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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Animals

Your search returns 124 documents

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• 1.   Administration of antenatal glucocorticoids upregulates peptide growth factor gene expression in nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate antenatal glucocorticoids administration effect on gene expression of basic fibroblast growth factor, platelet-derived growth factor transforming growth factor-beta1 in congenital diaphragmatic hernia

  

  Abstract:

  BACKGROUND/PURPOSE: There is increasing evidence to suggest that various growth factors play a crucial role in fetal lung growth and morphogenesis. An array of peptide growth factors regulate cell proliferation, differentiation, and various other cell functions in the developing lung. The aim of this study was to investigate the effect of antenatal glucocorticoids administration on gene more...

  Categories:

  antenatal glucocorticoids administration; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 109-12 January 2000
  T. Oue; H. Shima; Y. Taira; P. Puri

  [Preview] [Read]

• 2.   Adriamycin effects on the chick embryo

  The aim of this study was to test the hypothesize that administration of adriamycin to chick embryos would cause similar anomalies to the vertebral, anorectal, cardiac, tracheoesophageal, renal, limb anomalies association seen in the Adriamycin rat mode

  

  Abstract:

  Adriamycin is an anthracycline, anti-neoplastic drug with known teratogenic effects on foetal rats in what is known as the Adriamycin rat model (ARM). This includes conditions similar to those in newborn humans, known collectively as the VACTERL association. This comprises vertebral (V), anorectal (A), cardiac (C), tracheoesophageal (TE), renal (R) and limb (L) anomalies. We designed more...

  Categories:

  adriamycin; VACTERL malformations - vertebral, anorectal, cardiac, tracheoesophageal, renal, limb anomalies

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 19 Page: 359-64 July 2003
  A. Mortell; J. Giles; J. Bannigan; P. Puri

  [Preview] [Read]

• 3.   Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model

  The aim of this study was to test the hypothesis that Shh-expressing ectopic notochord could contribute to an increased volume of notochord relative to total embryo volume, resulting in an increased concentration of Shh in the notochord of embryos

  

  Abstract:

  BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the Vertebral, Anorectal, Cardiac, Tracheoesophageal, Renal, Limb (VACTERL) association. The notochord, which expresses Sonic Hedgehog (Shh), has been found to be grossly malformed with ventral ectopic branches in the foregut region of embryos in the ARM. The authors designed this study to test the more...

  Categories:

  Shh-expressing ectopic notochord; total embryo volume

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 39 Page: 859-63 June 2004
  A. Mortell; A. M. O'Donnell; S. Giles; J. Bannigan; P. Puri

  [Preview] [Read]

• 4.   Airway proteins--surfactants

  This article discusses the airway proteins - surfactants

  

  Geography:

  Northern Ireland

  Pediatr Pulmonol Suppl, Vol: 26 Page: 143-6 2004
  H. L. Halliday

  [Preview] [Read]

• 5.   Alterations in cholinergic and neuropeptide innervation of urinary bladder following partial bladder outlet obstruction

  The aim of this study was to test the hypothesize that the functional changes in the bladder following bladder outlet obstruction are due to alteration in cholinergic and sensory neuropeptide innervation

  

  Abstract:

  Posterior urethral valves (PUV) are the most common cause of bladder outlet obstruction (BOO) in infancy. Bladder instability, poor compliance and myogenic failure are responsible for the poor long-term prognosis in these patients. Previous studies have reported abundance of sensory neuropeptides, e.g. substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal more...

  Categories:

  functional changes in the bladder; bladder outlet obstruction; neuropeptide innervation

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 19 Page: 427-31 August 2003
  B. Chertin; U. Rolle; S. Cascio; P. Puri

  [Preview] [Read]

• 6.   Altered expression of angiotensin II receptor subtypes and transforming growth factor-beta in the heart of nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to determine the expression of Ag-II receptor subtypes and TGF-beta1 in the hypoplastic heart of nitrofen-induced congenital diaphragmatic hernia

  

  Abstract:

  The renin-angitensin system (RAS) plays an important role as a growth factor in cardiac development. Angiotensin converting enzyme is involved in converting angiotensin I to angiotensin II (Ag-II). The effects of Ag-II are mediated by two primary receptors, type 1 (AT1) and type 2 (AT2). Ag-II stimulates transforming growth factor-beta1(TGF-beta1) and acts as a potent stimulant of more...

  Categories:

  hypoplastic heart; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 21 Page: 148-52 March 2005
  H. Teramoto; M. Shinkai; P. Puri

  [Preview] [Read]

• 7.   Altered gene level expression of thyroid hormone receptors alpha-1 and beta-1 in the lung of nitrofen-induced diaphragmatic hernia

  The aim of this study was to investigate gene level expression of TR-alpha1 and TR-beta1 in the lung of nitrofen-induced congenital diaphragmatic hernia using reverse transcription polymerase chain reaction (RT-PCR)

  

  Abstract:

  PURPOSE: Thyroid receptor alpha-1 (TR-alpha1) and thyroid receptor beta-1 (TR-beta1) are thought to be essential for the fetal and postnatal development of the lung. The authors investigated gene level expression of TR-alpha1 and TR-beta1 in the lung of nitrofen-induced congenital diaphragmatic hernia (CDH) using reverse transcription polymerase chain reaction (RT-PCR). METHODS: CDH was more...

  Categories:

  TR-alpha1 and TR-beta1; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 36 Page: 1675-8 November 2001
  H. Teramoto; N. Guarino; P. Puri

  [Preview] [Read]

• 8.   Altered renin-angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia

  The aim of this study was to test the hypothesize that abnormal expression of renin-angiotensin system components may be responsible for renal hypoplasia in congenital diaphragmatic hernia

  

  Abstract:

  The association between renal hypoplasia and pulmonary hypoplasia in congenital diaphragmatic hernia (CDH) has become recently appreciated. However, the underlying mechanisms responsible for this association are still unknown. Renin-angiotensin system (RAS) plays an important role in renal and somatic growth, angiogenesis and reproduction. We hypothesized that abnormal expression of RAS more...

  Categories:

  renin-angiotensin system; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 22 Page: 57-60 January 2006
  B. Chertin; N. Nakazawa; S. Montedonico; H. Shima; P. Puri

  [Preview] [Read]

• 9.   Animal models in pediatric surgery

  This article discusses animal models in pediatric surgery

  

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 22 Page: 111-28 February 2006
  A. Mortell; S. Montedonico; P. Puri

  [Preview] [Read]

• 10.   Antenatal dexamethasone administration increases fetal lung DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate the effect of antenatal glucocorticoid administration on DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia in rats

  

  Abstract:

  Antenatal glucocorticoids treatment has been shown to correct pulmonary immaturity. The thymidine analog bromodeoxyuridine (BrdU) is incorporated into S-phase cells and used as a marker of DNA synthesis. In this study, we investigated the effect of antenatal glucocorticoid administration on DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia more...

  Categories:

  antenatal glucocorticoid; DNA synthesis; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  Pediatr Res, Vol: 48 Page: 789-93 December 2000
  T. Oue; H. Shima; N. Guarino; P. Puri

  [Preview] [Read]

• 11.   Antenatal dexamethasone administration inhibits smooth-muscle-cell DNA synthesis in pulmonary-arterial media in nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate the effect of antenatal glucocorticoid therapy on smooth-muscle-cell DNA synthesis in the pulmonary arteries in a nitrofen-induced congenital diaphragmatic hernia rat model following nitrofen admin

  

  Abstract:

  The aim of this study was to investigate the effect of antenatal glucocorticoid therapy on smooth-muscle-cell (SMC) DNA synthesis in the pulmonary arteries (PA) in a nitrofen-induced congenital diaphragmatic hernia (CDH) rat model following nitrofen administration on day 9.5 of gestation. Antenatal dexamethasone (DEX) was given intraperitoneally on days 18.5 and 19.5 of gestation. more...

  Categories:

  antenatal glucocorticoid therapy; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 16 Page: 414-6 2000
  Y. Taira; H. Shima; E. Miyazaki; K. Ohshiro; P. Puri

  [Preview] [Read]

• 12.   Antenatal dexamethasone enhances endothelin receptorB expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to evaluate the effect of antenatal glucocorticoid administration on ET-1 system in nitrofen-induced congenital diaphragmatic hernia hypoplastic lung in rats

  

  Abstract:

  BACKGROUND/PURPOSE: The hypoplastic lung and persistent pulmonary hypertension (PPH) are the principle causes of high mortality and morbidity in infants with congenital diaphragmatic hernia (CDH). Endothelin-1 (ET-1), which is produced by vascular endothelial cells and some leukocytes, plays a key role in modulating pulmonary vascular tone in PPH. Two different receptors (ET(A) and more...

  Categories:

  antenatal glucocorticoid; congenital diaphragmatic hernia lung

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 203-7 February 2000
  H. Shima; T. Oue; Y. Taira; E. Miyazaki; P. Puri

  [Preview] [Read]

• 13.   Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats

  The aim of this study was to determine cardiac gene expression of ET-1 and of its receptor ET(A) and the cardiac ET-1 content in the heart of nitrofen-induced congenital diaphragmatic hernia in rats and evaluate antenatal Dexamethason treatment effects

  

  Abstract:

  BACKGROUND/PURPOSE: Although high levels of endothelin-1 (ET-1) in plasma may be relevant in certain pathophysiologic states, such as pulmonary hypertension accompanying congenital diaphragmatic hernia (CDH), experimental evidence favors a local, paracrine, or autocrine role for ET-1 in most tissues. Evidence of ET-1 production has been documented in fetal heart tissue where it exerts more...

  Categories:

  ET-1 and receptor ET(A) receptor; congenital diaphragmatic hernia;

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 37 Page: 1563-7 November 2002
  N. Guarino; P. Puri

  [Preview] [Read]

• 14.   Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate whether maternal administration of dexamethasone has any effect on the expression of surfactant protein A and surfactant protein B in nitrofen-induced experimental congenital diaphragmatic hernia rat model

  

  Abstract:

  BACKGROUND/PURPOSE: Pulmonary hypoplasia is one of the main causes for the high mortality rate in patients with congenital diaphragmatic hernia (CDH). The expression of surfactant protein A in the hypoplastic CDH lung is reduced, and its concentration is decreased in the amniotic fluid of pregnancies complicated by CDH. In a CDH experimental model, prenatal glucocorticoid treatment has more...

  Categories:

  maternal administration of dexamethason; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 1468-73 October 2000
  N. Guarino; T. Oue; H. Shima; P. Puri

  [Preview] [Read]

• 15.   Antenatal dexamethasone improves atrial natriuretic peptide receptors in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate the effect of antenatal glucocorticoid administration on the atrial natriuretic peptide system in nitrofen-induced congenital diaphragmatic hernia hypoplastic lung in rats.

  

  Abstract:

  Atrial natriuretic peptide (ANP) plays a major role in electrolyte and volume homeostasis through potent biological effects including vasorelaxation, bronchorelaxation, lung permeability, and clearance. There are two distinct biochemical and functional classes of ANP receptors, guanylate cyclase receptor (GC-R) and clearance receptors (clearance-R). Two subtypes of GC-R have been more...

  Categories:

  antenatal glucocorticoid; atrial natriuretic peptide system; congenital diaphragmatic hernia hypoplastic lung

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 16 Page: 252-5 2000
  H. Shima; N. Guarino; P. Puri

  [Preview] [Read]

• 16.   Anti-epileptic drugs in pregnancy: current safety and other issues

  This article discusses the need for women with epilepsy to both take their medication but also consider the effect of anti-epileptic drugs on their developing fetus

  

  Abstract:

  Women with epilepsy of child-bearing years have their own considerations, which must be taken into account if management of their epilepsy is to be optimised. The main issues to consider include the effects of: female hormones on seizure control, anti-epileptic drugs (AEDs) on hormonal methods of contraception, epilepsy and AEDs on fertility, epilepsy and AEDs on pregnancy itself, more...

  Geography:

  Northern Ireland

  Expert Opin Pharmacother, Vol: 4 Page: 445-56 April 2003
  J. I. Morrow; J. J. Craig

  [Preview] [Read]

• 17.   Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae

  The aim of this study was to investigate whether molecular mimicry by Helicobacter mustelae causes autoantibodies in infected ferrets

  

  Abstract:

  Infection with Helicobacter pylori has been associated with induction of autoantibodies that cross-react with the gastric mucosa. There have been discordant reports as to whether or not these autoantibodies arise due to molecular mimicry between H. pylori and host cell antigens on parietal cells. In this study, we investigated whether molecular mimicry by H. mustelae causes more...

  Categories:

  Helicobacter mustelae; autoantibodies

  Geography:

  Republic of Ireland

  Infect Immun, Vol: 69 Page: 2708-13 April 2001
  T. O. Croinin; M. Clyne; B. J. Appelmelk; B. Drumm

  [Preview] [Read]

• 18.   Baculovirus expression of parvovirus B19 (B19V) NS1: utility in confirming recent infection

  The aim of this study was to elucidate the role of anti-B19V NS1 (anti-parvovirus B19 ) antibody detection in recent infection, full-length B19V NS1 was expressed and purified

  

  Abstract:

  BACKGROUND: The presence of anti-parvovirus B19 (B19V) IgM against viral capsid proteins (VP1 and VP2) has long been used to detect recent infection. The utility of antibodies directed against B19V NS1 protein has received less attention as a serological indicator of recent infection, although anti-B19V NS1 IgG has been associated with persistent infection. OBJECTIVES: To elucidate the more...

  International Classification:

  Other - anti-parvovirus B19

  Categories:

  anti-parvovirus B19

  Geography:

  Republic of Ireland

  J Clin Virol, Vol: 22 Page: 55-60 August 2001
  O. Ennis; A. Corcoran; K. Kavanagh; B. P. Mahon; S. Doyle

  [Preview] [Read]

• 19.   Basis of the superiority of cefoperazone amphotericin teicoplanin for isolating Campylobacter upsaliensis from stools

  The aim of the study was to compare the basis of the superiority of cefoperazone amphotericin teicoplanin for isolating Campylobacter upsaliensis from stools

  

  Abstract:

  The optimum method for isolating Campylobacter upsaliensis from stools has not been clearly defined. In a preliminary study, cefoperazone amphotericin teicoplanin (CAT) selective medium isolated six C. upsaliensis strains which were not detected using modified cefoperazone charcoal deoxycholate (mCCDA). In order to identify the factors that underlie the superiority of CAT over mCCDA for more...

  International Classification:

  Bacterium - Campylobacter upsaliensis

  Categories:

  campylobacter upsaliensis

  Geography:

  Republic of Ireland

  J Clin Microbiol, Vol: 39 Page: 2713-6 July 2001
  C. Byrne; D. Doherty; A. Mooney; M. Byrne; D. Woodward; W. Johnson; F. Rodgers; B. Bourke

  [Preview] [Read]

• 20.   Bilateral megaureters in the Adriamycin rat model

  The aim of this study was to test the hypothesis that Adriamycin administration during a particular time frame could yield a high incidence of urinary tract anomalies

  

  Abstract:

  Congenital obstructive uropathy is associated with significant morbidity and mortality in the human neonate. The pathophysiology of congenital obstructive uropathy is poorly understood. There are very few experimental models of prenatal obstruction of the urinary tract, except in the fetal lamb or inbred rats. Prenatal exposure to Adriamycin in a rat model leads to a spectrum of more...

  Categories:

  adriamycin administration; urinary tract anomalies

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 21 Page: 212-6 March 2005
  A. Mortell; L. Fourcade; V. Solari; P. Puri

  [Preview] [Read]

• 21.   Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis

  The aim of this study was to examine if sufficient concentrations of 5-aminolevulinic acid could be achieved within the nail matrix, and at the nail bed, whether ALA-based photodynamic therapy may prove to be a useful treatment for onychomycosis.

  

  Abstract:

  The in vitro penetration of 5-aminolevulinic acid (ALA) across human nail and into neonate porcine hoof when released from a novel bioadhesive patch containing 50 mg cm(-2) ALA is described. ALA is a naturally occurring precursor of the photosensitiser protoporphyrin IX (PpIX). Topical application of excess ALA bypasses negative feedback inhibition and yields photosensitising more...

  International Classification:

  Certain infectious and parasitic diseases - Mycoses - onychomycosis

  Categories:

  5-aminolevulinic acid; onychomycosis.

  Geography:

  Northern Ireland

  J Control Release, Vol: 103 Page: 381-92 March 2005
  R. F. Donnelly; P. A. McCarron; J. M. Lightowler; A. D. Woolfson

  [Preview] [Read]

• 22.   Campylobacter jejuni adhere to and invade chicken intestinal epithelial cells in vitro

  The aim of this study was to compare the interaction of Campylobacter jejuni with primary intestinal cells from humans and poultry to identify factors that account for the divergent outcome following Campylobacter exposure

  

  Abstract:

  Campylobacter jejuni is a common cause of serious diarrhoeal disease in humans, in contrast to the avian population, where exposure results in prolonged colonization at high density without disease. Colonized poultry present a significant source of infection to humans worldwide. The aim of this work was to compare the interaction of Campylobacter with primary intestinal cells from more...

  International Classification:

  Bacterium - Campylobacter jejuni

  Categories:

  Campylobacter jejuni exposure

  Geography:

  Republic of Ireland

  Microbiology, Vol: 153 Page: 561-9 February 2007
  C. M. Byrne; M. Clyne; B. Bourke

  [Preview] [Read]

• 23.   Candidate genes and the behavioral phenotype in 22q11.2 deletion syndrome

  This article discusses candidate genes and the behavioural phenotype in 22q11.2 deletion syndrome and the association with schizophrenia

  

  Abstract:

  There is an overwhelming evidence that children and adults with 22q11.2 deletion syndrome (22q11.2DS) have a characteristic behavioral phenotype. In particular, there is a growing body of evidence that indicates an unequivocal association between 22q11.2DS and schizophrenia, especially in adulthood. Deletion of 22q11.2 is the third highest risk for the development of schizophrenia, with more...

  Geography:

  Republic of Ireland

  Dev Disabil Res Rev, Vol: 14 Page: 26-34 2008
  S. E. Prasad; S. Howley; K. C. Murphy

  [Preview] [Read]

• 24.   Cardiac gene expression and synthesis of atrial natriuretic peptide in the nitrofen model of congenital diaphragmatic hernia in rats: effect of prenatal dexamethazone treatment

  The aim of this study was to determine the gene and protein levels of atrial natriuretic peptide in the heart of nitrofen-induced congenital diaphragmatic hernia in rats and to evaluate the effect of antenatal dexamethazone treatment

  

  Abstract:

  BACKGROUND/PURPOSE:The aim of this study was to determine the gene and protein levels of atrial natriuretic peptide (ANP) in the heart of nitrofen-induced congenital diaphragmatic hernia (CDH) in rats and to evaluate the effect of antenatal dexamethazone (Dex) treatment. METHODS: CDH model was induced in pregnant rats after administration of 100 mg of nitrofen on day 9.5 of gestation more...

  Categories:

  antenatal dexamethazone treatment; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 36 Page: 1497-501 October 2001
  N. Guarino; H. Shima; P. Puri

  [Preview] [Read]

• 25.   Cell death in the early adriamycin rat model

  The aim of this study was to investigate the hypothesise of increased cell death in adriamycin-exposed embryos

  

  Abstract:

  The adriamycin rat model (ARM) exhibits many features of the VACTERL association. Adriamycin is a cytotoxic drug used in cancer chemotherapy. Although its exact mode of action is not clear, it is presumed to have a similar cytotoxic role in the developing embryo. Lysotracker red (LT) is a dye that stains phagolysosomes and apoptotic bodies and allows entire rodent embryos to be stained more...

  Categories:

  adriamycin-exposed embryos; increased cell death;

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 18 Page: 576-80 October 2002
  J. Gillick; S. Giles; J. Bannigan; P. Puri

  [Preview] [Read]

• 26.   Comparison of phenotypic and genotypic characteristics of Salmonella bredeney associated with a poultry-related outbreak of gastroenteritis in Northern Ireland

  The aim of this study was to investigate a combination of phenotypic and genotypic subspecies typing methods to aid in an epidemiological investigation of an outbreak of Salmonella bredeney

  

  Abstract:

  OBJECTIVES. To employ a combination of phenotypic and genotypic subspecies typing methods to aid in an epidemiological investigation of an outbreak of Salmonella bredeney involving ten persons. METHODS. Isolates were characterised by employing antibiogram typing, in addition to two genotyping techniques, including pulsed field gel electrophoresis (PFGE), random amplification of more...

  International Classification:

  Other - Salmonella bredeney

  Categories:

  Salmonella bredeney

  Geography:

  Northern Ireland

  J Infect, Vol: 47 Page: 33-9 July 2003
  J. E. Moore; L. Murray; S. Fanning; M. Cormican; M. Daly; N. Delappe; B. Morgan; P. G. Murphy

  [Preview] [Read]

• 27.   Corticosteroids in the prevention and management of bronchopulmonary dysplasia

  This article discusses evidence-based guidelines for postnatal steroid therapy in the management of chronic lung disease.

  

  Abstract:

  Corticosteroids were first prescribed for preterm neonates to treat respiratory distress syndrome, but they were found to have no beneficial effect in this disorder. About 20 years ago, dexamethasone was first used to treat infants with bronchopulmonary dysplasia who were ventilator dependent after the age of 3 weeks. There were short-term benefits, with an improvement in lung function more...

  Geography:

  Northern Ireland

  Semin Neonatol, Vol: 8 Page: 83-91 February 2003
  D. G. Grier; H. L. Halliday

  [Preview] [Read]

• 28.   Dead cattle, lead and child health

  This aim of this study was to screen for lead toxicity in a local school population

  

  Abstract:

  This study was carried out as part of a larger interagency investigation in response to concerns about human health following the death of three cattle from lead poisoning in an old lead mining area in Silvermines, Tipperary. Its aim was to screen for lead toxicity in the local child population. Screening consisted of measurement of blood lead concentrations and the completion of more...

  International Classification:

  Injury, poisoning and certain other consequences of external causes - Toxic effects of substances chiefly nonmedicinal as to source - lead toxicity

  Categories:

  lead toxicity

  Geography:

  Republic of Ireland

  Ir Med J, Vol: 96 Page: 232-4 September 2003
  E. Feely; C. Garavan; K. Kelleher

  [Preview] [Read]

• 29.   Decreased expression of voltage-gated K+ channels in pulmonary artery smooth muscles cells in nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to test the hypothesize that the hyperreactivity of the newborn pulmonary vasculature in congenital diaphragmatic hernia might reflect a relatively low level of smooth muscle K(+) channel activity because of hypoxemia

  

  Abstract:

  The newborn with congenital diaphragmatic hernia (CDH) is at high risk of developing persistent pulmonary hypertension (PPH). Recently, smooth muscle K(+) channels have been implicated in hypoxic pulmonary vasoconstriction in adults. We hypothesized that the hyperreactivity of the newborn pulmonary vasculature in CDH might reflect a relatively low level of smooth muscle K(+) channel more...

  Categories:

  smooth muscle K(+) channel activity; hyperreactivity; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 20 Page: 192-6 March 2004
  M. Sakai; K. Unemoto; V. Solari; P. Puri

  [Preview] [Read]

• 30.   Demonstration of intrinsic innervation of the guinea pig upper urinary tract using whole-mount preparation

  The aim of this study was to describe the morphology and functional importance of the autonomic nervous system in the upper urinary tract

  

  Abstract:

  AIMS: The morphology and functional importance of the autonomic nervous system in the upper urinary tract is still not completely understood. Previous histological studies investigating the innervation of the urinary tract have mainly used conventional sections in which the three-dimensional structure of the intramural innervation is difficult to achieve. In contrast, the whole-mount more...

  Categories:

  the autonomic nervous system; upper urinary tract

  Geography:

  Republic of Ireland

  Neurourol Urodyn, Vol: 27 Page: 341-7 2008
  U. Rolle; E. Brylla; B. Tillig; B. Chertin; S. Cascio; P. Puri

  [Preview] [Read]

• 31.   Demonstration of nitrergic and cholinergic innervation in whole-mount preparations of rabbit, pig, and human upper urinary tract

  The aim of this study was to investigate the distribution of nitrergic and cholinergic innervation in rabbit, pig, and human upper urinary tract

  

  Abstract:

  To investigate the distribution of nitrergic and cholinergic innervation in rabbit, pig, and human upper urinary tract, (UUT) whole-mount preparations and frozen sections were stained with nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase and acetylcholinesterase (AChE) histochemistry. NADPH-diaphorase and AChE staining demonstrated two neuronal plexuses in the submucous more...

  Categories:

  nitrergic and cholinergic innervation; upper urinary tract

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 18 Page: 315-8 September 2002
  U. Rolle; B. Chertin; L. Nemeth; P. Puri

  [Preview] [Read]

• 32.   Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder

  The aim of this study was detect measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder

  

  International Classification:

  Certain infectious and parasitic diseases - Viral infections characterized by skin and mucous membrane lesions - measles

  Categories:

  measles virus; ileo-colonic lymphoid nodular hyperplasia

  Geography:

  Republic of Ireland

  Mol Psychiatry, Vol: 7 Suppl 2 Page: S47-8 2002
  C. M. Martin; V. Uhlmann; A. Killalea; O. Sheils; J. J. O'Leary

  [Preview] [Read]

• 33.   Detection of multiple allergen-specific IgEs on microarrays by immunoassay with rolling circle amplification

  This study aimed to describe the detection of multiple allergen-specific IgEs on microarrays by immunoassay with rolling circle amplification

  

  International Classification:

  Effectiveness of measurement tool - detection of multiple allergen-specific IgEs

  Categories:

  Detection of multiple allergen-specific IgEs

  Geography:

  Northern Ireland

  Clin Chem, Vol: 46 Page: 1990-3 December 2000
  S. Wiltshire; S. O'Malley; J. Lambert; K. Kukanskis; D. Edgar; S. F. Kingsmore; B. Schweitzer

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• 34.   Developmental changes in submucosal nitrergic neurons in the porcine distal colon

  The aim of this study was to determine the normal nitrergic neuronal density and morphology in the submucosal plexus of the porcine distal bowel from fetal life to adulthood

  

  Abstract:

  BACKGROUND/PURPOSE: As our understanding of the enteric nervous system improves, it becomes clear that it is no longer sufficient to simply determine whether enteric ganglion cells are present but also to determine whether correct number and types of ganglion cells are present. Nitric oxide is recognized as a potent mediator of inhibitory nerves responsible for the relaxation of the more...

  Categories:

  nitrergic neuronal morphology; submucosal plexus of the bowel;

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 41 Page: 1029-35 May 2006
  S. Montedonico; T. Sri Paran; M. Pirker; U. Rolle; P. Puri

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• 35.   Developmental changes of the adrenergic network in the myenteric plexus of the porcine small bowel

  The aim of this study was to investigate the age-related changes in the sympathetic innervation of the myenteric plexus

  

  Abstract:

  Knowledge about the foetal development of the normal enteric nervous system (ENS) is crucial for the understanding of congenital and acquired functional abnormalities of the gut. The ENS is the largest and most complex division of the peripheral nervous system and consists of intrinsic and extrinsic components. Although previous studies have described sympathetic innervation of the more...

  Categories:

  sympathetic innervation of the myenteric plexus;

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 23 Page: 659-63 July 2007
  T. Sri Paran; U. Rolle; P. Puri

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• 36.   Differences in nitrergic innervation of the developing chick cloaca and colorectum

  The aim of this study was to investigate differences in nitrergic innervation of the developing chick cloaca and colorectum

  

  Abstract:

  The intrinsic innervation of the developing gut has long been a subject of investigation, but little is known regarding that of the embryonic cloaca. The cloaca, like the rest of the gastrointestinal tract, is intrinsically innervated by the enteric nervous system. Nitrergic neurons and fibres make up a large part of this system, thus, their distribution provides us with a useful more...

  Categories:

  nitrergic innervation

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 22 Page: 90-4 January 2006
  A. M. O'Donnell; J. Bannigan; P. Puri

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• 37.   Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention

  The aim of this study was to examine the executive function of two neurodevelopmental disorders attention deficit hyperactivity disorder and autism using a sustained attention task with a validated brain-behaviour basis

  

  Abstract:

  Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal circuits. We probed executive function in these disorders using a sustained attention task with a validated brain-behaviour basis. Twenty-three children with more...

  International Classification:

  Mental and behavioural disorders - Behavioural and emotional disorders with onset usually occurring in childhood and adolescence - attention deficit hyperactivity disorder

  Categories:

  sustained attention task; - attention deficit hyperactivity disorder; autism

  Geography:

  Republic of Ireland

  Neuropsychologia, Vol: 45 Page: 2234-45 June 2007
  K. A. Johnson; I. H. Robertson; S. P. Kelly; T. J. Silk; E. Barry; A. Daibhis; A. Watchorn; M. Keavey; M. Fitzgerald; L. Gallagher; M. Gill; M. A. Bellgrove

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• 38.   Distribution of megaplasmids in Lactobacillus salivarius and other lactobacilli

  The aim of this study was to examine the study characterised aspect of lactobacillus salivarius

  

  Abstract:

  The genome of Lactobacillus salivarius UCC118 includes a 242-kb megaplasmid, pMP118. We now show that 33 strains of L. salivarius isolated from humans and animals all harbor a megaplasmid, which hybridized with the repA and repE replication origin probes of pMP118. Linear megaplasmids that did not hybridize with the pMP118 repA probe were also found in some strains of L. salivarius, more...

  International Classification:

  Other - Lactobacillus salivarius

  Categories:

  Lactobacillus salivarius

  Geography:

  Republic of Ireland

  J Bacteriol, Vol: 189 Page: 6128-39 September 2007
  Y. Li; C. Canchaya; F. Fang; E. Raftis; K. A. Ryan; J. P. van Pijkeren; D. van Sinderen; P. W. O'Toole

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• 39.   Downregulation of GATA4 and GATA6 in the heart of rats with nitrofen-induced diaphragmatic hernia

  The aim of this study was to test the hypothesize that expression of GATA4 and GATA6 is reduced in early stages of gestation in a congenital diaphragmatic hernia hypoplastic heart

  

  Abstract:

  PURPOSE: The high incidence of cardiac malformations in humans and animal models with congenital diaphragmatic hernia (CDH) is well known. The precise molecular mechanisms underlying cardiac maldevelopment in CDH are still unclear. It has been reported that GATA4 and GATA6, members of the GATA transcription factor family, act cooperatively to regulate cardiovascular development, and the more...

  Categories:

  GATA4 and GATA6; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 43 Page: 362-6 February 2008
  H. Takayasu; H. Sato; K. Sugimoto; P. Puri

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• 40.   Down-regulation of Wnt signal pathway in nitrofen-induced hypoplastic lung

  The aim of this study was to test the hypothesize that Wnt-mediated signaling is altered in nitrofen-induced hypoplastic lungs

  

  Abstract:

  PURPOSE: The pathogenesis of pulmonary hypoplasia associated with congenital diaphragmatic hernia is poorly understood. Recently, it has been reported that Wnt signaling pathway plays a critical role in branching lung morphogenesis. Mice lacking Wnt7b gene die soon after birth because of respiratory failure and display severe lung hypoplasia. Wnt2 gene is expressed in the distal airway more...

  Categories:

  Wnt-mediated signaling; hypoplastic lungs

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 42 Page: 426-30 February 2007
  H. Takayasu; N. Nakazawa; S. Montedonico; P. Puri

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• 41.   Effect of hyperoxia on surfactant protein gene expression in hypoplastic lung in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate SP mRNA expression in hypoplastic congenital diaphragmatic hernia lung in rats during mechanical ventilation in order to determine the effect of O2 on SP synthesis in congenital diaphragmatic hernia

  

  Abstract:

  The hypoplastic lung in congenital diaphragmatic hernia (CDH) has both a quantitative and qualitative reduction in surfactant. Recently, the role of oxygen (O2) as a regulator of pulmonary surfactant-associated protein (SP) gene expression has been reported. The mRNA level of SP has been demonstrated to be increased in the lungs of animals exposed to hyperoxia. The aim of this study was more...

  Categories:

  SP mRNA expression; congenital diaphragmatic hernia lung

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 16 Page: 473-7 2000
  H. Shima; N. Guarino; P. Puri

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• 42.   Effect of mechanical ventilation on the pulmonary expression and production of elastin in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate the expression and production of elastin in the lung in newborn rats with congenital diaphragmatic hernia during mechanical ventilation

  

  Abstract:

  BACKGROUND/PURPOSE: Hypolastic lung in congenital diaphragmatic hernia (CDH) shows markedly thickened alveolar walls, increased interstitial tissue, and markedly diminished alveolar air space, showing morphologic immaturity. Decrease in lung compliance and distensibility often is seen in human CDH as well as experimentally produced CDH. Collagen and elastin, critical components of the more...

  Categories:

  mechanical ventilation; elastin; congenital diaphragmatic hernia;

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 37 Page: 1253-7 September 2002
  N. Guarino; H. Teramoto; H. Shima; T. Oue; P. Puri

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• 43.   Effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants

  The aim of this study was to investigate the effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants

  

  Abstract:

  PURPOSE: Nitric oxide (NO) can accelerate branching morphogenesis of fetal rat lung explants in vitro, whereas its exact mechanism remains unclear. In this study, we investigate the effect of NO on the expression of fibroblast growth factor-10 (FGF10) and bone morphogenetic protein-4 (BMP4), which plays an important role in bud formation. METHODS: Fetal rat lungs harvested on day 13.5 more...

  Categories:

  nitric oxide; fibroblast growth factor-10; branching morphogenesis of the lung

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 40 Page: 1030-3 June 2005
  M. Shinkai; T. Shinkai; M. A. Pirker; S. Montedonico; P. Puri

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• 44.   Effect of nitric oxide on the development of nitrofen-induced fetal hypoplastic lung explants

  The aim of this study was to evaluate the effect of nitric oxide on the morphogenesis of hypoplastic lung using nitrofen-induced rat lung explant model

  

  Abstract:

  BACKGROUND/PURPOSE: Nitric oxide (NO) is an important cell-signaling molecule, and its generators, nitric oxide synthases, are expressed temporospatially in fetal rat lung. Recently, NO has been reported to modulate branching of the fetal rat lung lobe in vitro. We designed this study to evaluate the effect of NO on the morphogenesis of hypoplastic lung using nitrofen-induced rat lung more...

  Categories:

  nitric oxide; hypoplastic lung

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 40 Page: 17-21 January 2005
  M. Shinkai; T. Shinkai; M. E. Pirker; S. Montedonico; P. Puri

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• 45.   Effect of VEGF on the branching morphogenesis of normal and nitrofen-induced hypoplastic fetal rat lung explants

  The aim of this study was to test the hypothesize that vascular endothelial growth factor may accelerate branching morphogenesis and thus may modulate lung growth in normal and nitrofen-induced pulmonary hypoplastic lungs

  

  Abstract:

  PURPOSE: Changes in vascular structures as well as vascular endothelial growth factor (VEGF) downregulation have been reported in hypoplastic lungs associated with congenital diaphragmatic hernia. We hypothesized that VEGF may accelerate branching morphogenesis and thus may modulate lung growth in normal and nitrofen-induced pulmonary hypoplastic lungs. METHODS: A hypoplastic fetal lung more...

  Categories:

  endothelial growth factor; pulmonary hypoplastic lungs

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 41 Page: 781-6 April 2006
  M. Shinkai; T. Shinkai; S. Montedonico; P. Puri

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• 46.   Enteric nervous system and developmental abnormalities in childhood

  This article reports on the enteric nervous system and developmental abnormalities in childhood

  

  Abstract:

  ENS consists of a complex network of neurons, organised in several plexuses, which interact by means of numerous neurotransmitters. It is capable of modulating the intestinal motility, exocrine and endocrine secretions, microcirculation and immune and inflammatory responses within the gastrointestinal tract, independent of the central nervous system. Though the embryological development more...

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 22 Page: 945-59 December 2006
  T. S. Paran; U. Rolle; P. Puri

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• 47.   Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions

  The aim of this study was to examine a innovative bioadhesive patch intended primarily as a vulval drug delivery system

  

  Abstract:

  An innovative bioadhesive patch intended primarily as a vulval drug delivery system and, specifically, as a means to deliver photosensitisers, or their prodrugs, for photodynamic purposes is described. The patch was formulated with a copolymer of methyl vinyl ether and maleic anhydride (PMVE/MA) as a bioadhesive matrix and poly(vinyl chloride) as a drug-impervious backing layer. more...

  International Classification:

  Drugs, pharmacological treatment - delivery systems

  Categories:

  vulval drug delivery system

  Geography:

  Northern Ireland

  Int J Pharm, Vol: 293 Page: 11-23 April 2005
  P. A. McCarron; R. F. Donnelly; A. Zawislak; A. D. Woolfson; J. H. Price; R. McClelland

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• 48.   Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding

  The aim of this study was to investigate the clinical disorder of recessive congenital methemoglobinemia

  

  Abstract:

  The clinical disorder of recessive congenital methemoglobinemia (RCM, OMIN 250800) is associated with mutations in NADH:cytochrome b5 reductase (cb5r) and manifests as cyanosis from birth. Screening a cyanotic infant indicated elevated methemoglobin levels and decreased cb5r activity suggesting RCM. Sequencing the DIA1 gene encoding cb5r revealed a novel mutation, C27161T (NCBI more...

  Categories:

  congenital methemoglobinemia

  Geography:

  Northern Ireland

  Arch Biochem Biophys, Vol: 447 Page: 59-67 March 2006
  M. J. Percy; L. J. Crowley; J. Boudreaux; M. J. Barber

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• 49.   Expression of vasoactive mediators during mechanical ventilation in nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to investigate mRNA expression of ET-1, eNOS, and CGRP in congenital diaphragmatic hernia lung in the perinatal period

  

  Abstract:

  The high mortality in patients with congenital diaphragmatic hernia (CDH) has been attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PPH). Endothelin-1 (ET-1), nitric oxide (NO), and calcitonin gene-related peptide (CGRP) have been reported to be important vasoactive mediators in the perinatal pulmonary circulation. The exact mechanism by which these vasoactive more...

  Categories:

  mRNA expression; congenital diaphragmatic hernia lung

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 21 Page: 143-7 March 2005
  T. Shinkai; H. Shima; V. Solari; P. Puri

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• 50.   Food allergies

  This article discusses aspects of true food allergies, implying immune-mediated adverse responses to food antigens, discussing the importance of IgE-mediated and non-IgE-mediated immune mechanisms

  

  Abstract:

  Adverse reactions to foods are commonly implicated in the causation of ill health. However, foreign antigens, including food proteins and commensal microbes encountered in the gastrointestinal tract, are usually well tolerated. True food allergies, implying immune-mediated adverse responses to food antigens, do exist, however, and are especially common in infants and young children. more...

  Geography:

  Republic of Ireland

  Curr Gastroenterol Rep, Vol: 4 Page: 373-82 October 2002
  P. F. O'Leary; F. Shanahan

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• 51.   Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats

  The aim of this study was to determine the gene level expression of fibroblast growth factors-10 and FGF-7 in the lung of nitrofen-induced congenital diaphragmatic hernia

  

  Abstract:

  BACKGROUND/PURPOSE: Newborns with congenital diaphragmatic hernia (CDH) still have a high mortality rate, which has been attributed to pulmonary hypoplasia and pulmonary hypertension. Fibroblast growth factors (FGFs) are essential components of the gene network that regulates lung development. Recent studies suggest that the new member of FGF family, FGF-10, plays a fundamental role in more...

  Categories:

  gene level expression; congenital diaphragmatic hernia

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 38 Page: 1021-4 July 2003
  H. Teramoto; A. Yoneda; P. Puri

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