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Irish Child Health Database - Peer Reviewed Papers

Database Search

How to use this database.

• Method 1- uses a free natural language approach.

  After choosing the object of the search – by ticking title, abstract, aims and objective, or author - enter a term, word or name in the ‘Search’ box to return references answering your research question.

• Method 2 - utilises key words.

  Those key words assigned from thesauruses of controlled vocabulary by the trained coders of international bibliographic databases.
  The controlled vocabularies key word are listed alphanumerically under 'Bibliographic database keywords' .
  Use the drop down menu to identity which 'key words' you are interested in to return references to answer your research question.

• Method 3 - is based on the indexing system

  developed by the researchers who compiled this database.
  It adopts a thematic approach to mapping Irish child health research. The themed areas represent outcomes mapped to the International Classification of Disease version 10 (ICD-10) or one of 23 other health-related themed outcomes. Themes are defined in Tables 5 to 7 (of the study report).
  Use the alphabetic drop down menu under ‘ICD-10 or themed health-related outcomes’ to identity which themed areas you are interested in to select references to answer your research question.

• Method 4 – allows papers to be searched by Study type.

  Indexing by study type offers a valuable insight into understanding the population impact of the topic of interest. More than 20 study types were identified across the 2,152 study papers. These are defined in Table 3 (of the study report). Within 'Study type' papers are further stratification by geographical region (Table 49), topic area of interest and study aims and objectives.
  Click on 'Study type' to select the type of study of interest, progressively select sub-categories by topic area or other sub-classification of interest to answer your research question.

The complete background, methods and findings from this mapping exercise are detailed in the study report.

Nitric Oxide Synthase Type II

Your search returns 5 documents

• 1.   Evidence of an inflammatory pathologic condition in "normal" appendices following emergency appendectomy

  The aim of the study was to study appendix specimens for the expression of inflammatory markers as an indicator of presence of an inflammatory response in this subgroup of patients

  

  Abstract:

  BACKGROUND: Appendices removed from patients with suspected appendicitis often appear normal on histologic examination. OBJECTIVE: To study appendix specimens for the expression of inflammatory markers as an indicator of presence of an inflammatory response in this subgroup of patients. METHODS: Cyclooxygenase 1 and 2, prostaglandin E(2), inducible nitric oxide synthase, and major more...

  International Classification:

  Diseases of the digestive system - Diseases of appendix - appendix

  Categories:

  appendix

  Geography:

  Republic of Ireland

  Arch Pathol Lab Med, Vol: 125 Page: 759-64 June 2001
  L. Nemeth; D. J. Reen; D. S. O'Briain; M. McDermott; P. Puri

  [Preview] [Read]

• 2.   Helicobacter pylori and tonsillectomy

  The aim of this study was to examine relationship between Helicobacter pylori and tonsillectomy

  

  Abstract:

  Tonsillar tissue is a component of mucosa-associated lymphoid tissue (MALT), which has evolved to protect vulnerable mucosal surfaces. Helicobacter pylori, implicated as an aetiological factor in duodenal ulcers and gastritis, induces the appearance of lymphoid aggregates (MALT) in the stomach. This organism is cytotoxic via a nitric oxide synthase cascade. The possibility that more...

  International Classification:

  Bacterium - Helicobacter pylori

  Categories:

  Helicobacter pylori and tonsillectomy

  Geography:

  Republic of Ireland

  Clin Otolaryngol Allied Sci, Vol: 26 Page: 505-9 December 2001
  L. J. Skinner; D. C. Winter; A. J. Curran; C. Barnes; S. Kennedy; A. J. Maguire; D. A. Charles; C. I. Timon; H. P. Burns

  [Preview] [Read]

• 3.   Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy

  The aim of this study was to investigate the expression of inducible nitric oxide synthase (iNOS) and M-CSF in the refluxing kidney, in order to further understand the pathogenesis of reflux nephropathy

  

  Abstract:

  BACKGROUND: Reflux nephropathy (RN) is a major cause of end-stage renal failure in children and young adults. Nitric oxide (NO) is an important mediator of tissue injury and inflammation. NO production is enhanced by hematopoietic growth factor including macrophage colony stimulating factor (M-CSF). M-CSF plays a pivotal role in the development of nephritis via macrophage activation. more...

  International Classification:

  Diseases of the genitourinary system - reflux nephropathy

  Categories:

  nitric oxide synthase; -reflux nephropathy

  Geography:

  Republic of Ireland

  Kidney Int, Vol: 62 Page: 507-13 August 2002
  U. Rolle; H. Shima; P. Puri

  [Preview] [Read]

• 4.   The role of nitric oxide in bladder urothelial injury after bladder outlet obstruction

  The aim of this study was to investigate the role of nitric oxide in the pathogenesis of injury to the bladder mucosa after bladder outlet obstruction

  

  Abstract:

  OBJECTIVE: To investigate the role of nitric oxide (NO) in the pathogenesis of injury to the bladder mucosa after bladder outlet obstruction (BOO). MATERIALS AND METHODS: The response of bladder mucosa to BOO consists of thickening with fibrous connective tissue; NO is a multipurpose messenger important in blood vessel relaxation, neuronal communication and inflammatory activities of more...

  Categories:

  nitric oxide; bladder injury

  Geography:

  Republic of Ireland

  BJU Int, Vol: 94 Page: 392-9 August 2004
  B. Chertin; U. Rolle; V. Solari; S. Cascio; P. Puri

  [Preview] [Read]

• 5.   The role of nitric oxide in reflux nephropathy

  The aim of this study was to investigate the expression of different isoforms of nitric oxide synthase in severe refluxing kidneys to understand the pathogenesis of reflux nephropathy in kidney specimens in children with severe reflux nephropathy

  

  Abstract:

  Reflux nephropathy (RN) is recognized as a major cause of end-stage renal failure in children and young adults. Inhibition of nitric oxide (NO) exacerbates and enhanced production ameliorates tubulointerstitial fibrosis (TIF) in experimental obstructive uropathy. NO is synthesised by NO synthase (NOS), three distinct isoforms of which have been identified: inducible (iNOS), endothelial more...

  International Classification:

  Diseases of the genitourinary system - reflux nephropathy

  Categories:

  nitric oxide synthase; refluxing kidneys/reflux nephropathy

  Geography:

  Republic of Ireland

  Pediatr Surg Int, Vol: 18 Page: 630-4 October 2002
  B. Chertin; U. Rolle; A. Farkas; P. Puri

  [Preview] [Read]