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Irish Child Health Database - Peer Reviewed Papers

Database Search

• Presence of multiple copies of the capsulation b locus in invasive Haemophilus influenzae type b (Hib) strains isolated from children with Hib conjugate vaccine failure

  Published in:

  Journal of Infectious Diseases, Vol: 192, Page: 819-823

  Publication Date:

  2005

  Aims & Objectives:

  The aim of this study was to verify whether amplification of invasive Haemophilus influenzae type b strains is involved in vaccine failure

  Abstract:

  Most invasive Haemophilus influenzae type b strains possess a duplication of the capsulation locus. Further amplification resulting in as many as 5 copies has been described. To verify whether amplification is involved in vaccine failure, the number of copies of the locus was determined by Southern blotting in 90 strains from children with true vaccine failure (TVF) between 1993 and 1999 and in 139 strains from unvaccinated children (50 collected between 1993 and 1999 and 89 collected between 1991 and 1992, before routine immunization was introduced). A significantly greater proportion of strains from TVFs contained multiple copies, compared with strains from control children (24% vs. 10%; P = .0379), which suggests that amplification of the capb locus may be a contributory factor in vaccine failure. The presence of multiple-copy strains was associated with disease other than meningitis. Copyright © 2005 Infectious Diseases Society of America

  Authors:

  M. Cerquetti; R. Cardines; Ml; M. Giufré; A. Bella; T. Sofia; P. Mastrantonio; M. Slack

  Study Type:

  Study Papers » Case Control Study » Analytical Studies

  Notes:

  Accession Number: 2009130773. Language: English. Entry Date: 20060331. Publication Type: journal article; research; tables/charts. Journal Subset: Biomedical; Editorial Board Reviewed; Peer Reviewed; USA. Special Interest: Pediatric Care; Public Health. Grant Information: Italian Ministry of Health Research Project (grant 3AIF). No. of Refs: 15 ref. NLM UID: 0413675. Email: mcerquet@iss.it. 0022-1899 PMID: 16088831

  Categories:

  haemophilus influenzae type b strains; - vaccine failure

  International Classification:

  Vaccination

  Keywords:

  • Blood-Brain Barrier
  • Chi Square Test
  • Child, Preschool
  • Confidence Intervals
  • Data Analysis Software
  • Disease Surveillance
  • Fisher''s Exact Test
  • Funding Source
  • Genotype
  • Haemophilus Infections -- Physiopathology
  • Haemophilus Infections -- Prevention and Control
  • HIB Vaccine
  • HIB Vaccine -- Administration and Dosage
  • HIB Vaccine -- Analysis
  • Infant
  • Ireland
  • Mann-Whitney U Test
  • Meningitis -- Microbiology
  • Meningitis -- Physiopathology
  • Odds Ratio
  • Polymerase Chain Reaction
  • United Kingdom
  • Vaccine Failure -- In Infancy and Childhood

  
  

  Geography:

  Republic of Ireland and the United Kingdom (UK and Republic of Ireland)