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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » P » Platelet-Derived Growth Factor/ physiology

Platelet-Derived Growth Factor/ physiology

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1. The hypoplastic heart in congenital diaphragmatic hernia: reduced expression of basic fibroblast growth factor and platelet-derived growth factor

The aim of this study was to investigate the presence of heart hypoplasia in nitrofen-induced congenital diaphragmatic hernia in rats and the role of specific tissue growth factors (bFGF and PDGF) in its genesis

Abstract:

Newborn infants with congenital diaphragmatic hernia (CDH) still have high mortality. Recently, the possible role of a cardiac maldevelopment in the high mortality has been suggested. Human and animal studies have demonstrated that heart weight is significantly reduced in the presence of CDH. Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) are pleiotropic more...

Categories:

growth factors; congenital diaphragmatic hernia

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 16 Page: 243-6 2000
N. Guarino; H. Shima; P. Puri

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