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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Proto-Oncogene Proteins c-kit/analysis

Your search returns 4 documents

• 1.   Altered expression of interstitial cells of Cajal in congenital ureteropelvic junction obstruction

  The aim of this study was to examine the expression of c-kit positive cells in the muscle layer of normal and obstructed ureteropelvic junction specimens

  

  Abstract:

  PURPOSE: Peristaltic contractions in the upper urinary tract serve to move urine from the kidney through the ureter to the bladder. Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children. To our knowledge the pathophysiology of UPJ obstruction is unknown. C-kit positive interstitial cells of Cajal (ICCs) are pacemaker cells that more...

  International Classification:

  Procedure - ureteropelvic junction obstruction

  Categories:

  c-kit positive cells; - ureteropelvic junction obstruction

  Geography:

  Republic of Ireland

  J Urol, Vol: 170 Page: 2420-2 December 2003
  V. Solari; A. P. Piotrowska; P. Puri

  [Preview] [Read]

• 2.   Distribution of heme oxygenase-2 in nerves and interstitial cells of Cajal in the normal pylorus and in infantile hypertrophic pyloric stenosis

  The aim of this study was to examine the immunocolocalization of HO-2 and interstitial cells of Cajal in the normal pylorus and in infantile hypertrophic pyloric stenosis

  

  Abstract:

  CONTEXT: Interstitial cells of Cajal (ICCs) are pacemaker cells, which are of fundamental importance in regulating gastrointestinal motility. Recent evidence suggests that carbon monoxide is a neurotransmitter involved in neurotransmission between ICC and smooth muscle cells. Heme oxygenase-2 (HO-2) is the major physiological mechanism for the generation of carbon monoxide in the more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - congenital hypertrophic pyloric stenosis

  Categories:

  hypertrophic pyloric stenosis; immunocolocalization of HO-2 and interstitial cells of Cajal; -infantile hypertrophic pyloric stenosis

  Geography:

  Republic of Ireland

  Arch Pathol Lab Med, Vol: 127 Page: 1182-6 September 2003
  A. P. Piotrowska; V. Solari; P. Puri

  [Preview] [Read]

• 3.   Distribution of interstitial cells of Cajal in the internal anal sphincter of patients with internal anal sphincter achalasia and Hirschsprung disease

  The aim of this study was to examine the distribution of interstitial cells of Cajal in the normal internal anal sphincter and that of children diagnosed with internal anal sphincter achalasia and Hirschsprung disease

  

  Abstract:

  CONTEXT: Interstitial cells of Cajal (ICCs) are pacemaker cells in the smooth muscles of the gut. The internal anal sphincter (IAS) is the most caudal part of gastrointestinal tract. It has the important function of maintaining fecal continence. It has been proposed that ICCs in the IAS mediate the inhibitory innervation of the recto-anal reflexes. OBJECTIVE: To investigate the more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  internal anal sphincter achalasia; -Hirschsprung disease: internal anal sphincter achalasia

  Geography:

  Republic of Ireland

  Arch Pathol Lab Med, Vol: 127 Page: 1192-5 September 2003
  A. P. Piotrowska; V. Solari; P. Puri

  [Preview] [Read]

• 4.   Immunolocalization of the gap junction protein Connexin43 in the interstitial cells of Cajal in the normal and Hirschsprung's disease bowel

  The aim of this study was to investigate the immunolocalization of the Gap junction protein Connexin43 in the normal and Hirschsprung's disease bowel

  

  Abstract:

  BACKGROUND: Interstitial cells of Cajal (ICC) are pacemaker cells between gastrointestinal smooth muscles; they generate spontaneous slow waves of the smooth muscle layers and mediate neurotransmission. The cellular network of ICC is connected by Gap junctions to each other and to the smooth muscle cells. Although there have been several studies reporting distribution of ICC in the more...

  International Classification:

  Congenital malformations, deformations and chromosomal abnormalities - Other congenital malformations of the digestive system - Hirschsprung disease

  Categories:

  immunolocalization of the Gap junction protein Connexin43; -Hirschsprung's disease

  Geography:

  Republic of Ireland

  J Pediatr Surg, Vol: 35 Page: 823-8 June 2000
  L. Nemeth; S. Maddur; P. Puri

  [Preview] [Read]