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Irish Child Health Database - Peer Reviewed Papers

Database Search

genetic polymorphism

Your search returns 3 documents

• 1.   Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD

  The aim of this study was to describe paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain derived neurotrophic factor gene with susceptibility to attention-deficit hyperactivity disorder

  

  Abstract:

  Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable, neurodevelopmental disorder with onset in early childhood. Genes involved in neuronal development and growth are, thus, important etiological candidates and brain-derived neurotrophic factor (BDNF), has been hypothesized to play a role in the pathogenesis of ADHD. BDNF is a member of the neurotrophin family more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  Republic of Ireland and the United Kingdom

  Molecular Psychiatry, Vol: 10 Page: 939-943 2005
  L. Kent; E. Green; Z. Hawi; A. Kirley; F. Dudbridge; N. Lowe; R. Raybould; K. Langley; N. Bray; M. Fitzgerald; M. J. Owen; M. C. O'Donovan; M. Gill; A. Thapar; N. Craddock

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• 2.   Genomic polymorphic profiles in an Irish population with meningococcaemia: Is it possible to predict severity and outcome of disease?

  The aim of this study was to investigated whether polymorphisms in genes encoding these cytokines, and in those encoding anti-inflammatory IL-10 and IL-1Ra, are associated with the outcome in patients with meningococcal disease

  

  Abstract:

  Patients with meningococcal disease have increased plasma levels of proinflammatory cytokines IL-6, IL-1(beta), and TNF-(alpha), with higher levels associated with fatal outcome. This study investigated whether polymorphisms in genes encoding these cytokines, and in those encoding anti-inflammatory IL-10 and IL-1Ra, are associated with the outcome in patients with meningococcal disease. more...

  International Classification:

  Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease

  Categories:

  cytokines; -meningococcal disease

  Geography:

  Republic of Ireland

  Genes and Immunity, Vol: 4 Page: 533-540 2003
  J. Balding; C. M. Healy; W. J. Livingstone; B. White; L. Mynett-Johnson; M. Cafferkey; O. P. Smith

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• 3.   Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder

  The aim of this study was to examine intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is predicted by either dopamine receptor/transporter genes or other previously identified risk alleles

  

  Abstract:

  A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention-deficit hyperactivity disorder

  Categories:

  attention-deficit hyperactivity disorder

  Geography:

  International

  American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol: 147 Page: 316-319 2008
  E. J. S. Sonuga-Barke; K. J. Brookes; J. Buitelaar; R. Anney; P. Bitsakou; D. Baeyens; C. Buschgens; W. Chen; H. Christiansen; J. Eisenberg; J. Kuntsi; I. Manor; A. Melia; A. Mulligan; N. Rommelse; U. C. Muller; H. Uebel; T. Banaschewski; R. Ebstein; B. Franke; M. Gill; A. Miranda; R. D. Oades; H. Roeyers; A. Rothenberger; J. Sergeant; H. C. Steinhausen; M. Thompson; E. Taylor; P. Asherson; S. V. Faraone

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