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Irish Child Health Database - Peer Reviewed Papers

Database Search

• The clinical outcome of non-RhD antibody affected pregnancies in Northern Ireland

  Published in:

  Ulster Med J, Vol: 70, Page: 89-94

  Publication Date:

  November 2001

  Aims & Objectives:

  This study examined the clinical outcome of pregnancies with non-Rh-D antibody using retrospective case note review.

  Abstract:

  We assessed the clinical outcome of pregnancies with non-Rh-D antibody in Northern Ireland using retrospective case note review. During the study period (April 1999- March 2000) 186 women with clinically significant antibodies were identified from the records of the antenatal laboratory of the Northern Ireland Blood Transfusion Service. Eighty-five women were included in the study using the criteria mentioned above. None of the fetuses required intrauterine transfusion during this period. One baby required exchange transfusion, three were given top-up transfusions and 17 had phototherapy. Nine babies with a positive direct antiglobulin test (DAT) received no treatment. The incidence of anti-Kell could be reduced by transfusing Kell negative red cells to premenopausal women. It is important that all pregnant women are tested at least twice in their pregnancy to detect the antibodies formed late in the pregnancy. It is useful to formulate a standard protocol for antenatal interventions. Non Rh-D antibodies can cause significant anaemia for up to six weeks in the neonatal period, hence early detection of maternal antibodies is important so that the neonates are followed up for an appropriate length of time.

  Authors:

  A. Chandrasekar; K. G. Morris; T. R. Tubman; S. Tharma; W. M. McClelland

  Study Type:

  Study Papers » Case Series Study » Descriptive Studies - Without a comparision

  Categories:

  pregnancies with non-Rh-D antibody

  International Classification:

  Pregnancy, childbirth and the puerperium - pregnancies with non-Rh-D antibody

  Keywords:

  • Blood Group Incompatibility/ epidemiology/immunology
  • Erythroblastosis, Fetal/ epidemiology/prevention & control
  • Female
  • Humans
  • Infant, Newborn
  • Isoantibodies/blood/ immunology
  • Kell Blood-Group System/immunology
  • Northern Ireland/epidemiology
  • Pregnancy Outcome
  • Pregnancy/blood/ immunology
  • Registries
  • Retrospective Studies
  • Rh Isoimmunization/ epidemiology

  
  

  Geography:

  Northern Ireland (Northern Ireland)