Irish Child Health Database - Peer Reviewed Papers
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Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection
Published in:
J Med Virol, Vol: 78, Page: 125-8
Publication Date:
January 2006
Aims & Objectives:
This case report discusses the establishment of functional B cell memory against parvovirus B19 capsid proteins which may be associated with resolution of persistent infection
Abstract:
Parvovirus B19 (B19) infection can occur during acute lymphoblastic leukemia and persistent viral infection can occur despite intravenous immunoglobulin administration. Here, evidence is presented that resolution of persistent B19 infection in an acute lymphoblastic leukemia patient may be associated with the simultaneous strengthening of antigen-specific B cell memory against the B19 capsid protein VP2 and diminution in the memory response against the B19 non-structural protein 1 (NS1). Determination of antigen-specific B cell memory status may enhance the serological and molecular analyses of persistent B19 infection.
Authors:
Study Type:
Study Papers » Case Report Study » Descriptive Studies - Without a comparision
Categories:
functional B cell memory; parvovirus B19
International Classification:
Other - parvovirus B19
Keywords:
- B-Lymphocytes/ immunology
- Capsid Proteins/ immunology
- Child, Preschool
- Female
- Humans
- Immunologic Memory
- Leukemia, Lymphoid/ complications
- Parvoviridae Infections/complications/ immunology
- Parvovirus B19, Human/ immunology
- Viral Nonstructural Proteins/immunology
Geography:
Republic of Ireland (Maynooth, Dublin)