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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Proto-Oncogene Proteins c-kit/physiology

Your search returns 2 documents

• 1.   Altered distribution of interstitial cells of Cajal in Hirschsprung disease

  The aim of this study was to examine distribution of myenteric and muscular interstitial cells of Cajal in different parts of the colon in Hirschsprung disease

  

  Abstract:

  CONTEXT: Constipation or recurrent intestinal dysmotility problems are common after definitive surgical treatment in Hirschsprung disease (HD). c-Kit-positive interstitial cells of Cajal (ICCs) play a key role in the motility function and development of the gastrointestinal tract. Interstitial cells of Cajal that carry the tyrosine kinase receptor (c-Kit) develop as either myenteric more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  interstitial cells of Cajal; -Hirschsprung disease

  Geography:

  Republic of Ireland

  Arch Pathol Lab Med, Vol: 126 Page: 928-33 August 2002
  U. Rolle; A. P. Piotrowska; L. Nemeth; P. Puri

  [Preview] [Read]

• 2.   Histopathological differences between recto-sigmoid Hirschsprung's disease and total colonic aganglionosis

  The aim of this study was to compare the innervation and interstitial cells of Cajal distribution in total colonic and recto-sigmoid Hirschsprung's disease

  

  Abstract:

  Total colonic aganglionosis (TCA) is a severe form of ultra long Hirschsprung's disease with an incidence of 2 to 14% among all forms of intestinal aganglionosis. C-kit positive interstitial cells of Cajal (ICCs) are pacemaker cells that play a key role in the motility function of the bowel. The aim of this study was to compare the innervation and ICCs distribution in total colonic and more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  interstitial cells of Cajal; -Hirsprung's Disease

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 19 Page: 349-54 July 2003
  V. Solari; A. P. Piotrowska; P. Puri

  [Preview] [Read]