Irish Child Health Database - Peer Reviewed Papers
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Biopsy
Your search returns 15 documents
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The aim of this study was to document prospectively the proportion of children with oral lesions at diagnosis of Crohn's disease
Abstract:
BACKGROUND & AIMS: Recent studies suggest that the mouth may be involved frequently in patients with Crohn's disease (CD). The aim of this study was to document prospectively the proportion of children with oral lesions at diagnosis of CD, to describe the type of lesions found, and to examine the ability of gastroenterologists to identify correctly oral Crohn's manifestations. METHODS: more...
International Classification:
Diseases of the digestive system - Noninfective enteritis and colitis - Crohn's disease
Crohn's disease
Categories:
oral lesions; Crohn's disease
Geography:
Republic of Ireland
Clin Gastroenterol Hepatol,
Vol: 3 Page: 886-91 September 2005
S. Harty; P. Fleming; M. Rowland; E. Crushell; M. McDermott; B. Drumm; B. Bourke
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The aim of this study was to investigate vascular abnormalities in large bowel biopsies from patients with isolated Hirschsprung's disease
Abstract:
Intestinal neuronal dysplasia (IND) is an intestinal motility disorder, which clinically resembles Hirschsprung's disease (HD). Adventitial fibromuscular dysplasia (AFMD) consists of proliferation of smooth muscle cells and collagen fibers in the adventitia of blood vessels. The purpose of this study was to investigate vascular abnormalities in large bowel biopsies from patients with more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
large bowel vascular abnormalities; - Hirschsprung's disease; Intestinal neuronal dysplasia
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 19 Page: 345-8 July 2003
U. Rolle; A. P. Piotrowska; P. Puri
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The aim of this study was to examine the distribution of c-Kit-positive interstitial cells of Cajal and their relationship to the autonomic intrinsic innervation in bowel specimens from patients with isolated hypoganglionosis
Abstract:
BACKGROUND/PURPOSE: C-Kit-positive interstitial cells of Cajal (ICCs) have a key role in the normal motility function and development of the bowel. They are pacemaker cells, which facilitate active propagation of electrical events and neurotransmission in the bowel wall. ICCs are present in the bowel as myenteric ICCs (ICC(my)S) and muscular ICCs (ICC(mus)S). The aim of this study was more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung's disease
Categories:
isolated hypoganglionosis
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 37 Page: 709-14 May 2002
U. Rolle; A. Yoneda; V. Solari; L. Nemeth; P. Puri
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The aim of this study was to provide insight into some of the less commonly observed abnormalities in neuroblastoma, by performing comparative genomic hybridization analysis on 24 primary and metastatic neuroblastomas
Abstract:
Neuroblastoma, the most common extracranial solid tumor of childhood, is associated with a number of genetic abnormalities that are prognostically significant. The most common abnormalities are associated with aggressive clinical behavior and include deletion of distal chromosome 1p, NMYC amplification, and unbalanced gain of the long arm of chromosome 17. There are also other more...
International Classification:
Neoplasms - Malignant neoplasms - neuroblastoma
Categories:
neuroblastoma
Geography:
Republic of Ireland
Cancer Genet Cytogenet,
Vol: 120 Page: 44-9 July 2000
C. J. Breen; A. O'Meara; M. McDermott; M. Mullarkey; R. L. Stallings
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The aim of this study was to analyse the expression of P2Y1 and P2Y2 receptors in the intestine of patients with Hirschsprung's disease
Abstract:
Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the intestine. ATP has long been established as an inhibitory more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
expression of P2Y1 and P2Y2 receptors; -Hirschsprung's disease
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 24 Page: 77-80 January 2008
O' Donnell AM ; P. Puri
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The aim of this study was detect measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder
International Classification:
Certain infectious and parasitic diseases - Viral infections characterized by skin and mucous membrane lesions - measles
Categories:
measles virus; ileo-colonic lymphoid nodular hyperplasia
Geography:
Republic of Ireland
Mol Psychiatry,
Vol: 7 Suppl 2 Page: S47-8 2002
C. M. Martin; V. Uhlmann; A. Killalea; O. Sheils; J. J. O'Leary
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This study examined the sensitivity for duodenal villous atrophy in a large series of patients undergoing GI endoscopy specifically for duodenal biopsy
Abstract:
OBJECTIVE: Endoscopic markers of duodenal villous atrophy (VA) can facilitate diagnosis of celiac disease during routine upper GI endoscopy. We studied their sensitivity for VA in a large series of patients undergoing GI endoscopy specifically for duodenal biopsy. Poor sensitivity in this setting would have significant and adverse implications for their performance during routine more...
International Classification:
Diagnostic tool (endoscopy) - duodenal biopsy
Categories:
duodenal villous atrophy; duodenal biopsy
Geography:
Northern Ireland
Am J Gastroenterol,
Vol: 96 Page: 2126-8 July 2001
W. Dickey; D. Hughes
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This study investigated immunohistochemical localization of epidermal growth factors-related peptides and its mRNA expression in pyloric smooth muscle cells to determine involvment with pyloric muscle hypertrophy in infantile hypertrophic pyloric stenosis
Abstract:
Infantile hypertrophic pyloric stenosis (IHPS) is characterized by hypertrophy of the pyloric muscle. The growth of smooth muscle cells is regulated by several growth factors. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor are potent mitogens for smooth muscle cells. In the present study, we investigated immunohistochemical localization of EGF and EGF-related more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis
Categories:
epidermal growth factors; -infantile hypertrophic pyloric stenosis
Geography:
Republic of Ireland
Pediatr Res,
Vol: 47 Page: 201-7 February 2000
H. Shima; K. Ohshiro; P. Puri
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This study examined outcomes after internal sphincter myectomy in patients with Internal Anal Sphincter Achalasia
Abstract:
BACKGROUND: Internal anal sphincter achalasia (IASA), also referred to as ultrashort segment Hirschsprung's disease (HD), is a clinical condition with presentation similar to HD, but with the presence of ganglion cells on rectal biopsy. The diagnosis of IASA is made on anorectal manometry, which shows the absence of rectosphincteric reflex on rectal balloon inflation. Altered more...
International Classification:
Diseases of the digestive system - Anal Sphincter Achalasia
Categories:
Internal Anal Sphincter Achalasia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 736-8 May 2001
D. De Caluwe; A. Yoneda; U. Akl; P. Puri
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This study reviewed the authors experience of intestinal neuronal dysplasia over an 8 year period
Abstract:
PURPOSE: Intestinal neuronal dysplasia (IND) is a disease of the enteric nervous system, which clinically resembles Hirschsprung's disease. The authors reviewed their experience of IND over an 8-year period. METHODS: Between 1992 and 1999, 418 patients underwent rectal suction biopsy for persistent constipation. Thirty-three (7.8%) patients had histologic evidence of IND. There were 26 more...
International Classification:
Other - lintestinal neuronal dysplasia
Categories:
intestinal neuronal dysplasia
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 36 Page: 777-9 May 2001
J. Gillick; H. Tazawa; P. Puri
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This case report discusses an 8-year-old girl, diagnosed with Familial cold auto-inflammatory syndrome
Abstract:
Familial cold auto-inflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurologic, cutaneous, articular syndrome are related disorders associated with mutations in the CIAS1 gene. They appear to represent a continuum of one disease characterized by IL-1-mediated inflammation. Until recently, these conditions have been difficult to treat; however, with the advent of more...
International Classification:
Syndrome
Categories:
cold auto-inflammatory syndrome
Geography:
Republic of Ireland
Pediatr Dermatol,
Vol: 24 Page: 85-9 2007 Jan-Feb
S. M. O'Connell; G. M. O'Regan; T. Bolger; H. M. Hoffman; A. Cant; A. D. Irvine; R. M. Watson
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This study examined robotically assisted minimally invasive surgery
Abstract:
Introduction: Reports of robotically assisted minimal access surgery (RMAS) in the adult patient population have increased over the last several years. Few reports have addressed RMAS in pediatric patients. We present our initial RMAS experience with the da Vinci(registered trademark) Surgical System (Intuitive Surgical, Sunnyvale, California), and discuss technical considerations, more...
International Classification:
Procedure - invasive surgery
Categories:
assisted minimally invasive surgery
Geography:
United States of America
Pediatric Endosurgery and Innovative Techniques,
Vol: 7 Page: 385-402 2003
B. N. Luebbe; R. Woo; S. A. Wolf; M. S. Irish
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The aim of this study was to define the nature and diagnostic importance of hypertrophic nerves in Hirschsprung disease and to clarify their relation to nearby smaller nerve fibres
Abstract:
OBJECTIVE: Hypertrophic nerves have long been considered a histopathologic feature of the aganglionic segment in Hirschsprung disease, but they remain incompletely explained. The purpose of this study was to define the nature and diagnostic importance of hypertrophic nerves in Hirschsprung disease and to clarify their relation to nearby smaller nerve fibers. METHODS: We used an more...
International Classification:
Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease
Categories:
hypertrophic nerves; - Hirschsprung disease
Geography:
Republic of Ireland
Arch Pathol Lab Med,
Vol: 124 Page: 1314-9 September 2000
Y. Kakita; K. Oshiro; D. S. O'Briain; P. Puri
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The aim of this study was to examine epidemiological, clinical & laboratory characteristics of juvenile dermatomyositis in a national multi-centre cohort, to review recent changes in the understanding of management and prognosis in the light of these data
Abstract:
OBJECTIVES: To identify epidemiological, clinical and laboratory characteristics of juvenile dermatomyositis (JDM) in a national multi-centre cohort of patients, and to review recent changes in the understanding of management and prognosis in the light of these data. METHODS: All children with idiopathic inflammatory myositis recruited to the Juvenile Dermatomyositis National Registry more...
International Classification:
Diseases of the musculoskeletal system and connective tissue - Systemic connective tissue disorders - dermatomyositis
Categories:
juvenile dermatomyositis
Geography:
Republic of Ireland and the United Kingdom
Rheumatology (Oxford),
Vol: 45 Page: 1255-60 October 2006
L. J. McCann; A. D. Juggins; S. M. Maillard; L. R. Wedderburn; J. E. Davidson; K. J. Murray; C. A. Pilkington
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This study examined oral cavity in Crohn's disease
Abstract:
We assessed the utility of expert oral examination as a part of the diagnostic evaluation of patients with suspected Crohn's disease. Of 45 patients with newly diagnosed CD, 25 had been examined by a dentist. Twelve (48%) of these had oral CD lesions. Mucosal tags constituted the most frequent form of oral lesion (8/12). Of 8 oral biopsy specimens, 6 (75%) contained non-caseating more...
International Classification:
Diseases of the digestive system - Noninfective enteritis and colitis - Crohn's disease
Categories:
Crohn's disease
Geography:
Republic of Ireland
J Pediatr,
Vol: 138 Page: 767-71 May 2001
S. Pittock; B. Drumm; P. Fleming; M. McDermott; C. Imrie; S. Flint; B. Bourke
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