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Irish Child Health Database - Peer Reviewed Papers

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Helicobacter pylori/ physiology

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• 1.   Helicobacter pylori interacts with the human single-domain trefoil protein TFF1

  This article discusses findings that helicobacter pylori interacts with the human single-domain trefoil protein TFF1

  

  Abstract:

  Why Helicobacter pylori colonizes only gastric tissue is unknown. It is found on gastric mucus-secreting cells and in the overlying gastric mucus but not deep in gastric glands. This localization mirrors the expression of trefoil factor 1, TFF1. We hypothesized that H. pylori interacting with TFF1 could explain the tropism of this bacteria for gastric tissue. Recombinant human TFF1 more...

  Geography:

  Republic of Ireland

  Proc Natl Acad Sci U S A, Vol: 101 Page: 7409-14 May 2004
  M. Clyne; P. Dillon; S. Daly; R. O'Kennedy; F. E. May; B. R. Westley; B. Drumm

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• 2.   Will treatment of Helicobacter pylori infection in childhood alter the risk of developing gastric cancer?

  This article discusses Helicobacter pylori infection in childhood as a risk factor for gastric cancer

  

  Abstract:

  Helicobacter pylori has been classified as a group 1 carcinogen for gastric cancer. It is estimated that there is between a two- and sixfold increase in the risk of developing gastric cancer among infected patients. Among different populations, the risk of H. pylori-infected individuals developing gastric cancer varies greatly. However, on a worldwide scale, gastric cancer is the second more...

  Geography:

  Republic of Ireland

  Can J Gastroenterol, Vol: 19 Page: 409-11 July 2005
  B. Bourke

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