Accessibility
Legal Notices
Text Version

Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Neutrophils/immunology

Your search returns 2 documents

• 1.   Children with stable asthma have reduced airway matrix metalloproteinase-9 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio

  The aim of this study was to examine the balance of MMP-8, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 in the airways of children with asthma

  

  Abstract:

  BACKGROUND: Childhood asthma is characterized by inflammation of the airways. Structural changes of the airway wall may also be seen in some children early in the course of the disease. Matrix metalloproteinases (MMPs) are key mediators in the metabolism of the extracellular matrix (ECM). OBJECTIVE: To investigate the balance of MMP-8, MMP-9 and tissue inhibitor of metalloproteinases more...

  International Classification:

  Diseases of the respiratory system - Chronic lower respiratory diseases - asthma

  Categories:

  asthma

  Geography:

  Northern Ireland

  Clin Exp Allergy, Vol: 35 Page: 1168-74 September 2005
  G. M. Doherty; S. V. Kamath; F. de Courcey; S. N. Christie; A. Chisakuta; J. D. Lyons; L. G. Heaney; M. Ennis; M. D. Shields

  [Preview] [Read]

• 2.   Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis

  The aim of this study was to test the hypothesize that exposure to antenatal risk factors for sepsis alters the perinatal neutrophil phenotype

  

  Abstract:

  The diagnosis of neonatal sepsis is difficult, resulting in unnecessary treatment to minimize morbidity and mortality. We hypothesized that exposure to antenatal risk factors for sepsis alters the perinatal neutrophil phenotype. The study setting was a tertiary referral university-affiliated maternity and neonatal hospital. Neutrophils from adults, normal neonates, neonates with more...

  International Classification:

  Pregnancy, childbirth and the puerperium

  Categories:

  antenatal sepsis;- altered perinatal neutrophil phenotype

  Geography:

  Republic of Ireland

  Clin Exp Immunol, Vol: 151 Page: 244-50 February 2008
  E. J. Molloy; A. J. O'Neill; J. J. Grantham-Sloan; D. W. Webb; R. W. Watson

  [Preview] [Read]