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Embryo, Mammalian/drug effects
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The aim of this study was to investigate the hypothesise of increased cell death in adriamycin-exposed embryos
Abstract:
The adriamycin rat model (ARM) exhibits many features of the VACTERL association. Adriamycin is a cytotoxic drug used in cancer chemotherapy. Although its exact mode of action is not clear, it is presumed to have a similar cytotoxic role in the developing embryo. Lysotracker red (LT) is a dye that stains phagolysosomes and apoptotic bodies and allows entire rodent embryos to be stained more...
Categories:
adriamycin-exposed embryos; increased cell death;
Geography:
Republic of Ireland
Pediatr Surg Int,
Vol: 18 Page: 576-80 October 2002
J. Gillick; S. Giles; J. Bannigan; P. Puri
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The aim of this study was to assess notochord volume sequentially from gestational days 10 to 14 to test the hypothesis that notochord hypertrophy occurs maximally soon after Adriamycin administration
Abstract:
BACKGROUND/PURPOSE: The Adriamycin rat model (ARM) is a well-established model of the vertebral, anorectal, cardiac, tracheoesophageal, renal, and limb association. An important finding in the ARM is that Adriamycin induces abnormal notochord morphology in the region of the foregut. Having recently demonstrated notochord hypertrophy in ARM embryos, the authors designed this study to more...
Categories:
notochord volume; Adriamycin
Geography:
Republic of Ireland
J Pediatr Surg,
Vol: 40 Page: 403-6 February 2005
A. Mortell; J. Gillick; S. Giles; J. Bannigan; P. Puri
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