Irish Child Health Database - Peer Reviewed Papers
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Increased bone marrow angiogenesis in children with severe chronic neutropenia treated with granulocyte colony-stimulating factor
Published in:
J Pediatr Hematol Oncol, Vol: 26, Page: 504-6
Publication Date:
August 2004
Aims & Objectives:
The aim of this study was to evaluate the effects of granulocyte colony-stimulating factor on angiogenesis in children with severe chronic neutropenia
Abstract:
Severe chronic neutropenia (SCN) is a heterogeneous group of conditions characterized by chronically low neutrophil counts and recurrent infections. Granulocyte colony-stimulating factor (G-CSF) is the mainstay of treatment, and evidence exists that G-CSF may promote angiogenesis. To evaluate the effects of G-CSF on angiogenesis in children with SCN, the authors assessed microvessel density in bone marrow biopsies from nine children with SCN before starting G-CSF treatment and while receiving G-CSF. In all patients, microvessel density was greater in the on-treatment biopsy. Increased angiogenesis may result from a direct effect of G-CSF on endothelial cells or may be an indirect effect from increased neutrophils.
Authors:
Study Type:
Study Papers » Case Control Study » Analytical Studies
Categories:
granulocyte colony-stimulating factor; angiogenesis; -severe chronic neutropenia
International Classification:
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism - neutropenia
Keywords:
- Bone Marrow/ blood supply/pathology
- Child
- Chronic Disease
- Granulocyte Colony-Stimulating Factor/ adverse effects
- Humans
- Neovascularization, Pathologic/ etiology
- Neutropenia/ therapy
Geography:
Republic of Ireland (Ireland)