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Irish Child Health Database - Peer Reviewed Papers

Database Search

• Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis

  Published in:

  J Neuroimmunol, Vol: 102, Page: 172-81

  Publication Date:

  January 2000

  Aims & Objectives:

  The aim of this study was to describe Bordetella pertussis respiratory infection, its expression of mRNA transcripts for IL-1beta and TNFalpha and transient expression of IL-6 in the hippocampus and hypothalamus

  Abstract:

  Parenteral injection of endotoxin has been used as a model to examine the role of pro-inflammatory cytokines in the centrally controlled responses to Gram-negative bacterial infection. However, the events that occur following mucosal exposure to live bacteria have received little attention. In this study, we have used a murine model to demonstrate that respiratory infection with Bordetella pertussis, which is associated with a number of systemic complications including fever, seizure and encephalopathy in children, resulted in persistent expression of mRNA transcripts for IL-1beta and TNFalpha and transient expression of IL-6 in the hippocampus and hypothalamus. These changes correlated with elevated levels of cytokine protein in the same brain areas. The results demonstrate that infection at a mucosal surface can result in the induction of pro-inflammatory cytokine production in the brain and suggest that these locally synthesized mediators may contribute to the centrally controlled clinical manifestations of B. pertussis infection.

  Authors:

  C. E. Loscher; S. Donnelly; M. A. Lynch; K. H. Mills

  Study Type:

  Study Papers » Animal Study » Papers reporting secondary research

  Categories:

  Bordetella pertussis respiratory infection; hippocampus and hypothalamus

  Keywords:

  • Animals
  • Bordetella pertussis/isolation & purification
  • Brain/ metabolism
  • Cytokines/blood/genetics/ metabolism
  • Female
  • Inflammation Mediators/blood/ metabolism
  • Lung/metabolism/microbiology
  • Mice
  • Mice, Inbred BALB C
  • Respiratory Tract Infections/ metabolism/microbiology
  • RNA, Messenger/metabolism
  • Tissue Distribution
  • Whooping Cough/ metabolism/microbiology

  
  

  Geography:

  Republic of Ireland (Republic of Ireland)