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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » E » Embryo, Mammalian/ metabolism/pathology

Embryo, Mammalian/ metabolism/pathology

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1. Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model

The aim of this study was to examine the hypothesis that adriamycin administration could promote upregulation of FN expression increasing gut-notochord adherence and development of abnormal ventral notochordal branching in the Adriamycin rat model

Abstract:

BACKGROUND: The VACTERL association is a spectrum of clinical conditions, including esophageal atresia (EA) and tracheoesophageal fistula (TEF), which affects approximately 1 in 5,000 live human births. The administration of intraperitoneal Adriamycin to pregnant rats reliably induces anomalies, such as EA and TEF, in their offspring, in what is known as the Adriamycin rat model (ARM). more...

Categories:

adriamycin; abnormal ventral notochordal branching

Geography:

Republic of Ireland

Pediatr Surg Int, Vol: 20 Page: 276-82 April 2004
A. Mortell; A. M. O'Donnell; S. Giles; J. Bannigan; P. Puri

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