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• Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations

  Published in:

  Blood, Vol: 105, Page: 1408-16

  Publication Date:

  February 2005

  Aims & Objectives:

  The aim of the study was to compare graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations

  Abstract:

  The association of ethnicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar.

  Authors:

  H. Oh; Jr. F. R. Loberiza; M. J. Zhang; O. Ringden; H. Akiyama; T. Asai; S. Miyawaki; S. Okamoto; M. M. Horowitz; J. H. Antin; A. Bashey; J. M. Bird; M. H. Carabasi; J. W. Fay; R. P. Gale; R. H. Giller; J. M. Goldman; G. A. Hale; R. E. Harris; J. Henslee-Downey; H. J. Kolb; M. R. Litzow; P. L. McCarthy; S. M. Neudorf; D. S. Serna; G. Socie; P. Tiberghien; A. J. Barrett

  Study Type:

  Study Papers » Comparison Study » Descriptive Studies - With a comparative dimension: time, geography, treatment, procedures

  Categories:

  bone marrow transplantation

  International Classification:

  Organ transplants

  Keywords:

  • Adult
  • Age Factors
  • Alleles
  • Bone Marrow Transplantation/ ethnology/immunology/ mortality
  • Child
  • Child, Preschool
  • Disease-Free Survival
  • Female
  • Gene Frequency
  • Graft vs Host Disease/ ethnology/genetics/immunology/ mortality
  • Histocompatibility Testing
  • HLA Antigens/ analysis/genetics
  • Humans
  • Infant
  • Infant, Newborn
  • Leukemia/etiology/mortality
  • Male
  • Recurrence
  • Siblings
  • Treatment Outcome

  
  

  Geography:

  International (Japanese, white American, Africian American, Scandinavians Irish,)