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Irish Child Health Database - Peer Reviewed Papers

Database Search

• HLA Cw*06 is not essential for streptococcal-induced psoriasis

  Published in:

  Br J Dermatol, Vol: 154, Page: 850-3

  Publication Date:

  May 2006

  Aims & Objectives:

  The aim of this study was to study Irish patients with psoriasis to investigate the relationship between streptococcal infections and Cw*06.

  Abstract:

  BACKGROUND: Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form. OBJECTIVES: To study 105 Irish patients with psoriasis to investigate the relationship between streptococcal infections and Cw*06. METHODS: The patients were divided into two groups: those with guttate psoriasis or guttate flare (guttate group, GG, n=64) and those with chronic plaque psoriasis (chronic plaque group, CPG, n=41). RESULTS: The incidence of Cw*06 was 86% in the GG and 73% in the CPG, which was not significantly different (P=0.1725) but the incidence in both groups was significantly higher than in an Irish control group (18%) (P<0.0001 vs. GG and P<0.0001 vs. CPG). Evidence for streptococcal infection was higher in the GG (56%) than in the CPG (32%) (P=0.0231). Of those patients with evidence of streptococcal infection, 30 of 36 GG (83%) and nine of 13 CPG (69%) patients possessed the Cw*06 genotype. CONCLUSIONS: Thus, not all patients with streptococcal-related psoriasis carry Cw*06. The role of Cw*06 in psoriasis, if any, has yet to be determined.

  Authors:

  L. Fry; A. V. Powles; S. Corcoran; S. Rogers; J. Ward; D. J. Unsworth

  Study Type:

  Study Papers » Case Control Study » Analytical Studies

  Categories:

  streptococcal infections; Cw*06; -psoriasis

  International Classification:

  Diseases of the skin and subcutaneous tissue - Papulosquamous disorders - psoriasis

  Keywords:

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Chronic Disease
  • Female
  • Genetic Predisposition to Disease
  • HLA-C Antigens/ genetics
  • Humans
  • Male
  • Pharyngitis/complications/microbiology
  • Polymerase Chain Reaction/methods
  • Psoriasis/ genetics/ microbiology
  • Recurrence
  • Streptococcal Infections/ complications

  
  

  Geography:

  Republic of Ireland (Ireland)