Irish Child Health Database - Peer Reviewed Papers
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1. Children with stable asthma have reduced airway matrix metalloproteinase-9 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio
BACKGROUND: Childhood asthma is characterized by inflammation of the airways. Structural changes of the airway wall may also be seen in some children early in the course of the disease. Matrix metalloproteinases (MMPs) are key mediators in the metabolism of the extracellular matrix (ECM). OBJECTIVE: To investigate the balance of MMP-8, MMP-9 and tissue inhibitor of metalloproteinases more...
Diseases of the respiratory system - Chronic lower respiratory diseases - asthma
Clin Exp Allergy, Vol: 35 Page: 1168-74 September 2005
G. M. Doherty; S. V. Kamath; F. de Courcey; S. N. Christie; A. Chisakuta; J. D. Lyons; L. G. Heaney; M. Ennis; M. D. Shields
2. Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis
The diagnosis of neonatal sepsis is difficult, resulting in unnecessary treatment to minimize morbidity and mortality. We hypothesized that exposure to antenatal risk factors for sepsis alters the perinatal neutrophil phenotype. The study setting was a tertiary referral university-affiliated maternity and neonatal hospital. Neutrophils from adults, normal neonates, neonates with more...
Pregnancy, childbirth and the puerperium
antenatal sepsis;- altered perinatal neutrophil phenotype
Republic of Ireland
Clin Exp Immunol, Vol: 151 Page: 244-50 February 2008
E. J. Molloy; A. J. O'Neill; J. J. Grantham-Sloan; D. W. Webb; R. W. Watson