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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Hematopoietic Stem Cell Transplantation

Your search returns 6 documents

• 1.   Cytomegalovirus infection in paediatric haemopoietic stem cell transplantation

  The aim of this study was to audit reports of Cytomegalovirus infection to determine prevalence and outcome in the national paediatric Haemopoietic Stem Cell Transplant unit, with particular reference to surveillance and treatment

  

  Abstract:

  A retrospective audit of CMV infection was undertaken to determine prevalence and outcome in the national paediatric Haemopoietic Stem Cell Transplant (HSCT) unit, with particular reference to surveillance and treatment. All patients undergoing HSCT (125 allogeneic, 50 autologous) from January 1994 to December 2004 were included. Nine underwent a second transplant for graft failure or more...

  International Classification:

  Certain infectious and parasitic diseases - Viral infections characterized by skin and mucous membrane lesions- cytomegalovirus infection

  Categories:

  cytomegalovirus infection

  Geography:

  Republic of Ireland

  Irish Medical Journal, Vol: 101 Page: 17-21 2008
  A. L. Chong; F. Clinton; F. Breatnach; A. O'Marcaigh; K. Butler; A. O'Meara

  [Preview] [Read]

• 2.   High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial

  The aim of this study was to assess the effectiveness of high-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma

  

  Abstract:

  Background: The current standard treatment for patients with high-risk neuroblastoma includes initial induction chemotherapy with a 21-day interval between induction treatments. We aimed to assess whether an intensive chemotherapy protocol that had a 10-day interval between treatments would improve event-free survival (EFS) in patients aged 1 year or over with high-risk neuroblastoma. more...

  International Classification:

  Evaluation of the effectiveness of treatments - neuroblastoma

  Categories:

  chemotherapy for neuroblastoma

  Geography:

  International

  The Lancet Oncology, Vol: 9 Page: 247-256 2008
  A. D. Pearson; C. R. Pinkerton; I. J. Lewis; J. Imeson; C. Ellershaw; D. Machin

  [Preview] [Read]

• 3.   Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation

  The aim of this study was to examine how aspects of cord blood T-cell biology that Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation.

  

  Abstract:

  The use of human umbilical cord blood as an alternative source of stem cells to bone marrow for the reconstitution of the immune system is associated with less frequent and less severe incidence of graft-versus-host disease (GVHD). This study focuses on aspects of cord blood T-cell biology that may contribute to a perceived increased tolerance associated with the neonatal immune more...

  International Classification:

  Other - cord blood T-cell biology

  Categories:

  aspects of cord blood T-cell biology

  Geography:

  Republic of Ireland

  Br J Haematol, Vol: 116 Page: 702-9 March 2002
  E. Rainsford; D. J. Reen

  [Preview] [Read]

• 4.   Invasive rhino-maxillary mucormycosis diagnosed before HSCT

  This case report discusses a case of successful allogeneic hematopoietic stem cell transplantation with full myeloablative conditioning in a patient with pre-existing invasive mucormycosis.

  

  Abstract:

  We report a case of successful allogeneic hematopoietic stem cell transplantation (HSCT) with full myeloablative conditioning in a patient with pre-existing invasive mucormycosis. The mucormycosis involved the maxilla, the nasal septum, and the hard palate. Sustained antifungal therapy and aggressive surgery both before and after HSCT were required. more...

  International Classification:

  Organ transplants

  Categories:

  allogeneic hematopoietic stem cell transplantation

  Geography:

  Republic of Ireland

  Pediatr Blood Cancer, Vol: 50 Page: 393-5 February 2008
  A. Piccin; J. D. Russell; P. Fleming; K. Butler; M. McDermott; O. P. Smith; A. O'Marcaigh

  [Preview] [Read]

• 5.   Mobility in Hurler syndrome

  This study examined the follow-up of 23 patients with Hurler syndrome at a mean of 8.5 years after successful hematopoietic stem cell transplant

  

  Abstract:

  Hurler syndrome is an autosomal recessive metabolic storage disease. Hematopoietic stem cell transplant increases life expectancy, but the effects on associated musculoskeletal abnormalities remains unclear, and long-term data are limited. We detail the follow-up of 23 patients at a mean of 8.5 years after successful hematopoietic stem cell transplant.All patients underwent clinical more...

  International Classification:

  Syndrome - Hurler

  Categories:

  Hurler syndrome

  Geography:

  Republic of Ireland

  J Pediatr Orthop, Vol: 28 Page: 163-8 March 2008
  C. Taylor; P. Brady; A. O'Meara; D. Moore; F. Dowling; E. Fogarty

  [Preview] [Read]

• 6.   The influence of cyclosporin alone, or cyclosporin and methotrexate, on the incidence of mixed haematopoietic chimaerism following allogeneic sibling bone marrow transplantation for severe aplastic anaemia

  The aim of this study was to assess chimaeric analysis and its influence on survival and GvHD occurrence in 45 of the original 71 patients in whom serial samples were available

  

  Abstract:

  We previously reported a randomized trial comparing Cyclosporin-A (CsA) and short-term methotrexate versus CsA alone for graft-versus-host disease (GvHD) prophylaxis in 71 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) from a human leucocyte antigen-identical sibling for severe aplastic anaemia (SAA). We found a better survival in the group receiving the more...

  International Classification:

  Evaluation of the effectiveness of procedures - chimaeric - analysis of molecular structures

  Categories:

  chimaeric - analysis of molecular structures

  Geography:

  International

  Bone Marrow Transplant, Vol: 39 Page: 109-14 January 2007
  S. McCann; J. Passweg; A. Bacigalupo; A. Locasciulli; F. Locatelli; J. Ryan; H. Schrezenmeier; M. Lawler

  [Preview] [Read]