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Irish Child Health Database - Peer Reviewed Papers

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• Giant inflammatory polyposis coli as a manifestation of Crohn's disease in patients with coexistent cystic fibrosis

  Published in:

  Pediatr Dev Pathol, Vol: 9, Page: 25-30

  Publication Date:

  2006 Jan-Feb

  Aims & Objectives:

  These case reports discuss the occurrence of giant inflammatory polyposis in 2 boys attending a tertiary care hospital, with an established diagnosis of cystic fibrosis who subsequently developed Crohn's disease

  Abstract:

  Crohn's disease (CD) arising in children with cystic fibrosis (CF) is well recognized. Indeed, reports suggest that CD is significantly more common in patients with CF than in the general population. Giant inflammatory polyposis is a rare manifestation of idiopathic inflammatory bowel disease and may complicate both ulcerative colitis and CD. Giant inflammatory polyposis has not been specifically reported in patients with coexistent CF and CD. Herein, we report the occurrence of giant inflammatory polyposis in 2 boys attending a tertiary care hospital, with an established diagnosis of CF who subsequently developed CD. Both boys required surgical treatment for CD. In addition to classical features of CD, both colonic resection specimens showed giant inflammatory polyposis. The appearances were modified by the presence of a layer of thick mucus. It is suggested that the coexistence of CF in patients with CD may predispose to the development of giant inflammatory polyposis. In addition to contributing to their development, it also appears that there is a propensity for CF to alter the morphological appearance of giant inflammatory polyposis. This may lead to diagnostic confusion when examining endoscopic biopsies.

  Authors:

  N. Banville; A. Broderick; R. Fitzgerald; B. Drumm; M. McDermott

  Study Type:

  Study Papers » Case Report Study » Descriptive Studies - Without a comparision

  Categories:

  cystic fibrosis

  International Classification:

  Endocrine, nutritional and metabolic diseases-Report

  Keywords:

  • Child
  • Colonic Polyps/complications/pathology
  • Colonoscopy
  • Crohn Disease/ etiology/pathology
  • Cystic Fibrosis/ complications
  • Humans
  • Infant
  • Intestinal Polyposis/ complications/pathology
  • Male
  • Mucins/metabolism

  
  

  Geography:

  Republic of Ireland (Dublin)