Irish Child Health Database - Peer Reviewed Papers
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Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease
Published in:
Arch Dis Child Fetal Neonatal Ed, Vol: 84, Page: F168-71
Publication Date:
May 2001
Aims & Objectives:
This study aimed to assess whether increased collagenolysis precedes severe chronic lung disease
Abstract:
OBJECTIVE: To assess whether increased collagenolysis precedes severe chronic lung disease (CLD). METHODS: Matrix metalloproteinase-1 (MMP-1) and MMP-8 (enzymes that degrade type I collagen, the main structural protein of lung extracellular matrix) were measured by enzyme linked immunosorbent assay in 100 bronchoalveolar lavage samples taken during the first 6 postnatal days from 45 ventilated preterm babies < 33 weeks gestation. The median value for each baby was calculated. CLD was defined as an oxygen requirement after the 36th week after conception. RESULTS: MMP-8 levels in bronchoalveolar lavage fluid were higher (median 13 ng/ml) in 20 babies who developed CLD than in 25 without CLD (median 2 ng/ml). No MMP-1 was detected in any sample. CONCLUSIONS: MMP-8 can be detected in bronchoalveolar lavage fluid from preterm babies, and higher levels are found in those who later develop CLD. MMP-8 may contribute to lung injury that occurs as a prelude to CLD.
Authors:
Study Type:
Study Papers » Study assessing the practice and/or knowledge of targeted professional or parent » Descriptive Studies - Measuring aspects of effectiveness
Categories:
severe chronic lung disease
International Classification:
Practice/knowledge - severe chronic lung disease
Keywords:
- Blood Gas Analysis
- Bronchoalveolar Lavage Fluid/ chemistry
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Infant, Newborn
- Infant, Premature/ physiology
- Logistic Models
- Lung Diseases, Obstructive/ etiology
- Male
- Matrix Metalloproteinase 1/ analysis
- Matrix Metalloproteinase 8/ analysis
- Normal Distribution
- Prospective Studies
- Risk Factors
- Statistics, Nonparametric
Geography:
Republic of Ireland and the United Kingdom (UK and Republic of Ireland)