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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » N » Neurons/ immunology

Neurons/ immunology

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1. Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination

The aim of this study was to present evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination

Abstract:

Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children. In contrast, the new acellular pertussis vaccines (Pa) have a considerably improved safety profile. The lack of an appropriate animal model has restricted more...

Categories:

toxin-induced interleukin-1beta; neuronal side effects of vaccination

Geography:

Republic of Ireland

Infect Immun, Vol: 69 Page: 4217-23 July 2001
S. Donnelly; C. E. Loscher; M. A. Lynch; K. H. Mills

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