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Irish Child Health Database - Peer Reviewed Papers

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Herbicides/administration & dosage/toxicity

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1. Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia

The aim of this study was to investigate molecular markers for AECs-I [ICAM-1, T1alpha, aquaporin 5 ] and molecular markers for AECs-II [thyroid transcription factor-1), surfactant protein in the nitrofen-induced congenital diaphragmatic hernia lung

Abstract:

Pulmonary hypoplasia is the principal cause of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Still, relatively little is known about the mechanisms causing lung hypoplasia associated with CDH. The differentiation from alveolar epithelial cells type II (AECs-II) into alveolar epithelial cells type I (AECs-I) is one of the key processes in lung development more...

Categories:

molecular markers; congenital diaphragmatic hernia lung

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 23 Page: 405-10 May 2007
H. Takayasu; N. Nakazawa; S. Montedonico; K. Sugimoto; H. Sato; P. Puri

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