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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Child, Preschool

Your search returns 731 documents

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• 1.   Human nucleus pulposis can respond to a pro-inflammatory stimulus

  The aim of this study was to describe if the human intervertebral disc is capable of responding to a pro-inflammatory stimulus

  

  Abstract:

  STUDY DESIGN: Disc tissue obtained from patients undergoing surgery for scoliosis, lumbar radiculopathy, and discogenic pain was cultured under basal and lipopolysaccharide-stimulated conditions and the medium analyzed for production of a range of pro-inflammatory mediators. OBJECTIVES: This study was conducted to confirm that the human intervertebral disc is capable of responding to a more...

  International Classification:

  Other - intervertebral disc

  Categories:

  intervertebral disc

  Geography:

  Republic of Ireland

  Spine, Vol: 28 Page: 2685-93 December 2003
  J. G. Burke; G. Watson RW ; D. Conhyea; D. McCormack; F. E. Dowling; M. G. Walsh; J. M. Fitzpatrick

  [Preview] [Read]

• 2.   Hydroxyapatite orbital implant exposure in children

  This study examined problems encountered using hydroxyapatite orbital implants during a 14-year period in a pediatric population

  

  Abstract:

  PURPOSE: Hydroxyapatite orbital implants are buried implants that may be integrated into the overlying prosthesis after enucleation. We report problems encountered using these implants during a 14-year period in a pediatric population. METHODS: Retrospective analysis of a pediatric population from 1987 through 2001. RESULTS: Indications for enucleation (N = 19) included retinoblastoma more...

  International Classification:

  Procedure - hydroxyapatite orbital implants

  Categories:

  hydroxyapatite orbital implants

  Geography:

  Republic of Ireland

  J Aapos, Vol: 7 Page: 345-8 October 2003
  L. M. Nolan; M. O'Keefe; B. Lanigan

  [Preview] [Read]

• 3.   Hypopharyngeal and distal esophageal pH monitoring in children with gastroesophageal reflux and respiratory symptoms

  The aim of this study was to determine if hypopharyngeal pH monitoring using pH 4 and pH 5 as reflux thresholds could predict children with reflux-related respiratory disease

  

  Abstract:

  PURPOSE: Fundoplication is frequently required for gastroesophageal reflux (GER)-related respiratory disease. Correlation between esophageal pH data and respiratory symptoms is poor but may be improved by monitoring hypopharyngeal pH. Reflux to the hypopharynx is underestimated by salivary bicarbonate. The aim of this study was to determine if hypopharyngeal pH monitoring using pH 4 and more...

  International Classification:

  Diseases of the respiratory system - respiratory disease

  Categories:

  hypopharyngeal pH monitoring; - reflux-related respiratory disease

  Geography:

  International

  J Pediatr Surg, Vol: 40 Page: 1557-61 October 2005
  R. N. Ramaiah; M. Stevenson; W. A. McCallion

  [Preview] [Read]

• 4.   ICAM-1 expression is upregulated in reflux nephropathy

  The aim of this study was to test the hypothesize that ICAM-1 local synthesis is altered in reflux nephropathy and therefore designated this study to investigate ICAM-1 expression in reflux nephropathy

  

  Abstract:

  Reflux nephropathy (RN) is a major cause of end-stage renal failure in children and young adults. Intercellular adhesion molecule-1 (ICAM-1), a cell surface glycoprotein, has a role in the regulation of interaction among immune cells. It has been demonstrated that increased levels of tubular ICAM-1 correlate with an extent of tubular damage in diabetic nephropathy. We hypothesized that more...

  International Classification:

  Diseases of the genitourinary system - reflux nephropathy

  Categories:

  ICAM-1 local synthesis; - reflux nephropathy

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 19 Page: 391-4 July 2003
  K. Unemoto; B. Chertin; H. Shima; X. Bi; M. Sakai; P. Puri

  [Preview] [Read]

• 5.   Idiopathic interstitial pneumonitis in children: a national survey in the United Kingdom and Ireland

  The aim of this study was to examine idiopathic interstitial pneumonitis in children

  

  Abstract:

  Interstitial lung disease (ILD) of unknown etiology in immunocompetent patients is rare in children. A national survey was carried out in the United Kingdom and Ireland over a 3-year period in order to identify prevalence, age distribution, histopathology, natural history of the illness, and response to current treatment.Forty-six cases were identified, including 29 males and 17 more...

  International Classification:

  Diseases of the respiratory system - pneumonitis

  Categories:

  Idiopathic interstitial pneumonitis

  Geography:

  Republic of Ireland and the United Kingdom

  Pediatr Pulmonol, Vol: 34 Page: 23-9 July 2002
  R. Dinwiddie; N. Sharief; O. Crawford

  [Preview] [Read]

• 6.   Idiopathic intracranial hypertension; incidence, presenting features and outcome in Northern Ireland (1991-1995)

  The aim of this study was to examine incidence rates, presenting features, and visual outcome of idiopathic intracranial hypertension

  

  Abstract:

  OBJECTIVES: To determine the age and sex specific incidence rates, presenting features, and visual outcome of idiopathic intracranial hypertension in Northern Ireland. METHODS: A case-note review of all patients with idiopathic intracranial hypertension, diagnosed at the Royal Victoria Hospital, Belfast between 1991 and 1995. RESULTS: Forty-two patients were identified corresponding to more...

  International Classification:

  Diseases of the nervous system - Other disorders of the nervous system - idiopathic intracranial hypertension

  Categories:

  idiopathic intracranial hypertension

  Geography:

  Northern Ireland

  Ulster Med J, Vol: 70 Page: 31-5 May 2001
  J. J. Craig; D. A. Mulholland; J. M. Gibson

  [Preview] [Read]

• 7.   Imaging the less seriously head injured child

  This article discusses the aspect of classification and management of imaging the less seriously head injured child

  

  Geography:

  Northern Ireland

  Arch Dis Child, Vol: 82 Page: 333 April 2000
  J. F. Glasgow; S. J. McGovern

  [Preview] [Read]

• 8.   Immunocolocalization of the heme oxygenase-2 and interstitial cells of Cajal in normal and aganglionic colon

  The aim of this study was to investigate the immunocolocalization of the HO-2 and interstitial cells of Cajal in normal and aganglionic bowel of Hirschsprung's disease

  

  Abstract:

  PURPOSE: Interstitial cells of Cajal (ICCs) are pacemaker cells that play an important role in the control of gut motility. Carbon monoxide (CO) has been proposed as an endogenous messenger molecule between ICC and smooth muscle cells in the gastrointestinal tract (GIT). Heme oxygenase-2 (HO-2) is the main physiologic mechanism for generating CO in human cells. The aim of this study was more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  immunocolocalization of the HO-2 and interstitial cells of Cajal;-Hirschsprung's disease

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 38 Page: 73-7 January 2003
  A. P. Piotrowska; V. Solari; D. de Caluwe; P. Puri

  [Preview] [Read]

• 9.   Immunolocalization of the gap junction protein Connexin43 in the interstitial cells of Cajal in the normal and Hirschsprung's disease bowel

  The aim of this study was to investigate the immunolocalization of the Gap junction protein Connexin43 in the normal and Hirschsprung's disease bowel

  

  Abstract:

  BACKGROUND: Interstitial cells of Cajal (ICC) are pacemaker cells between gastrointestinal smooth muscles; they generate spontaneous slow waves of the smooth muscle layers and mediate neurotransmission. The cellular network of ICC is connected by Gap junctions to each other and to the smooth muscle cells. Although there have been several studies reporting distribution of ICC in the more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  immunolocalization of the Gap junction protein Connexin43; -Hirschsprung's disease

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 823-8 June 2000
  L. Nemeth; S. Maddur; P. Puri

  [Preview] [Read]

• 10.   Immunologic changes during unplanned treatment interruptions of highly active antiretroviral therapy in children with human immunodeficiency virus type 1 infection

  The aim of this study was to describe the decline of CD4 cells or percentage during unplanned treatment interruptions in HIV-infected children

  

  Abstract:

  BACKGROUND: There are few data on the decline of CD4 cells or percentage during unplanned treatment interruptions in HIV-infected children. METHODS: Data were analyzed on children undergoing interruptions of three or four drug antiretroviral therapy (HAART) in the United Kingdom and Irish Collaborative HIV Paediatric Study and from Sophia Children's Hospital, Rotterdam. Children were more...

  International Classification:

  Certain infectious and parasitic diseases - Human immunodeficiency virus [HIV] disease - HIV

  Categories:

  HIV

  Geography:

  International

  Pediatr Infect Dis J, Vol: 23 Page: 446-50 May 2004
  D. M. Gibb; T. Duong; V. A. Leclezio; A. S. Walker; G. Verweel; D. T. Dunn

  [Preview] [Read]

• 11.   Impact of dedicated skate parks on the severity and incidence of skateboard- and rollerblade-related pediatric fractures

  This study undertook a prospective analysis of all patients presenting to their unit with fractures sustained while Rollerblading or skateboarding over a 5-month period

  

  Abstract:

  Dedicated skate parks have led to an increase in pediatric fractures referred to the authors' unit. The authors performed a prospective analysis of all patients presenting to their unit with fractures sustained while Rollerblading or skateboarding over a 5-month period. Epidemiologic data, user experience, wearing of protective gear, place of injury, and mechanism of injury were more...

  International Classification:

  Injury, poisoning and certain other consequences of external causes - fractures

  Categories:

  fractures

  Geography:

  Republic of Ireland

  J Pediatr Orthop, Vol: 23 Page: 440-2 2003 Jul-Aug
  E. Sheehan; K. J. Mulhall; S. Kearns; P. O'Connor; F. McManus; M. Stephens; D. McCormack

  [Preview] [Read]

• 12.   Impact of MTHFR C677T polymorphism on risk of neural tube defects: case-control study

  The aim of this study was to assess the impact of MTHFR C677T polymorphism on risk of neural tube defects

  

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - neural tube defects - condiction

  Categories:

  MTHFR C677T polymorphism; - neural tube defects

  Geography:

  Republic of Ireland

  BMJ: British Medical Journal, Vol: 328 Page: 1535-1536 2004
  P. N. Kirke; J. L. Mills; A. M. Molloy; L. C. Brody; V. B. O'Leary; L. Daly; S. Murray; M. Conley; P. D. Mayne; O. Smith; J. M. Scott

  [Preview] [Read]

• 13.   Importance of Hib booster stressed as winter approaches

  This article discusses the importance of Hib booster as winter approaches

  

  Geography:

  Northern Ireland

  Paediatric Nursing, Vol: 15 Page: 4-4 2003

  [Preview] [Read]

• 14.   Importance of parental conceptual model of illness in severe recurrent abdominal pain

  The aim of this study was to examine whether the parental conceptual model of illness is a factor in the long-term outcome of children with severe recurrent abdominal pain

  

  Abstract:

  OBJECTIVES: Recurrent abdominal pain (RAP) affects up to 15% of children. A biopsychosocial approach to the treatment of children with RAP has been proposed as an alternative to the traditional medical model. The aim of this study was to examine whether the parental conceptual model of illness is a factor in the long-term outcome of children with severe RAP. METHODS: The study was more...

  International Classification:

  Other - severe recurrent abdominal pain

  Categories:

  parental conceptual model of illness

  Geography:

  Republic of Ireland

  Pediatrics, Vol: 112 Page: 1368-72 December 2003
  E. Crushell; M. Rowland; M. Doherty; S. Gormally; S. Harty; B. Bourke; B. Drumm

  [Preview] [Read]

• 15.   Imported malaria to Northern Ireland: improving surveillance for better intervention

  This study sought to evaluate the current surveillance arrangements in Northern Ireland, describe the epidemiology of malaria and make appropriate recommendations

  

  Abstract:

  Malaria is a preventable disease, which is under notified in the U.K. This study sought to evaluate the current surveillance arrangements in Northern Ireland (NI), describe the epidemiology of malaria and make appropriate recommendations. A case was defined as a resident or visitor to NI with laboratory confirmed malaria, diagnosed by the NI haematology laboratories and/or the Malaria more...

  International Classification:

  Certain infectious and parasitic diseases - Report

  Categories:

  malaria

  Geography:

  Northern Ireland

  Ulster Med J, Vol: 75 Page: 129-35 May 2006
  G. M. Ong; B. Smyth

  [Preview] [Read]

• 16.   In vivo expression of the 25-kDa laminin-binding protein of Helicobacter pylori

  This aim of this study was to determine whether the 25-kDa protein is produced by Helicobacter pylori in infected hosts

  

  Abstract:

  The gastroduodenal pathogen Helicobacter pylori has been shown to inhibit the interaction between the extracellular matrix protein laminin and its receptor on gastric epithelial cells, potentially contributing to a loss of mucosal integrity. As a 25-kDa outer membrane protein of H. pylori in association with the bacterial lipopolysaccharides (LPS) mediates attachment to laminin, the aim more...

  International Classification:

  Bacterium - Helicobacter pylori

  Categories:

  Helicobacter pylori; 25-kDa protein;

  Geography:

  Republic of Ireland

  FEMS Immunol Med Microbiol, Vol: 43 Page: 331-7 March 2005
  A. P. Moran; S. A. Broaders; A. Rapa; G. Oderda

  [Preview] [Read]

• 17.   Inadequacies in the first aid management of burns presenting to plastic surgery services

  The aim of this study was to examine first aid measures taken by both patients and their primary carers following burn injury

  

  Abstract:

  Burn injury is a significant cause of mortality and morbidity in Ireland. Simple first aid measures such as immediate wound cooling and removal of the source of injury can significantly improve clinical outcome. We conducted a six-month study, investigating the first aid measures taken by both patients and their primary carers following burn injury. Of the 63 patients referred to the more...

  International Classification:

  Injury, poisoning and certain other consequences of external causes - injury

  Categories:

  burn injury

  Geography:

  Republic of Ireland

  Ir Med J, Vol: 98 Page: 15-6 January 2005
  A. C. O'Neill; E. Purcell; D. Jones; N. Pasha; J. McCann; P. Regan

  [Preview] [Read]

• 18.   Incidence and management of hypoglycaemia in children

  The aim of this study was to examine the incidence and management of hypoglyceaemia in children under 16 Years

  

  International Classification:

  Endocine, nutritional and metabolic diseases - Other disorders of glucose regulation and pancreatic internal secretion - hypoglyceaemia

  Categories:

  hypoglyceaemia

  Geography:

  Northern Ireland

  Br J Gen Pract, Vol: 50 Page: 324 April 2000
  D. Carson; M. C. McGovern

  [Preview] [Read]

• 19.   Incidence and outcome of middle ear disease in cleft lip and/or cleft palate

  The aim of this study was to examine the incidence, natural history, treatment, and outcome of middle ear disease in children with clefts

  

  Abstract:

  OBJECTIVE: Otitis media with effusion is known to be very common among children with cleft palate, however, less is known regarding the natural history and outcome in this group. The purpose of the present study was to examine the incidence, natural history, treatment, and outcome of middle ear disease in children with clefts. METHODS: A questionnaire was sent to the parents of all more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Cleft lip and cleft palate - Cleft lip and/or palate

  Categories:

  middle ear disease; clefts

  Geography:

  Republic of Ireland

  Int J Pediatr Otorhinolaryngol, Vol: 67 Page: 785-93 July 2003
  P. Sheahan; I. Miller; J. N. Sheahan; M. J. Earley; A. W. Blayney

  [Preview] [Read]

• 20.   Incidence of systemic lupus erythematosus in the United Kingdom, 1990-1999

  The aim of this study was to examine the annual incidence of systemic lupus erythematosus (SLE) over a 10-year period in the UK

  

  Abstract:

  OBJECTIVE: To estimate the annual incidence of systemic lupus erythematosus (SLE) over a 10-year period in the UK, and to examine age-, sex-, and region-specific rates. METHODS: The study was based on the UK General Practice Research Database (GPRD), which covers approximately 5% of the UK population. We estimated SLE incidence rates, during the period 1990-1999, among persons more...

  International Classification:

  Diseases of the skin and subcutaneous tissue - Other disorders of the skin and subcutaneous tissue - systemic lupus erythematosus

  Categories:

  systemic lupus erythematosus

  Geography:

  the United Kingdom

  Arthritis Rheum, Vol: 57 Page: 612-8 May 2007
  E. C. Somers; S. L. Thomas; L. Smeeth; W. M. Schoonen; A. J. Hall

  [Preview] [Read]

• 21.   Incidence of type 1 diabetes mellitis in children aged under 15 years in the Republic of Ireland

  The aim of this study was to examine the incidence of type 1 diabetes mellitis in children aged under 15 years in the Republic of Ireland

  

  International Classification:

  Endocrine, nutritional and metabolic diseases - Diabetes mellitus - type 1 diabetes mellitus

  Categories:

  type 1 diabetes mellitis

  Geography:

  Republic of Ireland

  J Pediatr Endocrinol Metab, Vol: 15 Page: 1191-4 2002 Sep-Oct
  E. F. Roche; A. Menon; D. Gill; H. M. Hoey

  [Preview] [Read]

• 22.   Increased angiogenesis in bone marrow of children with acute lymphoblastic leukaemia has no prognostic significance

  The aim of this study was to investigate bone marrow trephine biopsies from children with acute lymphoblastic leukaemia at diagnosis and following treatment.

  

  Abstract:

  The importance of angiogenesis for the growth and viability of solid tumours has been established. Similarly, prognostic information may be gained from the extent of angiogenesis in these tumours. Haematopoietic malignancies should have equal requirements for angiogenesis and important prognostic information may be derived from quantification of bone marrow angiogenic activity. We more...

  International Classification:

  Neoplasms - lymphoblastic leukemia

  Categories:

  bone marrow trephine biopsies; - acute lymphoblastic leukaemia

  Geography:

  Republic of Ireland

  Br J Haematol, Vol: 118 Page: 991-8 September 2002
  M. A. Pule; C. Gullmann; D. Dennis; C. McMahon; M. Jeffers; O. P. Smith

  [Preview] [Read]

• 23.   Increased c-Met tyrosine kinase expression in segmental renal dysplasia

  The aim of this study was to investigate the immunoreactivity of c-Met tyrosine kinase in the dysplastic kidney in order to further understand the pathogenesis of renal dysplasia

  

  Abstract:

  Renal dysplasia (RD) is a disorganized development of renal parenchyma that results in a deficit of functional renal tissue. It has been suggested in the animal model that increased expression of HGF receptor, c-Met tyrosine kinase in the epithelial cells during kidney development may induce a growth of dysplastic epithelia and result in RD. The aim of this study was to investigate the more...

  International Classification:

  Other - renal dysplasia

  Categories:

  immunoreactivity of c-Met tyrosine; -renal dysplasia

  Geography:

  Republic of Ireland

  Pediatr Nephrol, Vol: 18 Page: 706-9 July 2003
  V. Solari; B. Chertin; H. Shima; P. Puri

  [Preview] [Read]

• 24.   Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8

  The aim of this study was to examine whether neutrophils from individuals with cystic fibrosis release more neutrophil elastase than neutrophils from normal subjects

  

  Abstract:

  Cystic fibrosis (CF) is a lethal, hereditary disorder characterized by a neutrophil-dominated inflammation of the lung. We sought to determine whether neutrophils from individuals with CF release more neutrophil elastase (NE) than neutrophils from normal subjects. Our results showed that peripheral blood neutrophils (PBNs) from normal subjects and individuals with CF contained similar more...

  International Classification:

  Endocrine, nutritional and metabolic diseases - Metabolic disorders - cystic fibrosis

  Categories:

  neutrophil elastase; neutrophils; -Cystic fibrosis

  Geography:

  Republic of Ireland

  Am J Physiol Lung Cell Mol Physiol, Vol: 278 Page: L33-41 January 2000
  C. Taggart; R. J. Coakley; P. Greally; G. Canny; S. J. O'Neill; N. G. McElvaney

  [Preview] [Read]

• 25.   Increased expression of EGFR and TGF-alpha in segmental renal dysplasia in duplex kidney

  The aim of the study was to analyse the expression of TGF-alpha and epidermal growth factor receptor in the dysplastic kidney

  

  Abstract:

  Renal dysplasia (RD) is a disorganised development of renal parenchyma that results in a deficit of functional renal tissue. It is known that the epidermal growth factor (EGF) and the transforming growth factor-alpha (TGF-alpha) enhance renal cell proliferation, migration and differentiation during kidney development through binding to the same EGF receptor (EGFR). The aim of the study more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Congenital malformations of the urinary system - dysplastic kidney

  Categories:

  TGF-alpha; epidermal growth factor; - dysplastic kidney

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 20 Page: 243-7 April 2004
  V. Solari; H. Shima; P. Puri

  [Preview] [Read]

• 26.   Increased expression of fibroblast growth factors in segmental renal dysplasia

  The aim of this study was to investigate the immunoactivity of basic fibroblast growth factors and keratinocyte growth factor and their receptors in the dysplastic kidney in order to further understand the pathogenesis of Renal Dysplasia

  

  Abstract:

  Renal dysplasia (RD) is a disorganized development of renal parenchyma that results in a deficit of functional renal tissue. Dysplastic renal tissue is characterized by primitive tubular epithelium associated with increased mesenchyme. Several polypeptide growth factors (GF), which interact with target cells through a cell-surface membrane receptor, have been reported to be involved in more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Congenital malformations of the urinary system - dysplastic kidney

  Categories:

  polypeptide growth factors; - dysplastic kidney

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 16 Page: 306-9 2000
  H. Shima; H. Tazawa; P. Puri

  [Preview] [Read]

• 27.   Increased expression of mast cells in reflux nephropathy

  The aim of this study was to examine the distribution of mast cells in kidneys with reflux nephropathy and to determine the relationship between mast cells and the interstitial fibrotic process in reflux nephropathy

  

  Abstract:

  End-stage renal disease is characterized by interstitial infiltrate of inflammatory cells in association with tubular atrophy and interstitial fibrosis. Mast cells (MCs) secrete a large number of fibrogenic factors and have been implicated in chronic inflammatory processes with fibrous tissue deposition. The aim of this study was to investigate the distribution of MCs in kidneys with more...

  International Classification:

  Diseases of the genitourinary system - reflux nephropathy

  Categories:

  kidney mast cells; - reflux nephropathy

  Geography:

  Republic of Ireland

  Pediatr Nephrol, Vol: 19 Page: 157-63 February 2004
  V. Solari; K. Unemoto; A. Piaseczna Piotrowska; P. Puri

  [Preview] [Read]

• 28.   Increased influenza activity in Ireland, January 2005

  This study reports influenza activity in Ireland in January 2005

  

  International Classification:

  Surveillance - Diseases of the respiratory system - Influenza and pneumonia - influenza

  Categories:

  influenza

  Geography:

  Republic of Ireland

  Euro Surveill, Vol: 10 Page: E050120 3 January 2005
  K. Hunter; J. O'Donnell; S. Cotter; N. Murphy; D. O'Flanagan; M. Joyce; S. Coughlan; B. Condon; S. Dooley

  [Preview] [Read]

• 29.   Indirect costs, cost-utility variations and the funding of paediatric cochlear implantation

  The aim of this study was to demonstrate variations in cost-utility associated with indirect costs in paediatric cochlear implantation; to illustrate implications of purchasing decisions and; to posit a potential solution to anomalies in purchasing

  

  Abstract:

  Objective: To demonstrate the existence of variations in cost-utility associated with indirect costs in paediatric cochlear implantation; to illustrate the implications of this for purchasing decisions and; to posit a potential solution to anomalies in purchasing that may otherwise result when services are publicly funded. Methods: Data was taken from published sources on the cost of more...

  International Classification:

  Economic - Cochlear implantation

  Geography:

  Northern Ireland

  Int J Pediatr Otorhinolaryngol, Vol: 58 Page: 53-7 April 2001
  C. O'Neill; S. M. Archbold; G. M. O'Donoghue; D. A. McAlister; T. P. Nikolopoulos

  [Preview] [Read]

• 30.   Infant and toddler diabetes

  This article discusses infant and toddler diabetes

  

  Geography:

  Republic of Ireland

  Arch Dis Child, Vol: 92 Page: 716-9 August 2007
  D. Cody

  [Preview] [Read]

• 31.   Influence of serogroup on the presentation, course, and outcome of invasive meningococcal disease in children in the Republic of Ireland, 1995-2000

  The aim of this study was to examine the hypothesis that the infecting meningococcal serogroup modulates the presentation, course, and outcome of invasive meningococcal disease (IMD)

  

  Abstract:

  To test the hypothesis that the infecting meningococcal serogroup modulates the presentation, course, and outcome of invasive meningococcal disease (IMD), we performed a retrospective review of cases of IMD in 407 children from 2 tertiary referral centers and 2 regional centers in Ireland. Patients infected with serogroup C meningococci (n=104) were older than those infected with more...

  International Classification:

  Certain infectious and parasitic diseases - Other bacterial diseases - meningococcal disease

  Categories:

  invasive meningococcal disease

  Geography:

  Republic of Ireland

  Clin Infect Dis, Vol: 34 Page: 1323-30 May 2002
  C. M. Healy; K. M. Butler; E. O. Smith; O. P. Hensey; T. Bate; A. C. Moloney; P. MacMahon; J. Cosgrove; M. T. Cafferkey

  [Preview] [Read]

• 32.   Influence soya-based infant formula consumption on isoflavone and gut microflora metabolite concentrations in urine and on faecal microflora composition and metabolic activity in infants and children

  The aim of this study was to examine the influence soya-based infant formula consumption on isoflavone and gut microflora metabolite concentrations in urine and on faecal microflora composition and metabolic activity in infants and children

  

  International Classification:

  Breastfeeding +/- formulae milk

  Categories:

  infant formula; isoflavone and gut microflora metabolite concentrations; faecal microflora composition; metabolic activity

  Geography:

  Northern Ireland

  British Journal of Nutrition, Vol: 91 Page: 607-616 2004
  L. Hoey; I. R. Rowland; A. S. Lloyd; D. B. Clarke; H. Wiseman

  [Preview] [Read]

• 33.   Ingested foreign bodies in the paediatric patient

  The aim of this study was to establish clear guidelines for management of paediatric foreign bodies ingestion

  

  Abstract:

  BACKGROUND: Paediatric foreign body (FB) ingestion is a common problem and while most can be managed conservatively, a sub-population require intervention. AIMS: To establish clear guidelines for management of paediatric FB ingestion. METHODS: A retrospective chart review analysing all paediatric admissions with FB ingestion over a 10-year period from 1990 to 1999. RESULTS: Of 339 more...

  International Classification:

  Procedure - paediatric foreign bodies

  Categories:

  paediatric foreign bodies

  Geography:

  Republic of Ireland

  Ir J Med Sci, Vol: 170 Page: 100-2 2001 Apr-Jun
  G. C. O'Brien; D. C. Winter; W. O. Kirwan; H. P. Redmond

  [Preview] [Read]

• 34.   Insulin-like growth factor-1 expression in reflux nephropathy

  The aim of this study was to investigate the expression of insulin like growth factor-1 in reflux nephropathy

  

  Abstract:

  BACKGROUND: Reflux nephropathy (RN) is recognised as a major cause of end-stage renal failure in children and young adults. Insulin-like growth factor-1 (IGF-1), a peptide growth factor produced by collecting ducts, and its receptor, insulin-like growth factor-1 receptor (IGF-1R), are present in the glomeruli and basolateral membrane of renal proximal tubular cells. Exogenous IGF-1 has more...

  International Classification:

  Diseases of the genitourinary system - reflux nephropathy

  Categories:

  insulin like growth factor-1; - reflux nephropathy

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 20 Page: 283-9 April 2004
  B. Chertin; A. Farkas; P. Puri

  [Preview] [Read]

• 35.   Integration of conventional cytogenetics, comparative genomic hybridisation and interphase fluorescence in situ hybridisation for the detection of genomic rearrangements in acute leukaemia

  The aim of this study was to screen for genomic imbalances in patients with acute leukaemia using conventional and molecular and fluorescence in situ hybridisation methods

  

  Abstract:

  AIMS: To screen for genomic imbalances in patients with acute leukaemia using conventional (G-banding) and molecular (comparative genomic hybridisation (CGH) and fluorescence in situ hybridisation (FISH)) methods to determine whether an integrative screening approach increases abnormality detection rate. METHODS: G-banded analysis was performed on unstimulated bone marrow (BM) or more...

  International Classification:

  Neoplasms - Malignant neoplasms - leukaemia

  Categories:

  leukaemia (acute)

  Geography:

  Northern Ireland

  J Clin Pathol, Vol: 61 Page: 903-8 August 2008
  P. McGrattan; S. Campbell; R. Cuthbert; F. G. Jones; M. F. McMullin; M. Humphreys

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• 36.   Intensive enteral nutrition support in paediatric bone marrow transplantation

  This study examined intensive enteral nutrition support in paediatric bone marrow transplantation

  

  Abstract:

  This study retrospectively analyses the experience with an intensive enteral feeding protocol in children undergoing BMT at the National Paediatric BMT Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin. Fifty-three patients were transplanted between January 1996 and December 1998; 42 patients received allogeneic transplants, (19 unrelated) and 11 were autologous. more...

  International Classification:

  Organ transplants - bone marrow

  Categories:

  paediatric bone marrow transplantation

  Geography:

  Republic of Ireland

  Bone Marrow Transplant, Vol: 27 Page: 741-6 April 2001
  A. Langdana; N. Tully; E. Molloy; B. Bourke; A. O'Meara

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• 37.   Interferon-gamma receptor deficiency mimicking Langerhans' cell histiocytosis

  This case report discusses two patients who were initially given a diagnosis of Langerhans' cell histiocytosis on the basis of the clinical, radiologic, and biopsy findings had mycobacterial infection subsequently identified

  

  Abstract:

  Two patients who were initially given a diagnosis of Langerhans' cell histiocytosis on the basis of the clinical, radiologic, and biopsy findings had mycobacterial infection subsequently identified. The correct diagnosis of dominant partial interferon-gamma receptor deficiency was established. more...

  International Classification:

  Endocrine, nutritional and metabolic diseases-Report

  Categories:

  Langerhans' cell histiocytosis

  Geography:

  Northern Ireland

  J Pediatr, Vol: 139 Page: 600-3 October 2001
  J. D. Edgar; A. E. Smyth; J. Pritchard; D. Lammas; E. Jouanguy; R. Hague; V. Novelli; S. Dempsey; L. Sweeney; A. J. Taggart; D. O'Hara; J. L. Casanova; D. S. Kumararatne

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• 38.   Interleukin-4 and interleukin-4 soluble receptor alpha levels in bronchoalveolar lavage from children with asthma

  This study tested the hypothesize that levels of IL-4 in bronchoalveolar lavage fluid would be increased in stable, atopic asthmatic children V. controls with corresponding decrease of its physiologic inhibitor IL-4 soluble receptor alpha levels

  

  Abstract:

  BACKGROUND: In asthma there is increased expression of the Th2-type cytokine interleukin-4 (IL-4). IL-4 is important in immunoglobulin isotype switching to immunoglobulin E and adhesion of eosinophils to endothelium. OBJECTIVE: We hypothesized that levels of IL-4 in bronchoalveolar lavage (BAL) fluid would be increased in stable, atopic asthmatic children compared with controls and that more...

  International Classification:

  Diseases of the respiratory system - Chronic lower respiratory diseases - asthma

  Categories:

  IL-4 soluble receptor alpha levels; - asthmatic

  Geography:

  Northern Ireland

  Ann Allergy Asthma Immunol, Vol: 90 Page: 429-33 April 2003
  P. S. Fitch; V. Brown; B. C. Schock; M. Ennis; M. D. Shields

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• 39.   Internal anal sphincter achalasia: outcome after internal sphincter myectomy

  This study examined outcomes after internal sphincter myectomy in patients with Internal Anal Sphincter Achalasia

  

  Abstract:

  BACKGROUND: Internal anal sphincter achalasia (IASA), also referred to as ultrashort segment Hirschsprung's disease (HD), is a clinical condition with presentation similar to HD, but with the presence of ganglion cells on rectal biopsy. The diagnosis of IASA is made on anorectal manometry, which shows the absence of rectosphincteric reflex on rectal balloon inflation. Altered more...

  International Classification:

  Diseases of the digestive system - Anal Sphincter Achalasia

  Categories:

  Internal Anal Sphincter Achalasia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 36 Page: 736-8 May 2001
  D. De Caluwe; A. Yoneda; U. Akl; P. Puri

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• 40.   Interventions for post-traumatic stress disorder in children and adolescents

  This article discusses interventions for post-traumatic stress disorder in children and adolescents

  

  Abstract:

  Clinical features, epidemiology and aetiology of post-traumatic stress disorder (PTSD) are outlined. Treatment outcome studies involving children with PTSD who have survived traumatic accidents, natural disasters and child sexual abuse are reviewed. An evidence-based assessment and treatment protocol is outlined for children and adolescents with PTSD. Key components of effective more...

  Geography:

  Republic of Ireland

  Pediatr Rehabil, Vol: 7 Page: 231-44 2004 Oct-Dec
  A. Carr

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• 41.   Intestinal neuronal dysplasia: results of treatment in 33 patients

  This study reviewed the authors experience of intestinal neuronal dysplasia over an 8 year period

  

  Abstract:

  PURPOSE: Intestinal neuronal dysplasia (IND) is a disease of the enteric nervous system, which clinically resembles Hirschsprung's disease. The authors reviewed their experience of IND over an 8-year period. METHODS: Between 1992 and 1999, 418 patients underwent rectal suction biopsy for persistent constipation. Thirty-three (7.8%) patients had histologic evidence of IND. There were 26 more...

  International Classification:

  Other - lintestinal neuronal dysplasia

  Categories:

  intestinal neuronal dysplasia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 36 Page: 777-9 May 2001
  J. Gillick; H. Tazawa; P. Puri

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• 42.   Intracranial pressure complicating severe traumatic brain injury in children: monitoring and management

  The aim of this study was to examine the use of intracranial pressure monitoring and to establish which ICP-targeted therapies are being used in children with severe traumatic brain injury in the United Kingdom

  

  Abstract:

  OBJECTIVE: To identify factors associated with the use of intracranial pressure (ICP) monitoring and to establish which ICP-targetted therapies are being used in children with severe traumatic brain injury (TBI) in the United Kingdom. To evaluate current practice against recently published guidelines. DESIGN AND SETTING: Prospective data collection of clinical and demographic more...

  International Classification:

  Injury, poisoning and certain other consequences of external causes - injury

  Categories:

  severe traumatic brain injury

  Geography:

  Republic of Ireland and the United Kingdom

  Intensive Care Med, Vol: 32 Page: 1606-12 October 2006
  K. P. Morris; R. J. Forsyth; R. C. Parslow; R. C. Tasker; C. A. Hawley

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• 43.   Intractable pulmonary aspiration in children: which operation?

  This case report discusses which operation to undertake for intractable pulmonary aspiration in children

  

  Abstract:

  Intractable aspiration is a life-threatening medical problem. There are many surgical procedures for the treatment of intractable aspiration. Our experience with three children was reported here. After failing initial conservative measures, the first two patients had supraglottic laryngeal closure performed through an endoscopic approach with a small hole left superiorly for phonation. more...

  International Classification:

  Health service provision

  Categories:

  pulmonary aspiration

  Geography:

  Republic of Ireland

  Int J Pediatr Otorhinolaryngol, Vol: 70 Page: 19-25 January 2006
  M. A. Hafidh; O. Young; J. D. Russell

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• 44.   Intraoperative findings in revision canal wall down mastoidectomy

  This study reviewed all cases of canal wall down mastoid requiring revision surgery at the Royal Victoria Eye and Ear Hospital over a 6 year period 1999-2004

  

  Abstract:

  Effective canal wall down mastoid surgery requires attention to certain key principles. We reviewed all cases requiring revision surgery at the Royal Victoria Eye and Ear Hospital over a 6 year period 1999-2004. Intraoperative findings which contributed to the need for revision surgery were identified. During this 6 year period 291 canal wall down mastoidectomies were performed. more...

  International Classification:

  Procedure - surgery for canal wall down mastoid

  Categories:

  canal wall down mastoid

  Geography:

  Republic of Ireland

  Ir Med J, Vol: 101 Page: 14 January 2008
  E. Phelan; M. Harney; H. Burns

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• 45.   Invasive pneumococcal disease in children in Ireland--the anticipated benefit of conjugate pneumococcal vaccination

  The aim of this study was to examine the incidence of invasive pneumococcal disease in children in Ireland

  

  Abstract:

  BACKGROUND: Streptococcus pneumoniae is an important cause of childhood illness. Recently a safe and effective 7-valent conjugate pneumococcal vaccine for children has been licensed in the EU. AIMS: To calculate the incidence of invasive pneumococcal disease (IPD) in children in Ireland, to estimate the burden of disease and to anticipate the protective effect of the conjugate vaccine. more...

  International Classification:

  Bacterium - pneumococcal disease

  Categories:

  invasive pneumococcal disease

  Geography:

  Republic of Ireland

  Ir J Med Sci, Vol: 177 Page: 225-31 September 2008
  J. J. Fitzsimons; A. L. Chong; M. T. Cafferkey; K. M. Butler

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• 46.   Investigating painless rectal bleeding--is there scope for improvement?

  This study examined the diagnostic yield of limited colorectal endoscopy with total colonoscopy in children with recurrent painless rectal bleeding

  

  Abstract:

  INTRODUCTION: Most patients with recurrent painless rectal bleeding warrant endoscopic examination of the lower gastrointestinal tract. This is often limited to rectum or distal colon. The purpose of this study was to compare the diagnostic yield of limited colorectal endoscopy with total colonoscopy in children with recurrent painless rectal bleeding. METHODS: Retrospective review of more...

  International Classification:

  Diagnostic tool (endoscopy) - rectal bleeding

  Categories:

  limited colorectal endoscopy; otal colonoscopy

  Geography:

  Northern Ireland

  J Pediatr Surg, Vol: 40 Page: 1920-2 December 2005
  G. Clarke; A. Robb; I. Sugarman; W. A. McCallion

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• 47.   Is a once daily dose of gentamicin safe and effective in the treatment of uti in infants and children?

  This case report discusses whether a once daily dose of gentamicin safe and effective in the treatment of urinary tract infection in infants and children

  

  International Classification:

  Diseases of the genitourinary system - Report

  Categories:

  urinary tract infection

  Geography:

  Republic of Ireland

  Arch Dis Child, Vol: 92 Page: 823-4 September 2007
  M. Shahid; R. Cooke

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• 48.   Is contralateral exploration necessary in girls with unilateral inguinal hernia?

  This study examined the incidence of contralateral hernia development in girls after Unilateral Inguinal Hernia repair

  

  Abstract:

  BACKGROUND/PURPOSE: Routine contralateral groin exploration in girls with unilateral inguinal hernia (UIH) continues to be controversial. The aim of this study was to determine the incidence of contralateral hernia development in girls after UIH repair. METHODS: Between 1972 and 2000, 391 girls underwent repair of UIH. Ninety-one (23%) of the 391 girls underwent routine contralateral more...

  International Classification:

  Procedure - unilateral inguinal hernia repair

  Categories:

  contralateral hernia development

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 38 Page: 756-7 May 2003
  B. Chertin; D. De Caluwe; M. Gajaharan; A. Piaseczna-Piotrowska; P. Puri

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• 49.   Is intralesional cidofovir worthwhile in juvenile recurrent respiratory papillomatosis?

  This study investigated the efficacy of intralesional cidofovir in the treatment of recurrent respiratory papillomatosis in children

  

  Abstract:

  OBJECTIVE: To investigate the efficacy of intralesional cidofovir in the treatment of recurrent respiratory papillomatosis (RRP) in children. METHODS: Prospective observational study of four consecutive children with RRP treated at an academic tertiary children's hospital. Laryngo-bronchoscopy was performed at three- to five-weekly intervals. Photodocumentation was obtained and disease more...

  International Classification:

  Neoplasms - Benign neoplasms - respiratory papillomatosis

  Categories:

  respiratory papillomatosis

  Geography:

  Republic of Ireland

  J Laryngol Otol, Vol: 120 Page: 561-5 July 2006
  P. Sheahan; S. Sexton; J. D. Russell

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• 50.   Is Panton-Valentine leucocidin associated with the pathogenesis of Staphylococcus aureus bacteraemia in the UK?

  The aim of this study was to determine the prevalence of Panton-Valentine leucocidin (PVL)-encoding genes among isolates of S. aureus from bacteraemic patients.

  

  Abstract:

  BACKGROUND: The morbidity and mortality associated with Panton-Valentine leucocidin (PVL)-positive Staphylococcus aureus suggest that this toxin is a key marker of disease severity. Nevertheless, the importance of PVL in the pathogenesis of primary bacteraemia caused by S. aureus is uncertain. We have determined the prevalence of PVL-encoding genes among isolates of S. aureus from more...

  International Classification:

  Bacterium - Staphylococcus aureus

  Categories:

  Panton-Valentine leucocidin-encoding genes; S. aureus

  Geography:

  the United Kingdom

  J Antimicrob Chemother, Vol: 60 Page: 402-5 August 2007
  M. J. Ellington; R. Hope; M. Ganner; M. Ganner; C. East; G. Brick; A. M. Kearns

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• 51.   Is primary endoscopic puncture of ureterocele a long-term effective procedure?

  This study examined the long-term effectiveness of primary endoscopic puncture of ureterocele

  

  Abstract:

  BACKGROUND/PURPOSE: For more than a decade, endoscopic puncture of ureterocele has been recommended as an initial and, in the majority of the patients, as a definitive procedure. This study evaluates the long-term effectiveness of primary endoscopic puncture of ureterocele. METHODS: Over the last 18 years (1984 through 2001), 52 patients (median age 3 months) underwent primary more...

  International Classification:

  Diseases of the genitourinary system - Other disorders of kidney and ureter-ureterocele

  Categories:

  ndoscopic puncture of ureterocele

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 38 Page: 116-9; discussion 116-9 January 2003
  B. Chertin; D. de Caluwe; P. Puri

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