DNA derived from Irish patients with (cases; n=200) and without (controls; n=200) type 1 diabetic nephropathy. Allele image profiles were generated for 5353 (89.2%) more...
International Classification:
Endocrine, nutritional and metabolic diseases - diabetic nephropathy
Categories:
susceptibility genes; -diabetic nephropathy
Geography:
Northern Ireland
J Am Soc Nephrol,
Vol: 17 Page: 831-6 March 2006
A. J. McKnight; A. P. Maxwell; S. Sawcer; A. Compston; E. Setakis; C. C. Patterson; H. R. Brady; D. A. Savage
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The aim of this study was to investigate the influence of analytical design on the variability of published results in studies on sudden infant death syndrome
Abstract:
AIMS: To investigate the influence of analytical design on the variability of published results in studies of sudden infant death syndrome (SIDS). METHODS: The results of a prospective case-control study, of 203 cases of SIDS, and 622 control infants are presented. All variables significant on univariate analysis were included in a multivariate model analysed in nine stages, starting more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified- Ill-defined and unknown causes of mortality - Sudden infant death syndrome
Categories:
analytical design of studies; -sudden infant death syndrome
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 89 Page: 267-71 March 2004
T. Matthews; M. McDonnell; C. McGarvey; G. Loftus; M. O'Regan
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The aim of this study was to examine new anthropomorphic parameters as indicators of Cephalopelvic disproportion
Abstract:
Cephalopelvic disproportion (CPD) is a recognised obstetric problem with potential risk to both mother and infant. Identification of those mothers at risk of CPD is difficult and has concentrated in the past on such measurements as maternal shoe size and height. Our objective in this study was to examine new anthropomorphic parameters as indicators of CPD. This was a case controlled more...
International Classification:
Pregnancy, childbirth and the puerperium - cephalopelvic disproportion
Categories:
anthropomorphic parameters; - Cephalopelvic disproportion
Geography:
Republic of Ireland
J Obstet Gynaecol,
Vol: 23 Page: 27-9 January 2003
G. Connolly; C. Naidoo; R. M. Conroy; P. Byrne; P. McKenna
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The aim of study was to examine the expression of contractile and cytoskeleton proteins in smooth muscle contractile and distribution of interstitial cells of Cajal in megacystis microcolon intestinal hypoperistalsis syndrome bowel.
Abstract:
BACKGROUND/PURPOSE: Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is characterized by decreased or absent peristalsis. Gastrointestinal motility depends on the enteric nervous system, smooth muscle cells (SMCs), and the interstitial cells of Cajal (ICCs). Contractile and cytoskeleton proteinase are important structural and functional components of SMCs. The aim of more...
International Classification:
Syndrome - megacystis microcolon intestinal hypoperistalsis
Categories:
smooth muscle contractile; -megacystis microcolon intestinal hypoperistalsis syndrome
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 749-55 May 2003
A. P. Piotrowska; U. Rolle; B. Chertin; D. De Caluwe; A. Bianchi; P. Puri
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The aim of this study was to examine gene expression in a highly purified isolate of enterocytes taken from patients with active coeliac disease
Abstract:
BACKGROUND: Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion of gluten in genetically susceptible individuals. Genes within the HLA-DQ locus are considered to contribute some 40% of the genetic influence on this disease. However, information on other disease causing genes is sparse. Since enterocytes are considered to play a central role in more...
International Classification:
Diseases of the digestive system - Other diseases of the digestive system - coeliac disease
Categories:
coeliac disease
Geography:
Republic of Ireland
BMC Genomics,
Vol: 9 Page: 377 2008
S. Bracken; G. Byrne; J. Kelly; J. Jackson; C. Feighery
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The aim of this study was to measure the effect of bed-sharing during the last sleep period on risk factors for sudden infant death syndrome
Abstract:
BACKGROUND: It is unclear if it is safe for babies to bed share with adults. In Ireland 49% of sudden infant death syndrome (SIDS) cases occur when the infant is bed-sharing with an adult. OBJECTIVE: To evaluate the effect of bed-sharing during the last sleep period on risk factors for SIDS in Irish infants. DESIGN: An 8 year (1994-2001) population based case control study of 287 SIDS more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified- Ill-defined and unknown causes of mortality - Sudden infant death syndrome
Categories:
bed-sharing; sudden infant death syndrome
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 91 Page: 318-23 April 2006
C. McGarvey; M. McDonnell; K. Hamilton; M. O'Regan; T. Matthews
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The aim of this study was to analysis the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
Abstract:
BACKGROUND: Polymorphisms in the serine protease inhibitor gene serine peptidase inhibitor Kazal type 5 (SPINK5) and the serine protease kallikrein-related peptidase 7 gene (KLK7) appear to confer risk to eczema in some cohorts, but these findings have not been widely replicated. These genes encode proteins thought to be involved in the regulation of posttranslation processing of more...
International Classification:
Diseases of the skin and subcutaneous tissue - Dermatitis and eczema - eczema
Categories:
range of polymorphisms; -eczema risk
Geography:
International
J Allergy Clin Immunol,
Vol: 122 Page: 560-8 e4 September 2008
S. Weidinger; H. Baurecht; S. Wagenpfeil; J. Henderson; N. Novak; A. Sandilands; H. Chen; E. Rodriguez; G. M. O'Regan; R. Watson; H. Liao; Y. Zhao; J. N. Barker; M. Allen; N. Reynolds; S. Meggitt; K. Northstone; G. D. Smith; C. Strobl; C. Stahl; T. Kneib; N. Klopp; T. Bieber; H. Behrendt; C. N. Palmer; H. E. Wichmann; J. Ring; T. Illig; W. H. McLean; A. D. Irvine
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The aim of this study was to examine the association between the 1298A-->C polymorphism and 677C-->T polymorphism and neural tube defect in 276 complete triades (mother, father and child affected with an NTD)
Abstract:
The thermolabile variant (677TT) of methylenetetrahydrofolate reductase (MTHFR) is a known risk factor for neural tube defects (NTDs). The relationship between a second MTHFR polymorphism (1298A-->C) and NTD risk has been inconsistent between studies. We genotyped 276 complete NTD triads (mother, father and child affected with an NTD) and 256 controls for MTHFR 1298A-->C. Our findings more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
neural tube defects - MTHFR 1298A-->C polymorphism; -
Geography:
Republic of Ireland
J Hum Genet,
Vol: 48 Page: 190-3 2003
A. Parle-McDermott; J. L. Mills; P. N. Kirke; V. B. O'Leary; D. A. Swanson; F. Pangilinan; M. Conley; A. M. Molloy; C. Cox; J. M. Scott; L. C. Brody
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The aim of this study was to examine the association between proline oxidase and schizophrenia
International Classification:
Mental and behavioural disorders - Schizophrenia, schizotypal and delusional disorders - schizophrenia
Categories:
proline oxidase; -schizophrenia
Geography:
Republic of Ireland and the United Kingdom
Mol Psychiatry,
Vol: 8 Page: 644-5 July 2003
H. J. Williams; N. Williams; G. Spurlock; N. Norton; D. Ivanov; R. G. McCreadie; A. Preece; V. Sharkey; S. Jones; S. Zammit; I. Nikolov; I. Kehaiov; A. Thapar; K. C. Murphy; G. Kirov; M. J. Owen; M. C. O'Donovan
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The aim of this study was to examine the association between the allele 2 of the interleukin 1 receptor antagonist gene
Abstract:
BACKGROUND AND AIMS: An association between the allele 2 of the interleukin 1 receptor antagonist gene variable number tandem repeats polymorphism in intron 2 and ulcerative colitis was first reported in 1994. Subsequent studies in Caucasian Northern European patients have not confirmed this, although trends towards an association were observed. The lack of statistical significance more...
International Classification:
Diseases of the digestive system - Noninfective enteritis and colitis - ulcerative colitis
Categories:
allele 2 of the interleukin 1 receptor antagonist gene variable; -ulcerative colitis
Geography:
International
Gut,
Vol: 48 Page: 461-7 April 2001
M. J. Carter; F. S. di Giovine; S. Jones; J. Mee; N. J. Camp; A. J. Lobo; G. W. Duff
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The aim of this study was to investigate genotype frequencies for polymorphisms of the TGF-beta1 gene at position -509, codon 10 and 25, and examine circulating levels of TGF-beta1 in patients with reflux nephropathy
Abstract:
PURPOSE: Reflux nephropathy (RN) is recognized as a major cause of end stage renal failure in children and young adults. Transforming growth factor-beta1 (TGF-beta1) is a potent proinflammatory and fibrogenetic cytokine known to have a key role in the regulation of renal tissue fibrosis. We investigate genotype frequencies for polymorphisms of the TGF-beta1 gene at position -509, codon more...
International Classification:
Diseases of the genitourinary system - reflux nephropathy
Categories:
genotype frequencies for polymorphisms of the TGF-beta1 gene; - reflux nephropathy
Geography:
Republic of Ireland
J Urol,
Vol: 174 Page: 1609-11; discussion 1611 October 2005
V. Solari; D. Owen; P. Puri
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The aim of this study was to investigate atopy and home environment (such as children living at home, sharing a bedroom and house moves) as potential risk factors for type 1 diabetes
Abstract:
BACKGROUND: The marked increases in the incidence of type 1 diabetes in recent decades strongly suggest the role of environmental influences. These environmental influences remain largely unknown. OBJECTIVE: To investigate atopy and home environment (such as children living at home, sharing a bedroom and house moves) as potential risk factors for type 1 diabetes. SUBJECTS AND METHOD: In more...
International Classification:
Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus
Categories:
home environment; atopy -type 1 diabetes
Geography:
Northern Ireland
Pediatr Diabetes,
Vol: 9 Page: 191-6 June 2008
C. R. Cardwell; D. J. Carson; J. Yarnell; M. D. Shields; C. C. Patterson
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The aim of the study was to examine attachment styles and psychological profiles of child sex offenders in Ireland
Abstract:
When 29 child sex offenders, 30 violent offenders, 30 nonviolent offenders, and 30 community controls were compared, a secure adult attachment style was 4 times less common in the child sex offender group than in any of the other three groups. Ninety-three percent of sex offenders had an insecure adult attachment style. Compared with community controls, the child sex offender group more...
International Classification:
Sexual abuse - child sex offenders profiles
Categories:
attachment styles; psychological profiles
Geography:
Republic of Ireland
J Interpers Violence,
Vol: 19 Page: 228-51 February 2004
F. Marsa; G. O'Reilly; A. Carr; P. Murphy; M. O'Sullivan; A. Cotter; D. Hevey
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The aim of this study was to examine an algorithm which automatically determines the transitions between stance and swing phase of gait using kinematic data recorded by a motion capture system, which is routinely used in gait analysis laboratories.
Abstract:
The timing of heel strike (HS) and toe off (TO), the events that mark the transitions between stance and swing phase of gait, is essential when analysing gait. Force plate recordings are routinely used to identify these events. Additional instrumentation, such as force sensitive resistors, can also been used. These approaches, however, include restrictions on the number of steps that more...
International Classification:
Gait
Categories:
gait
Geography:
Republic of Ireland
Gait Posture,
Vol: 25 Page: 469-74 March 2007
C. M. O'Connor; S. K. Thorpe; M. J. O'Malley; C. L. Vaughan
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The aim of the study was to examine the bacterial colonization of the prepuce in boys with vesicoureteral reflux who receive antibiotic prophylaxis
Abstract:
Culture swabs were taken from the periurethral area of 59 consecutive uncircumcised boys with vesicoureteral reflux (VUR) and 36 boys undergoing circumcision. A pure growth of a uropathogen was isolated in 22 (37%) boys with VUR who were receiving antibiotic prophylaxis and in 10 (28%) boys who underwent circumcision. Antibiotic prophylaxis in patients with VUR was not effective in more...
International Classification:
Diseases of the genitourinary system - Renal tubulo-interstitial diseases - vesicoureteric reflux
Categories:
bacterial colonization of the prepuce
Geography:
Republic of Ireland
J Pediatr,
Vol: 139 Page: 160-2 July 2001
S. Cascio; E. Colhoun; P. Puri
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The aim of this study was to examined the barriers to prenatal care uptake among pregnant women
Abstract:
BACKGROUND: In Europe, it is sometimes assumed that few barriers to prenatal care exist because extensive programs of health insurance and initiatives to promote participation in prenatal care have been established for many decades. METHODS: A case-control study was performed in ten European countries (Austria, Denmark, Germany, Greece, Hungary, Ireland, Italy, Portugal, Spain, and more...
International Classification:
Other - barriers to prenatal care
Categories:
barriers to prenatal care
Geography:
International
Am J Prev Med,
Vol: 21 Page: 52-9 July 2001
T. Delvaux; P. Buekens; I. Godin; M. Boutsen
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The aim of this study was to examine the balance of MMP-8, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 in the airways of children with asthma
Abstract:
BACKGROUND: Childhood asthma is characterized by inflammation of the airways. Structural changes of the airway wall may also be seen in some children early in the course of the disease. Matrix metalloproteinases (MMPs) are key mediators in the metabolism of the extracellular matrix (ECM). OBJECTIVE: To investigate the balance of MMP-8, MMP-9 and tissue inhibitor of metalloproteinases more...
International Classification:
Diseases of the respiratory system - Chronic lower respiratory diseases - asthma
Categories:
asthma
Geography:
Northern Ireland
Clin Exp Allergy,
Vol: 35 Page: 1168-74 September 2005
G. M. Doherty; S. V. Kamath; F. de Courcey; S. N. Christie; A. Chisakuta; J. D. Lyons; L. G. Heaney; M. Ennis; M. D. Shields
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The aim of this study was to determine concentrations of antimony in infants dying from sudden infant death syndrome and infants dying from other causes
Abstract:
OBJECTIVES: Raised concentrations of antimony have been found in infants dying of sudden infant death syndrome (SIDS). The presumed source of this antimony is toxic gases generated from fire retardants that are present in cot mattresses. The aim of this study was to determine the role of antimony in SIDS. DESIGN: Samples of liver, brain, serum, and urine were collected from all patients more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified- Ill-defined and unknown causes of mortality - Sudden infant death syndrome
Categories:
concentrations of antimony; -sudden infant death syndrome
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 82 Page: 244-7 March 2000
A. Cullen; B. Kiberd; D. Devaney; J. Gillan; P. Kelehan; T. G. Matthews; P. Mayne; N. Murphy; M. O'Regan; W. Shannon; L. Thornton
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The aim of this study was to quantify the occurrence of congenital anomalies in proximity to municipal landfill sites, was examined by small area, distance and clustering tendencies in relation to 83 landfills, five of which were major sites
Abstract:
The occurrence of congenital anomalies in proximity to municipal landfill sites in the Eastern Region (counties Dublin, Kildare, Wicklow) was examined by small area (district electoral division), distance and clustering tendancies in relation to 83 landfills, five of which were major sites. The study included 2136 cases of congenital anomaly, 37,487 births and 1423 controls between 1986 more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital anomalie
Categories:
landfill sites; -congenital anomalie
Geography:
Republic of Ireland
Ir Med J,
Vol: 97 Page: 16-8 January 2004
E. Boyle; H. Johnson; A. Kelly; R. McDonnell
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The aim of this study was to examine a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population
Abstract:
Genetic and environmental factors contribute to the etiology of neural tube defects (NTDs). While periconceptional folic acid supplementation is known to significantly reduce the risk of NTDs, folate metabolic pathway related factors do not account for all NTDs. Evidence from mouse models indicates that the tumor protein p53 (TP53) is involved in implantation and normal neural tube more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
genetic variation in TP53; -neural tube defect
Geography:
Republic of Ireland
Am J Med Genet A,
Vol: 146A Page: 2617-25 October 2008
F. Pangilinan; K. Geiler; J. Dolle; J. Troendle; D. A. Swanson; A. M. Molloy; M. Sutton; M. Conley; P. N. Kirke; J. M. Scott; J. L. Mills; L. C. Brody
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The aim of this study was to determine if day-care attendance was a risk factor for meningococcal disease
Abstract:
The Republic of Ireland has the highest incidence of meningococcal disease in Europe with 40% of all cases occurring in children under the age of 5 years. Attending day-care increases the risk of certain infections, including Haemophilus influenzae type b (Hib) meningitis. The risk of meningococcal disease associated with day-care is not known. We conducted a case-control study among more...
International Classification:
Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease
Categories:
day-care attendance; - meningococcal disease
Geography:
Republic of Ireland
Epidemiol Infect,
Vol: 127 Page: 435-41 December 2001
T. Grein; D. O'Flanagan
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The aim of this study was to examine caries experience and initial access to dental services in a group of children with cleft lip/palate in the west of Ireland
Abstract:
AIM: To investigate caries experience and initial access to dental services in a group of children with cleft lip/palate in the west of Ireland. DESIGN AND METHOD: Cross sectional study with prospective data capture and matched control. Details of children born with a cleft were obtained from all health professionals likely to be involved in delivering care to these children. Existing more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Cleft lip and/or palate
Categories:
caries; dental services; cleft lip/palate
Geography:
Republic of Ireland
Int Dent J,
Vol: 51 Page: 73-6 April 2001
A. R. Hewson; C. M. McNamara; T. F. Foley; J. R. Sandy
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The aim of this study was to examine the relationship between tobacco smoking during pregnancy and neonatal Polycythaemia, and to assess the dose-response relationship
Abstract:
The objective of this observational study was to determine the relationship between tobacco smoking during pregnancy and neonatal Polycythaemia, and to assess the dose-response relationship. Thirty two pregnant women who smoked tobacco (cases), and ninety pregnant women who did not smoke (controls), were randomly selected from the annual obstetrics population in the Erinville hospital more...
International Classification:
Certain conditions originating in the perinatal period - neonatal polycythaemia
Categories:
maternal smoking; -neonatal Polycythaemia
Geography:
Republic of Ireland
Ir Med J,
Vol: 93 Page: 175-6 September 2000
E. al-Alawi; D. Jenkins
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The aim of this study was to determine the effect of further vaginal delivery on anal sphincter function in women after apparently uncomplicated primiparous forceps delivery
Abstract:
PURPOSE: The study was designed to determine the effect of further vaginal delivery on anal sphincter function in women after apparently uncomplicated primiparous forceps delivery. METHODS: Fifty-two secundigravid women whose first child was forceps-assisted were compared with a control group of 20 women who had undergone spontaneous first vaginal delivery. Both groups were studied more...
International Classification:
Pregnancy, childbirth and the puerperium - anal sphincter function
Categories:
uncomplicated primiparous forceps delivery; -vaginal delivery; anal sphincter function
Geography:
Republic of Ireland
Dis Colon Rectum,
Vol: 51 Page: 1361-6 September 2008
R. Mahony; M. Behan; P. R. O'Connell; C. O'Herlihy
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The aim of this study was to examine whether low parental social class increases children's risk of subsequently developing Schizophrenia or modifies the presentation
Abstract:
OBJECTIVES: To examine if low parental social class increases children's risk of subsequently developing schizophrenia or modifies the presentation. DESIGN: Case-control study with historical controls. SETTING: Geographically defined region in south Dublin. Participants: 352 patients with first presentation of schizophrenia matched with the next registered same sex birth from the same more...
International Classification:
Mental and behavioural disorders - Schizophrenia, schizotypal and delusional disorders - schizophrenia
Categories:
low parental social class; -Schizophrenia
Geography:
Republic of Ireland
Bmj,
Vol: 323 Page: 1398-401 December 2001
F. Mulvany; E. O'Callaghan; N. Takei; M. Byrne; P. Fearon; C. Larkin
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The aim of this study was to define the expression of epidermal growth factor and monocyte chemotactic peptide-1 in severe reflux nephropathy in order to further understand the pathogenesis of reflux nephropathy
Abstract:
OBJECTIVES: Reflux nephropathy (RN) is recognised as a major cause of end stage renal failure in children and young adults. The histological findings of RN are tubular atrophy and interstitial monocyte infiltration. Epidermal growth factor (EGF) produced by tubular cells playing a pivotal role in the modulation of tubular cell growth, while monocyte chemotactic peptide-1 (MCP-1) is a more...
International Classification:
Diseases of the genitourinary system - reflux nephropathy
Categories:
epidermal growth factor; monocyte chemotactic peptide-1; - reflux nephropathy
Geography:
Republic of Ireland
Eur Urol,
Vol: 44 Page: 144-9 July 2003
B. Chertin; A. Farkas; P. Puri
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The aim of this study was to investigate whether six common polymorphisms in the TCII gene influence neural tube defect risk
Abstract:
BACKGROUND: Decreased maternal folate levels are associated with having a child with a neural tube defect (NTD), and periconceptual folic acid supplementation reduces this risk by >50%. Vitamin B(12) (as methylcobalamin) is a cofactor for methionine synthase, an enzyme that plays a key role in folate metabolism. Alterations in vitamin B(12) metabolism may influence the development of more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
six common polymorphisms; -neural tube defect
Geography:
Republic of Ireland
Birth Defects Res A Clin Mol Teratol,
Vol: 73 Page: 239-44 April 2005
D. A. Swanson; F. Pangilinan; J. L. Mills; P. N. Kirke; M. Conley; A. Weiler; T. Frey; A. Parle-McDermott; V. B. O'Leary; R. R. Seltzer; K. A. Moynihan; A. M. Molloy; H. Burke; J. M. Scott; L. C. Brody
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The aim of the study was to study appendix specimens for the expression of inflammatory markers as an indicator of presence of an inflammatory response in this subgroup of patients
Abstract:
BACKGROUND: Appendices removed from patients with suspected appendicitis often appear normal on histologic examination. OBJECTIVE: To study appendix specimens for the expression of inflammatory markers as an indicator of presence of an inflammatory response in this subgroup of patients. METHODS: Cyclooxygenase 1 and 2, prostaglandin E(2), inducible nitric oxide synthase, and major more...
International Classification:
Diseases of the digestive system - Diseases of appendix - appendix
Categories:
appendix
Geography:
Republic of Ireland
Arch Pathol Lab Med,
Vol: 125 Page: 759-64 June 2001
L. Nemeth; D. J. Reen; D. S. O'Briain; M. McDermott; P. Puri
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The aim of this study was to examine the expression of HO-1 and endothelial nitric oxide synthase (eNOS) in the congenital diaphragmatic hernia lung
Abstract:
BACKGROUND/PURPOSE: Heme oxygenase (HO-1), an inducible isoform of HO is a regulator of vascular tone and cell proliferation through the production of endogenous carbon monoxide (CO). Endothelium-derived nitric oxide (NO) occurs in the endothelial layers of blood vessels and mediates vasorelaxation. Both CO and NO have similar properties and are potent vasodilators. The aim of this more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital diaphragmatic hernia
Categories:
endothelial nitric oxide synthase; -congenital diaphragmatic hernia lung
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 38 Page: 808-13 May 2003
V. Solari; A. P. Piotrowska; P. Puri
[Preview]
[Read]
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The aim of this study was to identify risk factors for sudden infant death syndrome in the sleeping environment of Irish infants
Abstract:
AIM: To identify risk factors for sudden infant death syndrome (SIDS) in the sleeping environment of Irish infants. METHODS: A five year population based case-control study with parental interviews conducted for each case and three controls matched for age, place of birth, and last sleep period. A total of 203 SIDS cases and 622 control infants born 1994-98 were studied. RESULTS: In a more...
International Classification:
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified- Ill-defined and unknown causes of mortality - Sudden infant death syndrome
Categories:
sleeping environment; -sudden infant death syndrome
Geography:
Republic of Ireland
Arch Dis Child,
Vol: 88 Page: 1058-64 December 2003
C. McGarvey; M. McDonnell; A. Chong; M. O'Regan; T. Matthews
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This study aimed to evaluate the occurrence of focally enhance & other gastric histological abnormalities in children with inflammatory bowel disease and examine the utility of focally enhanced gastritis in determining ulcerative colitis orCrohn's disease
Abstract:
OBJECTIVES: Focally enhanced gastritis (FEG) has been suggested as a specific diagnostic marker for patients with Crohn's disease. However, the utility of FEG for distinguishing Crohn's disease from ulcerative colitis is uncertain in adults, and the occurrence of this lesion in children has not been defined. The aim of this study was to evaluate the occurrence of FEG and other gastric more...
International Classification:
Diseases of the digestive system - Noninfective enteritis and colitis - ulcerative colitis & Crohn's disease
Categories:
focally enhanced gastritis; ulcerative colitis; -ulcerative colitis & Crohn's disease
Geography:
Republic of Ireland
Am J Gastroenterol,
Vol: 97 Page: 1415-20 June 2002
F. Sharif; M. McDermott; M. Dillon; B. Drumm; M. Rowland; C. Imrie; S. Kelleher; S. Harty; B. Bourke
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The aim of this study was to whether genetic risk for psychosis related to differences in foetal brain development as measured by prenatal ultrasonography
Abstract:
Cerebral ventricular enlargement and reduced cortical volume are correlates of chronic schizophrenia. We investigated whether genetic risk for psychosis related to differences in foetal brain development as measured by prenatal ultrasonography. Routine foetal cerebral measures at 19-23 weeks of gestation were compared between the offspring of 35 women with a history of psychosis and 105 more...
International Classification:
Mental and behavioural disorders - psychosis
Categories:
foetal brain development; -psychosis
Geography:
the United Kingdom
Br J Psychiatry,
Vol: 190 Page: 445-6 May 2007
M. C. Clarke; M. Cannon; M. W. Hogg; M. N. Marks; S. Conroy; S. J. Pawlby; A. Greenough; K. Nicolaides
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The aim of this study was to investigate the ACE I/D genotype, the M235 T polymorphism of the angiotensinogen gene and the A1166 C polymorphism of AT1R in the lungs of congenital diaphragmatic hernia complicated by persistent pulmonary hypertension
Abstract:
BACKGROUND/PURPOSE: The renin-angiotensin system plays an important role in pulmonary artery remodelling. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the angiotensin converting enzyme (ACE), the angiotensinogen (AGT) gene, and the angiotensin II type 1 receptor (ATIR) have been associated with the development of pulmonary hypertension. more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital diaphragmatic hernia
Categories:
angiotensinogen; -congenital diaphragmatic hernia complicated by persistent pulmonary hypertension
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 39 Page: 302-6; discussion 302-6 March 2004
V. Solari; P. Puri
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The aim of this study was to investigate a large cohort of children with juvenile dermatomyositis, and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization.
Abstract:
OBJECTIVES: To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization. METHODS: Children (114) with JDM were recruited, and clinical data collected, through the JDM National Registry and Repository (UK and Ireland). Sera were more...
International Classification:
Diseases of the musculoskeletal system and connective tissue - Systemic connective tissue disorders - dermatomyositis
Categories:
HLA class II genotyping; juvenile dermatomyositis
Geography:
Republic of Ireland and the United Kingdom
Rheumatology (Oxford),
Vol: 46 Page: 1786-91 December 2007
L. R. Wedderburn; N. J. McHugh; H. Chinoy; R. G. Cooper; F. Salway; W. E. Ollier; L. J. McCann; H. Varsani; J. Dunphy; J. North; J. E. Davidson
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This aim of this study was to determine whether the 25-kDa protein is produced by Helicobacter pylori in infected hosts
Abstract:
The gastroduodenal pathogen Helicobacter pylori has been shown to inhibit the interaction between the extracellular matrix protein laminin and its receptor on gastric epithelial cells, potentially contributing to a loss of mucosal integrity. As a 25-kDa outer membrane protein of H. pylori in association with the bacterial lipopolysaccharides (LPS) mediates attachment to laminin, the aim more...
International Classification:
Bacterium - Helicobacter pylori
Categories:
Helicobacter pylori; 25-kDa protein;
Geography:
Republic of Ireland
FEMS Immunol Med Microbiol,
Vol: 43 Page: 331-7 March 2005
A. P. Moran; S. A. Broaders; A. Rapa; G. Oderda
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The aim of this study was to investigate bone marrow trephine biopsies from children with acute lymphoblastic leukaemia at diagnosis and following treatment.
Abstract:
The importance of angiogenesis for the growth and viability of solid tumours has been established. Similarly, prognostic information may be gained from the extent of angiogenesis in these tumours. Haematopoietic malignancies should have equal requirements for angiogenesis and important prognostic information may be derived from quantification of bone marrow angiogenic activity. We more...
International Classification:
Neoplasms - lymphoblastic leukemia
Categories:
bone marrow trephine biopsies; - acute lymphoblastic leukaemia
Geography:
Republic of Ireland
Br J Haematol,
Vol: 118 Page: 991-8 September 2002
M. A. Pule; C. Gullmann; D. Dennis; C. McMahon; M. Jeffers; O. P. Smith
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The aim of this study was to examine the distribution of mast cells in kidneys with reflux nephropathy and to determine the relationship between mast cells and the interstitial fibrotic process in reflux nephropathy
Abstract:
End-stage renal disease is characterized by interstitial infiltrate of inflammatory cells in association with tubular atrophy and interstitial fibrosis. Mast cells (MCs) secrete a large number of fibrogenic factors and have been implicated in chronic inflammatory processes with fibrous tissue deposition. The aim of this study was to investigate the distribution of MCs in kidneys with more...
International Classification:
Diseases of the genitourinary system - reflux nephropathy
Categories:
kidney mast cells; - reflux nephropathy
Geography:
Republic of Ireland
Pediatr Nephrol,
Vol: 19 Page: 157-63 February 2004
V. Solari; K. Unemoto; A. Piaseczna Piotrowska; P. Puri
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This study aimed to evaluate the efficacy of 'Switch Off-Get Active', a 16-week controlled health education intervention, in increasing physical activity and reducing screen time and BMI in primary school children
Abstract:
Low levels of physical activity coupled with high levels of television viewing have been linked with obesity in children. The objective of this study was to assess the efficacy of 'Switch Off-Get Active', a 16-week controlled health education intervention, in increasing physical activity and reducing screen time and BMI in primary school children. A secondary objective was to compare more...
International Classification:
Other - 'Switch Off-Get Active
Categories:
'Switch Off-Get Active
Geography:
Republic of Ireland
J Sci Med Sport,
Vol: 9 Page: 388-94 October 2006
M. Harrison; C. F. Burns; M. McGuinness; J. Heslin; N. M. Murphy
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The aim of this study was to examine the relationships between maternal and cord leptin concentrations, maternal and neonatal outcomes, and measures of glycemic control in diabetic and nondiabetic pregnancy
Abstract:
OBJECTIVE: The purpose of this study was to examine the relationships between maternal and cord leptin concentrations, maternal and neonatal outcomes, and measures of glycemic control in diabetic and nondiabetic pregnancy. STUDY DESIGN: This was a prospective study of 60 type 1 diabetic and 50 nondiabetic pregnancies in a university teaching hospital. Serum leptin and hemoglobin A(1c) more...
International Classification:
Other - maternal and cord leptin concentrations
Categories:
maternal and cord leptin concentrations
Geography:
Northern Ireland
Am J Obstet Gynecol,
Vol: 188 Page: 1326-32 May 2003
J. G. Manderson; C. C. Patterson; D. R. Hadden; A. I. Traub; H. Leslie; D. R. McCance
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This aim of this study was to examine maternal folate status and neural tube defects in Ireland and the need for a national food fortification program
Abstract:
To determine the present risk of a Neural Tube Defect [NTD] pregnancy in the caucasian primigravid population in Dublin by comparing the serum folate and red cell folate status of primigravid patients attending the first prenatal booking clinic with data from the late 80's. This Cross-sectional population study looking at blood folate status of over 400 sequential primigravid caucasian more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
maternal folate status; neural tube defects; national food fortification program
Geography:
Republic of Ireland
Ir Med J,
Vol: 100 Page: 469-72 May 2007
T. Walsh; S. O'Broin; S. Cooley; J. Donnelly; C. Collins; H. McMillan; R. F. Harrison; C. McMahon; M. Geary
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The aim of this study was to examine the prevalence of variant genotypes in mothers who had given birth to a child with Down syndrome and in control mothers, and investigated the biochemical factors influenced by the presence of MTRR A66G and MTHFR C677T
Abstract:
Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome. We examined the prevalence of these variant genotypes in mothers who had given birth to a child with Down syndrome (n = 48) and in control mothers (n = 192), and investigated the more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Chromosomal abnormalities, not elsewhere classified - Down Syndrome
Categories:
variant genotypes; -Down syndrome
Geography:
Republic of Ireland
Am J Med Genet,
Vol: 107 Page: 151-5 January 2002
V. B. O'Leary; A. Parle-McDermott; A. M. Molloy; P. N. Kirke; Z. Johnson; M. Conley; J. M. Scott; J. L. Mills
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The aim of this study was to evaluate alterations in perinatal neutrophil phenotype following systemic hypoxia-ischemia compared with normal controls
Abstract:
Systemic hypoxia-ischemia at birth may alter the neonatal neutrophil phenotype. In this study, we evaluated alterations in perinatal neutrophil phenotype following systemic hypoxia-ischemia compared with normal controls. Neutrophils from adults (n = 15), normal newborns (n = 20), newborns requiring resuscitation at birth (n = 17), and their respective maternal samples were incubated more...
International Classification:
Immunology - neutrophil responses
Categories:
neutrophil; -hypoxia-ischemia orencephalopathy
Geography:
Republic of Ireland
Am J Perinatol,
Vol: 24 Page: 525-30 October 2007
E. J. Molloy; A. J. O'Neill; J. J. Grantham-Sloan; M. Sheridan-Pereira; J. M. Fitzpatrick; D. W. Webb; R. W. Watson
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The aim of the study was to compare neurologic and developmental disability at six years of age in infants born extremely preterm
Abstract:
BACKGROUND: Birth before 26 weeks of gestation is associated with a high prevalence of neurologic and developmental disabilities in the infant during the first two years of life. METHODS: We studied at the time of early school age children who had been born at 25 or fewer completed weeks of gestation in the United Kingdom and Ireland in 1995. Each child had been evaluated at 30 months more...
International Classification:
Premature - infants
Categories:
neurologic and developmental disability
Geography:
Republic of Ireland and the United Kingdom
N Engl J Med,
Vol: 352 Page: 9-19 January 2005
N. Marlow; D. Wolke; M. A. Bracewell; M. Samara
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The aim of this study was to examine the extent of consultant-diagnosed toxocaral eye disease among a population of schoolchildren
Abstract:
Ocular toxocariasis in humans is typically a unilateral disease caused by second-stage larvae of the Toxocara species. Serological evidence of widespread infection in humans provides little information on clinical disease. There is only a single previous estimate of the prevalence of ocular toxocariasis (from Alabama). The present survey examined the extent of consultant-diagnosed more...
International Classification:
Certain infectious and parasitic diseases - Helminthiases - toxocaral eye disease
Categories:
consultant-diagnosed toxocaral eye disease
Geography:
Republic of Ireland
Clin Infect Dis,
Vol: 39 Page: 173-8 July 2004
B. Good; C. V. Holland; M. R. Taylor; J. Larragy; P. Moriarty; M. O'Regan
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The aim of this study was to determine the opinion of parents regarding the psychosocial functioning of their child with cleft lip and/or palate and to identify predictors of psychosocial functioning
Abstract:
OBJECTIVES: (1) to determine the opinion of parents regarding the psychosocial functioning of their child with cleft lip and/or palate (CLP); (2) to identify predictors of psychosocial functioning; and (3) to determine the level of agreement between children with CLP and their parents. Participants: One hundred twenty-nine parents of children with CLP and 96 parents of children without more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Cleft lip and/or palate
Categories:
cleft lip and/or palate; psychosocial functioning
Geography:
Northern Ireland
Cleft Palate Craniofac J,
Vol: 44 Page: 304-11 May 2007
O. Hunt; D. Burden; P. Hepper; M. Stevenson; C. Johnston
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The aim of this study was to examine perinatal risk factors for childhood Type 1 diabetes
Abstract:
AIMS: To investigate perinatal risk factors for childhood Type 1 diabetes in a UK population cohort. METHODS: Perinatal data have been routinely recorded in Northern Ireland for all births in the period 1971-86 (n = 447 663). Diabetes status at the age of 15 years was ascertained in this cohort by identifying 991 children from 1079 registered with Type 1 diabetes diagnosed from 1971 to more...
International Classification:
Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus
Categories:
type 1 diabetes
Geography:
the United Kingdom
Diabet Med,
Vol: 22 Page: 200-6 February 2005
C. R. Cardwell; D. J. Carson; C. C. Patterson
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The aim of this study was to explore the impact on mortality and morbidity of parenteral penicillin given to children before admission to hospital with suspected meningococcal disease
Abstract:
OBJECTIVE: To explore the impact on mortality and morbidity of parenteral penicillin given to children before admission to hospital with suspected meningococcal disease. DESIGN: Retrospective comparison of fatal and non-fatal cases. SETTING: England, Wales, and Northern Ireland; December 1997 to February 1999. PARTICIPANTS: 158 children aged 0-16 years (26 died, 132 survived) in whom a more...
International Classification:
Other - parenteral penicillin
Categories:
parenteral penicillin; -mortality; morbidity;
Geography:
the United Kingdom
Bmj,
Vol: 332 Page: 1295-8 June 2006
A. Harnden; N. Ninis; M. Thompson; R. Perera; M. Levin; D. Mant; R. Mayon-White
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The aim of this study was to examine polymorphisms within the vitamin B12 dependent methylmalonyl-coA mutase are not risk factors for neural tube defects
Abstract:
Methionine synthase and methylmalonyl-CoA mutase (mutase) are the only two known vitamin B(12) (B(12)) dependent enzymes in humans. A lower level of B(12) has been shown to be an independent maternal risk factor for neural tube defects (NTDs) prompting an investigation of common genetic variants within B(12) dependent enzymes. To investigate the role of methylmalonyl-CoA mutase variants more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction
Categories:
vitamin B12 dependent methylmalonyl-coA mutase; -neural tube defects
Geography:
Republic of Ireland
Mol Genet Metab,
Vol: 80 Page: 463-8 December 2003
A. Parle-McDermott; E. J. McManus; J. L. Mills; V. B. O'Leary; F. Pangilinan; C. Cox; A. Weiler; A. M. Molloy; M. Conley; D. Watson; J. M. Scott; L. C. Brody; P. N. Kirke
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The aim of this study was to investigate the presence of persistent measles virus in the intestinal tissue of patients with new variant inflammatory bowel disease and controls
Abstract:
AIMS: A new form of inflammatory bowel disease (ileocolonic lymphonodular hyperplasia) has been described in a cohort of children with developmental disorder. This study investigates the presence of persistent measles virus in the intestinal tissue of these patients (new variant inflammatory bowel disease) and a series of controls by molecular analysis. METHODS: Formalin fixed, paraffin more...
International Classification:
Inflammatory bowel disease - Non specific
Categories:
measles virus; - inflammatory bowel disease
Geography:
Republic of Ireland
Mol Pathol,
Vol: 55 Page: 84-90 April 2002
V. Uhlmann; C. M. Martin; O. Sheils; L. Pilkington; I. Silva; A. Killalea; S. B. Murch; J. Walker-Smith; M. Thomson; A. J. Wakefield; J. J. O'Leary
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The aim of this study was to examine health outcomes in women infected with Hep C type 1b during pregnancy with a matched control group
Abstract:
A large cohort of rhesus-negative women in Ireland were inadvertently infected with hepatitis C virus following exposure to contaminated anti-D immunoglobulin in 1977-8. This major iatrogenic episode was discovered in 1994. We studied 36 women who had been infected after their first pregnancy, and compared them to an age- and parity-matched control group of rhesus-positive women. The more...
International Classification:
Certain infectious and parasitic diseases - Viral hepatitis - hepatitis C
Categories:
hepatitis C type 1b; health outcomes
Geography:
Republic of Ireland
Qjm,
Vol: 93 Page: 597-601 September 2000
T. Jabeen; B. Cannon; J. Hogan; M. Crowley; C. Devereux; L. Fanning; E. Kenny-Walsh; F. Shanahan; M. J. Whelton
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