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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Dexamethasone/ therapeutic use

Your search returns 5 documents

• 1.   Capillary haemangioma of the eyelids and orbit: a clinical review of the safety and efficacy of intralesional steroid

  This study described the presenting features, investigations, treatment and outcome of a series of patients with capillary haemangioma of the eyelids and orbit.

  

  Abstract:

  PURPOSE: To describe the presenting features, investigations, treatment and outcome of a series of patients with capillary haemangioma of the eyelids and orbit. METHODS: A retrospective analysis of 21 patients, presenting between the years 1985 and 2000. Effectiveness of treatment was determined by final visual acuity and cosmetic result. RESULTS: Lesions were more common in females and more...

  International Classification:

  Neoplasms - Benign neoplasms - haemangioma

  Categories:

  capillary haemangioma of the eyelids and orbit

  Geography:

  Republic of Ireland

  Acta Ophthalmol Scand, Vol: 81 Page: 294-8 June 2003
  M. O'Keefe; B. Lanigan; S. A. Byrne

  [Preview] [Read]

• 2.   Delayed (>3 weeks) postnatal corticosteroids for chronic lung disease in preterm infants

  The aim of this review was to determine if late (> 3 weeks) postnatal corticosteroid treatment vs control is of benefit in the treatment of chronic lung disease (CLD) in the preterm infant

  

  Abstract:

  BACKGROUND: Many preterm babies who survive, having had respiratory distress syndrome (RDS) or not, go on to develop chronic lung disease (CLD). This is probably due to persistence of inflammation in the lung. Corticosteroids have powerful anti-inflammatory effects and have been used to treat established CLD. However it is unclear whether any beneficial effects outweigh the adverse more...

  International Classification:

  Systematic Review

  Geography:

  Systematic Review

  Cochrane Database Syst Rev, 2001
  H. L. Halliday; R. A. Ehrenkranz

  [Preview] [Read]

• 3.   Increased expression of ICAM-1 and VCAM-1 in the lung of nitrofen-induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate pulmonary ICAM-1 and VCAM-1 expression in congenital diaphragmatic hernia lung in rats and to determine the effect of antenatal glucocorticoid

  

  Abstract:

  Recently, increased expression of inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been reported in both humans and animal models with CDH and the decreased TNF-alpha expression in CDH lung after antenatal dexamethasone (Dex) treatment. Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 are induced by several inflammatory cytokines such as more...

  Categories:

  antenatal glucocorticoid; congenital diaphragmatic hernia lung

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 19 Page: 365-70 July 2003
  K. Unemoto; M. Sakai; H. Shima; N. Guarino; P. Puri

  [Preview] [Read]

• 4.   Increased vascular endothelial growth factor peptide and gene expression in hypoplastic lung in nitrofen induced congenital diaphragmatic hernia in rats

  The aim of this study was to investigate mRNA and protein levels of vascular endothelial growth factor in congenital diaphragmatic hernia lung and to determine whether antenatal Dex treatment has any effect Vascular endothelial growth factor production

  

  Abstract:

  Persistent pulmonary hypertension (PPH) in congenital diaphragmatic hernia (CDH) lung has been shown to be associated with structural changes in the pulmonary vasculature, including medial and adventitial thickening. Vascular endothelial growth factor (VEGF) is a potent mitogenic and permeability factor targeting predominantly endothelial cells. mRNA encoding VEGF is detected in all more...

  Categories:

  mRNA and protein levels; congenital diaphragmatic hernia lung; vascular endothelial growth factor

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 18 Page: 221-6 May 2002
  T. Oue; A. Yoneda; H. Shima; Y. Taira; P. Puri

  [Preview] [Read]

• 5.   Postnatal steroids and chronic lung disease in the newborn

  This article discusse systematic reviews of randomised controlled trials of postnatal steroids (either systemic or inhaled) for CLD in the Cochrane Library were evaluated as a guide to clinical practice

  

  Abstract:

  INTRODUCTION: Chronic lung disease (CLD) represents a condition of persistent inflammation within the airways which may have its origin either in utero or after birth. Corticosteroids, because of their anti- inflammatory actions, have been used to modify the course of CLD. There have been almost 40 randomised controlled trials of postnatal dexamethasone and 12 of inhaled steroids. more...

  Geography:

  Northern Ireland

  Paediatr Respir Rev, Vol: 5 Suppl A Page: S245-8 2004
  H. L. Halliday

  [Preview] [Read]