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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » H » Heart/ physiopathology

Heart/ physiopathology

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1. Gene expression of insulin-like growth factor-1 and epidermal growth factor is downregulated in the heart of rats with nitrofen-induced diaphragmatic hernia

The aim of this study was to determine the gene-level expression of insulin-like growth factor-1 and epidermal growth factor in the hearts of rats with nitrofen-induced congenital diaphragmatic hernia

Abstract:

Newborns with congenital diaphragmatic hernia (CDH) still have high mortality. Recently, a possible role of cardiac maldevelopment has been suggested. Human and experimental studies have demonstrated that heart weight is significantly reduced in the presence of CDH. Recent studies have suggested an important role for insulin-like growth factor-I (IGF-I) in the regulation of cardiac more...

Categories:

insulin-like growth factor-1; epidermal growth factor; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 17 Page: 284-7 May 2001
H. Teramoto; P. Puri

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