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Irish Child Health Database - Peer Reviewed Papers

Database Search

• Pregnancy and perinatal outcomes after assisted reproduction: a comparative study

  Published in:

  Ir J Med Sci, Vol: 177, Page: 233-41

  Publication Date:

  September 2008

  Aims & Objectives:

  The aim of this study was to quantify the risk of adverse perinatal outcomes birth defects and pregnancy complications following assisted reproductive technology

  Abstract:

  BACKGROUND: Increasing use of fertility therapy has elicited concerns regarding adverse effects for expectant mothers and the health of children thus conceived. AIMS: To study the risk of adverse perinatal outcomes, birth defects and pregnancy complications following assisted reproductive technology (ART). METHODS: Questionnaire-based study involving 1,524 children and 1,182 pregnancies conceived following in vitro fertilisation (IVF) in two units. Outcomes were compared with the general population. RESULTS: In the study group versus the general population; multi-foetal gestations, 26 versus 2%; singleton preterm delivery and low birth weight, 8.7 and 6.4 versus 4.3 and 4%, respectively; non-lethal congenital malformation rate, 2.6 versus 2.1%; placenta praevia, 2.8 versus 0.5%. CONCLUSIONS: Multi-foetal gestations remain the principal cause of adverse perinatal outcomes after ART. Singleton ART pregnancies have an increased risk of preterm delivery and low birth weight at term. Non-lethal congenital malformation rates are not increased following ART. Placenta praevia is increased following ART.

  Authors:

  C. Allen; S. Bowdin; R. F. Harrison; A. G. Sutcliffe; L. Brueton; G. Kirby; J. Kirkman-Brown; C. Barrett; W. Reardon; E. Maher

  Study Type:

  Study Papers » Comparison Study » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures

  Categories:

  assisted reproductive technology

  International Classification:

  Pregnancy, childbirth and the puerperium

  Keywords:

  • Adult
  • Chi-Square Distribution
  • Congenital Abnormalities/epidemiology/etiology
  • Female
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Ireland/epidemiology
  • Placenta Previa/epidemiology/etiology
  • Pregnancy
  • Pregnancy Complications/ epidemiology/ etiology
  • Pregnancy Outcome
  • Pregnancy, Multiple
  • Premature Birth/epidemiology/etiology
  • Questionnaires
  • Reproductive Techniques, Assisted/ adverse effects
  • Risk Factors

  
  

  Geography:

  International (Dublin/Birmingham)