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Severe osteopenia with recurrent fractures after bone marrow transplant for Wiskott-Aldrich syndrome: a case report
Published in:
J Pediatr Orthop, Vol: 20, Page: 402-4
Publication Date:
2000 May-Jun
Aims & Objectives:
This case report discusses the case of a boy who developed osteopenia and sustained multiple long-bone fractures over a 5-year period after bone marrow transplant for Wiskott-Aldrich syndrome
Abstract:
Wiskott-Aldrich syndrome (WAS) is a rare inherited disorder characterised by thrombocytopenia, eczema, and immunodeficiency. Bone marrow transplantation (BMT) is a well-established modality of treatment now routinely used and often curative. We report the case of a boy who developed osteopenia and sustained multiple long-bone fractures over a 5-year period after bone marrow transplant for WAS. The femora and tibiae of both lower limbs were involved with a clinical presentation similar to osteogenesis imperfecta. After commencing calcitriol treatment at the age of 8 years, the patient has not sustained any further fractures. He is now 11 years old. Although short-term changes in bone metabolism after BMT have been documented, the occurrence of repeated fractures associated with osteopenia has not been previously reported.
Authors:
Study Type:
Study Papers » Case Report Study » Descriptive Studies - Without a comparision
Categories:
osteopenia and sustained multiple long-bone fractures
International Classification:
Diseases of the musculoskeletal system and connective tissue - Report
Keywords:
- Bone Diseases, Metabolic/drug therapy/ etiology
- Bone Marrow Transplantation
- Calcitriol/therapeutic use
- Calcium Channel Agonists/therapeutic use
- Humans
- Infant, Newborn
- Male
- Postoperative Complications
- Wiskott-Aldrich Syndrome/ surgery
Geography:
Republic of Ireland (Dublin)