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Irish Child Health Database - Peer Reviewed Papers

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Irish Child Health Database » » N » Notochord/ drug effects/pathology/secretion

Notochord/ drug effects/pathology/secretion

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1. Adriamycin induces notochord hypertrophy with conservation of sonic hedgehog expression in abnormal ectopic notochord in the adriamycin rat model

The aim of this study was to test the hypothesis that Shh-expressing ectopic notochord could contribute to an increased volume of notochord relative to total embryo volume, resulting in an increased concentration of Shh in the notochord of embryos

Abstract:

BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the Vertebral, Anorectal, Cardiac, Tracheoesophageal, Renal, Limb (VACTERL) association. The notochord, which expresses Sonic Hedgehog (Shh), has been found to be grossly malformed with ventral ectopic branches in the foregut region of embryos in the ARM. The authors designed this study to test the more...

Categories:

Shh-expressing ectopic notochord; total embryo volume

Geography:

Republic of Ireland

J Pediatr Surg, Vol: 39 Page: 859-63 June 2004
A. Mortell; A. M. O'Donnell; S. Giles; J. Bannigan; P. Puri

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