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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » F » Factor VIII/ biosynthesis/genetics/ therapeutic use

Factor VIII/ biosynthesis/genetics/ therapeutic use

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1. Low risk of inhibitor formation in haemophilia patients after a change in treatment from Chinese hamster ovary cell-produced to baby hamster kidney cell-produced recombinant factor VIII

This study examined the low risk of inhibitor formation in haemophilia patients after a change in treatment from Chinese hamster ovary cell-produced to baby hamster kidney cell-produced recombinant factor VIII

Abstract:

This retrospective survey of haemophilia A patients from multiple treatment centres in Ireland assessed the development of inhibitors following a switch in the prescribed treatment from recombinant factor VIII (rFVIII) produced by Chinese hamster ovary (CHO) cells (rFVIII-CHO) to rFVIII produced by baby hamster kidney (BHK) cells (rFVIII-BHK). Ninety-four patients participated in the more...

International Classification:

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - Coagulation defects, purpura and other haemorrhagic conditions - haemophilia

Categories:

inhibitor formation in haemophilia patients

Geography:

Republic of Ireland

Thromb Haemost, Vol: 98 Page: 1188-92 December 2007
E. Singleton; J. Smith; M. Kavanagh; B. Nolan; B. White

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